AU2013292356B2 - Difluorolactam compositions for EP4-mediated osteo related diseases and conditions - Google Patents

Difluorolactam compositions for EP4-mediated osteo related diseases and conditions Download PDF

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Publication number
AU2013292356B2
AU2013292356B2 AU2013292356A AU2013292356A AU2013292356B2 AU 2013292356 B2 AU2013292356 B2 AU 2013292356B2 AU 2013292356 A AU2013292356 A AU 2013292356A AU 2013292356 A AU2013292356 A AU 2013292356A AU 2013292356 B2 AU2013292356 B2 AU 2013292356B2
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Australia
Prior art keywords
difluoro
methyl
hydroxy
oxopyrrolidin
propyl
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AU2013292356A
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AU2013292356A1 (en
Inventor
Stephen Douglas Barrett
Fred Lawrence Ciske
Joseph Michael Colombo
Gregory William Endres
Bradlee David Germain
Andriy Kornilov
James Bernard Kramer
James Paul O'malley
Thomas Allen Owen
Adam Uzieblo
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MYOMETRICS LLC
Cayman Chemical Co Inc
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MYOMETRICS LLC
Cayman Chemical Co Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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  • Orthopedic Medicine & Surgery (AREA)
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  • Inorganic Chemistry (AREA)
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  • Rheumatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
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  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2013292356A 2012-07-19 2013-07-19 Difluorolactam compositions for EP4-mediated osteo related diseases and conditions Ceased AU2013292356B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673514P 2012-07-19 2012-07-19
US61/673,514 2012-07-19
US201361793929P 2013-03-15 2013-03-15
US61/793,929 2013-03-15
PCT/US2013/051261 WO2014015246A1 (en) 2012-07-19 2013-07-19 Difluorolactam compositions for ep4-mediated osteo related diseases and conditions

Publications (2)

Publication Number Publication Date
AU2013292356A1 AU2013292356A1 (en) 2015-02-19
AU2013292356B2 true AU2013292356B2 (en) 2018-02-01

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Application Number Title Priority Date Filing Date
AU2013292356A Ceased AU2013292356B2 (en) 2012-07-19 2013-07-19 Difluorolactam compositions for EP4-mediated osteo related diseases and conditions
AU2013292357A Ceased AU2013292357C1 (en) 2012-07-19 2013-07-19 Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions
AU2017200044A Ceased AU2017200044B2 (en) 2012-07-19 2017-01-04 Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions

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AU2013292357A Ceased AU2013292357C1 (en) 2012-07-19 2013-07-19 Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions
AU2017200044A Ceased AU2017200044B2 (en) 2012-07-19 2017-01-04 Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions

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US (8) US9180116B2 (https=)
EP (4) EP3176162B1 (https=)
JP (3) JP6141430B2 (https=)
KR (2) KR102131378B1 (https=)
CN (4) CN104583201B (https=)
AU (3) AU2013292356B2 (https=)
CA (2) CA2879507A1 (https=)
CY (1) CY1118929T1 (https=)
DK (2) DK2875022T3 (https=)
ES (3) ES2612921T3 (https=)
HR (1) HRP20170045T1 (https=)
HU (2) HUE031885T2 (https=)
IL (3) IL236637A (https=)
LT (1) LT2875022T (https=)
NZ (2) NZ704171A (https=)
PH (1) PH12015500111A1 (https=)
PL (1) PL2875022T3 (https=)
PT (2) PT3175852T (https=)
SI (1) SI2875022T1 (https=)
WO (2) WO2014015247A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2014015247A1 (en) 2012-07-19 2014-01-23 Cayman Chemical Company, Inc. Difluorolactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated disease and conditions
PT2989098T (pt) 2013-03-15 2017-08-16 Cayman Chemical Co Inc Compostos de lactama como agonistas selectivos do receptor ep4 para uso no tratamento de doenças e condições mediadas por ep4
CA2903314C (en) 2013-03-15 2023-02-14 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
KR20160048054A (ko) 2013-07-19 2016-05-03 카이맨 케미칼 컴파니 인코포레이티드 골 성장의 촉진을 위한 방법, 시스템 및 조성물
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