AU2014205043B2 - 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives - Google Patents
3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives Download PDFInfo
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- AU2014205043B2 AU2014205043B2 AU2014205043A AU2014205043A AU2014205043B2 AU 2014205043 B2 AU2014205043 B2 AU 2014205043B2 AU 2014205043 A AU2014205043 A AU 2014205043A AU 2014205043 A AU2014205043 A AU 2014205043A AU 2014205043 B2 AU2014205043 B2 AU 2014205043B2
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- phenyl
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- 0 *[C@](CCC(N1)=C)(C1=O)N(C(*)=Nc1cccc(*)c11)C1=O Chemical compound *[C@](CCC(N1)=C)(C1=O)N(C(*)=Nc1cccc(*)c11)C1=O 0.000 description 15
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361752055P | 2013-01-14 | 2013-01-14 | |
| US61/752,055 | 2013-01-14 | ||
| US201361786024P | 2013-03-14 | 2013-03-14 | |
| US61/786,024 | 2013-03-14 | ||
| PCT/US2014/011440 WO2014110558A1 (en) | 2013-01-14 | 2014-01-14 | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014205043A1 AU2014205043A1 (en) | 2015-07-23 |
| AU2014205043B2 true AU2014205043B2 (en) | 2018-10-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014205043A Active AU2014205043B2 (en) | 2013-01-14 | 2014-01-14 | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9540340B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2943201B2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6359563B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014205043B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2935495C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014110558A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5388854B2 (ja) | 2006-09-26 | 2014-01-15 | セルジーン コーポレイション | 5−置換キナゾリノン誘導体、それを含む組成物、及びその使用方法 |
| SMT201800032T1 (it) | 2011-03-11 | 2018-03-08 | Celgene Corp | Forme solide di 3-(5-ammino-2-metil-4-osso-4h-chinazolin-3-il)-piperidina-2,6-dione, e loro composizioni farmaceutiche e usi |
| AU2012236655B2 (en) | 2011-03-28 | 2016-09-22 | Deuterx, Llc, | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| US9682952B2 (en) * | 2012-09-04 | 2017-06-20 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof |
| WO2014110558A1 (en) | 2013-01-14 | 2014-07-17 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| EP2968334A4 (en) | 2013-03-14 | 2016-08-03 | Deuterx Llc | 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES |
| EP3199532A1 (en) * | 2013-05-01 | 2017-08-02 | Celgene Corporation | Intermediate for the synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione |
| TW201540323A (zh) * | 2014-01-15 | 2015-11-01 | Celgene Corp | 3-(5-胺基-2-甲基-4-側氧基-4h-喹唑啉-3-基)-哌啶-2,6-二酮之調配物 |
| US10973822B2 (en) | 2015-07-02 | 2021-04-13 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
| KR102331013B1 (ko) | 2016-01-14 | 2021-11-26 | 강푸 바이오파마슈티칼즈 리미티드 | 퀴나졸리논 유도체, 이의 제조방법, 약학 조성물 및 적용 |
| DK3527210T3 (da) | 2016-12-16 | 2021-08-09 | Kangpu Biopharmaceuticals Inc | Kombineret sammensætning omfattende en benzoheterocyklisk forbindelse og en androgenreceptorvejsmodulator samt anvendelser deraf |
| KR102014478B1 (ko) | 2017-05-12 | 2019-08-26 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| WO2018208123A1 (ko) * | 2017-05-12 | 2018-11-15 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| WO2019126704A1 (en) * | 2017-12-22 | 2019-06-27 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-azepanediones and related compounds and methods of treating medical disorders using same |
| US11807620B2 (en) | 2020-02-21 | 2023-11-07 | Plexium, Inc. | Quinazolinone compounds and related compounds |
| CN116194440A (zh) * | 2020-07-24 | 2023-05-30 | 伊尼制药公司 | 喹唑啉酮hsd17b13抑制剂及其用途 |
| EP4244210A4 (en) | 2020-11-13 | 2024-10-30 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
| WO2024108028A1 (en) * | 2022-11-16 | 2024-05-23 | Salarius Pharmaceuticals, Inc. | Methods of use of deuterium-enriched compounds |
| AU2024206378A1 (en) * | 2023-01-06 | 2025-07-10 | Salarius Pharmaceuticals, Inc | Solid forms and methods of use |
| WO2024220489A1 (en) | 2023-04-18 | 2024-10-24 | Salarius Pharmaceuticals, Inc. | Deuterium-enriched compound for use in a method of treatment of multiple myeloma |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014039421A1 (en) * | 2012-09-04 | 2014-03-13 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof |
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| US9540340B2 (en) | 2017-01-10 |
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