AU2013209492B2 - Anti-CXCR3 antibodies - Google Patents

Anti-CXCR3 antibodies Download PDF

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Publication number
AU2013209492B2
AU2013209492B2 AU2013209492A AU2013209492A AU2013209492B2 AU 2013209492 B2 AU2013209492 B2 AU 2013209492B2 AU 2013209492 A AU2013209492 A AU 2013209492A AU 2013209492 A AU2013209492 A AU 2013209492A AU 2013209492 B2 AU2013209492 B2 AU 2013209492B2
Authority
AU
Australia
Prior art keywords
seq
pct
amino acid
antibody
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013209492A
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English (en)
Other versions
AU2013209492A1 (en
Inventor
Karen B. Carter
Ruiyin Chu
Timothy D. Connors
Tracey Lodie
Elizabeth MASTERJOHN
Jason Robert Pinckney
Jennifer TEDSTONE
Michele Youd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AU2013209492A1 publication Critical patent/AU2013209492A1/en
Application granted granted Critical
Publication of AU2013209492B2 publication Critical patent/AU2013209492B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013209492A 2012-01-20 2013-01-18 Anti-CXCR3 antibodies Ceased AU2013209492B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588936P 2012-01-20 2012-01-20
US61/588,936 2012-01-20
PCT/US2013/022280 WO2013109974A2 (en) 2012-01-20 2013-01-18 Anti-cxcr3 antibodies

Publications (2)

Publication Number Publication Date
AU2013209492A1 AU2013209492A1 (en) 2014-08-14
AU2013209492B2 true AU2013209492B2 (en) 2018-02-08

Family

ID=47633576

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013209492A Ceased AU2013209492B2 (en) 2012-01-20 2013-01-18 Anti-CXCR3 antibodies

Country Status (26)

Country Link
US (4) US8865870B2 (https=)
EP (1) EP2804878B1 (https=)
JP (3) JP6352812B6 (https=)
KR (2) KR102073034B1 (https=)
CN (1) CN104507967B (https=)
AR (1) AR090056A1 (https=)
AU (1) AU2013209492B2 (https=)
BR (1) BR112014017814A8 (https=)
CA (1) CA2862222A1 (https=)
CY (1) CY1121335T1 (https=)
DK (1) DK2804878T3 (https=)
ES (1) ES2698606T3 (https=)
HR (1) HRP20181874T1 (https=)
HU (1) HUE041900T2 (https=)
IL (2) IL233694A0 (https=)
LT (1) LT2804878T (https=)
MX (1) MX359854B (https=)
PL (1) PL2804878T3 (https=)
PT (1) PT2804878T (https=)
RS (1) RS58141B1 (https=)
RU (1) RU2663141C2 (https=)
SG (2) SG10201700735PA (https=)
SI (1) SI2804878T1 (https=)
TW (1) TWI596112B (https=)
UY (1) UY34582A (https=)
WO (1) WO2013109974A2 (https=)

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US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
WO2016028523A2 (en) 2014-08-22 2016-02-25 Sorrento Therapeutics, Inc. Antigen binding proteins that bind cxcr3
CA3003458A1 (en) 2015-10-29 2017-05-04 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
EP3464349A4 (en) * 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
EP3559036A1 (en) * 2016-12-22 2019-10-30 Sanofi Anti-human cxcr3 antibodies for treatment of vitiligo
KR20190095943A (ko) * 2016-12-22 2019-08-16 사노피 고갈 활성을 갖는 인간화 cxcr3 항체 및 이의 사용 방법
TW201840585A (zh) 2016-12-22 2018-11-16 法商賽諾菲公司 用於白斑病的治療的抗人cxcr3抗體
WO2019158675A1 (en) * 2018-02-16 2019-08-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating vitiligo
KR102074798B1 (ko) * 2018-06-15 2020-02-07 코아스템(주) 자가면역질환 치료에 대한 유효성 예측용 바이오마커, 진단키트 및 치료용 용도
EP3880239A4 (en) 2018-11-14 2022-11-23 Arch Oncology, Inc. THERAPEUTIC SIRPalpha ANTIBODIES
SG11202110145SA (en) 2020-02-26 2021-10-28 Vir Biotechnology Inc Antibodies against sars-cov-2 and methods of using the same
CN116234572A (zh) * 2020-04-30 2023-06-06 安驰肿瘤公司 治疗性SIRPα抗体
US20240101673A1 (en) 2021-02-03 2024-03-28 Mozart Therapeutics, Inc. Binding agents and methods of using the same
JP2024508304A (ja) * 2021-03-02 2024-02-26 ノヴァロック バイオセラピューティクス， リミテッド Ｃｌａｕｄｉｎ－６に対する抗体およびそれの使用
EP4384218A4 (en) * 2021-08-09 2025-11-05 Merck Patent Gmbh Proteins that uncouple T-lymphocyte-mediated tumor cytotoxicity from the release of pro-inflammatory cytokines
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
CN120112292A (zh) 2022-09-09 2025-06-06 爱杜西亚药品有限公司 包含抗-cd3抗体及cxcr3拮抗剂的药物组合
WO2025185738A1 (zh) * 2024-03-08 2025-09-12 演生潮(北京)生物科技有限公司 靶向cxcr3的抗原结合蛋白及其应用
WO2026069312A1 (en) 2024-09-24 2026-04-02 Yeda Research And Development Co. Ltd. Immune cells expressing an inducible therapeutic agent and uses thereof

Citations (4)

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WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
WO2005030793A2 (en) * 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
WO2008094942A2 (en) * 2007-02-01 2008-08-07 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against cxcr3

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WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
WO2005030793A2 (en) * 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
WO2008094942A2 (en) * 2007-02-01 2008-08-07 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against cxcr3

Also Published As

Publication number Publication date
IL271697A (en) 2020-02-27
AU2013209492A1 (en) 2014-08-14
US8865870B2 (en) 2014-10-21
US9765144B2 (en) 2017-09-19
SI2804878T1 (sl) 2018-12-31
EP2804878A2 (en) 2014-11-26
HRP20181874T1 (hr) 2019-01-11
HUE041900T2 (hu) 2019-06-28
PL2804878T3 (pl) 2019-03-29
US20140377806A1 (en) 2014-12-25
JP6352812B2 (ja) 2018-07-04
KR102073034B1 (ko) 2020-02-05
CA2862222A1 (en) 2013-07-25
MX359854B (es) 2018-10-12
CN104507967A (zh) 2015-04-08
US20130251733A1 (en) 2013-09-26
TWI596112B (zh) 2017-08-21
CY1121335T1 (el) 2020-05-29
JP2015506945A (ja) 2015-03-05
JP6352812B6 (ja) 2018-08-08
TW201335188A (zh) 2013-09-01
UY34582A (es) 2013-09-02
RS58141B1 (sr) 2019-02-28
HK1208684A1 (en) 2016-03-11
PT2804878T (pt) 2018-11-29
SG10201700735PA (en) 2017-02-27
LT2804878T (lt) 2018-12-10
DK2804878T3 (en) 2018-12-17
IL233694A0 (en) 2014-09-30
AR090056A1 (es) 2014-10-15
JP2020072715A (ja) 2020-05-14
KR20200014441A (ko) 2020-02-10
BR112014017814A8 (pt) 2017-07-11
KR20140116525A (ko) 2014-10-02
RU2663141C2 (ru) 2018-08-01
JP2018166506A (ja) 2018-11-01
BR112014017814A2 (https=) 2017-06-20
RU2014134043A (ru) 2016-03-20
EP2804878B1 (en) 2018-08-22
MX2014008728A (es) 2015-07-06
JP6646100B2 (ja) 2020-02-14
SG11201406762QA (en) 2014-11-27
ES2698606T3 (es) 2019-02-05
US20180086838A1 (en) 2018-03-29
WO2013109974A3 (en) 2013-11-07
CN104507967B (zh) 2018-10-12
WO2013109974A2 (en) 2013-07-25
US20190119391A1 (en) 2019-04-25

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