AU2013308494B2 - Modified amino acids comprising an azido group - Google Patents

Modified amino acids comprising an azido group Download PDF

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Publication number
AU2013308494B2
AU2013308494B2 AU2013308494A AU2013308494A AU2013308494B2 AU 2013308494 B2 AU2013308494 B2 AU 2013308494B2 AU 2013308494 A AU2013308494 A AU 2013308494A AU 2013308494 A AU2013308494 A AU 2013308494A AU 2013308494 B2 AU2013308494 B2 AU 2013308494B2
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Australia
Prior art keywords
polypeptide
antibody
amino acid
payload
compound
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AU2013308494A1 (en
Inventor
Ryan STAFFORD
Christopher D. Thanos
Wenjin Yang
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Sutro Biopharma Inc
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Sutro Biopharma Inc
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Priority to AU2018203568A priority Critical patent/AU2018203568B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
AU2013308494A 2012-08-31 2013-08-30 Modified amino acids comprising an azido group Active AU2013308494B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018203568A AU2018203568B2 (en) 2012-08-31 2018-05-21 Modified amino acids

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261696087P 2012-08-31 2012-08-31
US61/696,087 2012-08-31
PCT/US2013/057677 WO2014036492A1 (en) 2012-08-31 2013-08-30 Modified amino acids comprising an azido group

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018203568A Division AU2018203568B2 (en) 2012-08-31 2018-05-21 Modified amino acids

Publications (2)

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AU2013308494A1 AU2013308494A1 (en) 2015-03-26
AU2013308494B2 true AU2013308494B2 (en) 2018-03-01

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AU2018203568A Active AU2018203568B2 (en) 2012-08-31 2018-05-21 Modified amino acids

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US (7) US9682934B2 (cg-RX-API-DMAC7.html)
EP (3) EP2890402B1 (cg-RX-API-DMAC7.html)
JP (2) JP6826367B2 (cg-RX-API-DMAC7.html)
KR (1) KR102182800B1 (cg-RX-API-DMAC7.html)
CN (1) CN104981254B (cg-RX-API-DMAC7.html)
AU (2) AU2013308494B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015004022B1 (cg-RX-API-DMAC7.html)
CA (1) CA2881978C (cg-RX-API-DMAC7.html)
DK (2) DK3584255T3 (cg-RX-API-DMAC7.html)
ES (2) ES2728864T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20220455T1 (cg-RX-API-DMAC7.html)
HU (1) HUE045227T2 (cg-RX-API-DMAC7.html)
IL (1) IL237401B (cg-RX-API-DMAC7.html)
PL (2) PL2890402T3 (cg-RX-API-DMAC7.html)
SG (1) SG11201501464TA (cg-RX-API-DMAC7.html)
SI (2) SI3584255T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014036492A1 (cg-RX-API-DMAC7.html)

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HK1210034A1 (en) 2016-04-15
ES2728864T3 (es) 2019-10-29
ES2907763T3 (es) 2022-04-26
US12269801B2 (en) 2025-04-08
JP2015529208A (ja) 2015-10-05
WO2014036492A1 (en) 2014-03-06
KR20150048781A (ko) 2015-05-07
HRP20220455T1 (hr) 2022-05-27
EP4074728A1 (en) 2022-10-19
EP2890402B1 (en) 2019-04-17
IL237401B (en) 2018-12-31
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US10112900B2 (en) 2018-10-30
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