AU2012372640B2 - Crystalline forms of 5alpha-androstane-3beta,5, 6beta-triol and preparation therefor - Google Patents

Crystalline forms of 5alpha-androstane-3beta,5, 6beta-triol and preparation therefor Download PDF

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Publication number
AU2012372640B2
AU2012372640B2 AU2012372640A AU2012372640A AU2012372640B2 AU 2012372640 B2 AU2012372640 B2 AU 2012372640B2 AU 2012372640 A AU2012372640 A AU 2012372640A AU 2012372640 A AU2012372640 A AU 2012372640A AU 2012372640 B2 AU2012372640 B2 AU 2012372640B2
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Prior art keywords
solvent
crystalline form
triol
androstane
crystalline
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AU2012372640A1 (en
Inventor
Xinhua Li
Suizhen LIN
Jingxia Zhang
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GUANGZHOU CELPROTEK PHARMACEUTICAL CO Ltd
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GUANGZHOU CELPROTEK PHARMACEUTICAL CO Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU2012372640A 2012-03-08 2012-04-11 Crystalline forms of 5alpha-androstane-3beta,5, 6beta-triol and preparation therefor Active AU2012372640B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201210060611.6 2012-03-08
CN201210060611.6A CN102617685B (zh) 2012-03-08 2012-03-08 雄甾-3β,5α,6β-三醇的晶型化合物及其制备方法
PCT/CN2012/073854 WO2013131305A1 (zh) 2012-03-08 2012-04-11 雄甾-3β,5α,6β-三醇的晶型化合物及其制备方法

Publications (2)

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AU2012372640A1 AU2012372640A1 (en) 2014-09-25
AU2012372640B2 true AU2012372640B2 (en) 2015-07-09

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ID=46557937

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AU2012372640A Active AU2012372640B2 (en) 2012-03-08 2012-04-11 Crystalline forms of 5alpha-androstane-3beta,5, 6beta-triol and preparation therefor

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US (3) US9688716B2 (enExample)
EP (2) EP3112374A1 (enExample)
JP (1) JP2015511587A (enExample)
KR (1) KR20150002653A (enExample)
CN (4) CN103626817B (enExample)
AU (1) AU2012372640B2 (enExample)
CA (2) CA2866398C (enExample)
IL (1) IL234492A (enExample)
IN (1) IN2014DN08198A (enExample)
RU (1) RU2608894C2 (enExample)
SG (1) SG11201405376TA (enExample)
TW (1) TW201336861A (enExample)
WO (1) WO2013131305A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9815258B2 (en) 2012-05-07 2017-11-14 The Procter & Gamble Company Flexible containers
CN109985048B (zh) * 2017-12-29 2021-06-29 广州市赛普特医药科技股份有限公司 2β,3α,5α-三羟基雄甾-6-酮用于炎症反应的治疗
US11532903B2 (en) * 2021-04-01 2022-12-20 Ideal Industries, Inc. Universal electrical connector

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191576A (en) * 1936-11-21 1940-02-27 Soc Of Chemical Ind 3,5,6-trihydroxy androstane and pregnane compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191578A (en) 1939-07-24 1940-02-27 Crosley Corp Ice-cream tray
ATE15206T1 (de) * 1981-09-21 1985-09-15 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
US6046185A (en) * 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
CN101884638B (zh) * 2010-07-09 2011-11-09 中山大学 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用
CN101961311B (zh) * 2010-09-21 2012-11-21 中山大学 一种5α-雄甾(烷)-3β,5,6β-三醇注射剂及其制备方法
CN102180928B (zh) * 2011-03-15 2013-01-16 广州市赛普特医药科技有限公司 3β,5α,6β-三羟基甾体化合物及其合成方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191576A (en) * 1936-11-21 1940-02-27 Soc Of Chemical Ind 3,5,6-trihydroxy androstane and pregnane compounds

Also Published As

Publication number Publication date
CN103626819A (zh) 2014-03-12
US20170305957A1 (en) 2017-10-26
US9688716B2 (en) 2017-06-27
IN2014DN08198A (enExample) 2015-05-01
CA2866398A1 (en) 2013-09-12
KR20150002653A (ko) 2015-01-07
CN102617685A (zh) 2012-08-01
IL234492A (en) 2017-02-28
CN103626818A (zh) 2014-03-12
CN103626817A (zh) 2014-03-12
CN102617685B (zh) 2014-01-22
US20170305958A1 (en) 2017-10-26
CA2909998A1 (en) 2013-09-12
CN103626818B (zh) 2016-03-30
RU2014136891A (ru) 2016-05-10
WO2013131305A1 (zh) 2013-09-12
US9944673B2 (en) 2018-04-17
EP3112374A1 (en) 2017-01-04
CA2866398C (en) 2016-06-28
SG11201405376TA (en) 2014-11-27
EP2889303A1 (en) 2015-07-01
US20150045566A1 (en) 2015-02-12
US9944672B2 (en) 2018-04-17
TW201336861A (zh) 2013-09-16
JP2015511587A (ja) 2015-04-20
AU2012372640A1 (en) 2014-09-25
RU2608894C2 (ru) 2017-01-26
EP2889303A4 (en) 2016-02-17
CN103626817B (zh) 2016-01-20
CN103626819B (zh) 2016-01-20

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ CRYSTALLINE FORMS OF 5A-ANDROSTANE-3B,5,6B-TRIOL AND PREPATION METHOD

TH Corrigenda

Free format text: IN VOL 28 , NO 38 , PAGE(S) 5097 UNDER THE HEADING AMENDMENTS - AMENDMENTS MADE UNDER THE NAME GUANGZHOU CELPROTEK PHARMACEUTICAL CO., LTD., APPLICATION NO. 2012372640, UNDER INID (54) CORRECT THE TITLE TO READ CRYSTALLINE FORMS OF 5A-ANDROSTANE-3B,5,6B-TRIOL AND PREPARATION METHOD

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ CRYSTALLINE FORMS OF 5ALPHA-ANDROSTANE-3BETA,5,6BETA-TRIOL AND PREPARATION METHOD

TH Corrigenda

Free format text: IN VOL 28 , NO 46 , PAGE(S) 6203 UNDER THE HEADING AMENDMENTS - AMENDMENTS MADE UNDER THE NAME GUANGZHOU CELPROTEK PHARMACEUTICAL CO., LTD., APPLICATION NO. 2012372640, UNDER INID (54) CORRECT THE TITLE TO READ CRYSTALLINE FORMS OF 5ALPHA-ANDROSTANE-3BETA,5, 6BETATRIOL AND PREPARATION METHOD

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ CRYSTALLINE FORMS OF 5ALPHA-ANDROSTANE-3BETA,5, 6BETA-TRIOL AND PREPARATION THEREFOR

FGA Letters patent sealed or granted (standard patent)