AU2013214783B2 - CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer - Google Patents
CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer Download PDFInfo
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Applications Claiming Priority (5)
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| US201261594023P | 2012-02-02 | 2012-02-02 | |
| US61/594,023 | 2012-02-02 | ||
| US201261673419P | 2012-07-19 | 2012-07-19 | |
| US61/673,419 | 2012-07-19 | ||
| PCT/US2013/024515 WO2013116786A1 (en) | 2012-02-02 | 2013-02-01 | Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer |
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| AU2013214783A1 AU2013214783A1 (en) | 2014-08-28 |
| AU2013214783B2 true AU2013214783B2 (en) | 2017-07-06 |
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| NZ703851A (en) * | 2012-07-27 | 2017-01-27 | Biogen Ma Inc | Compounds that are s1p modulating agents and/or atx modulating agents |
| HK1206741A1 (en) * | 2012-08-23 | 2016-01-15 | 霍夫曼-拉罗奇有限公司 | Novel phenyl-pyridine/pyrazine amides for the treatment of cancer |
| KR20160014568A (ko) | 2012-11-01 | 2016-02-11 | 유니버시티 오브 싸우스 캐롤라이나 | 전립선암을 치료하는 방법 |
| EP2961409A1 (en) * | 2013-02-26 | 2016-01-06 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
| AU2014369834B2 (en) | 2013-12-24 | 2018-12-20 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| US9957251B2 (en) | 2014-04-18 | 2018-05-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| AU2015296968A1 (en) * | 2014-06-10 | 2017-02-02 | University Of South Carolina | Methods and compositions for treatment of HER-positive cancers |
| WO2016100782A1 (en) | 2014-12-18 | 2016-06-23 | University Of South Carolina | Suppression of neointimal formation following vascular surgery using cdk8 inhibitors |
| KR20180003597A (ko) * | 2015-05-08 | 2018-01-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유도체로의 치료를 위한 환자의 표적화된 선택 |
| WO2016182932A1 (en) | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| EP3316889A4 (en) | 2015-07-01 | 2018-11-14 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| EP3370720A1 (en) * | 2015-11-03 | 2018-09-12 | Lu License AB | Compounds for treatment of hypoproliferative disorders |
| WO2017091836A1 (en) * | 2015-11-25 | 2017-06-01 | University Of South Carolina | Enhancement of cytarabine activity by inhibiting cdk8/19 |
| WO2017164230A1 (ja) * | 2016-03-23 | 2017-09-28 | 国立大学法人 岡山大学 | リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用 |
| WO2018027082A1 (en) | 2016-08-03 | 2018-02-08 | The Broad Institute, Inc. | Use of cdk8 inhibitors to treat diseases of inflammation and autoimmunity |
| US11578067B2 (en) * | 2017-01-30 | 2023-02-14 | Kyoto University | Compound, and method for producing regulatory T cells |
| WO2018151633A1 (ru) * | 2017-02-20 | 2018-08-23 | Закрытое Акционерное Общество "Биокад" | Способы получения производных 4-(((нафталин-2-ил)алкил)амино)хинозалин-6-карбонитрилов |
| WO2018156858A1 (en) * | 2017-02-23 | 2018-08-30 | University Of South Carolina | Use of cdk8/19 inhibitors for treatment of established colon cancer hepatic metastasis |
| EP3591040A4 (en) | 2017-03-03 | 2020-11-11 | Kyoto University | METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS |
| US11013728B2 (en) | 2017-04-03 | 2021-05-25 | Kyoto Pharmaceutical Industries, Ltd. | Cyclin-dependent kinase 8 and/or 19 inhibitor |
| RU2641001C1 (ru) * | 2017-04-03 | 2018-01-15 | Закрытое Акционерное Общество "Биокад" | Соли 4-((2-(6-(4-метилпиперазин-1-карбонил)нафталин-2-ил)этил)амино)хиназолин-6-карбонитрила и фармацевтическая композиция |
| CN111278469A (zh) * | 2017-09-18 | 2020-06-12 | 陈扎克伯格生物中心公司 | 用于治疗三阴性乳腺癌的方法 |
| EP3691642B1 (en) | 2017-10-02 | 2024-03-06 | Boehringer Ingelheim International GmbH | [1,6]naphthyridine compounds and derivatives as cdk8/cdk19 inhibitors |
| RU2763347C2 (ru) * | 2018-03-01 | 2021-12-28 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| CN113677341B (zh) | 2019-02-01 | 2024-07-05 | 南卡罗莱纳大学 | 双环吡啶组合物及其用于癌症治疗的方法 |
| EP4249587A4 (en) | 2020-11-20 | 2025-02-19 | Orizuru Therapeutics, Inc. | RIPENING AGENT |
| CA3208794A1 (en) | 2021-02-09 | 2022-08-18 | Orizuru Therapeutics, Inc. | Maturation agent |
| CA3214794A1 (en) * | 2021-03-25 | 2022-09-29 | University Of South Carolina | Cdk8/19 inhibitors for the treatment of cytokine storm |
| AU2022349176A1 (en) | 2021-09-27 | 2024-04-11 | Kyoto University | Method for producing t cell |
| WO2023095801A1 (ja) | 2021-11-24 | 2023-06-01 | レグセル株式会社 | ヒト誘導性制御性ｔ細胞およびその作製方法 |
| TW202334397A (zh) | 2021-11-24 | 2023-09-01 | 日商雷格細胞股份有限公司 | 用於治療或預防t細胞相關疾病之醫藥組合物 |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| JPWO2023210578A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2022-04-25 | 2023-11-02 | ||
| KR20250036837A (ko) | 2022-07-14 | 2025-03-14 | 오리즈루 세라퓨틱스 가부시키가이샤 | 세포 이식용의 피브린 겔 시트 |
| KR20250077533A (ko) | 2022-09-26 | 2025-05-30 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | T 세포 제조 방법 |
| CN119948155A (zh) | 2022-09-26 | 2025-05-06 | 雷格细胞股份有限公司 | 含有嵌合抗原受体（car）的诱导性调节性t细胞 |
| WO2024166969A1 (ja) | 2023-02-08 | 2024-08-15 | レグセル株式会社 | 天疱瘡を治療または予防するための医薬組成物 |
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| US20080033000A1 (en) * | 2006-05-15 | 2008-02-07 | Senex Biotechnology, Inc. | Identification of CDKI pathway inhibitors |
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| JP2004500304A (ja) * | 1997-10-27 | 2004-01-08 | アグロン ファ−マシュ−テイカルズ インコ−ポレイテッド | ４−アミノチアゾ−ル誘導体、その製造法およびサイクリン依存キナ−ゼ抑制剤としての使用法 |
| US6440959B1 (en) * | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| US20040180844A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| US20040180848A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| MXPA05010824A (es) | 2003-04-10 | 2005-12-05 | Pfizer | Compuestos biciclicos como antagonistas del receptor nr2b. |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
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| US20080033000A1 (en) * | 2006-05-15 | 2008-02-07 | Senex Biotechnology, Inc. | Identification of CDKI pathway inhibitors |
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| EP3431087A1 (en) | 2019-01-23 |
| MY165446A (en) | 2018-03-22 |
| CL2014002062A1 (es) | 2015-03-20 |
| EP2809324B1 (en) | 2018-08-01 |
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| US20170071942A1 (en) | 2017-03-16 |
| UA117342C2 (uk) | 2018-07-25 |
| BR112014019052A8 (pt) | 2017-07-11 |
| EA201491399A1 (ru) | 2015-04-30 |
| EA032429B1 (ru) | 2019-05-31 |
| WO2013116786A1 (en) | 2013-08-08 |
| EA028595B1 (ru) | 2017-12-29 |
| EP2809324A1 (en) | 2014-12-10 |
| EA201791284A1 (ru) | 2017-10-31 |
| US9321737B2 (en) | 2016-04-26 |
| PH12014501862A1 (en) | 2014-11-24 |
| AU2013214783A1 (en) | 2014-08-28 |
| US10993945B2 (en) | 2021-05-04 |
| US20140038958A1 (en) | 2014-02-06 |
| JP2015506376A (ja) | 2015-03-02 |
| CN104363913B (zh) | 2018-08-21 |
| JP6193268B2 (ja) | 2017-09-06 |
| CO7151516A2 (es) | 2014-12-29 |
| KR20150023223A (ko) | 2015-03-05 |
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