AU2013323572B2 - Improved methods for the acylation of maytansinol - Google Patents
Improved methods for the acylation of maytansinol Download PDFInfo
- Publication number
- AU2013323572B2 AU2013323572B2 AU2013323572A AU2013323572A AU2013323572B2 AU 2013323572 B2 AU2013323572 B2 AU 2013323572B2 AU 2013323572 A AU2013323572 A AU 2013323572A AU 2013323572 A AU2013323572 A AU 2013323572A AU 2013323572 B2 AU2013323572 B2 AU 2013323572B2
- Authority
- AU
- Australia
- Prior art keywords
- formula
- maytansinol
- reaction mixture
- carboxyanhydride
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- DSIHBQNYLRWOJI-VPNNSHPQSA-N C[C@@H](C(OC(CC(N(C)c(cc(C/C(/C)=C/C=C/C(C(C1)(N2)O)OC)cc3OC)c3Cl)=O)C3(C)OC3C(C)C1OC2=O)=O)N(C)C(CCCCCN(C(C=C1)O)C1=O)=O Chemical compound C[C@@H](C(OC(CC(N(C)c(cc(C/C(/C)=C/C=C/C(C(C1)(N2)O)OC)cc3OC)c3Cl)=O)C3(C)OC3C(C)C1OC2=O)=O)N(C)C(CCCCCN(C(C=C1)O)C1=O)=O DSIHBQNYLRWOJI-VPNNSHPQSA-N 0.000 description 1
- ANHBJISROJTYCJ-YIBIOVSBSA-N C[C@@H](C(OC(CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)(N3)O)OC)cc(OC)c1Cl)=O)C1(C)OC1C(C)C2OC3=O)=O)NC Chemical compound C[C@@H](C(OC(CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)(N3)O)OC)cc(OC)c1Cl)=O)C1(C)OC1C(C)C2OC3=O)=O)NC ANHBJISROJTYCJ-YIBIOVSBSA-N 0.000 description 1
- WOJKKJKETHYEAC-UHFFFAOYSA-N OC(CCCCCN(C(C=C1)=O)C1=O)=O Chemical compound OC(CCCCCN(C(C=C1)=O)C1=O)=O WOJKKJKETHYEAC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
- H01R12/50—Fixed connections
- H01R12/51—Fixed connections for rigid printed circuits or like structures
- H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
- H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
- H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
- H05K1/0203—Cooling of mounted components
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
- H05K1/115—Via connections; Lands around holes or via connections
- H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/18—Printed circuits structurally associated with non-printed electric components
- H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018201392A AU2018201392B2 (en) | 2012-09-26 | 2018-02-27 | Improved methods for the acylation of maytansinol |
| AU2020203823A AU2020203823B2 (en) | 2012-09-26 | 2020-06-10 | Improved methods for the acylation of maytansinol |
| AU2022201557A AU2022201557A1 (en) | 2012-09-26 | 2022-03-07 | Improved methods for the acylation of maytansinol |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705731P | 2012-09-26 | 2012-09-26 | |
| US61/705,731 | 2012-09-26 | ||
| PCT/US2013/061839 WO2014052537A1 (en) | 2012-09-26 | 2013-09-26 | Improved methods for the acylation of maytansinol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018201392A Division AU2018201392B2 (en) | 2012-09-26 | 2018-02-27 | Improved methods for the acylation of maytansinol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013323572A1 AU2013323572A1 (en) | 2015-04-02 |
| AU2013323572B2 true AU2013323572B2 (en) | 2017-12-07 |
Family
ID=49328648
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013323572A Active AU2013323572B2 (en) | 2012-09-26 | 2013-09-26 | Improved methods for the acylation of maytansinol |
| AU2018201392A Active AU2018201392B2 (en) | 2012-09-26 | 2018-02-27 | Improved methods for the acylation of maytansinol |
| AU2020203823A Active AU2020203823B2 (en) | 2012-09-26 | 2020-06-10 | Improved methods for the acylation of maytansinol |
| AU2022201557A Abandoned AU2022201557A1 (en) | 2012-09-26 | 2022-03-07 | Improved methods for the acylation of maytansinol |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018201392A Active AU2018201392B2 (en) | 2012-09-26 | 2018-02-27 | Improved methods for the acylation of maytansinol |
| AU2020203823A Active AU2020203823B2 (en) | 2012-09-26 | 2020-06-10 | Improved methods for the acylation of maytansinol |
| AU2022201557A Abandoned AU2022201557A1 (en) | 2012-09-26 | 2022-03-07 | Improved methods for the acylation of maytansinol |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US9012629B2 (enExample) |
| EP (3) | EP2900676B1 (enExample) |
| JP (7) | JP6517693B2 (enExample) |
| CN (2) | CN108586487B (enExample) |
| AU (4) | AU2013323572B2 (enExample) |
| BR (2) | BR122021022582B1 (enExample) |
| CA (2) | CA2884873C (enExample) |
| CY (2) | CY1121415T1 (enExample) |
| DK (2) | DK2900676T3 (enExample) |
| ES (2) | ES2716561T3 (enExample) |
| HR (2) | HRP20190473T1 (enExample) |
| HU (2) | HUE043285T2 (enExample) |
| IL (2) | IL237899A (enExample) |
| LT (2) | LT3486248T (enExample) |
| MX (2) | MX366701B (enExample) |
| MY (1) | MY169250A (enExample) |
| NZ (2) | NZ739573A (enExample) |
| PL (2) | PL3486248T3 (enExample) |
| PT (2) | PT2900676T (enExample) |
| RS (2) | RS58493B1 (enExample) |
| RU (2) | RU2648992C2 (enExample) |
| SG (1) | SG11201501918UA (enExample) |
| SI (2) | SI2900676T1 (enExample) |
| SM (2) | SMT201900170T1 (enExample) |
| TR (1) | TR201903625T4 (enExample) |
| WO (1) | WO2014052537A1 (enExample) |
| ZA (1) | ZA201501898B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE043285T2 (hu) * | 2012-09-26 | 2019-08-28 | Immunogen Inc | Javított eljárás maytansinol acilezésére |
| CN105585579A (zh) * | 2014-10-24 | 2016-05-18 | 南京联宁生物制药有限公司 | 一种化合物及其制备方法以及美登素dm1的制备方法 |
| AU2016233227B2 (en) | 2015-03-17 | 2020-03-12 | Regeneron Pharmaceuticals, Inc. | Amino acid acylation reagents and methods of using the same |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
| PL3956332T3 (pl) | 2019-04-18 | 2023-05-29 | Indena S.P.A. | Diastereoselektywny sposób wytwarzania estrów majtanzynoidowych zawierających tiol lub dwusiarczek i ich produkty pośrednie |
| EP4067497A4 (en) | 2019-11-29 | 2024-03-13 | MicroBiopharm Japan Co., Ltd. | Method for enzymatically producing maytansinol |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078809A2 (en) * | 2005-01-21 | 2006-07-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| WO2007021674A2 (en) * | 2005-08-09 | 2007-02-22 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
| WO2012074757A1 (en) * | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| JPS6034556B2 (ja) * | 1977-03-31 | 1985-08-09 | 武田薬品工業株式会社 | 抗生物質ｃ−１５００３ |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5622790A (en) * | 1979-07-31 | 1981-03-03 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JP3054741B2 (ja) * | 1989-09-29 | 2000-06-19 | 武田薬品工業株式会社 | Ｔａｎ―１３１３およびそのアシル誘導体 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP1229934B1 (en) * | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| TWI298067B (en) * | 2002-01-31 | 2008-06-21 | Daiso Co Ltd | New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| PL1651162T3 (pl) * | 2003-05-20 | 2016-04-29 | Immunogen Inc | Maitansynoidy w leczeniu nowotworów |
| CN1894259A (zh) * | 2003-08-22 | 2007-01-10 | 活跃生物工艺学公司 | 利福霉素类似物及其应用 |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| WO2006062779A2 (en) * | 2004-12-09 | 2006-06-15 | Centocor, Inc. | Anti-integrin immunoconjugates, methods and uses |
| WO2007011721A1 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| US20090082386A1 (en) * | 2006-11-06 | 2009-03-26 | Erzsebet Meszarosne Sos | Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| JP2008288289A (ja) | 2007-05-16 | 2008-11-27 | Oki Electric Ind Co Ltd | 電界効果トランジスタとその製造方法 |
| ME03479B (me) | 2009-06-03 | 2020-01-20 | Immunogen Inc | Metodi konjugacije |
| WO2011051960A2 (en) * | 2009-09-25 | 2011-05-05 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| HUE043285T2 (hu) * | 2012-09-26 | 2019-08-28 | Immunogen Inc | Javított eljárás maytansinol acilezésére |
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2013
- 2013-09-26 HU HUE13774881A patent/HUE043285T2/hu unknown
- 2013-09-26 EP EP13774881.0A patent/EP2900676B1/en active Active
- 2013-09-26 RS RS20190314A patent/RS58493B1/sr unknown
- 2013-09-26 LT LTEP18213678.8T patent/LT3486248T/lt unknown
- 2013-09-26 PL PL18213678T patent/PL3486248T3/pl unknown
- 2013-09-26 PL PL13774881T patent/PL2900676T3/pl unknown
- 2013-09-26 HU HUE18213678A patent/HUE055443T2/hu unknown
- 2013-09-26 LT LTEP13774881.0T patent/LT2900676T/lt unknown
- 2013-09-26 PT PT13774881T patent/PT2900676T/pt unknown
- 2013-09-26 MX MX2015003745A patent/MX366701B/es active IP Right Grant
- 2013-09-26 NZ NZ73957313A patent/NZ739573A/en unknown
- 2013-09-26 DK DK13774881.0T patent/DK2900676T3/en active
- 2013-09-26 PT PT182136788T patent/PT3486248T/pt unknown
- 2013-09-26 EP EP21166484.2A patent/EP3904358A1/en active Pending
- 2013-09-26 SI SI201331374T patent/SI2900676T1/sl unknown
- 2013-09-26 CN CN201810251853.0A patent/CN108586487B/zh active Active
- 2013-09-26 EP EP18213678.8A patent/EP3486248B1/en active Active
- 2013-09-26 AU AU2013323572A patent/AU2013323572B2/en active Active
- 2013-09-26 CN CN201380049853.8A patent/CN104768955B/zh active Active
- 2013-09-26 RS RS20210825A patent/RS62075B1/sr unknown
- 2013-09-26 DK DK18213678.8T patent/DK3486248T3/da active
- 2013-09-26 US US14/037,657 patent/US9012629B2/en active Active
- 2013-09-26 MY MYPI2015000663A patent/MY169250A/en unknown
- 2013-09-26 BR BR122021022582-6A patent/BR122021022582B1/pt active IP Right Grant
- 2013-09-26 RU RU2015111635A patent/RU2648992C2/ru active
- 2013-09-26 SM SM20190170T patent/SMT201900170T1/it unknown
- 2013-09-26 CA CA2884873A patent/CA2884873C/en active Active
- 2013-09-26 RU RU2018109295A patent/RU2765072C2/ru active
- 2013-09-26 JP JP2015534641A patent/JP6517693B2/ja active Active
- 2013-09-26 ES ES13774881T patent/ES2716561T3/es active Active
- 2013-09-26 ES ES18213678T patent/ES2880754T3/es active Active
- 2013-09-26 BR BR112015006505-8A patent/BR112015006505B1/pt active IP Right Grant
- 2013-09-26 HR HRP20190473TT patent/HRP20190473T1/hr unknown
- 2013-09-26 SG SG11201501918UA patent/SG11201501918UA/en unknown
- 2013-09-26 MX MX2019008652A patent/MX390615B/es unknown
- 2013-09-26 NZ NZ706019A patent/NZ706019A/en unknown
- 2013-09-26 TR TR2019/03625T patent/TR201903625T4/tr unknown
- 2013-09-26 SM SM20210390T patent/SMT202100390T1/it unknown
- 2013-09-26 CA CA3133906A patent/CA3133906C/en active Active
- 2013-09-26 WO PCT/US2013/061839 patent/WO2014052537A1/en not_active Ceased
- 2013-09-26 SI SI201331899T patent/SI3486248T1/sl unknown
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2015
- 2015-03-17 US US14/660,050 patent/US9469655B2/en active Active
- 2015-03-19 ZA ZA2015/01898A patent/ZA201501898B/en unknown
- 2015-03-23 IL IL237899A patent/IL237899A/en active IP Right Grant
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2016
- 2016-09-19 US US15/269,163 patent/US9796731B2/en active Active
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2017
- 2017-08-14 IL IL253988A patent/IL253988B/en active IP Right Grant
- 2017-09-19 US US15/708,346 patent/US10100062B2/en active Active
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2018
- 2018-02-27 JP JP2018032684A patent/JP2018109044A/ja not_active Ceased
- 2018-02-27 AU AU2018201392A patent/AU2018201392B2/en active Active
- 2018-09-12 US US16/129,268 patent/US10461449B2/en active Active
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2019
- 2019-03-13 CY CY20191100302T patent/CY1121415T1/el unknown
- 2019-09-18 US US16/574,718 patent/US10944190B2/en active Active
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2020
- 2020-04-06 JP JP2020068137A patent/JP6735000B1/ja active Active
- 2020-06-10 AU AU2020203823A patent/AU2020203823B2/en active Active
- 2020-07-10 JP JP2020118929A patent/JP2020180150A/ja active Pending
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2021
- 2021-06-29 HR HRP20211030TT patent/HRP20211030T1/hr unknown
- 2021-07-02 CY CY20211100594T patent/CY1124337T1/el unknown
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2022
- 2022-02-28 JP JP2022029253A patent/JP2022068367A/ja active Pending
- 2022-03-07 AU AU2022201557A patent/AU2022201557A1/en not_active Abandoned
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2023
- 2023-09-05 US US18/242,321 patent/US20240145953A1/en not_active Abandoned
- 2023-10-23 JP JP2023181529A patent/JP2024010055A/ja active Pending
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2024
- 2024-01-19 US US18/417,406 patent/US20240313444A1/en not_active Abandoned
- 2024-05-31 US US18/679,863 patent/US20250007192A1/en active Pending
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2025
- 2025-03-31 JP JP2025058629A patent/JP2025098242A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078809A2 (en) * | 2005-01-21 | 2006-07-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| WO2007021674A2 (en) * | 2005-08-09 | 2007-02-22 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
| WO2012074757A1 (en) * | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
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| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |