DK2683245T4 - Fremgangsmåder og sammensætninger til behandling af depression ved anvendelse af cyclobenzaprin - Google Patents

Fremgangsmåder og sammensætninger til behandling af depression ved anvendelse af cyclobenzaprin Download PDF

Info

Publication number
DK2683245T4
DK2683245T4 DK12755254.5T DK12755254T DK2683245T4 DK 2683245 T4 DK2683245 T4 DK 2683245T4 DK 12755254 T DK12755254 T DK 12755254T DK 2683245 T4 DK2683245 T4 DK 2683245T4
Authority
DK
Denmark
Prior art keywords
cyclobenzaprine
compositions
methods
treating depression
depression
Prior art date
Application number
DK12755254.5T
Other languages
English (en)
Other versions
DK2683245T3 (da
Inventor
Seth Lederman
Original Assignee
Tonix Pharma Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46796107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2683245(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tonix Pharma Holdings Ltd filed Critical Tonix Pharma Holdings Ltd
Publication of DK2683245T3 publication Critical patent/DK2683245T3/da
Application granted granted Critical
Publication of DK2683245T4 publication Critical patent/DK2683245T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK12755254.5T 2011-03-07 2012-03-06 Fremgangsmåder og sammensætninger til behandling af depression ved anvendelse af cyclobenzaprin DK2683245T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161449838P 2011-03-07 2011-03-07
PCT/US2012/027926 WO2012122193A1 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine

Publications (2)

Publication Number Publication Date
DK2683245T3 DK2683245T3 (da) 2020-02-24
DK2683245T4 true DK2683245T4 (da) 2023-01-09

Family

ID=46796107

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12755254.5T DK2683245T4 (da) 2011-03-07 2012-03-06 Fremgangsmåder og sammensætninger til behandling af depression ved anvendelse af cyclobenzaprin

Country Status (17)

Country Link
US (1) US11998516B2 (da)
EP (2) EP2683245B2 (da)
JP (2) JP2014507475A (da)
AU (4) AU2012225548B2 (da)
CA (1) CA2829200C (da)
CY (1) CY1122998T1 (da)
DK (1) DK2683245T4 (da)
ES (1) ES2773834T5 (da)
FI (1) FI2683245T4 (da)
HR (1) HRP20200142T4 (da)
HU (1) HUE048596T2 (da)
LT (1) LT2683245T (da)
PL (1) PL2683245T5 (da)
PT (1) PT2683245T (da)
RS (1) RS60240B2 (da)
SI (1) SI2683245T2 (da)
WO (1) WO2012122193A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2501234T (lt) * 2009-11-20 2017-12-11 Tonix Pharma Holdings Limited Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
PT2968992T (pt) 2013-03-15 2020-02-18 Tonix Pharma Holdings Ltd Formulações eutécticas de cloridrato de ciclobenzaprina e manitol
WO2015150948A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited Modified release solid oral pharmaceutical compositions of cyclobenzaprine or a salt thereof
MX2017003644A (es) 2014-09-18 2017-10-31 Tonix Pharma Holdings Ltd Formulaciones eutecticas de clorhidrato de ciclobenzaprina.
CN106890129A (zh) * 2015-12-18 2017-06-27 健乔信元医药生技股份有限公司 环苄普林之延释剂型
US11826321B2 (en) * 2017-12-11 2023-11-28 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882246A (en) 1971-05-21 1975-05-06 Merck & Co Inc Treatment of skeletal muscle disorders with cyclobenzaprine
US4968507A (en) 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
FR2635461B1 (fr) 1988-08-18 1992-01-17 Adir Utilisation de derives tricycliques pour l'obtention de medicaments destines au traitement du stress
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
CA2155947C (en) 1993-02-22 2007-08-21 Mark W. Grinstaff Methods for in vivo delivery of biologics and compositions useful therefor
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5354566A (en) 1993-06-02 1994-10-11 Kraft General Foods, Inc. Preparation of yeast-leavened dough crusts
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5834025A (en) 1995-09-29 1998-11-10 Nanosystems L.L.C. Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
US6649186B1 (en) 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (en) 1997-10-16 1999-04-22 Merck & Co., Inc. New cyclobenzaprine composition
PT1077683E (pt) 1998-05-14 2003-04-30 Alza Corp Terapia anti-depressiva
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6358944B1 (en) 1999-08-13 2002-03-19 Vela Pharmaceuticals, Inc. Methods and compositions for treating generalized anxiety disorder
WO2001012175A1 (en) * 1999-08-13 2001-02-22 Vela Pharmaceuticals Inc. Uses compositions for treating or preventing sleep disturbances using very low doses of cyclobenzaprine
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
WO2001089476A1 (en) 2000-05-19 2001-11-29 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
PT1441708E (pt) 2001-11-05 2009-06-18 Krele Pharmaceuticals Llc Composições e métodos para aumentar a observância de terapias utilizando inibidores da aldeído desidrogenase e para tratar alcoolismo
US7105486B2 (en) 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7659253B2 (en) 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US7038085B2 (en) 2002-10-25 2006-05-02 Collegium Pharmaceutical, Inc. Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
EP3470084A1 (en) 2002-12-09 2019-04-17 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
US20050059656A1 (en) 2003-04-07 2005-03-17 Cornell Research Foundation, Inc. Compositions and methods for protecting against mitochondria component-mediated pathology
BRPI0410792B8 (pt) 2003-05-29 2021-05-25 New River Pharmaceuticals Inc compostos de anfetamina resistentes à dependencia
EP1685115A1 (en) 2003-11-03 2006-08-02 Warner-Lambert Company LLC Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
JP2007516259A (ja) 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
JP5179757B2 (ja) 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ, インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
TW200531680A (en) 2004-03-03 2005-10-01 Merz Pharma Gmbh & Co Kgaa Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease
US8216610B2 (en) 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
US20070196364A1 (en) 2004-07-27 2007-08-23 Human Genome Sciences, Inc. Pharmaceutical Formulation and Process
US7532935B2 (en) 2005-07-29 2009-05-12 Cyberonics, Inc. Selective neurostimulation for treating mood disorders
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
US20090069267A1 (en) 2006-01-17 2009-03-12 Abrams Daniel J Central administration of stable formulations of therapeutic agents for cns conditions
US20080146672A1 (en) 2006-12-08 2008-06-19 Denton Marcia Marye Topical Eutectic Anesthetic Composition for Oral or Dermal Tissue
EP2514417A3 (en) 2007-05-07 2013-01-30 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
WO2009002770A1 (en) 2007-06-22 2008-12-31 Merck & Co., Inc. 6.5-pyrrolopiperidine tachykinin receptor antagonists
WO2009015248A1 (en) 2007-07-23 2009-01-29 Synosia Therapeutics Treatment of post-traumatic stress disorder
US20090060983A1 (en) 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
DK2200588T3 (da) 2007-09-25 2019-07-01 Solubest Ltd Sammensætninger, som omfatter lipofile aktive forbindelser, og fremgangsmåde til fremstilling deraf
WO2009058950A2 (en) 2007-10-30 2009-05-07 Dr. Reddy's Laboratories Ltd. Pharmaceutical formulations comprising telmisartan and hydrochlorothiazide
US20090148532A1 (en) 2007-12-06 2009-06-11 Venkatesh Gopi M Preparation of controlled release skeletal muscle relaxant dosage forms
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
CA2714514C (en) 2008-02-08 2016-08-16 Qps Llc Non-polymeric compositions for controlled drug delivery
US9314469B2 (en) 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
JP5380909B2 (ja) 2008-05-30 2014-01-08 株式会社ブリヂストン 金型及び樹脂発泡成形品の成形方法
US20100266682A1 (en) 2008-12-10 2010-10-21 Nipun Davar Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
US20100247586A1 (en) 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
US8343533B2 (en) 2009-09-24 2013-01-01 Mcneil-Ppc, Inc. Manufacture of lozenge product with radiofrequency
LT2501234T (lt) 2009-11-20 2017-12-11 Tonix Pharma Holdings Limited Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
KR20130132774A (ko) 2010-09-01 2013-12-05 토닉스 파마슈티컬스, 아이엔씨. 코카인 중독에 대한 치료
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
ITMI20110558A1 (it) 2011-04-06 2012-10-07 Campiglio Consulting Srl Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale
CN104684550A (zh) 2012-06-15 2015-06-03 通尼克斯制药有限公司 用于跨粘膜吸收的组合物和方法
EP2914585B1 (en) 2012-11-05 2018-03-07 Emory University 7,8-dihydroxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto
PT2968992T (pt) 2013-03-15 2020-02-18 Tonix Pharma Holdings Ltd Formulações eutécticas de cloridrato de ciclobenzaprina e manitol
US20160015818A1 (en) 2014-07-18 2016-01-21 Medipath, Inc. Compositions and methods for physiological delivery using cannabidiol
MX2017003644A (es) 2014-09-18 2017-10-31 Tonix Pharma Holdings Ltd Formulaciones eutecticas de clorhidrato de ciclobenzaprina.
US11826321B2 (en) 2017-12-11 2023-11-28 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
WO2023250036A1 (en) 2022-06-21 2023-12-28 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for post-acute sequelae of (sars)-cov-2 infection (pasc)

Also Published As

Publication number Publication date
EP2683245A1 (en) 2014-01-15
PL2683245T3 (pl) 2020-10-05
AU2018204633A1 (en) 2018-07-12
AU2018204633B2 (en) 2020-03-12
WO2012122193A1 (en) 2012-09-13
EP2683245A4 (en) 2014-08-27
ES2773834T3 (es) 2020-07-15
HRP20200142T1 (hr) 2020-06-26
RS60240B2 (sr) 2023-05-31
NZ614725A (en) 2016-07-29
AU2012225548B2 (en) 2016-06-02
FI2683245T4 (fi) 2023-01-13
AU2016222412B2 (en) 2018-03-29
AU2020203874A1 (en) 2020-07-02
AU2016222412A1 (en) 2016-09-22
PL2683245T5 (pl) 2023-03-20
JP2014507475A (ja) 2014-03-27
AU2018204633C1 (en) 2020-09-10
EP2683245B2 (en) 2022-12-07
US20120232159A1 (en) 2012-09-13
EP2683245B1 (en) 2019-12-25
NZ714294A (en) 2017-06-30
RS60240B1 (sr) 2020-06-30
AU2012225548A1 (en) 2013-09-19
JP2016053095A (ja) 2016-04-14
EP3682885A1 (en) 2020-07-22
CA2829200C (en) 2022-05-03
US11998516B2 (en) 2024-06-04
PT2683245T (pt) 2020-02-21
LT2683245T (lt) 2020-03-25
DK2683245T3 (da) 2020-02-24
HUE048596T2 (hu) 2020-08-28
SI2683245T2 (sl) 2023-04-28
SI2683245T1 (sl) 2020-07-31
HRP20200142T4 (hr) 2023-02-17
AU2020203874B2 (en) 2021-09-09
CA2829200A1 (en) 2012-09-13
CY1122998T1 (el) 2021-10-29
ES2773834T5 (es) 2023-03-16

Similar Documents

Publication Publication Date Title
DK2890780T3 (da) Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
DK4011364T3 (da) Fremgangsmåder og sammensætninger til behandling af ADD (Attention Deficit Disorder)
DK2709613T4 (da) Fremgangsmåder til behandling af hcv
DK2900061T3 (da) Fremgangsmåde til forstærkning af specifikke immunterapier ved cancerbehandling
DK2914741T3 (da) Hidtil ukendte sammensætninger og fremgangsmåder til forbedring af PCR-specificitet
DK2776567T3 (da) Sammensætninger og fremgangsmåder til behandling af cytomegalovirus.
DK2812452T3 (da) Fremgangsmåder og sammensætninger til screening og behandling af udviklingsforstyrrelser
DK3141542T3 (da) Substituerede benzaldehydforbindelser og fremgangsmåder til anvendelse deraf ved øgning af vævsiltning
DK2768321T3 (da) Fremgangsmåder og sammensætninger til induktion af mæthed
DK2683245T4 (da) Fremgangsmåder og sammensætninger til behandling af depression ved anvendelse af cyclobenzaprin
BR112013019732A2 (pt) composições e métodos para tratamento de doenças cardiovasculares
DK2699553T3 (da) Substituerede diaminocarboxamid- og diaminocarbonitrilpyrimidiner, sammensætninger deraf og fremgangsmåder til behandling dermed
DK3586861T3 (da) Lipidnanopartikelsammensætninger og fremgangsmåder til mrna-indgivelse
DK2884999T3 (da) Fremgangsmåde og sammensætninger til cellulær immunterapi
DK2739293T3 (da) Fremgangsmåder og sammensætninger til frembringelse af vaccinavirus
DK2583586T4 (da) Indretning til registrering af kollisioner og tilsvarende fremgangsmåde
DK2766483T3 (da) Fremgangsmåder og sammensætninger til screening for og behandling af udviklingsforstyrrelser
DK2830654T3 (da) Metoder og sammensætninger til behandling af inflammation
BR112014010450A2 (pt) composição e método
DK2552484T3 (da) Fremgangsmåder og sammensætninger til reducering af parathyroidniveauer
DK2877856T3 (da) Fremgangsmåde til forbedring af implantationssucces ved assisteret befrugtning
DK2680829T3 (da) Sammensætninger og metoder til ikke-kirurgisk behandling af ptosis
DK2917231T3 (da) Lipopeptider til anvendelse ved behandling af leversygdomme og hjerte-kar-sygdomme
DK2442832T3 (da) Sammensætninger og fremgangsmåder til behandling af dissemineret sclerose
DK2683371T3 (da) Forbindelser og fremgangsmåder til forbedring af forringet endogen fibrinolyse ved anvendelse af histondeacetylasehæmmere