AU2014363428B2 - A chromone derivative as a dopamine D3 receptor antagonist for its use for the treatment of autism spectrum disorder - Google Patents

A chromone derivative as a dopamine D3 receptor antagonist for its use for the treatment of autism spectrum disorder Download PDF

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Publication number
AU2014363428B2
AU2014363428B2 AU2014363428A AU2014363428A AU2014363428B2 AU 2014363428 B2 AU2014363428 B2 AU 2014363428B2 AU 2014363428 A AU2014363428 A AU 2014363428A AU 2014363428 A AU2014363428 A AU 2014363428A AU 2014363428 B2 AU2014363428 B2 AU 2014363428B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
dioxolo
piperazin
dopamine
methanesulfonamide
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Ceased
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AU2014363428A
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AU2014363428A1 (en
Inventor
Agnes Auclair
Paul Moser
Pierre Sokoloff
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Pierre Fabre Medicament SA
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Pierre Fabre Medicament SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014363428A 2013-12-13 2014-12-12 A chromone derivative as a dopamine D3 receptor antagonist for its use for the treatment of autism spectrum disorder Ceased AU2014363428B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13306726.4 2013-12-13
EP13306726 2013-12-13
PCT/EP2014/077635 WO2015086836A1 (en) 2013-12-13 2014-12-12 A chromone derivative as a dopamine d3 receptor antagonist for its use for the treatment of autism spectrum disorder

Publications (2)

Publication Number Publication Date
AU2014363428A1 AU2014363428A1 (en) 2016-06-23
AU2014363428B2 true AU2014363428B2 (en) 2019-09-12

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AU2014363428A Ceased AU2014363428B2 (en) 2013-12-13 2014-12-12 A chromone derivative as a dopamine D3 receptor antagonist for its use for the treatment of autism spectrum disorder

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US (1) US10028948B2 (OSRAM)
EP (1) EP3079688B1 (OSRAM)
JP (1) JP6419826B2 (OSRAM)
KR (1) KR102280530B1 (OSRAM)
CN (1) CN105792824B (OSRAM)
AU (1) AU2014363428B2 (OSRAM)
BR (1) BR112016012552A8 (OSRAM)
CA (1) CA2932791C (OSRAM)
CY (1) CY1119907T1 (OSRAM)
DK (1) DK3079688T3 (OSRAM)
ES (1) ES2657706T3 (OSRAM)
HR (1) HRP20180323T8 (OSRAM)
HU (1) HUE036035T2 (OSRAM)
IL (1) IL245996B (OSRAM)
LT (1) LT3079688T (OSRAM)
MA (1) MA39076A1 (OSRAM)
MX (1) MX372922B (OSRAM)
MY (1) MY172937A (OSRAM)
NO (1) NO3079688T3 (OSRAM)
NZ (1) NZ720868A (OSRAM)
PL (1) PL3079688T3 (OSRAM)
PT (1) PT3079688T (OSRAM)
RS (1) RS56931B1 (OSRAM)
RU (2) RU2019104946A (OSRAM)
SA (1) SA516371298B1 (OSRAM)
SI (1) SI3079688T1 (OSRAM)
TN (1) TN2016000213A1 (OSRAM)
UA (1) UA117271C2 (OSRAM)
WO (1) WO2015086836A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ590852A (en) 2008-07-16 2013-03-28 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands trans-1{ 4-[2-[4-(2,3-dichlorophenyl)-piperizin-1-yl]-ethyl]-cyclohexyl} -3,3-dimethyl-urea also known as cariprazine
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN114787380A (zh) * 2019-09-11 2022-07-22 牛津生物动力公共有限公司 诊断用染色体标志物
KR20220021157A (ko) 2020-08-13 2022-02-22 원광대학교산학협력단 옥시토신 호르몬 증가효과를 갖는 자폐스펙트럼장애 아동 개선용 교육시스템

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539281A1 (fr) * 1991-10-23 1993-04-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés de naphtamides, leur procédé de préparation et leur application dans le domaine thérapeutique
DE4229880A1 (de) * 1992-09-04 1994-03-31 Knauf Siegfried Medikament bzw. Medikamentenzusammensetzung
WO2000021951A1 (en) * 1998-10-08 2000-04-20 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
WO2006034187A2 (en) * 2004-09-20 2006-03-30 Mount Sinai School Of Medicine Use of memantine (namenda) to treat autism, compulsivity, and impulsivity
EP2263665A1 (en) * 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
FR2949465A1 (fr) * 2009-09-01 2011-03-04 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
WO2011150380A1 (en) * 2010-05-28 2011-12-01 Xenoport, Inc. Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
WO2012168411A1 (fr) * 2011-06-09 2012-12-13 Pierre Fabre Medicament Utilisation de la carpipramine dans le traitement de troubles psychiatriques et du developpement chez l'enfant et l'adolescent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012157463A1 (en) * 2011-05-13 2012-11-22 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539281A1 (fr) * 1991-10-23 1993-04-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés de naphtamides, leur procédé de préparation et leur application dans le domaine thérapeutique
DE4229880A1 (de) * 1992-09-04 1994-03-31 Knauf Siegfried Medikament bzw. Medikamentenzusammensetzung
WO2000021951A1 (en) * 1998-10-08 2000-04-20 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
WO2006034187A2 (en) * 2004-09-20 2006-03-30 Mount Sinai School Of Medicine Use of memantine (namenda) to treat autism, compulsivity, and impulsivity
EP2263665A1 (en) * 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
FR2949465A1 (fr) * 2009-09-01 2011-03-04 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
WO2011150380A1 (en) * 2010-05-28 2011-12-01 Xenoport, Inc. Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
WO2012168411A1 (fr) * 2011-06-09 2012-12-13 Pierre Fabre Medicament Utilisation de la carpipramine dans le traitement de troubles psychiatriques et du developpement chez l'enfant et l'adolescent

Non-Patent Citations (4)

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Title
KING, B. H. et al. "Double-blind, Placebo-Controlled Study of Amantadine Hydrochloride in the Treatment of Children with Autistic Disorder" J. Am. Acad. Child Adolesc. Psychiatry (2001) vol. 40, no. 6, pages 658-665 *
LEMONNIER, E. "A randomised controlled trial of bumetanide in the treatment of autism in children" Transl. Psychiatry (2012) vol. 2, no. 12, page e202 *
MICHALON, A. et al. "Chronic Pharmacological mGlu5 Inhibtion Corrects Fragile X in Adult Mice" Neuron (2012) vol. 74, no. 1, pages 49-56 *
YOCHUM, C. L. et al. "Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice" Brain Research (2010) vol. 1349 pages 97-104 *

Also Published As

Publication number Publication date
JP6419826B2 (ja) 2018-11-07
SI3079688T1 (en) 2018-03-30
TN2016000213A1 (en) 2017-10-06
ES2657706T3 (es) 2018-03-06
RS56931B1 (sr) 2018-05-31
HRP20180323T1 (hr) 2018-04-06
WO2015086836A1 (en) 2015-06-18
PL3079688T3 (pl) 2018-05-30
PT3079688T (pt) 2018-02-28
HK1223563A1 (zh) 2017-08-04
MA39076A1 (fr) 2017-05-31
IL245996A0 (en) 2016-07-31
KR20160088886A (ko) 2016-07-26
LT3079688T (lt) 2018-02-12
JP2016540000A (ja) 2016-12-22
CA2932791A1 (en) 2015-06-18
AU2014363428A1 (en) 2016-06-23
CN105792824A (zh) 2016-07-20
KR102280530B1 (ko) 2021-07-21
DK3079688T3 (da) 2018-01-29
MX372922B (es) 2020-04-27
NO3079688T3 (OSRAM) 2018-04-21
MY172937A (en) 2019-12-16
MX2016007612A (es) 2016-09-09
NZ720868A (en) 2022-04-29
SA516371298B1 (ar) 2018-06-07
EP3079688B1 (en) 2017-11-22
CN105792824B (zh) 2018-08-03
BR112016012552A8 (pt) 2022-11-08
HRP20180323T8 (hr) 2019-01-25
RU2686110C1 (ru) 2019-04-24
US10028948B2 (en) 2018-07-24
UA117271C2 (uk) 2018-07-10
HUE036035T2 (hu) 2018-06-28
IL245996B (en) 2018-11-29
EP3079688A1 (en) 2016-10-19
US20160303117A1 (en) 2016-10-20
CY1119907T1 (el) 2018-06-27
CA2932791C (en) 2021-11-09
RU2019104946A (ru) 2019-04-01

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