AU2014225052B2 - Novel nucleoside phosphoramidate compound and use thereof - Google Patents

Novel nucleoside phosphoramidate compound and use thereof Download PDF

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Publication number
AU2014225052B2
AU2014225052B2 AU2014225052A AU2014225052A AU2014225052B2 AU 2014225052 B2 AU2014225052 B2 AU 2014225052B2 AU 2014225052 A AU2014225052 A AU 2014225052A AU 2014225052 A AU2014225052 A AU 2014225052A AU 2014225052 B2 AU2014225052 B2 AU 2014225052B2
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alkyl
phenyl
alkenyl
halogenated
alkoxy
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AU2014225052A
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AU2014225052A1 (en
Inventor
Sheng BI
Hongyan Chen
Yiping Gao
Yuxiu LI
Yang Nan
Dezhong Wang
Yong Wang
Cang Zhang
Di Zhang
Xian Zhang
Liwen ZHAO
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Nanjing Sanhome Pharmaceutical Co Ltd
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Nanjing Sanhome Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epidemiology (AREA)
AU2014225052A 2013-03-08 2014-03-06 Novel nucleoside phosphoramidate compound and use thereof Active AU2014225052B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310075423 2013-03-08
CN201310075423.5 2013-03-08
PCT/CN2014/073004 WO2014135107A1 (zh) 2013-03-08 2014-03-06 新的核苷氨基磷酸酯化合物及其应用

Publications (2)

Publication Number Publication Date
AU2014225052A1 AU2014225052A1 (en) 2015-08-20
AU2014225052B2 true AU2014225052B2 (en) 2016-11-10

Family

ID=51462121

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014225052A Active AU2014225052B2 (en) 2013-03-08 2014-03-06 Novel nucleoside phosphoramidate compound and use thereof

Country Status (11)

Country Link
US (1) US9963480B2 (https=)
EP (1) EP2940031B1 (https=)
JP (1) JP6219414B2 (https=)
KR (1) KR101857337B1 (https=)
CN (4) CN108314697B (https=)
AU (1) AU2014225052B2 (https=)
BR (1) BR112015020472B1 (https=)
CA (1) CA2899763C (https=)
MX (1) MX374244B (https=)
RU (1) RU2621709C2 (https=)
WO (1) WO2014135107A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963480B2 (en) 2013-03-08 2018-05-08 Nanjing Sanhome Pharmaceutical Co., Ltd. Nucleoside phosphoramidate compound and use thereof

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CN104761604A (zh) * 2014-01-02 2015-07-08 江苏豪森药业股份有限公司 尿嘧啶核苷酸类似物及其制备方法和应用
CN105315319B (zh) * 2014-07-30 2020-11-20 南京圣和药业股份有限公司 丙型肝炎病毒抑制剂及其应用
US10526363B2 (en) 2014-08-15 2020-01-07 Merck Sharp & Dohme Corp. Substituted phosphoramidate compounds and uses thereof
WO2016044243A1 (en) * 2014-09-16 2016-03-24 Achillion Pharmaceuticals, Inc. Pyrimidine nucleoside phosphoramidate
CN105348342B (zh) * 2014-09-30 2018-09-21 南京正大天晴制药有限公司 核苷氨基磷酸酯化合物及药物组合物和用途
CN106132972B (zh) * 2015-02-06 2018-08-31 银杏树药业(苏州)有限公司 用于治疗hcv感染的氨基磷酸酯
CN106866737B (zh) * 2015-12-11 2020-11-20 南京圣和药物研发有限公司 膦酸衍生物及其应用
DK3512863T3 (da) * 2016-09-07 2022-03-07 Atea Pharmaceuticals Inc 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus
CN108602842B (zh) * 2016-11-02 2020-10-09 四川科伦博泰生物医药股份有限公司 杂环化合物及其制备方法和用途
US20190358214A1 (en) * 2016-11-17 2019-11-28 Abbvie Inc. Compositions and Methods for Treating HCV Infection
CN108218938B (zh) * 2016-12-13 2022-06-07 南京圣和药业股份有限公司 联苯核苷氨基磷酸酯化合物的晶型及其制备方法与用途
CN108218939B (zh) * 2016-12-13 2022-05-17 南京汇诚制药有限公司 联苯核苷氨基磷酸酯化合物的新晶型及制备方法
CN108218940A (zh) * 2016-12-13 2018-06-29 南京圣和药业股份有限公司 核苷氨基磷酸酯类化合物、其制备方法及用途
CN108218936B (zh) * 2016-12-13 2022-06-07 南京圣和药业股份有限公司 联苯核苷氨基磷酸酯化合物的异构体及其无定型物
CN121221626A (zh) * 2016-12-13 2025-12-30 南京汇诚制药有限公司 新的核苷氨基磷酸脂化合物的组合物及其制备方法
CN108218937B (zh) * 2016-12-13 2022-06-07 南京圣和药业股份有限公司 核苷氨基磷酸酯类化合物的光学异构体及其应用
CN108201539B (zh) * 2016-12-16 2022-04-19 南京汇诚制药有限公司 联苯核苷氨基磷酸酯化合物的应用
CN109419806B (zh) * 2017-08-23 2023-06-20 南京圣和药业股份有限公司 抗病毒组合物及其应用
CN108997426B (zh) * 2018-07-19 2020-11-13 大连理工大学 靶向Hsp60的黄酮烷氧基氨基磷酸酯衍生物、制备及应用
EP3997098A4 (en) * 2019-07-12 2023-10-11 Canopy Growth Corporation CANNABINOIDS DERIVATIVES

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WO2008121634A2 (en) * 2007-03-30 2008-10-09 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs

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US20020147175A1 (en) * 2000-11-16 2002-10-10 Shepard H. Michael Synergistic ECTA compositions
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CA2584367A1 (en) 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection
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AR056327A1 (es) * 2005-04-25 2007-10-03 Genelabs Tech Inc Compuestos de nucleosidos para el tratamiento de infecciones virales
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PT2376088T (pt) 2008-12-23 2017-05-02 Gilead Pharmasset Llc Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
JO3027B1 (ar) * 2009-05-14 2016-09-05 Janssen Products Lp نيوكليوسيدات يوراسيل سبيرواوكسيتان
BR112013005872A2 (pt) * 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2755985B1 (en) * 2011-09-12 2017-11-01 Idenix Pharmaceuticals LLC Compounds and pharmaceutical compositions for the treatment of viral infections
MY171577A (en) * 2011-12-20 2019-10-21 Hoffmann La Roche 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
JP6219414B2 (ja) 2013-03-08 2017-10-25 ナンジン・サンホーム・ファーマシューティカル・カンパニー・リミテッドＮａｎｊｉｎｇ Ｓａｎｈｏｍｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． 新規なヌクレオシドホスホロアミデート化合物およびその使用
CN104761604A (zh) * 2014-01-02 2015-07-08 江苏豪森药业股份有限公司 尿嘧啶核苷酸类似物及其制备方法和应用

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2008121634A2 (en) * 2007-03-30 2008-10-09 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963480B2 (en) 2013-03-08 2018-05-08 Nanjing Sanhome Pharmaceutical Co., Ltd. Nucleoside phosphoramidate compound and use thereof

Also Published As

Publication number Publication date
EP2940031A1 (en) 2015-11-04
CN104031104B (zh) 2018-04-10
JP6219414B2 (ja) 2017-10-25
HK1210619A1 (en) 2016-04-29
CA2899763C (en) 2020-03-10
MX2015011473A (es) 2016-05-31
KR101857337B1 (ko) 2018-05-11
US9963480B2 (en) 2018-05-08
BR112015020472B1 (pt) 2021-01-19
CN108546277A (zh) 2018-09-18
EP2940031A4 (en) 2016-01-27
JP2016510043A (ja) 2016-04-04
US20150361123A1 (en) 2015-12-17
CN109503686A (zh) 2019-03-22
KR20150132230A (ko) 2015-11-25
EP2940031B1 (en) 2017-09-27
RU2621709C2 (ru) 2017-06-07
CA2899763A1 (en) 2014-09-12
MX374244B (es) 2025-03-05
RU2015142682A (ru) 2017-04-13
CN109503686B (zh) 2022-03-11
CN104031104A (zh) 2014-09-10
BR112015020472A2 (pt) 2020-01-28
AU2014225052A1 (en) 2015-08-20
CN108546277B (zh) 2021-05-07
CN108314697A (zh) 2018-07-24
CN108314697B (zh) 2021-05-07
WO2014135107A1 (zh) 2014-09-12

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