AU2012288846B2 - Anti-VEGF single variable domains fused to fc domains - Google Patents

Anti-VEGF single variable domains fused to fc domains Download PDF

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Publication number
AU2012288846B2
AU2012288846B2 AU2012288846A AU2012288846A AU2012288846B2 AU 2012288846 B2 AU2012288846 B2 AU 2012288846B2 AU 2012288846 A AU2012288846 A AU 2012288846A AU 2012288846 A AU2012288846 A AU 2012288846A AU 2012288846 B2 AU2012288846 B2 AU 2012288846B2
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AU
Australia
Prior art keywords
dab
seq
vegf
linker
antigen binding
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Ceased
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AU2012288846A
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AU2012288846A1 (en
Inventor
Claire Ashman
Ian Richard Catchpole
Zoe HUGHES-THOMAS
Alan Peter Lewis
Michael Steward
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2012288846A 2011-07-27 2012-07-25 Anti-VEGF single variable domains fused to fc domains Ceased AU2012288846B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161512138P 2011-07-27 2011-07-27
US61/512,138 2011-07-27
PCT/EP2012/064632 WO2013014208A2 (fr) 2011-07-27 2012-07-25 Constructions de liaison à un antigène

Publications (2)

Publication Number Publication Date
AU2012288846A1 AU2012288846A1 (en) 2014-02-06
AU2012288846B2 true AU2012288846B2 (en) 2016-05-19

Family

ID=46579044

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Application Number Title Priority Date Filing Date
AU2012288846A Ceased AU2012288846B2 (en) 2011-07-27 2012-07-25 Anti-VEGF single variable domains fused to fc domains

Country Status (18)

Country Link
US (2) US9499612B2 (fr)
EP (1) EP2736925A2 (fr)
JP (1) JP5987057B2 (fr)
KR (1) KR101632620B1 (fr)
CN (1) CN103842380A (fr)
AU (1) AU2012288846B2 (fr)
BR (1) BR112014001855A2 (fr)
CA (1) CA2842099A1 (fr)
CL (1) CL2014000204A1 (fr)
CO (1) CO7020847A2 (fr)
CR (1) CR20140047A (fr)
DO (1) DOP2014000017A (fr)
EA (1) EA028886B1 (fr)
HK (1) HK1198446A1 (fr)
MA (1) MA35352B1 (fr)
MX (1) MX2014001019A (fr)
PE (1) PE20141659A1 (fr)
WO (1) WO2013014208A2 (fr)

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US20130236467A1 (en) * 2010-11-24 2013-09-12 Jeremy Griggs Multispecific antigen binding proteins targeting hgf
CN108659121A (zh) 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
EA201791029A1 (ru) 2014-11-10 2017-12-29 Дженентек, Инк. Антитела против интерлейкина-33 и их применение
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CN108712911A (zh) 2015-12-30 2018-10-26 科达制药股份有限公司 抗体及其缀合物
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US20200040084A1 (en) * 2017-01-06 2020-02-06 Momenta Pharmaceuticals, Inc. Compositions and methods related to engineered fc-antigen binding domain constructs
CN109021103B (zh) * 2017-06-12 2022-08-23 上海睿智化学研究有限公司 抗人血管内皮生长因子的抗体及其制备方法和应用
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
IL296256A (en) 2020-03-13 2022-11-01 Genentech Inc Antibodies against interleukin-33 and uses thereof
AU2022222311A1 (en) * 2021-02-19 2023-09-21 Dotbio Pte. Ltd. Vegfa-binding molecules
WO2023014892A1 (fr) * 2021-08-04 2023-02-09 Alpine Biotherapeutics Corporation Administration intraoculaire durable médiée par des cellules oculaires d'agents thérapeutiques cellulaires pour le traitement de maladies ou de troubles oculaires
CA3229250A1 (fr) * 2021-08-13 2023-02-16 Innovent Biologics (Suzhou) Co., Ltd. Anticorps bispecifique anti-vegf a et anti-vegf c et son utilisation
WO2024029876A1 (fr) * 2022-08-02 2024-02-08 주식회사 파노로스바이오사이언스 Protéine de fusion modifiée et son utilisation
WO2024055995A1 (fr) * 2022-09-14 2024-03-21 寻济生物科技（北京）有限公司 Protéine de fusion anti-vegfa, son procédé de préparation et son utilisation

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WO2008149150A2 (fr) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, domaines variables d'anticorps et antagonistes
WO2009074634A2 (fr) * 2007-12-13 2009-06-18 Glaxo Group Limited Compositions pour administration pulmonaire

Also Published As

Publication number Publication date
MX2014001019A (es) 2014-05-13
US20140205604A1 (en) 2014-07-24
MA35352B1 (fr) 2014-08-01
JP2014523746A (ja) 2014-09-18
WO2013014208A2 (fr) 2013-01-31
US9499612B2 (en) 2016-11-22
EA201391812A1 (ru) 2014-06-30
EP2736925A2 (fr) 2014-06-04
WO2013014208A3 (fr) 2013-05-10
CL2014000204A1 (es) 2014-07-25
JP5987057B2 (ja) 2016-09-06
EA028886B1 (ru) 2018-01-31
DOP2014000017A (es) 2014-04-30
CR20140047A (es) 2014-03-24
US20170029494A1 (en) 2017-02-02
CO7020847A2 (es) 2014-08-11
KR101632620B1 (ko) 2016-06-23
PE20141659A1 (es) 2014-11-21
CA2842099A1 (fr) 2013-01-31
CN103842380A (zh) 2014-06-04
AU2012288846A1 (en) 2014-02-06
KR20140041908A (ko) 2014-04-04
HK1198446A1 (en) 2015-04-24
BR112014001855A2 (pt) 2017-02-21

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