PT2714675T - Inibidores de pectina-acetilesterase de notum à base de 4h-tieno[3,2-c]cromeno e métodos para a sua utilização - Google Patents

Inibidores de pectina-acetilesterase de notum à base de 4h-tieno[3,2-c]cromeno e métodos para a sua utilização

Info

Publication number
PT2714675T
PT2714675T PT12725227T PT12725227T PT2714675T PT 2714675 T PT2714675 T PT 2714675T PT 12725227 T PT12725227 T PT 12725227T PT 12725227 T PT12725227 T PT 12725227T PT 2714675 T PT2714675 T PT 2714675T
Authority
PT
Portugal
Prior art keywords
chromene
thieno
methods
based inhibitors
notum pectinacetylesterase
Prior art date
Application number
PT12725227T
Other languages
English (en)
Portuguese (pt)
Inventor
Barbosa Joseph
Gordon Carson Kenneth
Walter Gardyan Michael
patrick healy Jason
Han Qiang
Mabon Ross
Praveen Pabba
Jr Tarver James
M Terranova Kristen
Tunoori Ashok
Xu Xiaolian
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of PT2714675T publication Critical patent/PT2714675T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT12725227T 2011-05-27 2012-05-23 Inibidores de pectina-acetilesterase de notum à base de 4h-tieno[3,2-c]cromeno e métodos para a sua utilização PT2714675T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161490839P 2011-05-27 2011-05-27

Publications (1)

Publication Number Publication Date
PT2714675T true PT2714675T (pt) 2019-04-12

Family

ID=46201840

Family Applications (1)

Application Number Title Priority Date Filing Date
PT12725227T PT2714675T (pt) 2011-05-27 2012-05-23 Inibidores de pectina-acetilesterase de notum à base de 4h-tieno[3,2-c]cromeno e métodos para a sua utilização

Country Status (12)

Country Link
US (2) US20120302562A1 (enExample)
EP (1) EP2714675B1 (enExample)
JP (1) JP6166718B2 (enExample)
CN (1) CN103649072A (enExample)
AU (1) AU2012262748B2 (enExample)
CA (1) CA2837084C (enExample)
DK (1) DK2714675T3 (enExample)
ES (1) ES2715832T3 (enExample)
HU (1) HUE043221T2 (enExample)
PL (1) PL2714675T3 (enExample)
PT (1) PT2714675T (enExample)
WO (1) WO2012166458A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012262748B2 (en) * 2011-05-27 2017-03-02 Lexicon Pharmaceuticals, Inc. 4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use
KR102836360B1 (ko) 2016-04-15 2025-07-23 베크만 컬터, 인코포레이티드 광활성 거대분자 및 그의 용도
WO2019044946A1 (ja) 2017-08-31 2019-03-07 第一三共株式会社 抗体－薬物コンジュゲートの新規製造方法
CN108948011A (zh) * 2018-08-14 2018-12-07 华南农业大学 一种普拉多沙星的制备方法
GB201814151D0 (en) 2018-08-31 2018-10-17 Ucl Business Plc Compounds
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN112094182B (zh) * 2020-09-22 2021-11-12 中国海洋大学 一种医药中间体苯并环己酮化合物的绿色合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1917601C3 (de) * 1969-04-05 1980-09-25 Bayer Ag, 5090 Leverkusen Benzoxazolyl-(2)-dihydronaphtho [4,5-b] thiophene und deren Verwendung als optische Aufheller
DE2628878A1 (de) * 1976-06-26 1978-01-05 Bayer Ag Beschichtungszusammensetzung
US4487778A (en) * 1983-01-27 1984-12-11 Fmc Corporation Insecticidal esters derived from benzocycloalkane-thiophenemethyl compounds
GB8504702D0 (en) * 1985-02-23 1985-03-27 Zyma Sa Tricyclic compounds
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
FR2790959B1 (fr) 1999-03-15 2003-06-27 Pf Medicament Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant
UY26026A1 (es) * 1999-03-16 2000-10-31 Smithkline Beecham Corportion Inhibidores de proteasas
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
JP2005536518A (ja) 2002-07-19 2005-12-02 ファルマシア コーポレイション 炎症治療のための置換チオフェンカルボキサミド化合物
EP1650202A4 (en) * 2003-07-31 2007-04-04 Taisho Pharmaceutical Co Ltd 4.5-dihydronaphtho [1,2-B] thiophene
WO2006080406A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
WO2006080439A1 (ja) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
RU2506267C2 (ru) * 2008-03-31 2014-02-10 Дженентек, Инк. Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение
AU2012262748B2 (en) * 2011-05-27 2017-03-02 Lexicon Pharmaceuticals, Inc. 4H-thieno[3,2-c]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use

Also Published As

Publication number Publication date
EP2714675B1 (en) 2019-01-02
EP2714675A1 (en) 2014-04-09
ES2715832T3 (es) 2019-06-06
CA2837084C (en) 2019-09-17
US20120302562A1 (en) 2012-11-29
US9624238B2 (en) 2017-04-18
US20140256784A1 (en) 2014-09-11
WO2012166458A1 (en) 2012-12-06
CN103649072A (zh) 2014-03-19
AU2012262748A1 (en) 2013-11-28
PL2714675T3 (pl) 2019-07-31
CA2837084A1 (en) 2012-12-06
JP6166718B2 (ja) 2017-07-19
HUE043221T2 (hu) 2019-08-28
AU2012262748B2 (en) 2017-03-02
JP2014517848A (ja) 2014-07-24
DK2714675T3 (en) 2019-04-15

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