AU2012237287B2 - Methods of treating immune disorders with single domain antibodies against TNF-alpha - Google Patents

Methods of treating immune disorders with single domain antibodies against TNF-alpha Download PDF

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Publication number
AU2012237287B2
AU2012237287B2 AU2012237287A AU2012237287A AU2012237287B2 AU 2012237287 B2 AU2012237287 B2 AU 2012237287B2 AU 2012237287 A AU2012237287 A AU 2012237287A AU 2012237287 A AU2012237287 A AU 2012237287A AU 2012237287 B2 AU2012237287 B2 AU 2012237287B2
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amino acid
seq
acid sequence
human
sdab
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AU2012237287A1 (en
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Gail COMER
Martin Hegen
Amarnath Sharma
Kathy SHIELDS
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Ablynx NV
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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AU2012237287A 2011-03-30 2012-03-30 Methods of treating immune disorders with single domain antibodies against TNF-alpha Ceased AU2012237287B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161469388P 2011-03-30 2011-03-30
US61/469,388 2011-03-30
PCT/EP2012/055830 WO2012131053A1 (en) 2011-03-30 2012-03-30 Methods of treating immune disorders with single domain antibodies against tnf-alpha

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AU2012237287A1 AU2012237287A1 (en) 2013-04-04
AU2012237287B2 true AU2012237287B2 (en) 2016-09-08

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JP (1) JP6130350B2 (enrdf_load_stackoverflow)
KR (1) KR20140018299A (enrdf_load_stackoverflow)
CN (2) CN106039306A (enrdf_load_stackoverflow)
AU (1) AU2012237287B2 (enrdf_load_stackoverflow)
MX (1) MX361242B (enrdf_load_stackoverflow)
WO (1) WO2012131053A1 (enrdf_load_stackoverflow)

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JP7090347B2 (ja) 2017-05-12 2022-06-24 ハープーン セラピューティクス,インク. メソテリン結合タンパク質
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