AU2012321246C1 - Methods of treating pediatric patients using dexmedetomidine - Google Patents

Methods of treating pediatric patients using dexmedetomidine Download PDF

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Publication number
AU2012321246C1
AU2012321246C1 AU2012321246A AU2012321246A AU2012321246C1 AU 2012321246 C1 AU2012321246 C1 AU 2012321246C1 AU 2012321246 A AU2012321246 A AU 2012321246A AU 2012321246 A AU2012321246 A AU 2012321246A AU 2012321246 C1 AU2012321246 C1 AU 2012321246C1
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AU
Australia
Prior art keywords
dexmedetomidine
dose
infusion
subjects
age
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012321246A
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English (en)
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AU2012321246A1 (en
AU2012321246B2 (en
Inventor
Marcelo GARCIA DE ROCHA
Edward KOO
Dennis J. Stalker
Wayne WISEMANDLE
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Hospira Inc
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Hospira Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47226666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2012321246(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hospira Inc filed Critical Hospira Inc
Publication of AU2012321246A1 publication Critical patent/AU2012321246A1/en
Application granted granted Critical
Publication of AU2012321246B2 publication Critical patent/AU2012321246B2/en
Priority to AU2017206211A priority Critical patent/AU2017206211B2/en
Publication of AU2012321246C1 publication Critical patent/AU2012321246C1/en
Priority to AU2019203564A priority patent/AU2019203564A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2012321246A 2011-10-14 2012-09-27 Methods of treating pediatric patients using dexmedetomidine Ceased AU2012321246C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017206211A AU2017206211B2 (en) 2011-10-14 2017-07-20 Methods of treating pediatric patients using dexmedetomidine
AU2019203564A AU2019203564A1 (en) 2011-10-14 2019-05-21 Methods of treating pediatric patients using dexmedetomidine

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161547626P 2011-10-14 2011-10-14
US61/547,626 2011-10-14
US13/343,693 2012-01-04
US13/343,693 US20130096170A1 (en) 2011-10-14 2012-01-04 Methods of treating pediatric patients using dexmedetomidine
US13/471,403 US8324260B1 (en) 2011-10-14 2012-05-14 Methods of treating pediatric patients using dexmedetomidine
US13/471,403 2012-05-14
PCT/US2012/057652 WO2013055528A1 (en) 2011-10-14 2012-09-27 Methods of treating pediatric patients using dexmedetomidine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017206211A Division AU2017206211B2 (en) 2011-10-14 2017-07-20 Methods of treating pediatric patients using dexmedetomidine

Publications (3)

Publication Number Publication Date
AU2012321246A1 AU2012321246A1 (en) 2014-05-01
AU2012321246B2 AU2012321246B2 (en) 2017-05-04
AU2012321246C1 true AU2012321246C1 (en) 2017-11-02

Family

ID=47226666

Family Applications (3)

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AU2012321246A Ceased AU2012321246C1 (en) 2011-10-14 2012-09-27 Methods of treating pediatric patients using dexmedetomidine
AU2017206211A Ceased AU2017206211B2 (en) 2011-10-14 2017-07-20 Methods of treating pediatric patients using dexmedetomidine
AU2019203564A Abandoned AU2019203564A1 (en) 2011-10-14 2019-05-21 Methods of treating pediatric patients using dexmedetomidine

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017206211A Ceased AU2017206211B2 (en) 2011-10-14 2017-07-20 Methods of treating pediatric patients using dexmedetomidine
AU2019203564A Abandoned AU2019203564A1 (en) 2011-10-14 2019-05-21 Methods of treating pediatric patients using dexmedetomidine

Country Status (23)

Country Link
US (8) US20130096170A1 (ja)
EP (2) EP3446691A1 (ja)
JP (5) JP6270727B2 (ja)
KR (3) KR20200019791A (ja)
CN (2) CN109700806A (ja)
AU (3) AU2012321246C1 (ja)
BR (1) BR112014008983A2 (ja)
CA (2) CA2851780C (ja)
CY (1) CY1121041T1 (ja)
DK (1) DK2766014T3 (ja)
ES (1) ES2685814T3 (ja)
HK (1) HK1200333A1 (ja)
HR (1) HRP20181378T1 (ja)
HU (1) HUE039671T2 (ja)
IL (2) IL232070A0 (ja)
IN (1) IN2014KN00996A (ja)
LT (1) LT2766014T (ja)
MX (1) MX362626B (ja)
PL (1) PL2766014T3 (ja)
PT (1) PT2766014T (ja)
RS (1) RS57660B1 (ja)
SI (1) SI2766014T1 (ja)
WO (1) WO2013055528A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
EP3054930B1 (en) * 2013-10-07 2020-12-02 Teikoku Pharma USA, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
WO2015054059A2 (en) 2013-10-07 2015-04-16 Teikoku Pharma Usa, Inc. Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
CN105764494A (zh) 2013-10-07 2016-07-13 帝国制药美国公司 右旋美托咪啶经皮递送装置及其使用方法
TWI629061B (zh) * 2013-10-07 2018-07-11 美商帝國製藥美國股份有限公司 包含右美托嘧啶(dexmedetomidine)經皮組成物之疼痛處理用方法及組成物
US11017330B2 (en) * 2014-05-20 2021-05-25 Elasticsearch B.V. Method and system for analysing data
CN106572820B (zh) * 2014-08-18 2020-09-15 Epat有限公司 一种疼痛评估系统
CN104784174A (zh) * 2015-03-06 2015-07-22 北京大学第一医院 右美托咪定的药物新用途
US9717796B1 (en) * 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
EP3532038A4 (en) * 2016-10-31 2020-06-03 Teikoku Pharma USA, Inc. METHOD FOR MANAGING PAIN BY MEANS OF DEVMEDETOMIDINE TRANSDERMAL ADMINISTRATION DEVICES
CN106539778A (zh) * 2016-12-08 2017-03-29 武汉大学 一种小儿麻醉术前含服口腔泡腾片及其制备方法
KR20240031326A (ko) 2016-12-31 2024-03-07 바이오엑셀 테라퓨틱스 인코포레이티드 불안의 치료를 위한 설하 덱스메데토미딘의 용도
US11621969B2 (en) 2017-04-26 2023-04-04 Elasticsearch B.V. Clustering and outlier detection in anomaly and causation detection for computing environments
US11783046B2 (en) 2017-04-26 2023-10-10 Elasticsearch B.V. Anomaly and causation detection in computing environments
CN108042533B (zh) * 2017-12-25 2020-11-13 苏州格兰科医药科技有限公司 右美托米定在制备用于预防和/或抑制创伤性脑损伤后的神经元死亡的药物组合物中的用途
MX2020014000A (es) 2018-06-27 2021-06-15 Bioxcel Therapeutics Inc Formulaciones en lámina que contienen dexmedetomidina y métodos para producirlas.
US20210267944A1 (en) * 2018-06-27 2021-09-02 Bioxcel Therapeutics, Inc. Methods for treating agitation using dexmedetomidine hydrochloride
KR20210056361A (ko) * 2018-09-12 2021-05-18 호 이어 인스티튜트 인공 와우 수술에 따른 난청의 치료 방법
CN112654348A (zh) * 2018-09-13 2021-04-13 台湾微脂体股份有限公司 含镇静药物的缓释药物组合物及其用途
US20220051802A1 (en) * 2018-12-13 2022-02-17 Dignity Health System and method for detection and monitoring of over sedation to prevent harm to patients
US10817669B2 (en) 2019-01-14 2020-10-27 International Business Machines Corporation Automatic classification of adverse event text fragments
CN109793709A (zh) * 2019-02-22 2019-05-24 青岛农业大学 一种斑海豹用复方注射剂及其制备方法
US11000488B2 (en) * 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol
MX2022000709A (es) 2019-07-19 2022-05-19 Bioxcel Therapeutics Inc Regimenes de tratamiento con dexmedetomidina no sedante.
WO2021211507A1 (en) * 2020-04-17 2021-10-21 Bioventures, Llc Methods and systems for predicting the effect of inhaled and infused anesthetics
KR20230094816A (ko) 2021-12-21 2023-06-28 충남대학교산학협력단 감염 환자에서 반코마이신 최적 용량을 결정하는 방법
EP4386768A1 (en) * 2022-12-13 2024-06-19 Koninklijke Philips N.V. Active sleep apnea case finding and scheduling system and method of operation thereof
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
JPS6058890A (ja) 1983-09-13 1985-04-05 Mizusawa Ind Chem Ltd 感熱記録紙用填剤
FI844786A0 (fi) 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
GB2206880B (en) 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5344840A (en) 1988-02-29 1994-09-06 Orion-Yhtyma Oy 4-substituted imidazole derivatives useful in perioperative care
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (fi) 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
US5304569A (en) 1989-11-13 1994-04-19 Orion-Yhtyma Oy Compositions and their use in lowering intraocular pressure
DE69221484T2 (de) 1991-04-25 1998-02-19 Univ Brown Res Found Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
EP0679088B1 (en) 1992-09-29 2002-07-10 Inhale Therapeutic Systems Pulmonary delivery of active fragments of parathyroid hormone
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
KR100365171B1 (ko) 1994-08-08 2003-02-19 드바이오팜 에스.아. 약학적으로안정한옥살리플라티늄제제
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19749724A1 (de) 1997-11-11 1999-06-10 Gruenenthal Gmbh Verwendung einer Kombination aus Opioid und alpha-adrenergem Agonisten in Schmerzmitteln
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) * 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
PE20001396A1 (es) 1999-01-18 2000-12-23 Gruenenthal Chemie Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
US6806291B1 (en) 2003-10-09 2004-10-19 The Foundation For The Lsu Health Sciences Center Analgesic compounds, their synthesis and pharmaceutical compositions containing them
US20080308444A1 (en) 2007-06-13 2008-12-18 Baxter International Inc. Packaging system and method of alerting a practitioner
US20100197694A1 (en) 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
EP2165706A1 (en) 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
US8100890B2 (en) 2008-10-15 2012-01-24 Bioquiddity, Inc. Special purpose fluid dispenser with pre-filled reservoir
US7896843B2 (en) * 2008-10-15 2011-03-01 Bioquiddity, Inc. Special purpose fluid dispenser
CN102196819B (zh) 2008-10-30 2013-01-30 国立大学法人冈山大学 局部麻醉用组合物
CA2762107A1 (en) 2009-05-15 2010-11-18 Recro Pharma, Inc. Sublingual dexmedetomidine compositions and methods of use thereof
US8410140B2 (en) 2009-06-01 2013-04-02 The Regents Of The University Of Michigan Anesthetic methods and compositions
WO2011075621A1 (en) 2009-12-17 2011-06-23 Alpha Synergy Development, Inc. Compositions and methods for ophthalmic delivery of nasal decongestants
FR2959414B1 (fr) 2010-04-30 2016-01-08 Luc Quintin Combinaison de molecules aux fins de traitement d'hypotension survenant au cours du choc septique, cardiogenique, ou anaphylactique refractaire, ou hemorragique terminal, apres correction de la volemie et de l'etat de mal asthmatique refractaire
US20130096170A1 (en) * 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AL-ZABEN K.R. et al., "Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children undergoing hypospadius surgery", European Journal of Anaesthesiology, 2010, Vol. 27, No. 3, pages 247-252 *
BERKENBOSCH J.W. et al., "Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children", Pediatric Critical Care Medicine, 2005, Vol. 6, No. 4, pages 435-439 *
BUCK M.L. et al., "Use of Dexmedetomidine in the Pediatric Intensive Care Unit", Pharmacotherapy, 2008, Vol. 28, No. 1, pages 51-57 *
CARROLL C.L. et al., "Use of Dexmedetomidine for Sedation of Children Hospitalized in the Intensive Care Unit", Journal of Hospital Medicine, 2008, Vol. 3, No. 2, pages 142-147 *
CHRYSOSTOMOU C. et al., "Dexmedetomidine use in a pediatric cardiac intensive care unit: can we safely use it in infants after cardiac surgery?", Pediatric Critical Care Medicine, 2007, Vol. 8, No. 3, Supplement, page A308 *
CHRYSOSTOMOU C. et al., "Dexmedetomidine: sedation, analgesia and beyond", Expert Opin. Drug Metab. Toxicol., 2008, Vol. 4, No. 5, pages 619-627 *
CHRYSOSTOMOU C. et al., "Use of dexmedetomidine in children after cardiac and thoracic surgery", Pediatric Critical Care Medicine, 2006, Vol. 7, No. 2, pages 126-131 *
EASLEY R.B. et al., "Pro: Dexmedetomidine Should Be Used for Infants and Children Undergoing Cardiac Surgery", Journal of Cardiothoracic and Vascular Anesthesia, 2008, Vol. 22, No. 1, pages 147-151 *
KOROGLU A. et al., "Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results", British Journal of Anaesthesia, 2005, Vol. 94, No. 6, pages 821-824 *
TOBIAS J.D., "Dexmedetomidine: Applications in pediatric critical care and anesthesiology", Pediatric Critical Care Medicine, 2007, Vol. 8, No. 2, pages 115-131 *

Also Published As

Publication number Publication date
RS57660B1 (sr) 2018-11-30
LT2766014T (lt) 2018-08-27
JP6270727B2 (ja) 2018-01-31
AU2017206211B2 (en) 2019-02-28
CA2851780A1 (en) 2013-04-18
CN103957906A (zh) 2014-07-30
KR20140094539A (ko) 2014-07-30
IN2014KN00996A (ja) 2015-09-04
AU2012321246A1 (en) 2014-05-01
AU2017206211A1 (en) 2017-08-03
IL232070A0 (en) 2014-05-28
JP2018027971A (ja) 2018-02-22
US20210137891A1 (en) 2021-05-13
CY1121041T1 (el) 2019-12-11
CN109700806A (zh) 2019-05-03
US20130096170A1 (en) 2013-04-18
PL2766014T3 (pl) 2019-02-28
EP2766014A4 (en) 2015-06-24
HUE039671T2 (hu) 2019-01-28
JP2022008828A (ja) 2022-01-14
MX362626B (es) 2019-01-28
US20190269657A1 (en) 2019-09-05
AU2019203564A1 (en) 2019-06-13
JP2014528474A (ja) 2014-10-27
EP2766014A1 (en) 2014-08-20
EP3446691A1 (en) 2019-02-27
US9314449B2 (en) 2016-04-19
WO2013055528A1 (en) 2013-04-18
KR20200019791A (ko) 2020-02-24
JP2020073529A (ja) 2020-05-14
CA2851780C (en) 2017-11-28
US8324260B1 (en) 2012-12-04
BR112014008983A2 (pt) 2017-05-02
KR20190029775A (ko) 2019-03-20
HK1200333A1 (en) 2015-08-07
ES2685814T3 (es) 2018-10-11
US20160067220A1 (en) 2016-03-10
US20130096171A1 (en) 2013-04-18
JP6640164B2 (ja) 2020-02-05
EP2766014B1 (en) 2018-07-18
DK2766014T3 (en) 2018-09-24
MX2014004548A (es) 2015-02-12
PT2766014T (pt) 2018-10-11
AU2012321246B2 (en) 2017-05-04
US8507542B2 (en) 2013-08-13
US20140005243A1 (en) 2014-01-02
HRP20181378T1 (hr) 2018-10-19
IL249991A0 (en) 2017-03-30
SI2766014T1 (sl) 2018-11-30
CA2978258A1 (en) 2013-04-18
JP2023179764A (ja) 2023-12-19
US20130096172A1 (en) 2013-04-18

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