HK1215701A1 - 苯達莫司汀衍生物及其使用方法 - Google Patents

苯達莫司汀衍生物及其使用方法 Download PDF

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Publication number
HK1215701A1
HK1215701A1 HK16100090.1A HK16100090A HK1215701A1 HK 1215701 A1 HK1215701 A1 HK 1215701A1 HK 16100090 A HK16100090 A HK 16100090A HK 1215701 A1 HK1215701 A1 HK 1215701A1
Authority
HK
Hong Kong
Prior art keywords
compound
cancer
alkyl group
bendamustine
formula
Prior art date
Application number
HK16100090.1A
Other languages
English (en)
Chinese (zh)
Inventor
羅格
P 巴卡列 罗格
巴卡列
D 布朗 彼得
彼得
陈建
布朗
S 查格尔 安东尼
陳建
Y 拉贝尔 拉切尔
安東尼
E 麦凯恩 罗伯特
查格爾
R 帕特尔 皮约什
拉切爾
C 勒姆麦尔 雷内
拉貝爾
羅伯特
麥凱恩
皮約什
帕特爾
雷內
勒姆麥爾
Original Assignee
易格尼塔公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 易格尼塔公司 filed Critical 易格尼塔公司
Publication of HK1215701A1 publication Critical patent/HK1215701A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16100090.1A 2012-11-12 2013-11-12 苯達莫司汀衍生物及其使用方法 HK1215701A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US201261725213P 2012-11-12
US201361776951P 2013-03-12 2013-03-12
US201361776951P 2013-03-12
PCT/US2013/069550 WO2014075035A1 (en) 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same

Publications (1)

Publication Number Publication Date
HK1215701A1 true HK1215701A1 (zh) 2016-09-09

Family

ID=49667594

Family Applications (2)

Application Number Title Priority Date Filing Date
HK16100090.1A HK1215701A1 (zh) 2012-11-12 2013-11-12 苯達莫司汀衍生物及其使用方法
HK16100891.2A HK1212977A1 (zh) 2012-11-12 2013-11-12 苯達莫司汀衍生物及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16100891.2A HK1212977A1 (zh) 2012-11-12 2013-11-12 苯達莫司汀衍生物及其使用方法

Country Status (17)

Country Link
US (7) US9452988B2 (cg-RX-API-DMAC10.html)
EP (1) EP2917183A1 (cg-RX-API-DMAC10.html)
JP (1) JP6262246B2 (cg-RX-API-DMAC10.html)
KR (1) KR20150086308A (cg-RX-API-DMAC10.html)
AR (1) AR093457A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013342015B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015010501A2 (cg-RX-API-DMAC10.html)
CA (1) CA2890462A1 (cg-RX-API-DMAC10.html)
CL (1) CL2015001246A1 (cg-RX-API-DMAC10.html)
EA (1) EA029706B1 (cg-RX-API-DMAC10.html)
HK (2) HK1215701A1 (cg-RX-API-DMAC10.html)
IL (1) IL238662A (cg-RX-API-DMAC10.html)
MX (1) MX2015005805A (cg-RX-API-DMAC10.html)
PH (1) PH12015501024A1 (cg-RX-API-DMAC10.html)
SG (1) SG11201503560TA (cg-RX-API-DMAC10.html)
TW (1) TWI598341B (cg-RX-API-DMAC10.html)
WO (1) WO2014075035A1 (cg-RX-API-DMAC10.html)

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TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3740486A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111630054B (zh) 2018-01-18 2023-05-09 奥瑞生物药品公司 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
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Also Published As

Publication number Publication date
US9913827B2 (en) 2018-03-13
KR20150086308A (ko) 2015-07-27
CN105051016A (zh) 2015-11-11
BR112015010501A2 (pt) 2017-07-11
TWI598341B (zh) 2017-09-11
EA201590925A1 (ru) 2015-09-30
US9149464B2 (en) 2015-10-06
CA2890462A1 (en) 2014-05-15
EP2917183A1 (en) 2015-09-16
US9630926B2 (en) 2017-04-25
AU2013342015A1 (en) 2015-05-28
US20160289198A1 (en) 2016-10-06
US20150232427A1 (en) 2015-08-20
WO2014075035A1 (en) 2014-05-15
US20160016912A1 (en) 2016-01-21
EA029706B1 (ru) 2018-05-31
JP2015536996A (ja) 2015-12-24
SG11201503560TA (en) 2015-06-29
AU2013342015B2 (en) 2016-11-24
US20180147186A1 (en) 2018-05-31
IL238662A (en) 2017-08-31
PH12015501024A1 (en) 2015-07-27
CL2015001246A1 (es) 2016-01-15
HK1212977A1 (zh) 2016-06-24
IL238662A0 (en) 2015-06-30
US9150517B2 (en) 2015-10-06
TW201439069A (zh) 2014-10-16
JP6262246B2 (ja) 2018-01-17
US9452988B2 (en) 2016-09-27
US20150274675A1 (en) 2015-10-01
AR093457A1 (es) 2015-06-10
US20150246023A1 (en) 2015-09-03
MX2015005805A (es) 2016-04-15
US20170182008A1 (en) 2017-06-29

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