AU2014249274B2 - Devices with anti-thrombogenic and anti-microbial treatment - Google Patents
Devices with anti-thrombogenic and anti-microbial treatment Download PDFInfo
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- AU2014249274B2 AU2014249274B2 AU2014249274A AU2014249274A AU2014249274B2 AU 2014249274 B2 AU2014249274 B2 AU 2014249274B2 AU 2014249274 A AU2014249274 A AU 2014249274A AU 2014249274 A AU2014249274 A AU 2014249274A AU 2014249274 B2 AU2014249274 B2 AU 2014249274B2
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- alexidine
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
- C09D175/04—Polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Textile Engineering (AREA)
- Wood Science & Technology (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017201270A AU2017201270B2 (en) | 2013-03-11 | 2017-02-24 | Devices with anti-thrombogenic and anti-microbial treatment |
| AU2019200709A AU2019200709A1 (en) | 2013-03-11 | 2019-02-01 | Devices with anti-thrombogenic and anti-microbial treatment |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361776104P | 2013-03-11 | 2013-03-11 | |
| US61/776,104 | 2013-03-11 | ||
| US201361879623P | 2013-09-18 | 2013-09-18 | |
| US61/879,623 | 2013-09-18 | ||
| PCT/US2014/022574 WO2014164487A1 (fr) | 2013-03-11 | 2014-03-10 | Dispositif avec traitement antithrombogénique et antimicrobien |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017201270A Division AU2017201270B2 (en) | 2013-03-11 | 2017-02-24 | Devices with anti-thrombogenic and anti-microbial treatment |
Publications (2)
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|---|---|
| AU2014249274A1 AU2014249274A1 (en) | 2015-07-23 |
| AU2014249274B2 true AU2014249274B2 (en) | 2016-11-24 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| AU2014249274A Active AU2014249274B2 (en) | 2013-03-11 | 2014-03-10 | Devices with anti-thrombogenic and anti-microbial treatment |
| AU2017201270A Active AU2017201270B2 (en) | 2013-03-11 | 2017-02-24 | Devices with anti-thrombogenic and anti-microbial treatment |
| AU2019200709A Abandoned AU2019200709A1 (en) | 2013-03-11 | 2019-02-01 | Devices with anti-thrombogenic and anti-microbial treatment |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2017201270A Active AU2017201270B2 (en) | 2013-03-11 | 2017-02-24 | Devices with anti-thrombogenic and anti-microbial treatment |
| AU2019200709A Abandoned AU2019200709A1 (en) | 2013-03-11 | 2019-02-01 | Devices with anti-thrombogenic and anti-microbial treatment |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11850331B2 (fr) |
| EP (2) | EP2968677B1 (fr) |
| JP (1) | JP6228290B2 (fr) |
| CN (1) | CN105025943B (fr) |
| AU (3) | AU2014249274B2 (fr) |
| CA (1) | CA2897860C (fr) |
| WO (1) | WO2014164487A1 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| ES2797649T3 (es) | 2011-07-12 | 2020-12-03 | Icu Medical Inc | Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico |
| EP2968677B1 (fr) | 2013-03-11 | 2018-02-21 | Teleflex Medical, Incorporated | Dispositif avec traitement antithrombogénique et antimicrobien |
| WO2015168677A1 (fr) | 2014-05-02 | 2015-11-05 | Excelsior Medical Corporation | Emballage de bande pour bouchon antiseptique |
| US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
| AU2016262400B2 (en) | 2015-05-08 | 2021-01-21 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
| EP3325034A4 (fr) * | 2015-07-24 | 2019-03-27 | Teleflex Medical Incorporated | Dispositifs orthopédiques implantables présentant des revêtements antimicrobiens |
| CN107921283A (zh) * | 2015-07-24 | 2018-04-17 | 泰利福医疗公司 | 包括阿来西定的伤口护理产品 |
| EP3324739A4 (fr) * | 2015-07-24 | 2019-02-13 | Teleflex Medical Incorporated | Compositions antimicrobiennes destinées à des applications chirurgicales |
| US10471183B2 (en) | 2015-12-22 | 2019-11-12 | Access Vascular, Inc. | High strength biomedical materials |
| ES2929769T3 (es) | 2016-10-14 | 2022-12-01 | Icu Medical Inc | Tapas desinfectantes para conectores médicos |
| WO2018204206A2 (fr) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Raccords de fluide médical et procédés pour fournir des additifs dans des conduites de fluide médical |
| US11577008B2 (en) | 2017-06-21 | 2023-02-14 | Access Vascular, Inc. | High strength porous materials incorporating water soluble polymers |
| CN113038976A (zh) * | 2018-09-06 | 2021-06-25 | 比奥莫迪克斯有限公司 | 医疗管状装置 |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| JP7262206B2 (ja) * | 2018-11-07 | 2023-04-21 | 東ソー株式会社 | 溶出物試験方法 |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| EP3883638A1 (fr) | 2018-11-21 | 2021-09-29 | ICU Medical, Inc. | Dispositif antimicrobien comprenant un capuchon avec bague et insert |
| CA3183979A1 (fr) | 2020-06-30 | 2022-01-06 | Michael Bassett | Articles comprenant des marquages et procedes associes |
| CA3204371A1 (fr) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Capuchons, systemes et procedes de dialyse peritoneale |
| US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
| US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
| US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
| US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5102401A (en) * | 1990-08-22 | 1992-04-07 | Becton, Dickinson And Company | Expandable catheter having hydrophobic surface |
| US5902283A (en) * | 1995-04-24 | 1999-05-11 | Baylor College Of Medicine Board Of Regents | Antimicrobial impregnated catheters and other medical implants |
| US8308699B2 (en) * | 2008-12-05 | 2012-11-13 | Semprus Biosciences Corp. | Layered non-fouling, antimicrobial antithrombogenic coatings |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734097A (en) | 1981-09-25 | 1988-03-29 | Nippon Oil Company, Ltd. | Medical material of polyvinyl alcohol and process of making |
| JPS60187737U (ja) | 1984-05-23 | 1985-12-12 | オリンパス光学工業株式会社 | 留置チユ−ブガイド装置 |
| US4807626A (en) | 1985-02-14 | 1989-02-28 | Mcgirr Douglas B | Stone extractor and method |
| US4601713A (en) | 1985-06-11 | 1986-07-22 | Genus Catheter Technologies, Inc. | Variable diameter catheter |
| US4781677A (en) | 1985-07-17 | 1988-11-01 | Wilcox Gilbert M | Method of treatment utilizing a double balloon nasobiliary occlusion catheter |
| US4671291A (en) | 1986-03-31 | 1987-06-09 | Siemens Medical Systems, Inc. | Angle encoding catheter |
| US4722344A (en) | 1986-05-23 | 1988-02-02 | Critikon, Inc. | Radiopaque polyurethanes and catheters formed therefrom |
| US4893621A (en) | 1986-08-22 | 1990-01-16 | Heyman Arnold M | Slipover antegrade loading calculus extraction instrument system |
| US4832023A (en) | 1987-06-03 | 1989-05-23 | Mcm Laboratories, Inc. | Method and apparatus for reducing blockage in body channels |
| US4917667A (en) | 1988-02-11 | 1990-04-17 | Retroperfusion Systems, Inc. | Retroperfusion balloon catheter and method |
| US4898591A (en) | 1988-08-09 | 1990-02-06 | Mallinckrodt, Inc. | Nylon-PEBA copolymer catheter |
| US4955377A (en) | 1988-10-28 | 1990-09-11 | Lennox Charles D | Device and method for heating tissue in a patient's body |
| US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
| US5165952A (en) | 1989-01-18 | 1992-11-24 | Becton, Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
| US4925668A (en) | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
| DE9010130U1 (de) | 1989-07-13 | 1990-09-13 | American Medical Systems, Inc., Minnetonka, Minn. | Instrument zum Anbringen eines Aufweitimplantats |
| US5108416A (en) | 1990-02-13 | 1992-04-28 | C. R. Bard, Inc. | Stent introducer system |
| US5084054A (en) | 1990-03-05 | 1992-01-28 | C.R. Bard, Inc. | Surgical gripping instrument |
| US5059177A (en) | 1990-04-19 | 1991-10-22 | Cordis Corporation | Triple lumen balloon catheter |
| US5328698A (en) | 1990-08-06 | 1994-07-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic and/or anti-infective |
| US5108366A (en) | 1990-09-28 | 1992-04-28 | Ovamed Corporation | Delivery catheter |
| US5273527A (en) | 1992-05-12 | 1993-12-28 | Ovamed Corporation | Delivery catheter |
| US5167623A (en) | 1990-12-27 | 1992-12-01 | The Kendall Company | Multilumen catheter |
| US5241970A (en) | 1991-05-17 | 1993-09-07 | Wilson-Cook Medical, Inc. | Papillotome/sphincterotome procedures and a wire guide specially |
| US5167239A (en) | 1991-05-30 | 1992-12-01 | Endomedix Corporation | Anchorable guidewire |
| US5154725A (en) | 1991-06-07 | 1992-10-13 | Advanced Cardiovascular Systems, Inc. | Easily exchangeable catheter system |
| US5147370A (en) | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
| NL9101534A (nl) | 1991-09-10 | 1993-04-01 | Cordis Europ | Werkwijze voor het vervaardigen van een dubbel-lumencatheter, daarmee vervaardigde catheter en cathetersamenstel. |
| US5242428A (en) | 1991-10-04 | 1993-09-07 | Aubrey Palestrant | Apparatus for wetting hydrophilic-coated guide wires and catheters |
| US5201732A (en) | 1992-04-09 | 1993-04-13 | Everest Medical Corporation | Bipolar sphincterotomy utilizing side-by-side parallel wires |
| US5334143A (en) | 1992-04-17 | 1994-08-02 | Carroll Brendon J | Method to remove common bile duct stones |
| US6039755A (en) | 1997-02-05 | 2000-03-21 | Impra, Inc., A Division Of C.R. Bard, Inc. | Radially expandable tubular polytetrafluoroethylene grafts and method of making same |
| US5980530A (en) | 1996-08-23 | 1999-11-09 | Scimed Life Systems Inc | Stent delivery system |
| EP0920467A4 (fr) * | 1996-08-26 | 1999-10-13 | Tyndale Plains Hunter Ltd | Polyether-polyurethannes hydrophiles et hydrophobes et utilisations correspondantes |
| AUPO251096A0 (en) | 1996-09-23 | 1996-10-17 | Cardiac Crc Nominees Pty Limited | Polysiloxane-containing polyurethane elastomeric compositions |
| JP4226670B2 (ja) | 1997-08-08 | 2009-02-18 | 富士重工業株式会社 | 自動変速機のサブオイルフィルタ配置構造 |
| US5897911A (en) * | 1997-08-11 | 1999-04-27 | Advanced Cardiovascular Systems, Inc. | Polymer-coated stent structure |
| US20010001113A1 (en) | 1998-04-21 | 2001-05-10 | Florencia Lim | Balloon catheter |
| US6224579B1 (en) | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
| AUPP991799A0 (en) | 1999-04-23 | 1999-05-20 | Cardiac Crc Nominees Pty Limited | Siloxane-containing polyurethane-urea compositions |
| EP1180013B1 (fr) * | 1999-05-27 | 2006-03-08 | Biocompatibles UK Limited | Administration de medicament localisee |
| US6716895B1 (en) * | 1999-12-15 | 2004-04-06 | C.R. Bard, Inc. | Polymer compositions containing colloids of silver salts |
| US6565591B2 (en) | 2000-06-23 | 2003-05-20 | Salviac Limited | Medical device |
| US7029467B2 (en) | 2002-07-16 | 2006-04-18 | Edwards Lifesciences Corporation | Multiple lumen catheter having a soft tip |
| US20040097880A1 (en) | 2002-11-19 | 2004-05-20 | Angiodynamics, Inc. | Combination thrombolytic infusion catheter and dilator system |
| BRPI0410324A (pt) | 2003-05-15 | 2006-05-23 | Biomerix Corp | dispositivo implantável, processos de liofilização para produção de matriz elastomérica possuindo uma estrutura reticulada, de polimerização para a preparação de matriz elastomérica reticulada e de preparação de dispositivo implantável elastomérico de compósito reticulado, e, método para tratamento de uma desordem ortopédica |
| WO2006106361A1 (fr) | 2005-04-06 | 2006-10-12 | Dow Corning Corporation | Compositions d'organosiloxane |
| JP5054692B2 (ja) | 2005-08-23 | 2012-10-24 | アクゾ ノーベル コーティングス インターナショナル ビー ヴィ | 分散性ポリウレタン樹脂 |
| EP1924654B1 (fr) | 2005-08-25 | 2020-05-06 | University of Washington | Materiaux ralentissant considerablement le depot de salissures, a base de sulfobetaine et de carboxybetaine et procedes associes |
| US20110097277A1 (en) | 2005-08-25 | 2011-04-28 | University Of Washington | Particles coated with zwitterionic polymers |
| CA2630454C (fr) * | 2005-11-18 | 2014-05-27 | The Board Of Regents Of The University Of Texas System | Procede permettant de revetir des surfaces d'un agent antimicrobien |
| WO2007100776A2 (fr) | 2006-02-28 | 2007-09-07 | Becton, Dickinson And Company | Compositions antimicrobiennes et méthodes pour verrouiller des cathéters |
| CN101389693B (zh) | 2006-03-31 | 2011-07-20 | 陶氏康宁公司 | 制备硅氧烷聚醚的方法 |
| EP2069412B1 (fr) | 2006-08-07 | 2019-01-02 | University of Washington | Copolymères et hydrogels à charges mixtes |
| US8895047B2 (en) * | 2007-06-01 | 2014-11-25 | Arrow International, Inc. | Combined fibrinolytic and antimicrobial catheter and uses thereof |
| US8932624B2 (en) | 2007-06-20 | 2015-01-13 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| JP5474808B2 (ja) | 2007-11-19 | 2014-04-16 | ユニヴァーシティ オブ ワシントン | 制御された生物学的特性を有する双性イオン性ベタインへのカチオン性ベタイン前駆体 |
| WO2009085096A2 (fr) | 2007-12-05 | 2009-07-09 | Semprus Biosciences Corporation | Revêtements antimicrobiens sans décoloration et sans encrassement |
| CA2715269C (fr) * | 2008-02-22 | 2016-09-13 | Angiotech International Ag | Catheters anti-infectieux |
| WO2010039828A1 (fr) * | 2008-10-01 | 2010-04-08 | Teleflex Medical Incorporated | Article contenant un biguanide et un acide de lewis séparés |
| US20100135949A1 (en) | 2008-12-01 | 2010-06-03 | Becton, Dickinson And Company | Antimicrobial compositions |
| JP6150267B2 (ja) | 2008-12-05 | 2017-06-21 | アロー インターナショナル インコーポレイテッド | 非ファウリングで抗菌の抗血栓形成性グラフト−フロム組成物 |
| US8644952B2 (en) | 2009-09-02 | 2014-02-04 | Cardiac Pacemakers, Inc. | Medical devices including polyisobutylene based polymers and derivatives thereof |
| JP2011156589A (ja) | 2010-02-01 | 2011-08-18 | Shoji Sawada | 自動攪拌圧縮成形機の製造方法 |
| WO2011156589A2 (fr) * | 2010-06-09 | 2011-12-15 | Semprus Biosciences Corp. | Compositions antithrombogènes, antimicrobiennes et antisalissures à forme greffée |
| EP2750625A4 (fr) * | 2011-08-31 | 2015-08-19 | Univ Columbia | Réduction des biofilms sur des dispositifs médicaux |
| EP2968677B1 (fr) | 2013-03-11 | 2018-02-21 | Teleflex Medical, Incorporated | Dispositif avec traitement antithrombogénique et antimicrobien |
-
2014
- 2014-03-10 EP EP14778192.6A patent/EP2968677B1/fr active Active
- 2014-03-10 CN CN201480012218.7A patent/CN105025943B/zh active Active
- 2014-03-10 EP EP18153381.1A patent/EP3332817B1/fr active Active
- 2014-03-10 JP JP2016501005A patent/JP6228290B2/ja active Active
- 2014-03-10 WO PCT/US2014/022574 patent/WO2014164487A1/fr active Application Filing
- 2014-03-10 CA CA2897860A patent/CA2897860C/fr active Active
- 2014-03-10 AU AU2014249274A patent/AU2014249274B2/en active Active
- 2014-03-10 US US14/774,602 patent/US11850331B2/en active Active
-
2017
- 2017-02-24 AU AU2017201270A patent/AU2017201270B2/en active Active
-
2019
- 2019-02-01 AU AU2019200709A patent/AU2019200709A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5102401A (en) * | 1990-08-22 | 1992-04-07 | Becton, Dickinson And Company | Expandable catheter having hydrophobic surface |
| US5902283A (en) * | 1995-04-24 | 1999-05-11 | Baylor College Of Medicine Board Of Regents | Antimicrobial impregnated catheters and other medical implants |
| US8308699B2 (en) * | 2008-12-05 | 2012-11-13 | Semprus Biosciences Corp. | Layered non-fouling, antimicrobial antithrombogenic coatings |
Also Published As
| Publication number | Publication date |
|---|---|
| US11850331B2 (en) | 2023-12-26 |
| AU2017201270B2 (en) | 2018-11-01 |
| US20160015863A1 (en) | 2016-01-21 |
| AU2017201270A1 (en) | 2017-03-16 |
| CA2897860C (fr) | 2019-08-20 |
| CN105025943A (zh) | 2015-11-04 |
| JP2016512459A (ja) | 2016-04-28 |
| EP2968677B1 (fr) | 2018-02-21 |
| JP6228290B2 (ja) | 2017-11-08 |
| WO2014164487A1 (fr) | 2014-10-09 |
| AU2014249274A1 (en) | 2015-07-23 |
| EP2968677A1 (fr) | 2016-01-20 |
| AU2019200709A1 (en) | 2019-02-21 |
| CA2897860A1 (fr) | 2014-10-09 |
| EP2968677A4 (fr) | 2016-07-06 |
| CN105025943B (zh) | 2020-07-10 |
| EP3332817B1 (fr) | 2021-05-05 |
| EP3332817A1 (fr) | 2018-06-13 |
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