AU2014310255B2 - Purification process for PTH - Google Patents

Purification process for PTH Download PDF

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Publication number
AU2014310255B2
AU2014310255B2 AU2014310255A AU2014310255A AU2014310255B2 AU 2014310255 B2 AU2014310255 B2 AU 2014310255B2 AU 2014310255 A AU2014310255 A AU 2014310255A AU 2014310255 A AU2014310255 A AU 2014310255A AU 2014310255 B2 AU2014310255 B2 AU 2014310255B2
Authority
AU
Australia
Prior art keywords
exchange chromatography
anion exchange
cation exchange
column
pth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014310255A
Other languages
English (en)
Other versions
AU2014310255A1 (en
Inventor
Sanjay Bandyopadhyay
Sanjeev Kumar Mendiratta
Avanish Kumar SINGH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AU2014310255A1 publication Critical patent/AU2014310255A1/en
Application granted granted Critical
Publication of AU2014310255B2 publication Critical patent/AU2014310255B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
AU2014310255A 2013-08-21 2014-08-21 Purification process for PTH Ceased AU2014310255B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2726/MUM/2013 2013-08-21
PCT/IN2014/000539 WO2015025335A1 (en) 2013-08-21 2014-08-21 Purification process for pth
IN2726MU2013 IN2013MU02726A (enExample) 2013-08-21 2014-08-21

Publications (2)

Publication Number Publication Date
AU2014310255A1 AU2014310255A1 (en) 2016-02-25
AU2014310255B2 true AU2014310255B2 (en) 2017-02-16

Family

ID=51862491

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014310255A Ceased AU2014310255B2 (en) 2013-08-21 2014-08-21 Purification process for PTH

Country Status (16)

Country Link
US (1) US20160200792A1 (enExample)
EP (1) EP3036252A1 (enExample)
JP (1) JP6046862B2 (enExample)
KR (1) KR101687686B1 (enExample)
CN (1) CN105473610A (enExample)
AU (1) AU2014310255B2 (enExample)
CA (1) CA2919604A1 (enExample)
EA (1) EA201690264A1 (enExample)
HK (1) HK1223378A1 (enExample)
IL (1) IL243642A (enExample)
IN (1) IN2013MU02726A (enExample)
MX (1) MX2016002274A (enExample)
NZ (1) NZ716205A (enExample)
SG (1) SG11201600511QA (enExample)
WO (1) WO2015025335A1 (enExample)
ZA (1) ZA201600424B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3012952B1 (fr) * 2013-11-08 2015-11-06 Essilor Int Methode de determination d'au moins un parametre de conception optique d'une lentille ophtalmique progressive
WO2019077432A1 (en) * 2017-10-16 2019-04-25 Intas Pharmaceuticals Ltd. IMPROVED PURIFICATION METHOD OF RECOMBINANT PTH (1-34)
CN107941983B (zh) * 2018-01-05 2020-05-15 北京博康健基因科技有限公司 一种rhPTH蛋白或rhPTH蛋白制剂的检测方法和纯度的分析方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019715A1 (en) * 2007-08-09 2009-02-12 Usv Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
WO2011151714A1 (en) * 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116952A (en) * 1986-07-18 1992-05-26 The University Of Melbourne Protein active in humoral hypercalcemia of malignancy-pthrp
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
ES2136458T3 (es) * 1996-06-14 1999-11-16 Takeda Chemical Industries Ltd Metodo para separar la metionina n-terminal.
AU7701398A (en) * 1997-05-30 1998-12-30 Bion, Inc. Large-scale isolation and purification of hif
DK1501369T3 (en) 2002-04-26 2015-09-28 Genentech Inc Non-affinity purification of proteins
EP1598075A1 (en) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Process for the isolation and / or purification of proteins
CN1706947A (zh) * 2004-06-04 2005-12-14 南京大学生物制药工程研究中心 重组人甲状旁腺激素在大肠杆菌中的构建、表达与纯化方法
DE602006014126D1 (de) * 2005-04-20 2010-06-17 Viromed Co Ltd Zusammensetzungen und verfahren zur trennung von fusionsproteinen
CN1861790A (zh) * 2006-04-25 2006-11-15 华东理工大学 重组人甲状旁腺激素1－84的制备方法
SG10201508401TA (en) * 2010-10-11 2015-11-27 Abbvie Bahamas Ltd Processes for purification of proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019715A1 (en) * 2007-08-09 2009-02-12 Usv Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
WO2011151714A1 (en) * 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins

Also Published As

Publication number Publication date
IN2013MU02726A (enExample) 2015-06-26
ZA201600424B (en) 2017-03-29
IL243642A0 (en) 2016-03-31
MX2016002274A (es) 2016-05-31
WO2015025335A8 (en) 2016-02-04
IL243642A (en) 2017-05-29
EP3036252A1 (en) 2016-06-29
US20160200792A1 (en) 2016-07-14
HK1223378A1 (zh) 2017-07-28
KR101687686B1 (ko) 2016-12-19
NZ716205A (en) 2017-05-26
CN105473610A (zh) 2016-04-06
EA201690264A1 (ru) 2016-06-30
KR20160027204A (ko) 2016-03-09
AU2014310255A1 (en) 2016-02-25
JP2016528173A (ja) 2016-09-15
WO2015025335A1 (en) 2015-02-26
JP6046862B2 (ja) 2016-12-21
SG11201600511QA (en) 2016-02-26
CA2919604A1 (en) 2015-02-26

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired