AU2013342015B2 - Bendamustine derivatives and methods of using same - Google Patents

Bendamustine derivatives and methods of using same Download PDF

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Publication number
AU2013342015B2
AU2013342015B2 AU2013342015A AU2013342015A AU2013342015B2 AU 2013342015 B2 AU2013342015 B2 AU 2013342015B2 AU 2013342015 A AU2013342015 A AU 2013342015A AU 2013342015 A AU2013342015 A AU 2013342015A AU 2013342015 B2 AU2013342015 B2 AU 2013342015B2
Authority
AU
Australia
Prior art keywords
cancer
bendamustine
alkyl
ester
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013342015A
Other languages
English (en)
Other versions
AU2013342015A1 (en
Inventor
Roger P. Bakale
Peter D. Brown
Jian Chen
Anthony S. Drager
Rachel Y. Labell
Robert E. Mckean
Piyush R. Patel
Renee C. Roemmele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ignyta Inc
Original Assignee
Ignyta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignyta Inc filed Critical Ignyta Inc
Publication of AU2013342015A1 publication Critical patent/AU2013342015A1/en
Application granted granted Critical
Publication of AU2013342015B2 publication Critical patent/AU2013342015B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013342015A 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same Ceased AU2013342015B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US61/725,213 2012-11-12
US201361776951P 2013-03-12 2013-03-12
US61/776,951 2013-03-12
PCT/US2013/069550 WO2014075035A1 (en) 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same

Publications (2)

Publication Number Publication Date
AU2013342015A1 AU2013342015A1 (en) 2015-05-28
AU2013342015B2 true AU2013342015B2 (en) 2016-11-24

Family

ID=49667594

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013342015A Ceased AU2013342015B2 (en) 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same

Country Status (17)

Country Link
US (7) US9452988B2 (cg-RX-API-DMAC10.html)
EP (1) EP2917183A1 (cg-RX-API-DMAC10.html)
JP (1) JP6262246B2 (cg-RX-API-DMAC10.html)
KR (1) KR20150086308A (cg-RX-API-DMAC10.html)
AR (1) AR093457A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013342015B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015010501A2 (cg-RX-API-DMAC10.html)
CA (1) CA2890462A1 (cg-RX-API-DMAC10.html)
CL (1) CL2015001246A1 (cg-RX-API-DMAC10.html)
EA (1) EA029706B1 (cg-RX-API-DMAC10.html)
HK (2) HK1215701A1 (cg-RX-API-DMAC10.html)
IL (1) IL238662A (cg-RX-API-DMAC10.html)
MX (1) MX2015005805A (cg-RX-API-DMAC10.html)
PH (1) PH12015501024A1 (cg-RX-API-DMAC10.html)
SG (1) SG11201503560TA (cg-RX-API-DMAC10.html)
TW (1) TWI598341B (cg-RX-API-DMAC10.html)
WO (1) WO2014075035A1 (cg-RX-API-DMAC10.html)

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EP2917183A1 (en) * 2012-11-12 2015-09-16 Ignyta, Inc. Bendamustine derivatives and methods of using same
CA2904143A1 (en) 2013-03-12 2014-10-09 Cephalon, Inc. Nanoparticulate and macroparticulate formulations
CA2992586A1 (en) 2015-07-16 2017-01-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
EP3484519A1 (en) * 2016-07-13 2019-05-22 Cephalon, Inc. Pharmaceutical prodrugs and methods of their preparation and use
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JP6888101B2 (ja) 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3740486A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111630054B (zh) 2018-01-18 2023-05-09 奥瑞生物药品公司 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
CA3108065C (en) 2018-07-31 2025-10-07 Loxo Oncology, Inc. SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE
ES2922314T3 (es) 2018-09-10 2022-09-13 Array Biopharma Inc Compuestos heterocíclicos condensados como inhibidores de cinasa RET

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Also Published As

Publication number Publication date
US9913827B2 (en) 2018-03-13
KR20150086308A (ko) 2015-07-27
HK1215701A1 (zh) 2016-09-09
CN105051016A (zh) 2015-11-11
BR112015010501A2 (pt) 2017-07-11
TWI598341B (zh) 2017-09-11
EA201590925A1 (ru) 2015-09-30
US9149464B2 (en) 2015-10-06
CA2890462A1 (en) 2014-05-15
EP2917183A1 (en) 2015-09-16
US9630926B2 (en) 2017-04-25
AU2013342015A1 (en) 2015-05-28
US20160289198A1 (en) 2016-10-06
US20150232427A1 (en) 2015-08-20
WO2014075035A1 (en) 2014-05-15
US20160016912A1 (en) 2016-01-21
EA029706B1 (ru) 2018-05-31
JP2015536996A (ja) 2015-12-24
SG11201503560TA (en) 2015-06-29
US20180147186A1 (en) 2018-05-31
IL238662A (en) 2017-08-31
PH12015501024A1 (en) 2015-07-27
CL2015001246A1 (es) 2016-01-15
HK1212977A1 (zh) 2016-06-24
IL238662A0 (en) 2015-06-30
US9150517B2 (en) 2015-10-06
TW201439069A (zh) 2014-10-16
JP6262246B2 (ja) 2018-01-17
US9452988B2 (en) 2016-09-27
US20150274675A1 (en) 2015-10-01
AR093457A1 (es) 2015-06-10
US20150246023A1 (en) 2015-09-03
MX2015005805A (es) 2016-04-15
US20170182008A1 (en) 2017-06-29

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired