AU2012225548B2 - Methods and compositions for treating depression using cyclobenzaprine - Google Patents

Methods and compositions for treating depression using cyclobenzaprine Download PDF

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Publication number
AU2012225548B2
AU2012225548B2 AU2012225548A AU2012225548A AU2012225548B2 AU 2012225548 B2 AU2012225548 B2 AU 2012225548B2 AU 2012225548 A AU2012225548 A AU 2012225548A AU 2012225548 A AU2012225548 A AU 2012225548A AU 2012225548 B2 AU2012225548 B2 AU 2012225548B2
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Prior art keywords
cyclobenzaprine
day
dose
depression
administered
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AU2012225548A1 (en
Inventor
Seth Lederman
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Tonix Pharma Holdings Ltd
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Tonix Pharma Holdings Ltd
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Publication of AU2012225548A1 publication Critical patent/AU2012225548A1/en
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Priority to AU2016222412A priority Critical patent/AU2016222412B2/en
Priority to AU2018204633A priority patent/AU2018204633C1/en
Assigned to TONIX PHARMA HOLDINGS LIMITED reassignment TONIX PHARMA HOLDINGS LIMITED Request for Assignment Assignors: Tonix Pharmaceuticals, Inc.
Priority to AU2020203874A priority patent/AU2020203874B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012225548A 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine Active AU2012225548B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2016222412A AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449838P 2011-03-07 2011-03-07
US61/449,838 2011-03-07
PCT/US2012/027926 WO2012122193A1 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016222412A Division AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine

Publications (2)

Publication Number Publication Date
AU2012225548A1 AU2012225548A1 (en) 2013-09-19
AU2012225548B2 true AU2012225548B2 (en) 2016-06-02

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ID=46796107

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2012225548A Active AU2012225548B2 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine
AU2016222412A Active AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A Active AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A Active AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2016222412A Active AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A Active AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A Active AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Country Status (18)

Country Link
US (1) US11998516B2 (OSRAM)
EP (2) EP2683245B2 (OSRAM)
JP (2) JP2014507475A (OSRAM)
AU (4) AU2012225548B2 (OSRAM)
CA (1) CA2829200C (OSRAM)
CY (1) CY1122998T1 (OSRAM)
DK (1) DK2683245T4 (OSRAM)
ES (1) ES2773834T5 (OSRAM)
FI (1) FI2683245T4 (OSRAM)
HR (1) HRP20200142T4 (OSRAM)
HU (1) HUE048596T2 (OSRAM)
LT (1) LT2683245T (OSRAM)
PL (1) PL2683245T5 (OSRAM)
PT (1) PT2683245T (OSRAM)
RS (1) RS60240B2 (OSRAM)
SI (1) SI2683245T2 (OSRAM)
SM (1) SMT202000083T1 (OSRAM)
WO (1) WO2012122193A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE037281T2 (hu) * 2009-11-20 2018-08-28 Tonix Pharma Holdings Ltd Eljárás és készítmény poszt-traumás stressz rendellenesség tüneteinek kezelésére ciklobenzaprin alkalmazásával
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
ES2769879T3 (es) 2013-03-15 2020-06-29 Tonix Pharma Holdings Ltd Formulaciones eutécticas de clorhidrato de ciclobenzaprina y manitol
WO2015150948A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited Modified release solid oral pharmaceutical compositions of cyclobenzaprine or a salt thereof
CN107072968B (zh) 2014-09-18 2021-01-12 通尼克斯制药控股有限公司 环苯扎林盐酸盐的低共熔混合物配制剂
CN106890129A (zh) * 2015-12-18 2017-06-27 健乔信元医药生技股份有限公司 环苄普林之延释剂型
MX2020006140A (es) * 2017-12-11 2020-08-13 Tonix Pharma Holdings Ltd Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas.

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US20050096327A1 (en) * 2003-11-03 2005-05-05 Caprathe Bradley W. Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders

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Also Published As

Publication number Publication date
LT2683245T (lt) 2020-03-25
AU2012225548A1 (en) 2013-09-19
US20120232159A1 (en) 2012-09-13
EP3682885A1 (en) 2020-07-22
CA2829200A1 (en) 2012-09-13
EP2683245A4 (en) 2014-08-27
DK2683245T4 (da) 2023-01-09
SI2683245T1 (sl) 2020-07-31
RS60240B1 (sr) 2020-06-30
JP2016053095A (ja) 2016-04-14
SI2683245T2 (sl) 2023-04-28
CY1122998T1 (el) 2021-10-29
AU2016222412A1 (en) 2016-09-22
CA2829200C (en) 2022-05-03
AU2018204633C1 (en) 2020-09-10
FI2683245T4 (fi) 2023-01-13
PL2683245T5 (pl) 2023-03-20
HRP20200142T4 (hr) 2023-02-17
JP2014507475A (ja) 2014-03-27
NZ714294A (en) 2017-06-30
NZ614725A (en) 2016-07-29
EP2683245B2 (en) 2022-12-07
US11998516B2 (en) 2024-06-04
AU2018204633A1 (en) 2018-07-12
AU2020203874B2 (en) 2021-09-09
DK2683245T3 (da) 2020-02-24
PL2683245T3 (pl) 2020-10-05
EP2683245B1 (en) 2019-12-25
HUE048596T2 (hu) 2020-08-28
PT2683245T (pt) 2020-02-21
ES2773834T5 (es) 2023-03-16
EP2683245A1 (en) 2014-01-15
AU2020203874A1 (en) 2020-07-02
SMT202000083T1 (it) 2020-05-08
AU2018204633B2 (en) 2020-03-12
AU2016222412B2 (en) 2018-03-29
ES2773834T3 (es) 2020-07-15
RS60240B2 (sr) 2023-05-31
HRP20200142T1 (hr) 2020-06-26
WO2012122193A1 (en) 2012-09-13

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