AU2012253335B2 - Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories - Google Patents
Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories Download PDFInfo
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- AU2012253335B2 AU2012253335B2 AU2012253335A AU2012253335A AU2012253335B2 AU 2012253335 B2 AU2012253335 B2 AU 2012253335B2 AU 2012253335 A AU2012253335 A AU 2012253335A AU 2012253335 A AU2012253335 A AU 2012253335A AU 2012253335 B2 AU2012253335 B2 AU 2012253335B2
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016222491A AU2016222491A1 (en) | 2011-05-12 | 2016-09-02 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
| AU2018203492A AU2018203492A1 (en) | 2011-05-12 | 2018-05-17 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485475P | 2011-05-12 | 2011-05-12 | |
| US61/485,475 | 2011-05-12 | ||
| PCT/US2012/037563 WO2012155062A1 (en) | 2011-05-12 | 2012-05-11 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
Related Child Applications (1)
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| AU2016222491A Division AU2016222491A1 (en) | 2011-05-12 | 2016-09-02 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
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| AU2012253335A1 AU2012253335A1 (en) | 2013-05-02 |
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| AU2016222491A Abandoned AU2016222491A1 (en) | 2011-05-12 | 2016-09-02 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
| AU2018203492A Abandoned AU2018203492A1 (en) | 2011-05-12 | 2018-05-17 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
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| AU2016222491A Abandoned AU2016222491A1 (en) | 2011-05-12 | 2016-09-02 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
| AU2018203492A Abandoned AU2018203492A1 (en) | 2011-05-12 | 2018-05-17 | Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories |
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| JP2665195B2 (ja) | 1995-05-19 | 1997-10-22 | 日本電気移動通信株式会社 | Ｍｃａシステムにおける移動局の個別番号表示方法 |
| US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| TW201808311A (zh) * | 2011-09-16 | 2018-03-16 | 遠景生物製藥股份有限公司 | 安定之普維酮-碘組成物 |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| KR102154880B1 (ko) | 2012-05-03 | 2020-09-10 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| US9056057B2 (en) | 2012-05-03 | 2015-06-16 | Kala Pharmaceuticals, Inc. | Nanocrystals, compositions, and methods that aid particle transport in mucus |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| AU2014216178B2 (en) | 2013-02-15 | 2018-06-28 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
| KR20150119303A (ko) | 2013-02-15 | 2015-10-23 | 센주 세이야꾸 가부시키가이샤 | 항균성 금속을 함유하는 디플루프레드네이트 유액 조성물 |
| EP2958895B1 (en) | 2013-02-20 | 2020-08-19 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| US11052094B2 (en) | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| LT3416654T (lt) | 2016-02-18 | 2022-01-10 | Invirsa, Inc. | 5’-adenozindifosfato ribozės (adpr) medicininis panaudojimas |
| EP3442519A4 (en) | 2016-04-14 | 2019-12-04 | Azura Opthalmics Ltd. | SELDISULFID COMPOSITIONS FOR USE IN THE TREATMENT OF THE MEIBOM DRESSING DYSFUNCTION |
| CA3023259A1 (en) * | 2016-05-05 | 2017-11-09 | Veloce Biopharma, Llc | Compositions and methods for treatment of inflammation or infection of the eye |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| AU2017324713B2 (en) | 2016-09-08 | 2020-08-13 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| KR101935250B1 (ko) * | 2017-07-04 | 2019-01-04 | 김대황 | 요오드제 및 삼투성 미각제를 포함하는 눈, 구강용, 비강용 또는 흡입용 항바이러스 및 항균 조성물 |
| ES2949441T3 (es) | 2018-03-27 | 2023-09-28 | Invirsa Inc | Métodos para el uso de 5'-adenosina difosfato ribosa (ADPR) |
| CN115279458A (zh) | 2020-01-10 | 2022-11-01 | 阿祖拉眼科有限公司 | 组合物和敏感性说明 |
| CN113797164B (zh) * | 2020-06-17 | 2023-07-14 | 成都瑞沐生物医药科技有限公司 | 一种眼用制剂的载体或辅料及其制备方法和应用 |
| CN112305115B (zh) * | 2020-10-29 | 2022-08-23 | 诺峰药业(成都)有限公司 | 一种检测二氟泼尼酯眼用乳剂中的降解杂质及其含量的高效液相色谱方法 |
| KR20220062790A (ko) | 2020-11-09 | 2022-05-17 | 정춘영 | 포비돈 아이오딘계 소독액 |
| KR102489633B1 (ko) * | 2021-01-21 | 2023-01-17 | 주식회사태준제약 | 점안 조성물 |
| JP2024507326A (ja) * | 2021-01-22 | 2024-02-19 | チョンドゥー ルイムー バイオファーマスーティカルズ カンパニー リミテッド | 点眼投与により乾燥型黄斑変性症および網膜光障害を予防・治療するための眼科用製剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151619A1 (en) * | 2008-06-12 | 2009-12-17 | Foresight Biotherapeutics, Inc. | Povidone iodine, a novel alternative preservative for ophthalmic compositions |
| US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| WO2011084473A1 (en) * | 2009-12-15 | 2011-07-14 | Foresight Biotherapeutics, Inc. | Non-irritating ophthalmic povidone-iodine compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886268A (en) | 1972-05-30 | 1975-05-27 | Synergistics | Iodophor-steroid compound pharmaceutical compositions |
| TW201808311A (zh) * | 2011-09-16 | 2018-03-16 | 遠景生物製藥股份有限公司 | 安定之普維酮-碘組成物 |
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2012
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- 2012-05-11 BR BR112013028735A patent/BR112013028735A2/pt not_active Application Discontinuation
- 2012-05-11 EP EP12781920.9A patent/EP2707006B1/en active Active
- 2012-05-11 TW TW106131033A patent/TWI717552B/zh not_active IP Right Cessation
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- 2012-05-11 AU AU2012253335A patent/AU2012253335B2/en not_active Ceased
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- 2012-05-11 CN CN201280034191.2A patent/CN103957922A/zh active Pending
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2018
- 2018-05-17 AU AU2018203492A patent/AU2018203492A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| WO2009151619A1 (en) * | 2008-06-12 | 2009-12-17 | Foresight Biotherapeutics, Inc. | Povidone iodine, a novel alternative preservative for ophthalmic compositions |
| WO2011084473A1 (en) * | 2009-12-15 | 2011-07-14 | Foresight Biotherapeutics, Inc. | Non-irritating ophthalmic povidone-iodine compositions |
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| AR086399A1 (es) | 2013-12-11 |
| AU2016222491A1 (en) | 2016-09-22 |
| EP2707006B1 (en) | 2019-07-03 |
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| CN103957922A (zh) | 2014-07-30 |
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| CA2835343A1 (en) | 2012-11-15 |
| MX360666B (es) | 2018-11-13 |
| PE20141070A1 (es) | 2014-09-14 |
| JP6072009B2 (ja) | 2017-02-01 |
| JP2014516954A (ja) | 2014-07-17 |
| JP6359619B2 (ja) | 2018-07-18 |
| TWI717552B (zh) | 2021-02-01 |
| ECSP13013069A (es) | 2015-03-31 |
| AU2012253335A1 (en) | 2013-05-02 |
| TWI632914B (zh) | 2018-08-21 |
| TW201811340A (zh) | 2018-04-01 |
| TW201311256A (zh) | 2013-03-16 |
| EP2707006A1 (en) | 2014-03-19 |
| CO6821949A2 (es) | 2013-12-31 |
| KR101967938B1 (ko) | 2019-04-10 |
| MX2013012971A (es) | 2013-12-12 |
| BR112013028735A2 (pt) | 2017-12-05 |
| US20150038473A1 (en) | 2015-02-05 |
| CL2013003016A1 (es) | 2014-05-02 |
| KR20140045375A (ko) | 2014-04-16 |
| JP2017095474A (ja) | 2017-06-01 |
| EP2707006A4 (en) | 2014-09-24 |
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