AU2013301577B2 - Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one - Google Patents

Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one Download PDF

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Publication number
AU2013301577B2
AU2013301577B2 AU2013301577A AU2013301577A AU2013301577B2 AU 2013301577 B2 AU2013301577 B2 AU 2013301577B2 AU 2013301577 A AU2013301577 A AU 2013301577A AU 2013301577 A AU2013301577 A AU 2013301577A AU 2013301577 B2 AU2013301577 B2 AU 2013301577B2
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AU
Australia
Prior art keywords
pyrazino
methyl
dihydro
indol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013301577A
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English (en)
Other versions
AU2013301577A1 (en
Inventor
Simona M. Ceccarelli
Ravi Jagasia
Roland Jakob-Roetne
Juergen Wichmann
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of AU2013301577A1 publication Critical patent/AU2013301577A1/en
Application granted granted Critical
Publication of AU2013301577B2 publication Critical patent/AU2013301577B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
AU2013301577A 2012-08-06 2013-08-05 Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one Ceased AU2013301577B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12179381.4 2012-08-06
EP12179381 2012-08-06
PCT/EP2013/066344 WO2014023674A1 (en) 2012-08-06 2013-08-05 Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

Publications (2)

Publication Number Publication Date
AU2013301577A1 AU2013301577A1 (en) 2014-12-18
AU2013301577B2 true AU2013301577B2 (en) 2017-03-30

Family

ID=48918402

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013301577A Ceased AU2013301577B2 (en) 2012-08-06 2013-08-05 Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

Country Status (24)

Country Link
US (1) US9284321B2 (https=)
EP (1) EP2880036B1 (https=)
JP (1) JP5974177B2 (https=)
KR (1) KR101716062B1 (https=)
CN (1) CN104540829B (https=)
AR (1) AR092041A1 (https=)
AU (1) AU2013301577B2 (https=)
BR (1) BR112015000313A2 (https=)
CA (1) CA2880682A1 (https=)
CL (1) CL2015000143A1 (https=)
CO (1) CO7141435A2 (https=)
CR (1) CR20140545A (https=)
EA (1) EA025884B1 (https=)
IL (1) IL236808B (https=)
MA (1) MA37791B1 (https=)
MX (1) MX362184B (https=)
MY (1) MY185216A (https=)
NZ (1) NZ703192A (https=)
PE (1) PE20150341A1 (https=)
PH (1) PH12015500059B1 (https=)
SG (1) SG11201408529VA (https=)
TW (1) TWI506027B (https=)
UA (1) UA113013C2 (https=)
WO (1) WO2014023674A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014127372A2 (en) * 2013-02-18 2014-08-21 Theranos, Inc. Image analysis and measurement of biological samples
CN105246895B (zh) * 2013-04-02 2017-09-22 豪夫迈·罗氏有限公司 哌嗪并[1，2‑a]吲哚‑1‑酮和[1，4]二氮杂环庚烷并[1，2‑a]吲哚‑1‑酮
RU2673489C2 (ru) * 2013-09-12 2018-11-27 Ф. Хоффманн-Ля Рош Аг Производные индолкарбоксамида

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065820A1 (en) * 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1965981C3 (de) * 1968-02-13 1978-08-31 Sumitomo Chemical Co., Ltd., Osaka (Japan) 9-Phenyl-lO-oxopiperazino [l,2-a]-indole und Verfahren zu ihrer Herstellung
GB0106177D0 (en) * 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
WO2008046072A2 (en) 2006-10-13 2008-04-17 The Board Of Regents Of The University Of Texas System Chemical inducers of neurogenesis
CA2668959A1 (en) * 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Indole and benzofuran 2-carboxamide derivatives
CA2804161A1 (en) 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN105246895B (zh) * 2013-04-02 2017-09-22 豪夫迈·罗氏有限公司 哌嗪并[1，2‑a]吲哚‑1‑酮和[1，4]二氮杂环庚烷并[1，2‑a]吲哚‑1‑酮

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065820A1 (en) * 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity

Also Published As

Publication number Publication date
US9284321B2 (en) 2016-03-15
SG11201408529VA (en) 2015-01-29
MX362184B (es) 2019-01-08
CL2015000143A1 (es) 2015-06-19
EA201590125A1 (ru) 2015-05-29
EP2880036A1 (en) 2015-06-10
WO2014023674A1 (en) 2014-02-13
CN104540829A (zh) 2015-04-22
CN104540829B (zh) 2017-04-26
IL236808B (en) 2018-05-31
UA113013C2 (uk) 2016-11-25
AU2013301577A1 (en) 2014-12-18
JP2015524456A (ja) 2015-08-24
NZ703192A (en) 2016-04-29
EA025884B1 (ru) 2017-02-28
MX2015001318A (es) 2015-04-17
MY185216A (en) 2021-04-30
PH12015500059A1 (en) 2015-03-02
HK1206355A1 (en) 2016-01-08
MA37791A1 (fr) 2016-05-31
MA37791B1 (fr) 2016-12-30
CO7141435A2 (es) 2014-12-12
BR112015000313A2 (pt) 2017-06-27
CA2880682A1 (en) 2014-02-13
JP5974177B2 (ja) 2016-08-23
EP2880036B1 (en) 2017-03-08
US20150246922A1 (en) 2015-09-03
PE20150341A1 (es) 2015-02-28
TWI506027B (zh) 2015-11-01
CR20140545A (es) 2015-01-12
PH12015500059B1 (en) 2015-03-02
KR20150027832A (ko) 2015-03-12
KR101716062B1 (ko) 2017-03-13
AR092041A1 (es) 2015-03-18
TW201410679A (zh) 2014-03-16

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