AU2013276565B2 - Tailored liposomes for the treatment of bacterial infections - Google Patents

Tailored liposomes for the treatment of bacterial infections Download PDF

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Publication number
AU2013276565B2
AU2013276565B2 AU2013276565A AU2013276565A AU2013276565B2 AU 2013276565 B2 AU2013276565 B2 AU 2013276565B2 AU 2013276565 A AU2013276565 A AU 2013276565A AU 2013276565 A AU2013276565 A AU 2013276565A AU 2013276565 B2 AU2013276565 B2 AU 2013276565B2
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AU
Australia
Prior art keywords
empty liposomes
liposomes
sphingomyelin
cholesterol
mixture
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AU2013276565A
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English (en)
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AU2013276565A1 (en
Inventor
Eduard Babiychuk
Annette Draeger
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Universitaet Bern
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Universitaet Bern
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Publication of AU2013276565B2 publication Critical patent/AU2013276565B2/en
Priority to AU2019201776A priority Critical patent/AU2019201776B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AU2013276565A 2012-06-14 2013-06-13 Tailored liposomes for the treatment of bacterial infections Active AU2013276565B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019201776A AU2019201776B2 (en) 2012-06-14 2019-03-14 Tailored liposomes for the treatment of bacterial infections

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12171924.9 2012-06-14
EP12171924 2012-06-14
EP13153039.6 2013-01-29
EP13153039 2013-01-29
PCT/EP2013/062207 WO2013186286A1 (en) 2012-06-14 2013-06-13 Tailored liposomes for the treatment of bacterial infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019201776A Division AU2019201776B2 (en) 2012-06-14 2019-03-14 Tailored liposomes for the treatment of bacterial infections

Publications (2)

Publication Number Publication Date
AU2013276565A1 AU2013276565A1 (en) 2014-12-18
AU2013276565B2 true AU2013276565B2 (en) 2018-12-20

Family

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AU2013276565A Active AU2013276565B2 (en) 2012-06-14 2013-06-13 Tailored liposomes for the treatment of bacterial infections
AU2019201776A Active AU2019201776B2 (en) 2012-06-14 2019-03-14 Tailored liposomes for the treatment of bacterial infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019201776A Active AU2019201776B2 (en) 2012-06-14 2019-03-14 Tailored liposomes for the treatment of bacterial infections

Country Status (19)

Country Link
US (4) US10744089B2 (https=)
EP (2) EP2861214B1 (https=)
JP (2) JP6382801B2 (https=)
CN (2) CN104602672B (https=)
AU (2) AU2013276565B2 (https=)
BR (1) BR112014031278B1 (https=)
CA (1) CA2875470C (https=)
CY (1) CY1123337T1 (https=)
DK (1) DK2861214T3 (https=)
ES (1) ES2821502T3 (https=)
HR (1) HRP20201761T1 (https=)
HU (1) HUE051761T2 (https=)
LT (1) LT2861214T (https=)
PL (1) PL2861214T3 (https=)
RS (1) RS60951B1 (https=)
RU (1) RU2672106C2 (https=)
SI (1) SI2861214T1 (https=)
SM (1) SMT202000584T1 (https=)
WO (1) WO2013186286A1 (https=)

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PL2861214T3 (pl) * 2012-06-14 2021-02-08 Universität Bern Liposomy przystosowane do leczenia zakażeń bakteryjnych
WO2015084677A1 (en) 2013-12-02 2015-06-11 Arytha Biosciences, Llc Toxoid preparation and uses thereof
US10739353B2 (en) * 2014-12-31 2020-08-11 Signpath Pharma, Inc. Suppression of cytokine release and cytokine storm
CA3009119A1 (en) 2015-12-28 2017-07-06 Mb Biotech Ltd. Liposomes for treatment of an autoimmune disease
EP3440187A1 (en) 2016-04-07 2019-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Francisella lipids as broad anti-inflammatory therapeutics and associated methods of use
SI3471732T1 (sl) 2016-06-16 2020-09-30 Combioxin Sa Liposomi za zdravljenje virusnih infekcij
EP3589278B1 (en) 2017-03-02 2026-01-14 Combioxin SA Liposomes for inhibiting biofilm formation
US11344497B1 (en) 2017-12-08 2022-05-31 Quicksilver Scientific, Inc. Mitochondrial performance enhancement nanoemulsion
SMT202300391T1 (it) 2018-04-17 2024-01-10 Combioxin Sa Trattamento della polmonite
FI3781210T3 (fi) * 2018-04-20 2024-09-12 Combioxin Sa Hypotension hoito sepsiksen tai septisen sokin yhteydessä
CN111214439B (zh) * 2018-11-23 2023-02-10 复旦大学 一种具有细菌成孔毒素吸附性能的纳米药物系统及其用途
WO2021150460A1 (en) 2020-01-20 2021-07-29 Arytha Biosciences Llc Devices containing cellular membrane and uses thereof
JP2023536833A (ja) * 2020-07-31 2023-08-30 サインパス ファルマ，インク． サイトカイン放出及びサイトカインストームの抑制
CN115054577B (zh) * 2022-05-17 2024-06-21 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 纳米解毒剂及其在中和mrsa穿孔毒素的应用

Citations (4)

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US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
WO2006052767A2 (en) * 2004-11-05 2006-05-18 Inex Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
US20070122466A1 (en) * 2001-08-13 2007-05-31 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders

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NL9000207A (https=) * 1990-01-29 1991-08-16 Duphar Int Res
AU2583892A (en) * 1991-09-11 1993-04-05 Pitman-Moore, Inc. Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
CA2467064C (en) * 2001-11-13 2011-02-08 Murray Webb Lipid carrier compositions with enhanced blood stability
CA2368656A1 (en) * 2002-01-21 2003-07-21 Vasogen Ireland Limited Receptor-ligand pairing for anti-inflammatory response
KR100746141B1 (ko) 2002-03-08 2007-08-06 에자이 알앤드디 매니지먼트 가부시키가이샤 전시냅스성 단백질 р120
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JP4874547B2 (ja) * 2002-11-26 2012-02-15 ギリアード サイエンシーズ， インコーポレイテッド 勾配によるリポソームへの薬物充填方法
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PL2861214T3 (pl) 2012-06-14 2021-02-08 Universität Bern Liposomy przystosowane do leczenia zakażeń bakteryjnych
WO2017222912A1 (en) 2016-06-20 2017-12-28 Vivacelle Bio, Inc. Compositions and methods for reducing reperfusion injury
EP3589278B1 (en) 2017-03-02 2026-01-14 Combioxin SA Liposomes for inhibiting biofilm formation
SMT202300391T1 (it) 2018-04-17 2024-01-10 Combioxin Sa Trattamento della polmonite

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US20070122466A1 (en) * 2001-08-13 2007-05-31 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
WO2006052767A2 (en) * 2004-11-05 2006-05-18 Inex Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations

Also Published As

Publication number Publication date
CY1123337T1 (el) 2021-12-31
JP6656321B2 (ja) 2020-03-04
SMT202000584T1 (it) 2020-11-10
DK2861214T3 (da) 2020-10-12
HRP20201761T1 (hr) 2020-12-25
RU2672106C2 (ru) 2018-11-12
RU2018138012A (ru) 2019-03-21
CN104602672B (zh) 2018-12-25
AU2019201776A1 (en) 2019-04-04
US20150157570A1 (en) 2015-06-11
EP2861214B1 (en) 2020-08-05
US10744089B2 (en) 2020-08-18
US20220087934A1 (en) 2022-03-24
CA2875470A1 (en) 2013-12-19
JP2015519383A (ja) 2015-07-09
JP6382801B2 (ja) 2018-08-29
JP2018184470A (ja) 2018-11-22
US20200345639A1 (en) 2020-11-05
CN109549925A (zh) 2019-04-02
SI2861214T1 (sl) 2021-01-29
RS60951B1 (sr) 2020-11-30
CN104602672A (zh) 2015-05-06
BR112014031278B1 (pt) 2020-12-01
CN109549925B (zh) 2022-06-17
LT2861214T (lt) 2020-12-28
WO2013186286A1 (en) 2013-12-19
AU2019201776B2 (en) 2020-11-12
AU2013276565A1 (en) 2014-12-18
US20230031648A1 (en) 2023-02-02
HK1210018A1 (en) 2016-04-15
ES2821502T3 (es) 2021-04-26
EP2861214A1 (en) 2015-04-22
CA2875470C (en) 2021-01-12
US12599558B2 (en) 2026-04-14
PL2861214T3 (pl) 2021-02-08
RU2014148284A (ru) 2016-08-10
BR112014031278A2 (pt) 2017-06-27
EP3782606A1 (en) 2021-02-24
HUE051761T2 (hu) 2021-03-29

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