AU2014320694B2 - Pyrrolidine derivatives as oxytocin / vasopressin V1a receptors antagonists - Google Patents

Pyrrolidine derivatives as oxytocin / vasopressin V1a receptors antagonists Download PDF

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AU2014320694B2
AU2014320694B2 AU2014320694A AU2014320694A AU2014320694B2 AU 2014320694 B2 AU2014320694 B2 AU 2014320694B2 AU 2014320694 A AU2014320694 A AU 2014320694A AU 2014320694 A AU2014320694 A AU 2014320694A AU 2014320694 B2 AU2014320694 B2 AU 2014320694B2
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compound
carbonyl
compound according
methyl
biphenyl
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AU2014320694A1 (en
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Andre Chollet
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Obseva SA
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Obseva SA
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    • C—CHEMISTRY; METALLURGY
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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AU2014320694A 2013-09-10 2014-07-25 Pyrrolidine derivatives as oxytocin / vasopressin V1a receptors antagonists Active AU2014320694B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018201730A AU2018201730B2 (en) 2013-09-10 2018-03-09 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS
AU2019201859A AU2019201859B2 (en) 2013-09-10 2019-03-18 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13183723.9 2013-09-10
EP13183723.9A EP2845850A1 (en) 2013-09-10 2013-09-10 Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
PCT/EP2014/066075 WO2015036160A1 (en) 2013-09-10 2014-07-25 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

Related Child Applications (1)

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AU2018201730A Division AU2018201730B2 (en) 2013-09-10 2018-03-09 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

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AU2014320694A1 AU2014320694A1 (en) 2016-04-21
AU2014320694B2 true AU2014320694B2 (en) 2017-12-14

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AU2014320694A Active AU2014320694B2 (en) 2013-09-10 2014-07-25 Pyrrolidine derivatives as oxytocin / vasopressin V1a receptors antagonists
AU2018201730A Active AU2018201730B2 (en) 2013-09-10 2018-03-09 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS
AU2019201859A Active AU2019201859B2 (en) 2013-09-10 2019-03-18 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

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Application Number Title Priority Date Filing Date
AU2018201730A Active AU2018201730B2 (en) 2013-09-10 2018-03-09 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS
AU2019201859A Active AU2019201859B2 (en) 2013-09-10 2019-03-18 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

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US (7) US20160221944A1 (enExample)
EP (4) EP2845850A1 (enExample)
JP (7) JP2016529258A (enExample)
KR (3) KR101749877B1 (enExample)
CN (4) CN109928905A (enExample)
AU (3) AU2014320694B2 (enExample)
BR (1) BR112016005276B1 (enExample)
CA (2) CA2979461C (enExample)
CY (1) CY1120152T1 (enExample)
DK (1) DK3044206T3 (enExample)
EA (2) EA202092300A1 (enExample)
ES (2) ES2914776T3 (enExample)
HU (1) HUE037578T2 (enExample)
IL (2) IL244152A (enExample)
MX (1) MX370602B (enExample)
PT (1) PT3044206T (enExample)
SG (2) SG10201800624SA (enExample)
SI (1) SI3044206T1 (enExample)
TR (1) TR201807175T4 (enExample)
UA (1) UA115708C2 (enExample)
WO (1) WO2015036160A1 (enExample)
ZA (1) ZA201704072B (enExample)

Families Citing this family (12)

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EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
AU2015283133B2 (en) * 2014-07-02 2019-05-16 ObsEva SA Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime useful in methods of treating conditions related to the OT-R activity
EP4144351A1 (en) 2016-01-04 2023-03-08 ObsEva S.A. Hydroxypropylthiazolidine carboxamide derivatives as inhibitors of the prostaglandin f receptor
US10780095B2 (en) 2016-04-06 2020-09-22 The Regents Of The University Of California Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
EP4541348A3 (en) * 2016-04-12 2025-06-04 Tonix Pharma Limited Magnesium-containing oxytocin formulations and methods of use
BR112019001047A2 (pt) * 2016-07-21 2019-04-30 ObsEva S.A. método para tratar um indivíduo submetido à terapia de transferência de embriões e kit
EP4025207A1 (en) * 2019-09-03 2022-07-13 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
EP4103750A1 (en) 2020-02-10 2022-12-21 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
RU2756027C1 (ru) * 2021-02-24 2021-09-24 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ диагностики наружного генитального эндометриоза
EP4593861A1 (en) * 2022-09-30 2025-08-06 Ferring B.V. Mixed vasopressin receptor agonist-antagonist for treating end-stage liver disease and complications associated thereof
TW202435864A (zh) 2023-02-09 2024-09-16 大陸商上海葆正醫藥科技有限公司 亞胺化合物及其製備方法和應用

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