AU2011337043A1 - Apparatus and methods for aliquotting frozen samples - Google Patents
Apparatus and methods for aliquotting frozen samples Download PDFInfo
- Publication number
- AU2011337043A1 AU2011337043A1 AU2011337043A AU2011337043A AU2011337043A1 AU 2011337043 A1 AU2011337043 A1 AU 2011337043A1 AU 2011337043 A AU2011337043 A AU 2011337043A AU 2011337043 A AU2011337043 A AU 2011337043A AU 2011337043 A1 AU2011337043 A1 AU 2011337043A1
- Authority
- AU
- Australia
- Prior art keywords
- sample
- frozen
- samples
- set forth
- platform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000012520 frozen sample Substances 0.000 title claims abstract description 271
- 238000000034 method Methods 0.000 title claims abstract description 38
- 239000000523 sample Substances 0.000 claims abstract description 286
- 239000000126 substance Substances 0.000 claims abstract description 33
- 238000004140 cleaning Methods 0.000 claims description 75
- 239000012530 fluid Substances 0.000 claims description 50
- 230000007246 mechanism Effects 0.000 claims description 43
- 238000007689 inspection Methods 0.000 claims description 35
- 210000004027 cell Anatomy 0.000 claims description 13
- 238000005452 bending Methods 0.000 claims description 10
- 210000002381 plasma Anatomy 0.000 claims description 10
- 210000002966 serum Anatomy 0.000 claims description 10
- -1 cell homogenates Substances 0.000 claims description 8
- 230000005670 electromagnetic radiation Effects 0.000 claims description 8
- 230000001580 bacterial effect Effects 0.000 claims description 5
- 230000008602 contraction Effects 0.000 claims description 5
- 230000002538 fungal effect Effects 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 238000005336 cracking Methods 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 206010003445 Ascites Diseases 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 3
- 210000004381 amniotic fluid Anatomy 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 239000013592 cell lysate Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims description 3
- 238000006731 degradation reaction Methods 0.000 claims description 3
- 210000004700 fetal blood Anatomy 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 210000001589 microsome Anatomy 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 210000003097 mucus Anatomy 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 210000003463 organelle Anatomy 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 210000004243 sweat Anatomy 0.000 claims description 3
- 210000001138 tear Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 238000010226 confocal imaging Methods 0.000 claims description 2
- 238000010191 image analysis Methods 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000020347 spindle assembly Effects 0.000 description 21
- 239000012472 biological sample Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- 230000008569 process Effects 0.000 description 12
- 239000007789 gas Substances 0.000 description 11
- 238000001035 drying Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000004891 communication Methods 0.000 description 3
- 238000005553 drilling Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108020005196 Mitochondrial DNA Proteins 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 239000013611 chromosomal DNA Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 244000078885 bloodborne pathogen Species 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002592 echocardiography Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015215836A AU2015215836A1 (en) | 2010-12-01 | 2015-08-18 | Apparatus and methods for aliquotting frozen samples |
| AU2017254905A AU2017254905A1 (en) | 2010-12-01 | 2017-11-01 | Apparatus and methods for aliquotting frozen samples |
| AU2019204194A AU2019204194A1 (en) | 2010-12-01 | 2019-06-14 | Apparatus and methods for aliquotting frozen samples |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41868810P | 2010-12-01 | 2010-12-01 | |
| US61/418,688 | 2010-12-01 | ||
| PCT/US2011/061214 WO2012074771A2 (en) | 2010-12-01 | 2011-11-17 | Apparatus and methods for aliquotting frozen samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015215836A Division AU2015215836A1 (en) | 2010-12-01 | 2015-08-18 | Apparatus and methods for aliquotting frozen samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2011337043A1 true AU2011337043A1 (en) | 2013-06-13 |
Family
ID=45044753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011337043A Abandoned AU2011337043A1 (en) | 2010-12-01 | 2011-11-17 | Apparatus and methods for aliquotting frozen samples |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140335554A1 (https=) |
| EP (1) | EP2646792B1 (https=) |
| JP (2) | JP2013545105A (https=) |
| CN (1) | CN103370610B (https=) |
| AU (1) | AU2011337043A1 (https=) |
| BR (1) | BR112013013505A2 (https=) |
| CA (1) | CA2819013C (https=) |
| WO (1) | WO2012074771A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9032854B2 (en) | 2011-12-21 | 2015-05-19 | Sakura Finetek U.S.A., Inc. | Reciprocating microtome drive system |
| US9134202B2 (en) | 2012-01-26 | 2015-09-15 | Cryoxtract Instruments, Llc | Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples |
| US20140267713A1 (en) * | 2013-03-15 | 2014-09-18 | Cryoxtract Instruments, Llc | Machine Vision System for Frozen Aliquotter for Biological Samples |
| US20130286192A1 (en) * | 2012-04-30 | 2013-10-31 | Cryoxtract Instruments, Llc | Machine Vision System for Frozen Aliquotter for Biological Samples |
| US12157595B2 (en) * | 2012-05-03 | 2024-12-03 | Vanrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| US12065347B2 (en) * | 2012-05-03 | 2024-08-20 | Vanrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| BR112015001460A2 (pt) * | 2012-07-24 | 2017-07-04 | Cryoxtract Instr Llc | sonda de escavação, sistemas para colher núcleo de amostras congelados de uma pluralidade de amostras congeladas, para coletar alíquotas congeladas de amostras biológicas congeladas contidas em contêineres de amostras, para armazenar amostras de tecido congeladas, métodos de colher um núcleo de amostra congelada de uma amostra congelada, para aumentar a probabilidade de um operador usar apenas as sondas de escavação, para preparar e amostrar uma amostra de tecido em um contêiner de amostra de tecido, e de armazenamento de uma amostra de tecido, dispositivo portátil de escavação, bandeja, contêiner de amostra de tecido, kit para preparação de u,a a,ostra de tecido, transporte de tecido para suportar a amostra de tecido, e, combinação de transporte de tecido e dispositivo de escavação. |
| FI10181U1 (fi) * | 2013-04-17 | 2013-08-14 | Konecranes Oyj | Tarttuja kuormankäsittelylaitetta varten ja nosturi |
| AU2014262888A1 (en) * | 2013-05-04 | 2015-11-19 | Cryoxtract Instruments, Llc | Targeting systems and methods for frozen aliquotter for biological samples |
| CN103636737B (zh) * | 2013-10-24 | 2016-05-11 | 杨公明 | 一种羊胎盘及羊水现场收集与保鲜的方法 |
| US12392692B2 (en) | 2017-03-09 | 2025-08-19 | Hologic, Inc. | Systems for automated preparation of biological specimens |
| CN110383034B (zh) * | 2017-03-09 | 2022-07-12 | 霍罗杰克股份有限公司 | 自动化制备生物样本的系统及方法 |
| CN107843453B (zh) * | 2017-12-21 | 2024-01-23 | 上海泽泉科技股份有限公司 | 可调速手持低温样本分装仪 |
| EP3811007A1 (en) * | 2018-06-20 | 2021-04-28 | Gen-Probe Incorporated | Method and apparatus for freezing dispensed droplets of liquid |
| WO2020165909A1 (en) * | 2019-02-17 | 2020-08-20 | National Scientific And Technical Research Council - Argentina (Conicet) | System for accessing biological samples in a cryogenic dewar vessel |
| CN113533762B (zh) * | 2020-04-22 | 2025-10-24 | 深圳迎凯生物科技有限公司 | 试剂存储装置 |
| CN111504691B (zh) * | 2020-05-10 | 2023-03-10 | 淮阴师范学院 | 一种便携式地理信息采集装置 |
| US11981473B2 (en) * | 2020-09-27 | 2024-05-14 | V Anrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| CN116643025B (zh) * | 2023-05-06 | 2024-04-02 | 中国地质大学（北京） | 一种用于环境地质土壤检测的检测装置 |
| CN117969196A (zh) * | 2023-10-08 | 2024-05-03 | 四川国际旅行卫生保健中心(成都海关口岸门诊部) | 一种无接触式粪便包虫的样本预处理设备 |
| WO2025111514A1 (en) * | 2023-11-22 | 2025-05-30 | Mitegen, Llc | Systems, methods, and devices for rapid warming of cells and other biological materials |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6166944A (ja) * | 1984-09-11 | 1986-04-05 | Nitsuteku Eng:Kk | 血清試料の秤取方法及びその装置 |
| US6117130A (en) * | 1998-09-24 | 2000-09-12 | Abiomed, Inc. | Coring device for myocardial revascularization |
| TW388790B (en) * | 1999-04-13 | 2000-05-01 | Inst Of Unclear Energy Res Roc | An automatic sampling method and facility for the heterogeneous materials |
| US20040085443A1 (en) * | 2000-12-13 | 2004-05-06 | Kallioniemi Olli P | Method and system for processing regions of interest for objects comprising biological material |
| US20020129975A1 (en) * | 2001-01-17 | 2002-09-19 | Barta Ernest G. | Ice auger system |
| US6635414B2 (en) * | 2001-05-22 | 2003-10-21 | Integrated Biosystems, Inc. | Cryopreservation system with controlled dendritic freezing front velocity |
| GB0325483D0 (en) * | 2003-10-31 | 2003-12-03 | Plasmacute As | Assay |
| JP4451263B2 (ja) * | 2004-10-13 | 2010-04-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 試料摘出装置 |
| CA2636792C (en) * | 2006-01-13 | 2014-03-11 | President And Fellows Of Harvard College | Systems, methods, and devices for frozen sample distribution |
| US7823818B2 (en) * | 2007-10-17 | 2010-11-02 | Max-Planck-Gessellschaft zur Foerderung der Wissenschafter E.V. | System and method for producing weighed portions of powder from at least one biological material at cryotemperatures |
| EP2261632B1 (en) * | 2008-03-31 | 2019-09-11 | Sysmex Corporation | Sample preparation device, and cell analyzing device with the same |
| JP5530613B2 (ja) * | 2008-10-06 | 2014-06-25 | シスメックス株式会社 | 検体処理システム及び検体搬送システム |
| JP5203889B2 (ja) * | 2008-10-28 | 2013-06-05 | シスメックス株式会社 | 検体分析装置及び検体分析方法 |
-
2011
- 2011-11-17 AU AU2011337043A patent/AU2011337043A1/en not_active Abandoned
- 2011-11-17 EP EP11788311.6A patent/EP2646792B1/en not_active Not-in-force
- 2011-11-17 CA CA2819013A patent/CA2819013C/en not_active Expired - Fee Related
- 2011-11-17 WO PCT/US2011/061214 patent/WO2012074771A2/en not_active Ceased
- 2011-11-17 US US13/991,103 patent/US20140335554A1/en not_active Abandoned
- 2011-11-17 BR BR112013013505A patent/BR112013013505A2/pt not_active Application Discontinuation
- 2011-11-17 CN CN201180057843.XA patent/CN103370610B/zh not_active Expired - Fee Related
- 2011-11-17 JP JP2013542034A patent/JP2013545105A/ja active Pending
-
2016
- 2016-03-31 JP JP2016071584A patent/JP2016122018A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2819013C (en) | 2020-04-14 |
| EP2646792A2 (en) | 2013-10-09 |
| US20140335554A1 (en) | 2014-11-13 |
| JP2013545105A (ja) | 2013-12-19 |
| EP2646792B1 (en) | 2019-07-10 |
| BR112013013505A2 (pt) | 2016-09-06 |
| CA2819013A1 (en) | 2012-06-07 |
| CN103370610A (zh) | 2013-10-23 |
| WO2012074771A3 (en) | 2012-08-16 |
| JP2016122018A (ja) | 2016-07-07 |
| CN103370610B (zh) | 2016-08-10 |
| WO2012074771A2 (en) | 2012-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2819013C (en) | Apparatus and methods for aliquotting frozen samples | |
| JP2013545105A5 (https=) | ||
| US20210116471A1 (en) | Automated method and system for obtaining and preparing microorganism sample for both identification and antibiotic susceptibility tests | |
| US20140326083A1 (en) | Targeting Systems and Methods for Frozen Aliquotter for Biological Samples | |
| US20090325309A1 (en) | Reagent Delivery System, Dispensing Device and Container for a Biological Staining Apparatus | |
| US9689780B2 (en) | Apparatus and methods for aliquotting frozen samples | |
| EP3161449B1 (en) | Automated specimen processing systems and methods | |
| EP2807465A1 (en) | Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples | |
| US6417007B1 (en) | Robotic harvesting of solids from fluids | |
| CN114437925B (zh) | 一种核酸提取仪及其控制方法 | |
| AU2019204194A1 (en) | Apparatus and methods for aliquotting frozen samples | |
| US20140267713A1 (en) | Machine Vision System for Frozen Aliquotter for Biological Samples | |
| JP4840931B2 (ja) | 基板乾燥用支持体及び乾燥装置 | |
| WO2025111515A1 (en) | Systems, methods, and devices for cryopreservation and recovery of cells and other biological materials | |
| WO2013166022A2 (en) | Machine vision system for frozen aliquotter for biological samples |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |