AU2014374043B2 - TRPA1 modulators - Google Patents

TRPA1 modulators Download PDF

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AU2014374043B2
AU2014374043B2 AU2014374043A AU2014374043A AU2014374043B2 AU 2014374043 B2 AU2014374043 B2 AU 2014374043B2 AU 2014374043 A AU2014374043 A AU 2014374043A AU 2014374043 A AU2014374043 A AU 2014374043A AU 2014374043 B2 AU2014374043 B2 AU 2014374043B2
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AU2014374043A1 (en
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Jeffrey M. Herz
Edward A. Kesicki
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ALGOMEDIX Inc
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ALGOMEDIX Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/10—Spiro-condensed systems
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    • C07D513/10—Spiro-condensed systems

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  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014374043A 2014-01-06 2014-12-23 TRPA1 modulators Ceased AU2014374043B2 (en)

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Application Number Priority Date Filing Date Title
US201461924119P 2014-01-06 2014-01-06
US61/924,119 2014-01-06
PCT/US2014/072291 WO2015103060A1 (en) 2014-01-06 2014-12-23 Trpa1 modulators

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AU2014374043A1 AU2014374043A1 (en) 2016-07-21
AU2014374043B2 true AU2014374043B2 (en) 2019-06-27

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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2936111C (en) 2014-01-06 2023-03-14 Algomedix, Inc. Trpa1 modulators
CA3006434C (en) * 2015-11-27 2021-03-16 Taiho Pharmaceutical Co., Ltd. Biphenyl compound or salt thereof
EP3481808A4 (en) * 2016-07-06 2020-07-15 Algomedix, Inc. TRPA1 ANTAGONISTS FOR THE TREATMENT OF DRY EYE SYNDROME, EYE PAIN AND INFLAMMATION
CN106580984A (zh) * 2016-12-12 2017-04-26 高群 一种治疗高血脂症的药物组合物
JP7178357B2 (ja) * 2017-03-07 2022-11-25 エフ．ホフマン－ラ ロシュ アーゲー オキサジアゾール一過性受容器電位チャネル阻害剤
HUE062769T2 (hu) 2017-05-26 2023-12-28 Taiho Pharmaceutical Co Ltd Antitumor potenciátor bifenil vegyület felhasználásával
CN110740991B (zh) 2017-05-26 2023-07-04 大鹏药品工业株式会社 新型联苯化合物或其盐
EP3633380A4 (en) 2017-05-31 2021-02-24 Taiho Pharmaceutical Co., Ltd. METHOD OF PREDICTING THE THERAPEUTIC EFFECT OF LSD1 INHIBITORS ON THE BASIS OF THE EXPRESSION OF INSM1
CN109596818B (zh) * 2018-12-13 2024-03-19 丁蓉 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法
WO2021095840A1 (en) 2019-11-13 2021-05-20 Taiho Pharmaceutical Co., Ltd. METHODS OF TREATING LSD1-RELATED DISEASES and Disorders WITH LSD1 INHIBITORS
JP7688339B2 (ja) * 2020-01-22 2025-06-04 国立研究開発法人理化学研究所 新規化合物、およびその利用
FR3114235A1 (fr) 2020-09-18 2022-03-25 Université Grenoble Alpes Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer
CN112694436B (zh) * 2020-12-30 2022-07-08 济南周行医药科技有限公司 一种槟榔碱的合成方法
IT202100015098A1 (it) 2021-06-09 2022-12-09 Flonext S R L Composto antagonista del canale trpa1 per uso in patologie degenerative della retina
WO2024099404A1 (zh) * 2022-11-10 2024-05-16 北京普祺医药科技股份有限公司 一种含氮螺环类化合物、药物组合物以及其用途
CN121735827A (zh) * 2026-02-27 2026-03-27 泰励生物科技（上海）有限公司 哌啶酮类化合物的制备方法
CN121735881A (zh) * 2026-02-27 2026-03-27 泰励生物科技（上海）有限公司 砜类化合物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015860A2 (en) * 2004-08-11 2006-02-16 Novartis Ag Pyrazole derivatives for treating conditions mediated by activation of the adenosine a2b or a3 receptor
EP1698626A1 (en) * 2003-12-26 2006-09-06 Daiichi Pharmaceutical Co., Ltd. Amidopyrazole derivative

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8429128D0 (en) * 1984-11-17 1984-12-27 Fisons Plc Heterocyclic compounds
EP0178035B1 (en) * 1984-05-12 1990-01-03 FISONS plc Anti-inflammatory 1,n-diarylpyrazol-3-amines, compositions containing them and processes for their preparation
JP2002502380A (ja) * 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼ阻害剤としてのピラゾール誘導体
JP2002514640A (ja) * 1998-05-14 2002-05-21 ジー・ディー・サール・アンド・カンパニー ｐ３８キナーゼ阻害剤としての１，５−ジアリール置換ピラゾール類
AU2004200420A1 (en) * 2003-03-11 2004-09-30 Astellas Pharma Inc. Inhibitor of cyclooxygenase
CN1809351A (zh) * 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
ES2297502T3 (es) 2003-10-23 2008-05-01 F. Hoffmann-La Roche Ag Derivados de triaza-espiropiperidinas para uso como inhibidores de glyt-1 en el tratamiento de trastornos neurologicos y neuropsiquiatricos.
ZA200605252B (en) * 2003-12-26 2007-11-28 Daiichi Seiyaku Co Amidopyrazole derivative
WO2007002563A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
AU2006327181A1 (en) 2005-12-22 2007-06-28 Hydra Biosciences, Inc. TRPA1 inhibitors for treating pain
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
CN101959861A (zh) 2008-01-04 2011-01-26 雅培制药有限公司 Trpa1拮抗剂
EP2300440B1 (en) 2008-06-02 2013-02-27 Janssen Pharmaceutica, N.V. 3,4-dihydropyrimidine trpa1 antagonists
WO2010125469A1 (en) * 2009-04-29 2010-11-04 Glenmark Pharmaceuticals, S.A. Pyrimidinedione-fused heterocyclic compounds as trpa1 modulators
EP2485737B1 (en) 2009-10-07 2014-06-25 Merck Sharp & Dohme Corp. Novel trpa1 antagonists
WO2012174362A1 (en) 2011-06-17 2012-12-20 Research Triangle Institute Pyrazole derivatives as cannabinoid receptor 1 antagonists
DE102011055815A1 (de) 2011-11-29 2013-05-29 Aicuris Gmbh & Co. Kg Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
SI2903965T1 (sl) 2012-10-01 2017-07-31 Orion Corporation Derivati n-prop-2-inil karboksamida in njihova uporaba kot antagonisti trpa1
CA2936111C (en) 2014-01-06 2023-03-14 Algomedix, Inc. Trpa1 modulators
EP3481808A4 (en) 2016-07-06 2020-07-15 Algomedix, Inc. TRPA1 ANTAGONISTS FOR THE TREATMENT OF DRY EYE SYNDROME, EYE PAIN AND INFLAMMATION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1698626A1 (en) * 2003-12-26 2006-09-06 Daiichi Pharmaceutical Co., Ltd. Amidopyrazole derivative
WO2006015860A2 (en) * 2004-08-11 2006-02-16 Novartis Ag Pyrazole derivatives for treating conditions mediated by activation of the adenosine a2b or a3 receptor

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