AU2013369288B2 - Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same - Google Patents

Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same Download PDF

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Publication number
AU2013369288B2
AU2013369288B2 AU2013369288A AU2013369288A AU2013369288B2 AU 2013369288 B2 AU2013369288 B2 AU 2013369288B2 AU 2013369288 A AU2013369288 A AU 2013369288A AU 2013369288 A AU2013369288 A AU 2013369288A AU 2013369288 B2 AU2013369288 B2 AU 2013369288B2
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AU
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propyl
disease
pct
sulphate salt
pharmaceutically acceptable
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AU2013369288A
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AU2013369288A8 (en
AU2013369288A1 (en
Inventor
Mathieu BARRIER
Luc Buee
Stephane Burlet
Cecilia Estrella
Patricia Melnyk
Nicolas Sergeant
Philippe Verwaerde
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Institut National de la Santé et de la Recherche Médicale
Université de Lille
Alzprotect SAS
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Institut National de la Santé et de la Recherche Médicale
Université de Lille
Alzprotect SAS
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Publication of AU2013369288A1 publication Critical patent/AU2013369288A1/en
Publication of AU2013369288A8 publication Critical patent/AU2013369288A8/en
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Priority to AU2018202218A priority Critical patent/AU2018202218B2/en
Assigned to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ALZPROTECT, Université de Lille reassignment INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) Request for Assignment Assignors: ALZPROTECT, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE LILLE 2 DROIT ET SANTE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013369288A 2012-12-27 2013-12-27 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same Active AU2013369288B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018202218A AU2018202218B2 (en) 2012-12-27 2018-03-28 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl) -1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306690.4 2012-12-27
EP12306690 2012-12-27
PCT/EP2013/078068 WO2014102339A1 (en) 2012-12-27 2013-12-27 Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018202218A Division AU2018202218B2 (en) 2012-12-27 2018-03-28 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl) -1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Publications (3)

Publication Number Publication Date
AU2013369288A1 AU2013369288A1 (en) 2015-07-02
AU2013369288A8 AU2013369288A8 (en) 2015-07-16
AU2013369288B2 true AU2013369288B2 (en) 2018-02-22

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AU2013369288A Active AU2013369288B2 (en) 2012-12-27 2013-12-27 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
AU2018202218A Active AU2018202218B2 (en) 2012-12-27 2018-03-28 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl) -1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same

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AU2018202218A Active AU2018202218B2 (en) 2012-12-27 2018-03-28 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl) -1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Country Status (23)

Country Link
US (3) US9562018B2 (enExample)
EP (1) EP2938597B1 (enExample)
JP (1) JP6384923B2 (enExample)
KR (1) KR102115060B1 (enExample)
CN (1) CN105008333B (enExample)
AU (2) AU2013369288B2 (enExample)
BR (1) BR112015015474B1 (enExample)
CA (1) CA2895285C (enExample)
DK (1) DK2938597T3 (enExample)
ES (1) ES2605494T3 (enExample)
HR (1) HRP20161612T2 (enExample)
HU (1) HUE030930T2 (enExample)
IL (1) IL239450B (enExample)
LT (1) LT2938597T (enExample)
MX (1) MX363367B (enExample)
NZ (1) NZ708959A (enExample)
PL (1) PL2938597T3 (enExample)
PT (1) PT2938597T (enExample)
RS (1) RS55511B1 (enExample)
RU (1) RU2655454C2 (enExample)
SI (1) SI2938597T1 (enExample)
WO (1) WO2014102339A1 (enExample)
ZA (1) ZA201504521B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105008333B (zh) 2012-12-27 2018-02-09 雅尔兹普罗泰特公司 N‑(3‑(4‑(3‑(二异丁基氨基)丙基)哌嗪‑1‑基)丙基)‑1H‑苯并[d]咪唑‑2‑胺的硫酸盐、其制备及其用途
HK1245272B (en) 2015-03-16 2019-09-27 Institut National De La Santé Et De La Recherche Médicale (Inserm) Novel 1,4-bis(3-aminopropyl)piperazine derivative and its use
TWI744300B (zh) * 2016-03-23 2021-11-01 里爾中央醫學中心 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途
CN116249693A (zh) * 2020-10-01 2023-06-09 雅尔兹普罗泰特公司 N-(3-(4-(3-(二异丁基氨基)丙基)哌嗪-1-基)丙基)-1H-苯并[d]咪唑-2-胺的琥珀酸盐，其制备及其用途
JP7500875B2 (ja) * 2020-10-07 2024-06-17 アルツプロテクト 運動ニューロン疾患及び神経筋接合部障害の処置のためのｎ－（３－（４－（３－（ジイソブチルアミノ）プロピル）ピペラジン－１－イル）プロピル）－１ｈ－ベンゾ［ｄ］イミダゾール－２－アミン硫酸塩及びそれらの溶媒和物の使用
IL313403A (en) * 2021-12-20 2024-08-01 Alzprotect USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE SUCCINATE SALTS AND SOLVATES THEREOF FOR THE TREATMENT OF MOTOR NEURON DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS
ES3075524T3 (en) 2022-03-25 2026-08-05 Alzprotect Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine salts and solvates thereof for the treatment of sensory neuron diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006051489A1 (en) * 2004-11-10 2006-05-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
JP2001500162A (ja) * 1997-06-12 2001-01-09 トランジェーヌ、ソシエテ、アノニム 少なくとも１種の治療上有効な物質、特にポリヌクレオチド、を標的細胞に導入するための新規脂質複合体および遺伝子治療における使用
CN1325397A (zh) * 1998-09-30 2001-12-05 纽罗根公司 2－哌嗪烷基氨基苯并吡咯衍生物∶多巴胺受体亚型特异配体
WO2002096431A1 (en) * 2001-05-25 2002-12-05 The Regents Of The University Of California Optically active compounds clearing malformed proteins
US20040116441A1 (en) * 2002-10-30 2004-06-17 Pfizer Inc Methods of using sulfonic acid derivatives
CA2509406C (en) * 2002-12-23 2012-07-03 Janssen Pharmaceutica N.V. Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
CN105008333B (zh) * 2012-12-27 2018-02-09 雅尔兹普罗泰特公司 N‑(3‑(4‑(3‑(二异丁基氨基)丙基)哌嗪‑1‑基)丙基)‑1H‑苯并[d]咪唑‑2‑胺的硫酸盐、其制备及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006051489A1 (en) * 2004-11-10 2006-05-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases

Also Published As

Publication number Publication date
HUE030930T2 (hu) 2017-06-28
LT2938597T (lt) 2017-01-25
BR112015015474B1 (pt) 2022-04-19
US20190381036A1 (en) 2019-12-19
AU2013369288A8 (en) 2015-07-16
PT2938597T (pt) 2016-12-09
NZ708959A (en) 2019-11-29
RS55511B1 (sr) 2017-05-31
HRP20161612T1 (hr) 2017-01-27
AU2018202218A1 (en) 2018-04-26
US10772884B2 (en) 2020-09-15
CN105008333B (zh) 2018-02-09
ES2605494T3 (es) 2017-03-14
AU2013369288A1 (en) 2015-07-02
US10537569B2 (en) 2020-01-21
EP2938597B1 (en) 2016-10-26
KR102115060B1 (ko) 2020-05-25
DK2938597T3 (en) 2017-01-09
BR112015015474A2 (enExample) 2017-08-15
US20170151235A1 (en) 2017-06-01
MX363367B (es) 2019-03-20
HRP20161612T2 (hr) 2017-02-24
HK1215582A1 (en) 2016-09-02
IL239450A0 (en) 2015-07-30
EP2938597A1 (en) 2015-11-04
RU2655454C2 (ru) 2018-05-29
US9562018B2 (en) 2017-02-07
ZA201504521B (en) 2016-11-30
RU2015130671A (ru) 2017-01-30
US20160108003A1 (en) 2016-04-21
CA2895285A1 (en) 2014-07-03
JP2016503813A (ja) 2016-02-08
AU2018202218B2 (en) 2019-02-21
CN105008333A (zh) 2015-10-28
SI2938597T1 (sl) 2017-03-31
WO2014102339A1 (en) 2014-07-03
MX2015008502A (es) 2015-12-16
IL239450B (en) 2018-06-28
KR20150105313A (ko) 2015-09-16
CA2895285C (en) 2021-03-30
JP6384923B2 (ja) 2018-09-05
PL2938597T3 (pl) 2017-03-31

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Free format text: IN VOL 29 , NO 25 , PAGE(S) 3709 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME UNIVERSITE LILLE 2 DROIT ET SANTE; ALZPROTECT, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), APPLICATION NO. 2013369288, UNDER INID (71) CORRECT THE APPLICANT NAME TO UNIVERSITE DE LILLE 2 DROIT ET SANTE, UNDER INID (54) CORRECT THE TITLE TO READ SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1HBENZO(D)IMIDAZOL-2-AMINE, PREPARATION THEREOF AND USE OF THE SAME

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Owner name: UNIVERSITE DE LILLE

Free format text: FORMER OWNER(S): UNIVERSITE DE LILLE 2 DROIT ET SANTE; ALZPROTECT; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Free format text: FORMER OWNER(S): UNIVERSITE DE LILLE 2 DROIT ET SANTE; ALZPROTECT; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Owner name: ALZPROTECT

Free format text: FORMER OWNER(S): UNIVERSITE DE LILLE 2 DROIT ET SANTE; ALZPROTECT; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)