AU2014352962B2 - APLNR modulators and uses thereof - Google Patents

APLNR modulators and uses thereof Download PDF

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Publication number
AU2014352962B2
AU2014352962B2 AU2014352962A AU2014352962A AU2014352962B2 AU 2014352962 B2 AU2014352962 B2 AU 2014352962B2 AU 2014352962 A AU2014352962 A AU 2014352962A AU 2014352962 A AU2014352962 A AU 2014352962A AU 2014352962 B2 AU2014352962 B2 AU 2014352962B2
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antibody
aplnr
apelin
antigen
binding fragment
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AU2014352962A1 (en
Inventor
Jesper Gromada
Jee H. Kim
Ivan B. Lobov
Andrew J. Murphy
Yonaton RAY
Panayiotis Stevis
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
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AU2014352962A 2013-11-20 2014-11-20 APLNR modulators and uses thereof Active AU2014352962B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361906568P 2013-11-20 2013-11-20
US61/906,568 2013-11-20
PCT/US2014/066687 WO2015077491A1 (en) 2013-11-20 2014-11-20 Aplnr modulators and uses thereof

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Publication Number Publication Date
AU2014352962A1 AU2014352962A1 (en) 2016-06-23
AU2014352962B2 true AU2014352962B2 (en) 2019-11-07

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US (7) US10155811B2 (enExample)
EP (1) EP3071600B1 (enExample)
JP (2) JP6483117B2 (enExample)
KR (1) KR20160086942A (enExample)
CN (1) CN105916881A (enExample)
AU (1) AU2014352962B2 (enExample)
BR (1) BR112016011401A2 (enExample)
CA (1) CA2931299C (enExample)
CL (1) CL2016001212A1 (enExample)
EA (1) EA201691027A1 (enExample)
IL (1) IL245733A0 (enExample)
MA (1) MA39061A1 (enExample)
MX (1) MX377716B (enExample)
PH (1) PH12016500943A1 (enExample)
WO (1) WO2015077491A1 (enExample)

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MY181199A (en) 2014-12-19 2020-12-21 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
CN107108729A (zh) 2015-02-05 2017-08-29 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il‑8‑结合抗体，及其应用
KR20180054824A (ko) * 2015-09-29 2018-05-24 셀진 코포레이션 Pd-1 결합 단백질 및 이의 사용 방법
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EP3228630A1 (en) 2016-04-07 2017-10-11 IMBA-Institut für Molekulare Biotechnologie GmbH Combination of an apelin antagonist and an angiogenesis inhibitor for the treatment of cancer
JP6527643B2 (ja) 2016-08-05 2019-06-05 中外製薬株式会社 Ｉｌ−８関連疾患の治療用又は予防用組成物
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BR112019004733A2 (pt) 2016-09-19 2019-05-28 Celgene Corp métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1
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CN110655577A (zh) * 2018-06-13 2020-01-07 鸿运华宁（杭州）生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用
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