SG11202107877WA - Platinum-based amphiphile prodrugs - Google Patents

Platinum-based amphiphile prodrugs

Info

Publication number
SG11202107877WA
SG11202107877WA SG11202107877WA SG11202107877WA SG11202107877WA SG 11202107877W A SG11202107877W A SG 11202107877WA SG 11202107877W A SG11202107877W A SG 11202107877WA SG 11202107877W A SG11202107877W A SG 11202107877WA SG 11202107877W A SG11202107877W A SG 11202107877WA
Authority
SG
Singapore
Prior art keywords
prodrugs
platinum
amphiphile
based amphiphile
amphiphile prodrugs
Prior art date
Application number
SG11202107877WA
Inventor
Minoo Jalili Moghaddam
Xiaojuan Gong
Ross Cyril Smith
Original Assignee
NanoMed Holdings Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2018902222A external-priority patent/AU2018902222A0/en
Application filed by NanoMed Holdings Pty Ltd filed Critical NanoMed Holdings Pty Ltd
Publication of SG11202107877WA publication Critical patent/SG11202107877WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
SG11202107877WA 2018-06-21 2019-06-21 Platinum-based amphiphile prodrugs SG11202107877WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2018902222A AU2018902222A0 (en) 2018-06-21 Platinum-based amphiphile prodrugs
PCT/AU2019/050646 WO2019241853A1 (en) 2018-06-21 2019-06-21 Platinum-based amphiphile prodrugs

Publications (1)

Publication Number Publication Date
SG11202107877WA true SG11202107877WA (en) 2021-08-30

Family

ID=68982513

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107877WA SG11202107877WA (en) 2018-06-21 2019-06-21 Platinum-based amphiphile prodrugs

Country Status (5)

Country Link
US (1) US20210275489A1 (en)
EP (1) EP3810622A4 (en)
JP (2) JP2021527675A (en)
SG (1) SG11202107877WA (en)
WO (1) WO2019241853A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115590879B (en) * 2021-06-28 2024-03-22 沈阳药科大学 Platinum drug lipid derivative and application thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9206593A (en) 1991-10-04 1995-11-28 Gs Biochem Ab Particles especially colloidal particles process of preparing them from a homogeneous liquid crystalline phase or L3 phase pharmaceutical composition and use of these particles
EP0646589A3 (en) * 1993-10-04 1995-06-28 Tanaka Precious Metal Ind Anti-tumor platinum (IV) complex.
SE511313C2 (en) 1997-01-13 1999-09-06 Gs Dev Ab A controlled release composition comprising diacylglycerol fatty acid ester
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
EP1867673B1 (en) 2005-03-18 2011-11-16 The University of Tokyo Coordination compound composed of diaminocyclohexane platinum (ii) and block copolymer and anti-cancer agent comprising the same
US8603999B2 (en) 2008-12-05 2013-12-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
DK177532B1 (en) 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
KR20150100706A (en) * 2012-12-28 2015-09-02 블렌드 세라퓨틱스, 인코포레이티드 Targeted conjugates encapsulated in particles and formulations thereof
WO2015102928A1 (en) * 2013-12-31 2015-07-09 Blend Therapeutics, Inc. Compounds, compositions, and methods for the treatment of cancers
EP3137473B1 (en) * 2014-05-02 2019-11-27 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Pt (iv) derivatives and nanocarriers comprising them
US20190290656A1 (en) * 2015-12-30 2019-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Pt(iv) prodrugs
GB2548084A (en) * 2016-02-26 2017-09-13 Midatech Ltd Nanoparticle production
CN109021026B (en) * 2018-07-18 2021-04-02 浙江大学 Cisplatin prodrug, preparation method and application

Also Published As

Publication number Publication date
WO2019241853A1 (en) 2019-12-26
EP3810622A1 (en) 2021-04-28
JP2023145470A (en) 2023-10-11
US20210275489A1 (en) 2021-09-09
JP2021527675A (en) 2021-10-14
EP3810622A4 (en) 2022-04-06

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