AU2013273965B2 - Microstructure-based wound closure devices - Google Patents
Microstructure-based wound closure devices Download PDFInfo
- Publication number
- AU2013273965B2 AU2013273965B2 AU2013273965A AU2013273965A AU2013273965B2 AU 2013273965 B2 AU2013273965 B2 AU 2013273965B2 AU 2013273965 A AU2013273965 A AU 2013273965A AU 2013273965 A AU2013273965 A AU 2013273965A AU 2013273965 B2 AU2013273965 B2 AU 2013273965B2
- Authority
- AU
- Australia
- Prior art keywords
- wound
- wound closure
- microstructures
- microstructure
- arrays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010052428 Wound Diseases 0.000 claims abstract description 474
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 474
- 238000000034 method Methods 0.000 claims abstract description 45
- 230000029663 wound healing Effects 0.000 claims abstract description 7
- 230000001681 protective effect Effects 0.000 claims abstract description 6
- 238000003491 array Methods 0.000 claims description 220
- 239000000463 material Substances 0.000 claims description 86
- 239000000853 adhesive Substances 0.000 claims description 84
- 230000001070 adhesive effect Effects 0.000 claims description 84
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 26
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 26
- 239000000017 hydrogel Substances 0.000 claims description 25
- 229920002101 Chitin Polymers 0.000 claims description 22
- 229920001296 polysiloxane Polymers 0.000 claims description 22
- 229920001661 Chitosan Polymers 0.000 claims description 18
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 24
- 238000004806 packaging method and process Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 115
- 210000001519 tissue Anatomy 0.000 description 41
- -1 (e.g. Substances 0.000 description 22
- 206010061218 Inflammation Diseases 0.000 description 22
- 230000004054 inflammatory process Effects 0.000 description 22
- 239000011295 pitch Substances 0.000 description 22
- 239000000203 mixture Substances 0.000 description 21
- 230000000670 limiting effect Effects 0.000 description 18
- 229940079593 drug Drugs 0.000 description 16
- 206010015150 Erythema Diseases 0.000 description 14
- 230000035876 healing Effects 0.000 description 14
- 231100000321 erythema Toxicity 0.000 description 12
- 238000013461 design Methods 0.000 description 11
- 210000003128 head Anatomy 0.000 description 11
- 230000036407 pain Effects 0.000 description 11
- 229920002635 polyurethane Polymers 0.000 description 11
- 239000004814 polyurethane Substances 0.000 description 11
- 239000000416 hydrocolloid Substances 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 239000002086 nanomaterial Substances 0.000 description 10
- 229920000728 polyester Polymers 0.000 description 10
- 239000002121 nanofiber Substances 0.000 description 9
- 229920002994 synthetic fiber Polymers 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000000149 penetrating effect Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 239000004698 Polyethylene Substances 0.000 description 7
- 210000004207 dermis Anatomy 0.000 description 7
- 210000002615 epidermis Anatomy 0.000 description 7
- 238000005530 etching Methods 0.000 description 7
- 229920000573 polyethylene Polymers 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000000820 replica moulding Methods 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000012384 transportation and delivery Methods 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 5
- 230000002500 effect on skin Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000037368 penetrate the skin Effects 0.000 description 5
- 230000037390 scarring Effects 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 208000034693 Laceration Diseases 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 238000004873 anchoring Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 230000000774 hypoallergenic effect Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000028709 inflammatory response Effects 0.000 description 4
- 238000005459 micromachining Methods 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 4
- 230000003000 nontoxic effect Effects 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 210000003813 thumb Anatomy 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 239000000648 calcium alginate Substances 0.000 description 3
- 235000010410 calcium alginate Nutrition 0.000 description 3
- 229960002681 calcium alginate Drugs 0.000 description 3
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000023753 dehiscence Effects 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 210000003811 finger Anatomy 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000003698 laser cutting Methods 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 238000001393 microlithography Methods 0.000 description 3
- 239000005445 natural material Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008093 supporting effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 206010011985 Decubitus ulcer Diseases 0.000 description 2
- 206010056340 Diabetic ulcer Diseases 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 208000004221 Multiple Trauma Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920005372 Plexiglas® Polymers 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 2
- 206010054880 Vascular insufficiency Diseases 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 239000012237 artificial material Substances 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229960005274 benzocaine Drugs 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 229940088623 biologically active substance Drugs 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000037237 body shape Effects 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 239000002729 catgut Substances 0.000 description 2
- 239000000769 chromic catgut Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000002682 general surgery Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 238000007386 incisional biopsy Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000002357 laparoscopic surgery Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 2
- 239000000622 polydioxanone Substances 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229920002781 resilin Polymers 0.000 description 2
- 108010019116 resilin Proteins 0.000 description 2
- 238000002432 robotic surgery Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 2
- 239000003106 tissue adhesive Substances 0.000 description 2
- 229940075469 tissue adhesives Drugs 0.000 description 2
- 208000023577 vascular insufficiency disease Diseases 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010061619 Deformity Diseases 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010021519 Impaired healing Diseases 0.000 description 1
- 241001514662 Leptospermum Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 241000219289 Silene Species 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 206010048031 Wound dehiscence Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229920005839 ecoflex® Polymers 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 229960001235 gentian violet Drugs 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000013003 healing agent Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000001053 micromoulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 238000007390 skin biopsy Methods 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000003631 wet chemical etching Methods 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B2017/081—Tissue approximator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/00723—Plasters adhesive non-adhesive skin fixation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Packages (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660561P | 2012-06-15 | 2012-06-15 | |
| US61/660,561 | 2012-06-15 | ||
| US201261710246P | 2012-10-05 | 2012-10-05 | |
| US61/710,246 | 2012-10-05 | ||
| PCT/US2013/046181 WO2013188884A1 (en) | 2012-06-15 | 2013-06-17 | Microstructure-based wound closure devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013273965A1 AU2013273965A1 (en) | 2014-12-18 |
| AU2013273965B2 true AU2013273965B2 (en) | 2017-11-23 |
Family
ID=48741554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013273965A Ceased AU2013273965B2 (en) | 2012-06-15 | 2013-06-17 | Microstructure-based wound closure devices |
Country Status (15)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931040B2 (en) | 2016-03-01 | 2024-03-19 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
| US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
| US11986613B2 (en) | 2020-02-19 | 2024-05-21 | Kitotech Medical, Inc. | Microstructure systems and methods for pain treatment |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013025232B1 (pt) | 2011-03-31 | 2021-06-29 | Felmont Eaves | Ponte de tecido para o direcionamento de forças sobre uma superfície do tecido |
| EP2768454B1 (en) | 2011-10-20 | 2018-04-18 | Emrge, Llc | Removable covering |
| SG11201408221YA (en) | 2012-06-15 | 2015-01-29 | Univ Washington Ct Commerciali | Microstructure-based wound closure devices |
| WO2015122719A1 (en) * | 2014-02-14 | 2015-08-20 | Industry-Academic Cooperation Foundation, Yonsei University | Microstructure-based drug delivery system comprising microporous structure |
| CN103800998B (zh) * | 2014-02-24 | 2016-03-30 | 苏州大学 | 一种丝素蛋白凝胶微针系统及其制备方法 |
| KR101724654B1 (ko) * | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | 마이크로 니들 패치 및 그의 제조 방법 |
| WO2015194260A1 (ja) * | 2014-06-18 | 2015-12-23 | 凸版印刷株式会社 | マイクロニードルユニット |
| US9986988B2 (en) | 2014-11-27 | 2018-06-05 | AOD Holdings, LLC | Surgical retractor |
| US10279533B1 (en) * | 2014-12-22 | 2019-05-07 | 10X Technology, Llc | Method and apparatus for fabricating bent microneedles for use as micro-sutures in a wound closure device |
| US9999759B2 (en) | 2015-01-15 | 2018-06-19 | Ethicon, Inc. | Linear staplers having resorbable microneedles containing active agents |
| US10792042B2 (en) | 2015-01-15 | 2020-10-06 | Ethicon, Inc. | Circular staplers having resorbable microneedles containing active agents |
| EP3315165A4 (en) * | 2015-06-23 | 2019-11-20 | Toppan Printing Co., Ltd. | NEEDLE ELEMENT AND METHOD FOR PRODUCING A NEEDLE ELEMENT |
| US10517592B2 (en) | 2015-10-29 | 2019-12-31 | Ethicon Llc | Surgical stapler buttress assembly with adhesion to wet end effector |
| CN108882994B (zh) * | 2015-11-11 | 2022-01-25 | 班德格列普公司 | 绷带 |
| KR102438234B1 (ko) * | 2015-11-16 | 2022-08-31 | 삼성전자주식회사 | 생체신호 센싱패치 및 이를 구비한 생체신호 모니터링 장치 |
| CN108430565B (zh) * | 2015-12-28 | 2021-07-20 | (株)安道德玛 | 用于经皮吸收的微结构体及其制备方法 |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| US11071717B2 (en) * | 2016-07-18 | 2021-07-27 | Ana R. Olivero | Anesthetic bandage |
| WO2018048954A1 (en) | 2016-09-06 | 2018-03-15 | Axion Biosystems, Inc. | Devices and methods for repairing damage to a nerve |
| TW201815356A (zh) * | 2016-10-18 | 2018-05-01 | 諾華公司 | 具有表面紋理的外科手術器械 |
| EP4252675A3 (en) | 2016-10-21 | 2023-11-15 | Brijjit Medical, Inc. | Force modulating tissue bridges |
| KR20180055938A (ko) * | 2016-11-09 | 2018-05-28 | 김주홍 | 주름 제거용 패치 |
| EP3586906A4 (en) * | 2017-02-24 | 2020-12-30 | Hisamitsu Pharmaceutical Co., Inc. | MICRO-NEEDLE DEVICE |
| US20210251628A1 (en) * | 2020-02-19 | 2021-08-19 | KitoTech Medical, Inc | Elastic and flexible wound closure device |
| WO2018230402A2 (en) * | 2017-06-12 | 2018-12-20 | Terumo Kabushiki Kaisha | Subcutaneous tissue device |
| TWI645870B (zh) * | 2017-06-27 | 2019-01-01 | 韓商安道德瑪股份有限公司 | 經皮吸收用微結構體及其製造方法 |
| KR102333037B1 (ko) * | 2017-08-17 | 2021-12-01 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 입술용 마이크로니들 어레이 |
| USD876641S1 (en) | 2017-10-20 | 2020-02-25 | Emrge, Llc. | Medical article for treating a wound and/or scar tissue |
| USD862695S1 (en) | 2017-10-20 | 2019-10-08 | Emrge, Llc | Medical tool for use in applying medical article |
| US20190125589A1 (en) * | 2017-11-02 | 2019-05-02 | BandGrip, Inc. | Bandage And Anchor For Bandages |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| US11291448B2 (en) | 2017-11-15 | 2022-04-05 | BandGrip, Inc. | Mechanical tissue coupling system, applicator therefor and method of use thereof |
| US11045187B2 (en) | 2018-02-28 | 2021-06-29 | BandGrip, Inc. | Subcutaneous wound closure assembly and method of use |
| JP7487181B2 (ja) * | 2018-05-18 | 2024-05-20 | ポステック アカデミー－インダストリー ファンデーション | 経皮透過型薬物伝達パッチの製造方法 |
| WO2019221318A1 (ko) * | 2018-05-18 | 2019-11-21 | 포항공과대학교 산학협력단 | 경피 투과형 약물 전달 패치 및 이의 제조 방법 |
| KR20220162600A (ko) * | 2018-10-01 | 2022-12-08 | 키토테크 메디컬 인코포레이티드 | 마이크로 구조를 포함하는 조직 케어 장치 |
| CN112996554B (zh) * | 2018-10-31 | 2023-07-11 | 富士胶片株式会社 | 微针阵列器件 |
| WO2020166744A1 (ko) * | 2019-02-15 | 2020-08-20 | 주식회사 하이로닉 | 변형 구조 마이크로 니들 및 피부 드레싱용 패드를 이용한 피부 리프팅 방법 |
| WO2020186730A1 (zh) * | 2019-03-19 | 2020-09-24 | 景润(上海)医疗器械有限公司 | 四肢深筋膜内无缝线闭合皮肤创口的外科辅助设备 |
| JP7305411B2 (ja) * | 2019-04-05 | 2023-07-10 | 株式会社三共 | スロットマシン |
| US11904125B2 (en) | 2019-06-07 | 2024-02-20 | Massachusetts Institute Of Technology | Manuka honey microneedle |
| WO2021007344A1 (en) * | 2019-07-08 | 2021-01-14 | Board Of Regents Of The University Of Nebraska | Drug delivery using microneedle arrays |
| GB2586475A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Methods |
| GB2586474A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Method of manufacturing microstructures |
| US20220346770A1 (en) | 2019-10-11 | 2022-11-03 | Emrge, Llc | Medical Device for Applying Force on Biological Tissue, or the Like |
| US20220361876A1 (en) * | 2019-10-15 | 2022-11-17 | The Regents Of The University Of California | Bio-Zipper Surgical Closure Device |
| US11672635B2 (en) * | 2020-04-29 | 2023-06-13 | Bvw Holding Ag | Microstructure soft tissue graft |
| KR102414580B1 (ko) * | 2020-07-17 | 2022-07-01 | 한국과학기술연구원 | 수술 전 감염 방지를 위한 마이크로니들 패치 및 마이크로니들 패치를 이용한 수술 전처리 방법 |
| KR20230039749A (ko) * | 2020-08-04 | 2023-03-21 | 비브이더블유 홀딩 에이쥐 | 미세 구조화된 연질 조직 이식편 |
| CN112716692A (zh) * | 2020-12-30 | 2021-04-30 | 无锡快邦医疗科技有限公司 | 伤口治疗用保护垫 |
| USD980434S1 (en) | 2021-01-14 | 2023-03-07 | Emrge, Llc | Medical article for treating a wound and/or scar tissue |
| US20220240935A1 (en) | 2021-01-29 | 2022-08-04 | Cheuk Yin Paul Leung | Wound closure device with wide spaced microstructures |
| CN116098669B (zh) * | 2023-03-22 | 2024-02-20 | 北京麦迪益康商贸有限公司 | 一种伤口闭合器 |
| CN117679101B (zh) * | 2024-02-04 | 2024-04-05 | 苏州大学附属第二医院 | 一种预埋式无痕皮肤缝合器 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430998A (en) * | 1982-06-01 | 1984-02-14 | Thoratec Laboratories Corporation | Wound closing device |
| US20030065360A1 (en) * | 2000-05-19 | 2003-04-03 | Daniel Jacobs | Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing |
| US20040010276A1 (en) * | 2000-05-19 | 2004-01-15 | Daniel Jacobs | Multi-point tissue tension distribution device and method, a chin lift variation |
| WO2010124712A1 (de) * | 2009-04-29 | 2010-11-04 | Aesculap Ag | Wundverschluss |
| WO2011016230A1 (ja) * | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| CA1006064A (en) * | 1971-12-17 | 1977-03-01 | Harrith M. Hasson | Surgical closure |
| US3926193A (en) * | 1971-12-17 | 1975-12-16 | Harrith M Hasson | Surgical closure having ease of assembly |
| US4330357A (en) * | 1980-10-23 | 1982-05-18 | Minnesota Mining And Manufacturing Company | Dispenser for liner-wound tape |
| US5047047A (en) * | 1988-10-26 | 1991-09-10 | Inbae Yoon | Wound closing device |
| US5234462A (en) * | 1991-08-29 | 1993-08-10 | Tufts University | Method and kit for accelerating the closing of open skin wounds |
| FR2690840B1 (fr) * | 1992-05-07 | 1994-08-19 | Patrick Frechet | Dispositif d'extension de tissu vivant. |
| WO1999064580A1 (en) | 1998-06-10 | 1999-12-16 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| EP1187653B1 (en) | 1999-06-04 | 2010-03-31 | Georgia Tech Research Corporation | Devices for enhanced microneedle penetration of biological barriers |
| AU3081601A (en) * | 1999-11-15 | 2001-05-30 | Velcro Industries B.V. | Skin attachment member |
| MXPA02011375A (es) | 2000-05-19 | 2004-08-12 | Coapt System Inc | Dispositivo de aproximacion de tejido y metodo que utiliza el mismo. |
| US7172615B2 (en) * | 2000-05-19 | 2007-02-06 | Coapt Systems, Inc. | Remotely anchored tissue fixation device |
| US20040260340A1 (en) * | 2000-05-19 | 2004-12-23 | Jacobs Daniel Irwin | Remotely anchored tissue fixation device and method |
| WO2002094368A1 (en) * | 2000-10-26 | 2002-11-28 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US7422567B2 (en) * | 2002-08-29 | 2008-09-09 | Becton, Dickinson And Company | Microabrader with controlled abrasion features |
| US20040138705A1 (en) | 2003-01-09 | 2004-07-15 | Harri Heino | Surgical staple for tissue treatment |
| US7972347B2 (en) * | 2003-06-27 | 2011-07-05 | Surgical Security, Llc | Device for surgical repair, closure, and reconstruction |
| US20060093658A1 (en) | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
| CA2607768A1 (en) * | 2005-05-12 | 2006-11-23 | Canica Design Inc. | Dynamic tensioning system and method |
| WO2007127976A2 (en) | 2006-05-01 | 2007-11-08 | Georgia Tech Research Corporation | Particle based molding |
| CN103494620B (zh) | 2006-08-03 | 2016-04-20 | 利兰斯坦福青年大学托管委员会 | 用于治疗或预防伤疤和/或瘢痕的设备和绷带及其方法和套件 |
| JPWO2008020632A1 (ja) * | 2006-08-18 | 2010-01-07 | 凸版印刷株式会社 | マイクロニードル及びマイクロニードルパッチ |
| EP2152196A1 (en) | 2007-05-01 | 2010-02-17 | The Brigham and Women's Hospital, Inc. | Wound healing device |
| CA2782710C (en) | 2009-12-01 | 2019-01-22 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device and methods of making and using the same |
| AU2011246880B2 (en) * | 2010-04-28 | 2015-10-29 | Sorrento Therapeutics, Inc. | Medical devices for delivery of siRNA |
| US8851284B2 (en) * | 2011-05-18 | 2014-10-07 | Thuban, Inc. | Adhesive bandage dispensing arrangements |
| US20140194379A1 (en) | 2011-06-03 | 2014-07-10 | University Of Washington Through Its Center For Commercialization | Methods for the production of chitin nanofibers and uses thereof |
| JP2014525291A (ja) | 2011-08-24 | 2014-09-29 | カルゴン カーボン コーポレーション | 活性炭を含む創傷被覆材 |
| SG11201408221YA (en) | 2012-06-15 | 2015-01-29 | Univ Washington Ct Commerciali | Microstructure-based wound closure devices |
-
2013
- 2013-06-17 SG SG11201408221YA patent/SG11201408221YA/en unknown
- 2013-06-17 EP EP19174754.2A patent/EP3574846A1/en not_active Withdrawn
- 2013-06-17 JP JP2015517482A patent/JP6833317B2/ja active Active
- 2013-06-17 US US14/408,244 patent/US10751050B2/en active Active
- 2013-06-17 AU AU2013273965A patent/AU2013273965B2/en not_active Ceased
- 2013-06-17 IN IN2939KON2014 patent/IN2014KN02939A/en unknown
- 2013-06-17 EP EP13733182.3A patent/EP2861181B1/en active Active
- 2013-06-17 BR BR112014031438A patent/BR112014031438A2/pt not_active IP Right Cessation
- 2013-06-17 NZ NZ702677A patent/NZ702677A/en not_active IP Right Cessation
- 2013-06-17 KR KR20157000949A patent/KR20150037826A/ko not_active Ceased
- 2013-06-17 HK HK15110283.8A patent/HK1209614A1/xx unknown
- 2013-06-17 MX MX2014015365A patent/MX2014015365A/es unknown
- 2013-06-17 ES ES13733182T patent/ES2743733T3/es active Active
- 2013-06-17 CA CA2875227A patent/CA2875227C/en active Active
- 2013-06-17 WO PCT/US2013/046181 patent/WO2013188884A1/en active Application Filing
-
2014
- 2014-12-12 ZA ZA2014/09196A patent/ZA201409196B/en unknown
-
2019
- 2019-01-10 JP JP2019002286A patent/JP6894454B2/ja active Active
-
2020
- 2020-07-15 US US16/930,217 patent/US20200345366A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430998A (en) * | 1982-06-01 | 1984-02-14 | Thoratec Laboratories Corporation | Wound closing device |
| US20030065360A1 (en) * | 2000-05-19 | 2003-04-03 | Daniel Jacobs | Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing |
| US20040010276A1 (en) * | 2000-05-19 | 2004-01-15 | Daniel Jacobs | Multi-point tissue tension distribution device and method, a chin lift variation |
| WO2010124712A1 (de) * | 2009-04-29 | 2010-11-04 | Aesculap Ag | Wundverschluss |
| WO2011016230A1 (ja) * | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931040B2 (en) | 2016-03-01 | 2024-03-19 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
| US11986613B2 (en) | 2020-02-19 | 2024-05-21 | Kitotech Medical, Inc. | Microstructure systems and methods for pain treatment |
| US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
| US12290260B2 (en) | 2022-02-18 | 2025-05-06 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201409196B (en) | 2015-12-23 |
| ES2743733T3 (es) | 2020-02-20 |
| AU2013273965A1 (en) | 2014-12-18 |
| EP2861181A1 (en) | 2015-04-22 |
| NZ702677A (en) | 2016-05-27 |
| BR112014031438A2 (pt) | 2017-06-27 |
| CA2875227C (en) | 2021-09-14 |
| JP6894454B2 (ja) | 2021-06-30 |
| US20150305739A1 (en) | 2015-10-29 |
| SG11201408221YA (en) | 2015-01-29 |
| HK1209614A1 (en) | 2016-04-08 |
| MX2014015365A (es) | 2015-05-11 |
| JP2019072534A (ja) | 2019-05-16 |
| JP6833317B2 (ja) | 2021-02-24 |
| JP2015523139A (ja) | 2015-08-13 |
| US10751050B2 (en) | 2020-08-25 |
| EP2861181B1 (en) | 2019-07-24 |
| KR20150037826A (ko) | 2015-04-08 |
| EP3574846A1 (en) | 2019-12-04 |
| US20200345366A1 (en) | 2020-11-05 |
| IN2014KN02939A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-05-08 |
| CA2875227A1 (en) | 2013-12-19 |
| WO2013188884A1 (en) | 2013-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200345366A1 (en) | Microstructure-based wound closure devices | |
| US11931040B2 (en) | Microstructure-based systems, apparatus, and methods for wound closure | |
| JP6305397B2 (ja) | 個体を治療するための医療製品 | |
| US20160270968A1 (en) | Two-part bandage with replaceable wound covering portion | |
| US11813143B2 (en) | Tissue care devices including microstructures | |
| JP2016513536A (ja) | 可変の縁の幾何学形状を有する創傷または皮膚治療デバイス | |
| US12290260B2 (en) | Force modulating deep skin staples and instruments | |
| US20220240935A1 (en) | Wound closure device with wide spaced microstructures | |
| WO2017213534A1 (ru) | Способ подготовки трансплантанта, перфоратор (варианты) для его реализации и способ лечения ожоговых ран | |
| WO2019119292A1 (zh) | 一种贴覆结构 | |
| HK40002514B (en) | Microstructure-based systems, apparatus, and methods for wound closure | |
| CN209059667U (zh) | 一种贴覆结构 | |
| HK40002514A (en) | Microstructure-based systems, apparatus, and methods for wound closure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |