AU2012204567B9 - Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2 - Google Patents

Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2 Download PDF

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Publication number
AU2012204567B9
AU2012204567B9 AU2012204567A AU2012204567A AU2012204567B9 AU 2012204567 B9 AU2012204567 B9 AU 2012204567B9 AU 2012204567 A AU2012204567 A AU 2012204567A AU 2012204567 A AU2012204567 A AU 2012204567A AU 2012204567 B9 AU2012204567 B9 AU 2012204567B9
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Prior art keywords
chloro
phenyl
tetrahydro
pyran
triol
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AU2012204567B2 (en
AU2012204567A1 (en
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Jinling Chen
Nasser N. Nyamweya
Kenneth K. H. Ong
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Lexicon Pharmaceuticals Inc
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Lexicon Pharmaceuticals Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2012204567A 2011-01-05 2012-01-03 Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2 Active AU2012204567B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430027P 2011-01-05 2011-01-05
US61/430,027 2011-01-05
PCT/US2012/020042 WO2012094293A1 (en) 2011-01-05 2012-01-03 Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2

Publications (3)

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AU2012204567A1 AU2012204567A1 (en) 2013-07-11
AU2012204567B2 AU2012204567B2 (en) 2016-12-08
AU2012204567B9 true AU2012204567B9 (en) 2016-12-22

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US (6) US20120172320A1 (https=)
EP (1) EP2661256B1 (https=)
JP (3) JP2014501780A (https=)
KR (1) KR102024204B1 (https=)
CN (1) CN103458875A (https=)
AR (1) AR084781A1 (https=)
AU (1) AU2012204567B9 (https=)
BR (1) BR112013017314B1 (https=)
CA (1) CA2823736C (https=)
DK (1) DK2661256T3 (https=)
ES (1) ES2710341T3 (https=)
HU (1) HUE041364T2 (https=)
IL (1) IL295438B1 (https=)
MX (1) MX360554B (https=)
PL (1) PL2661256T3 (https=)
PT (1) PT2661256T (https=)
RU (1) RU2669921C2 (https=)
SG (2) SG10201602670QA (https=)
TR (1) TR201901262T4 (https=)
TW (1) TWI631963B (https=)
WO (1) WO2012094293A1 (https=)
ZA (1) ZA201304694B (https=)

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PL3489226T3 (pl) * 2012-11-20 2021-08-02 Lexicon Pharmaceuticals, Inc. Inhibitory kotransportera glukozowo-sodowego 1
JP6727419B2 (ja) * 2016-05-25 2020-07-22 クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途
US11723929B2 (en) 2017-06-13 2023-08-15 The Regents Of The University Of California Methods of improving cell-based therapy
CN107540685B (zh) * 2017-09-04 2020-05-05 杭州科巢生物科技有限公司 一种Sotagliflozin的制备方法及其中间体
EP3456320A1 (de) * 2017-09-15 2019-03-20 Stada Arzneimittel Ag Dpp-4-inhibitor-mono-zusammensetzung
JP6917527B2 (ja) * 2018-01-05 2021-08-11 シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． Ｓｇｌｔ阻害剤及びその応用
CN110117304A (zh) * 2018-04-23 2019-08-13 中国科学院成都生物研究所 一种钠-葡萄糖协同转运蛋白1和2抑制剂的药物用途
CN110818722B (zh) * 2018-08-14 2022-12-02 苏州鹏旭医药科技有限公司 三种化合物及其制备方法和在合成索格列净中的用途
KR102951944B1 (ko) 2019-07-05 2026-04-10 산동 단홍 파머수티컬 컴퍼니., 리미티드. SGLTs 억제제의 결정형 및 그 응용
US12421269B2 (en) * 2019-07-26 2025-09-23 Cgenetech (Suzhou, China) Co., Ltd. SGLT2/DPP4 inhibitor and application thereof
CN114585358B (zh) 2019-07-26 2023-11-10 东宝紫星(杭州)生物医药有限公司 一种SGLTs/DPP4抑制剂及其应用
EP3771480A1 (en) * 2019-08-01 2021-02-03 Lexicon Pharmaceuticals, Inc. Continuous process for preparing the crystalline form ii of sotagliflozin
WO2021092341A1 (en) * 2019-11-07 2021-05-14 Increvet, Inc. Sodium-glucose linked transporter inhibitors for the management of chronic kidney disease, hypertension, and heart failure in companion animals
US20240100013A1 (en) 2021-01-04 2024-03-28 Lexicon Pharmaceuticals, Inc. Sotagliflozin for improving left atrial function
WO2022155303A1 (en) 2021-01-14 2022-07-21 Lexicon Pharmaceuticals, Inc. Sotagliflozin for treating or preventing cardiovascular diseases
US20250108032A1 (en) 2023-09-28 2025-04-03 Lexicon Pharmaceuticals, Inc. Methods of treating type 1 diabetes and kidney disease
US20250114323A1 (en) 2023-10-06 2025-04-10 Lexicon Pharmaceuticals, Inc. Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy

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