AU2012262748B2 - 4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use - Google Patents

4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use Download PDF

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Publication number
AU2012262748B2
AU2012262748B2 AU2012262748A AU2012262748A AU2012262748B2 AU 2012262748 B2 AU2012262748 B2 AU 2012262748B2 AU 2012262748 A AU2012262748 A AU 2012262748A AU 2012262748 A AU2012262748 A AU 2012262748A AU 2012262748 B2 AU2012262748 B2 AU 2012262748B2
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AU
Australia
Prior art keywords
mmol
compound
reaction
alkyl
added
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2012262748A
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English (en)
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AU2012262748A1 (en
Inventor
Joseph Barbosa
Kenneth Gordon Carson
Michael Walter Gardyan
Qiang Han
Jason Patrick Healy
Ross Mabon
Pabba PRAVEEN
James Tarver Jr.
Kristen M. TERRANOVA
Ashok Tunoori
Xiaolian Xu
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Lexicon Pharmaceuticals Inc
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Lexicon Pharmaceuticals Inc
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Publication of AU2012262748B2 publication Critical patent/AU2012262748B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2012262748A 2011-05-27 2012-05-23 4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use Ceased AU2012262748B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161490839P 2011-05-27 2011-05-27
US61/490,839 2011-05-27
PCT/US2012/039087 WO2012166458A1 (en) 2011-05-27 2012-05-23 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use

Publications (2)

Publication Number Publication Date
AU2012262748A1 AU2012262748A1 (en) 2013-11-28
AU2012262748B2 true AU2012262748B2 (en) 2017-03-02

Family

ID=46201840

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012262748A Ceased AU2012262748B2 (en) 2011-05-27 2012-05-23 4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use

Country Status (12)

Country Link
US (2) US20120302562A1 (enExample)
EP (1) EP2714675B1 (enExample)
JP (1) JP6166718B2 (enExample)
CN (1) CN103649072A (enExample)
AU (1) AU2012262748B2 (enExample)
CA (1) CA2837084C (enExample)
DK (1) DK2714675T3 (enExample)
ES (1) ES2715832T3 (enExample)
HU (1) HUE043221T2 (enExample)
PL (1) PL2714675T3 (enExample)
PT (1) PT2714675T (enExample)
WO (1) WO2012166458A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2714675B1 (en) * 2011-05-27 2019-01-02 Lexicon Pharmaceuticals, Inc. 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use
ES3046711T3 (en) 2016-04-15 2025-12-02 Beckman Coulter Inc Photoactive macromolecules and uses thereof
JP7248578B2 (ja) * 2017-08-31 2023-03-29 第一三共株式会社 抗体－薬物コンジュゲートの新規製造方法
CN108948011A (zh) * 2018-08-14 2018-12-07 华南农业大学 一种普拉多沙星的制备方法
GB201814151D0 (en) * 2018-08-31 2018-10-17 Ucl Business Plc Compounds
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN112094182B (zh) * 2020-09-22 2021-11-12 中国海洋大学 一种医药中间体苯并环己酮化合物的绿色合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1650202A1 (en) * 2003-07-31 2006-04-26 Taisho Pharmaceutical Co. Ltd. 4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
DE1917601C3 (de) * 1969-04-05 1980-09-25 Bayer Ag, 5090 Leverkusen Benzoxazolyl-(2)-dihydronaphtho [4,5-b] thiophene und deren Verwendung als optische Aufheller
DE2628878A1 (de) * 1976-06-26 1978-01-05 Bayer Ag Beschichtungszusammensetzung
US4487778A (en) * 1983-01-27 1984-12-11 Fmc Corporation Insecticidal esters derived from benzocycloalkane-thiophenemethyl compounds
GB8504702D0 (en) * 1985-02-23 1985-03-27 Zyma Sa Tricyclic compounds
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
FR2790959B1 (fr) 1999-03-15 2003-06-27 Pf Medicament Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant
UY26026A1 (es) * 1999-03-16 2000-10-31 Smithkline Beecham Corportion Inhibidores de proteasas
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
CA2492922A1 (en) 2002-07-19 2004-01-29 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
WO2006080439A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
WO2006080406A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
RU2506267C2 (ru) * 2008-03-31 2014-02-10 Дженентек, Инк. Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение
EP2714675B1 (en) * 2011-05-27 2019-01-02 Lexicon Pharmaceuticals, Inc. 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1650202A1 (en) * 2003-07-31 2006-04-26 Taisho Pharmaceutical Co. Ltd. 4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE

Also Published As

Publication number Publication date
PL2714675T3 (pl) 2019-07-31
PT2714675T (pt) 2019-04-12
ES2715832T3 (es) 2019-06-06
JP6166718B2 (ja) 2017-07-19
US20140256784A1 (en) 2014-09-11
US20120302562A1 (en) 2012-11-29
US9624238B2 (en) 2017-04-18
HUE043221T2 (hu) 2019-08-28
AU2012262748A1 (en) 2013-11-28
JP2014517848A (ja) 2014-07-24
DK2714675T3 (en) 2019-04-15
EP2714675A1 (en) 2014-04-09
CN103649072A (zh) 2014-03-19
CA2837084A1 (en) 2012-12-06
EP2714675B1 (en) 2019-01-02
CA2837084C (en) 2019-09-17
WO2012166458A1 (en) 2012-12-06

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