AU2013351947A1 - Method for evaluation of presence of or risk of colon tumors - Google Patents
Method for evaluation of presence of or risk of colon tumors Download PDFInfo
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- AU2013351947A1 AU2013351947A1 AU2013351947A AU2013351947A AU2013351947A1 AU 2013351947 A1 AU2013351947 A1 AU 2013351947A1 AU 2013351947 A AU2013351947 A AU 2013351947A AU 2013351947 A AU2013351947 A AU 2013351947A AU 2013351947 A1 AU2013351947 A1 AU 2013351947A1
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Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| US9726668B2 (en) | 2012-02-09 | 2017-08-08 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| AU2015237229A1 (en) * | 2014-03-28 | 2016-11-10 | Applied Proteomics, Inc. | Protein biomarker profiles for detecting colorectal tumors |
| KR20170029531A (ko) * | 2014-07-11 | 2017-03-15 | 익스프레션 패톨로지, 인크. | GTPase KRas 단백질(KRas)에 대한 SRM/MRM 검정 |
| CA3190715A1 (en) | 2014-08-14 | 2016-02-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| JP2017532699A (ja) * | 2014-09-05 | 2017-11-02 | ナントミクス,エルエルシー | 起源の判定のためのシステムと方法 |
| AU2015360420B2 (en) * | 2014-12-11 | 2021-12-09 | Wisconsin Alumni Research Foundation | Methods for detection and treatment of colorectal cancer |
| CN107209184B (zh) | 2014-12-11 | 2020-04-24 | 米密德诊断学有限公司 | 用于诊断多种感染的标记组合及其使用方法 |
| CN105807062A (zh) * | 2014-12-28 | 2016-07-27 | 复旦大学 | 人结肠癌蛋白Spondin-2在制备结肠癌诊断制剂中的应用 |
| CN105385752A (zh) * | 2015-03-23 | 2016-03-09 | 复旦大学 | 一种人结肠癌蛋白质标志物Spondin-2的检测方法及其检测试剂盒 |
| GB2545361B (en) * | 2015-04-10 | 2018-01-24 | Applied Proteomics Inc | Methods of assessing colorectal cancer status |
| JP7002037B2 (ja) * | 2015-07-01 | 2022-02-04 | デューク・ユニヴァーシティ | 急性呼吸器感染症を診断および処置するための方法 |
| EP3371605B1 (en) * | 2015-11-05 | 2021-06-23 | Vanderbilt University | Protein quantitation in multicellular tissue specimens |
| WO2017149548A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| US20190130994A1 (en) * | 2016-04-11 | 2019-05-02 | Discerndx, Inc. | Mass Spectrometric Data Analysis Workflow |
| JP6754116B2 (ja) * | 2016-04-26 | 2020-09-09 | 学校法人近畿大学 | 大腸癌マーカー |
| CN107345236A (zh) * | 2016-05-04 | 2017-11-14 | 北京美泽福临科技发展有限公司 | 一种amy2b信使rna的特异性扩增引物和肝癌辅助诊断试剂盒 |
| WO2017214625A1 (en) * | 2016-06-10 | 2017-12-14 | Wisconsin Alumni Research Foundation | Methods for detection, staging, and surveillance of colorectal adenomas and carcinomas |
| EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| EP3482201B1 (en) | 2016-07-10 | 2022-12-14 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| CN106202984B (zh) * | 2016-08-26 | 2018-09-04 | 赵毅 | 一种基于多层复杂网络对肿瘤miRNA标志物的筛选方法 |
| EP3519834A4 (en) * | 2016-09-29 | 2020-06-17 | MeMed Diagnostics Ltd. | RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS |
| WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| US20180100858A1 (en) * | 2016-10-07 | 2018-04-12 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| JP6813033B2 (ja) * | 2017-01-19 | 2021-01-13 | 株式会社島津製作所 | 分析データ解析方法および分析データ解析装置 |
| US11204355B2 (en) | 2017-02-20 | 2021-12-21 | Vanderbilt University | Immune checkpoint molecular fitness profiling by mass spectrometry |
| CN106919801B (zh) * | 2017-03-08 | 2023-07-18 | 杭州大伽信息科技有限公司 | 一种免疫组织化学染色辅助分析系统及使用方法 |
| CN106908608B (zh) * | 2017-04-17 | 2018-10-02 | 首都医科大学附属北京胸科医院 | 辅助诊断重症继发性肺结核的蛋白标志物 |
| US20180330059A1 (en) * | 2017-05-09 | 2018-11-15 | James Stewart Bates | Patient treatment systems and methods |
| US10455457B2 (en) | 2017-05-24 | 2019-10-22 | Qualcomm Incorporated | NR-SS unified operation mode in coordinated and uncoordinated bands |
| US11164679B2 (en) | 2017-06-20 | 2021-11-02 | Advinow, Inc. | Systems and methods for intelligent patient interface exam station |
| WO2019004430A1 (ja) * | 2017-06-30 | 2019-01-03 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 大腸がんを検出するためのバイオマーカー |
| AU2018301704A1 (en) * | 2017-07-14 | 2020-03-05 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| CN109406785A (zh) * | 2017-08-18 | 2019-03-01 | 山东泽济生物科技有限公司 | 肿瘤血液标志物及其应用 |
| US20200386759A1 (en) * | 2017-12-05 | 2020-12-10 | Discerndx, Inc. | Robust panels of colorectal cancer biomarkers |
| WO2019133717A1 (en) * | 2017-12-29 | 2019-07-04 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| ES2917629T3 (es) | 2018-01-22 | 2022-07-11 | Liquid Biopsy Res Llc | Métodos para la detección del cáncer de colon y monitorización del tratamiento |
| US11348688B2 (en) | 2018-03-06 | 2022-05-31 | Advinow, Inc. | Systems and methods for audio medical instrument patient measurements |
| JP7455757B2 (ja) * | 2018-04-13 | 2024-03-26 | フリーノーム・ホールディングス・インコーポレイテッド | 生体試料の多検体アッセイのための機械学習実装 |
| WO2020010256A1 (en) * | 2018-07-05 | 2020-01-09 | Edp Biotech Corporation | Kits and methods for detecting markers |
| SG11202100834SA (en) | 2018-08-08 | 2021-02-25 | Regeneron Pharma | Use of lc-ms/ms to quantitate protein biomarkers |
| EP3623813A1 (en) * | 2018-09-17 | 2020-03-18 | Institut d'Investigació Sanitària Pere Virgili | Methods for the prognosis of hiv-infected subjects |
| WO2020178620A1 (en) * | 2019-03-06 | 2020-09-10 | Diadem S.R.L. | p53 PEPTIDES AS MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF ALZHEIMER'S DISEASE |
| US12499537B2 (en) * | 2019-11-13 | 2025-12-16 | University Of South Florida | Systems and methods of deep learning for colorectal polyp screening |
| CN110951707B (zh) * | 2019-12-31 | 2022-11-11 | 南京医科大学 | 丙酮酸激酶m2突变体及其在心血管疾病中的应用 |
| CN115616230A (zh) * | 2020-03-18 | 2023-01-17 | 龙海市第一医院 | 用于肝癌早期诊断的检测岩藻糖基化载脂蛋白h的elisa试剂盒 |
| WO2022006628A1 (en) * | 2020-07-08 | 2022-01-13 | Southern Adelaide Local Health Network Inc. | Computer-implemented method and system for identifying measurable features for use in a predictive model |
| CN112194719A (zh) * | 2020-09-01 | 2021-01-08 | 中日友好医院(中日友好临床医学研究所) | Crt抗原和mage-a1抗原的制备及其应用 |
| CN112034182A (zh) * | 2020-09-01 | 2020-12-04 | 复旦大学附属中山医院 | 一种结肠癌转移预测方法和系统 |
| CN112266961B (zh) * | 2020-10-29 | 2023-05-12 | 中山大学附属第六医院 | Tsg-6基因在预测结直肠癌转移及预后方面的应用 |
| CN112710856B (zh) * | 2020-12-16 | 2022-12-02 | 江西省肿瘤医院(江西省癌症中心) | 检测血清igf1蛋白的制剂在制备结直肠癌疗效监测试剂中的应用 |
| CN113447658B (zh) * | 2021-07-01 | 2022-04-19 | 浙江大学 | 一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒 |
| CN113956327B (zh) * | 2021-10-11 | 2024-01-30 | 中山大学肿瘤防治中心 | 靶向人apc蛋白的多肽及其在制备药物中的应用 |
| WO2023183481A1 (en) * | 2022-03-23 | 2023-09-28 | Serum Detect, Inc. | Biomarker signatures indicative of early stages of cancer |
| CN114445406B (zh) * | 2022-04-07 | 2022-08-09 | 武汉大学 | 肠镜图像分析方法、装置和医学图像处理设备 |
| TWI796228B (zh) | 2022-05-25 | 2023-03-11 | 臺中榮民總醫院 | 急性腎損傷預測系統及其方法 |
| CN114668836B (zh) * | 2022-05-27 | 2022-08-19 | 暨南大学 | Pdia6在制备治疗脊髓损伤和修复的药物中的应用 |
| CN114958794B (zh) * | 2022-06-14 | 2023-06-02 | 南京工业大学 | 一种苯乙醇胺-N-甲基转移酶hPNMT54及其克隆表达与应用 |
| CN116593431B (zh) * | 2023-04-09 | 2025-11-07 | 湖南科技大学三亚研究院 | 一种基于亲和传感器法的米酵菌酸毒素便携式检测装置及检测方法 |
| WO2024232926A1 (en) * | 2023-05-08 | 2024-11-14 | Venn Biosciences Corporation | Diagnosis of colorectal cancer using targeted quantification of peptides |
| WO2025058445A1 (ko) * | 2023-09-15 | 2025-03-20 | 연세대학교 산학협력단 | 대장암에 대한 정보 제공 방법 |
| CN118067993B (zh) * | 2024-04-17 | 2024-07-05 | 弗雷米德生物医药技术(天津)有限公司 | 一种用于肠息肉检测的联检试剂盒及其制备方法、检测方法和应用 |
| CN118496322A (zh) * | 2024-05-09 | 2024-08-16 | 昆明医科大学 | 一种靶向降解β-catenin的多肽型抑制剂及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US4517289A (en) * | 1982-08-18 | 1985-05-14 | Brigham And Women's Hospital | Monoclonal antibodies for human tissue cross-matching |
| EP0854934A4 (en) * | 1995-08-18 | 2000-09-06 | Donald W Landry | DETECTION OF ORGANIC COMPOUNDS BY REGULATION OF ANTIBODY CATALYZED REACTIONS |
| US5800347A (en) * | 1995-11-03 | 1998-09-01 | The General Hospital Corporation | ROC method for early detection of disease |
| NO954667D0 (no) * | 1995-11-17 | 1995-11-17 | Dagfinn Oegreid | Fremgangsmåte til deteksjon av Ki-ras mutasjoner |
| EP1179092A2 (en) * | 1999-01-10 | 2002-02-13 | Exact Sciences Corporation | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
| US20010041365A1 (en) * | 2000-01-10 | 2001-11-15 | Michael Laposata | Methods for monitoring alcohol consumption |
| US20040018973A1 (en) * | 2002-01-25 | 2004-01-29 | University Of Pittsburgh | Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof |
| US20050153382A1 (en) * | 2002-06-06 | 2005-07-14 | Chengdu Kuachang Science And Technology Co., Ltd. | Biochip kit comprising biochip based on antigen-antibody reactions, and its usage |
| EP2026071B1 (en) * | 2004-02-19 | 2013-07-31 | Yale University | Identification of cancer protein biomarkers using proteomic techniques |
| JP4916441B2 (ja) * | 2004-08-13 | 2012-04-11 | インディヴュームド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 結腸直腸腺腫及び/又は癌腫に対するバイオマーカーとしてのトランスサイレチンの使用;検出方法及び試験システム |
| US20060105419A1 (en) * | 2004-08-16 | 2006-05-18 | Biosite, Inc. | Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions |
| WO2006094149A2 (en) * | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| CN101283280A (zh) * | 2005-08-18 | 2008-10-08 | Zadec私人有限公司 | 用于诊断结直肠癌的蛋白质标记和所述标记作为所述癌症类型治疗的药物靶点的用途 |
| CA2629013A1 (en) * | 2005-11-10 | 2007-12-13 | Aurelium Biopharma Inc. | Method of diagnosing breast cancer using protein markers |
| JP5715817B2 (ja) * | 2007-07-19 | 2015-05-13 | ビオメリューBiomerieux | 結腸直腸癌のインビトロ診断のための肝臓脂肪酸結合タンパク質、ceaおよびca19−9のアッセイのための方法 |
| WO2009040782A2 (en) * | 2007-09-28 | 2009-04-02 | Royal College Of Surgeons In Ireland | A method of assessing colorectal cancer status in an individual |
| CA2701970A1 (en) * | 2007-12-10 | 2009-06-18 | F. Hoffmann-La Roche Ag | Marker panel for colorectal cancer |
| ATE524740T1 (de) * | 2007-12-10 | 2011-09-15 | Hoffmann La Roche | Seprase als krebsmarker |
| CN102027128A (zh) * | 2008-02-11 | 2011-04-20 | 哈达斯特医学服务与开发有限公司 | 作为癌症标志物的结肠癌相关的转录物1(ccat-1) |
| US20110076700A1 (en) * | 2008-02-29 | 2011-03-31 | Nihon University | Anti-crp antibody and utilization of the same |
| US20110245087A1 (en) * | 2008-03-18 | 2011-10-06 | Gunter Weiss | Method for optimizing and validating an assay for determining the presence or absence of a medical condition |
| US20110065605A1 (en) * | 2008-05-14 | 2011-03-17 | Eth Zurich | Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith |
| EP2796878A1 (en) * | 2008-05-23 | 2014-10-29 | Biocartis NV | New biomarkers for diagnosis, prediction and/or prognosis of sepsis and uses thereof |
| KR20120105444A (ko) * | 2009-10-15 | 2012-09-25 | 오클라호마 메디컬 리써치 화운데이션 | 염증성 질병의 활성 측정 및 모니터링을 위한 바이오마커 및 방법 |
| US10119959B2 (en) * | 2010-06-25 | 2018-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Method of assaying an individual for immune impairment |
| ES2545515T3 (es) * | 2011-01-28 | 2015-09-11 | F. Hoffmann-La Roche Ag | Biomarcadores combinatorios para aplicaciones clínicas en la gestión del paciente con cáncer de pulmón |
| AU2012220872A1 (en) * | 2011-02-22 | 2013-09-12 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers |
| EP2744919A4 (en) * | 2011-08-19 | 2015-04-08 | Myriad Genetics Inc | GENE SIGNATURES FOR PROGNOSIS OF LUNG CANCER AND SELECTION OF THERAPY |
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| JP2016507723A (ja) | 2016-03-10 |
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| EP2926138A4 (en) | 2016-09-14 |
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| SG11201504241QA (en) | 2015-06-29 |
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