AU2011253057B2 - Nitrogen heterocyclic compounds useful as PDE10 inhibitors - Google Patents

Nitrogen heterocyclic compounds useful as PDE10 inhibitors Download PDF

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Publication number
AU2011253057B2
AU2011253057B2 AU2011253057A AU2011253057A AU2011253057B2 AU 2011253057 B2 AU2011253057 B2 AU 2011253057B2 AU 2011253057 A AU2011253057 A AU 2011253057A AU 2011253057 A AU2011253057 A AU 2011253057A AU 2011253057 B2 AU2011253057 B2 AU 2011253057B2
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Prior art keywords
azetidin
pyrazin
quinoline
quinolin
methanone
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AU2011253057A
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AU2011253057A1 (en
Inventor
Jennifer R. Allen
Jian J. Chen
Michael J. Frohn
Essa Hu Harrington
Qingyian Liu
Alexander J. Pickrell
Shannon Rumfelt
Robert M. Rzasa
Wenge Zhong
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Amgen Inc
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Amgen Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2011253057A 2010-05-13 2011-05-11 Nitrogen heterocyclic compounds useful as PDE10 inhibitors Ceased AU2011253057B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33452510P 2010-05-13 2010-05-13
US61/334,525 2010-05-13
PCT/US2011/036148 WO2011143365A1 (en) 2010-05-13 2011-05-11 Nitrogen heterocyclic compounds useful as pde10 inhibitors

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AU2011253057A1 AU2011253057A1 (en) 2012-11-29
AU2011253057B2 true AU2011253057B2 (en) 2014-11-20

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US (3) US8957073B2 (enExample)
EP (1) EP2569300A1 (enExample)
JP (1) JP5702855B2 (enExample)
KR (1) KR101564806B1 (enExample)
CN (1) CN103221404B (enExample)
AR (1) AR081627A1 (enExample)
AU (1) AU2011253057B2 (enExample)
BR (1) BR112012029026A2 (enExample)
CA (1) CA2798490A1 (enExample)
CL (1) CL2012003178A1 (enExample)
CO (1) CO6630189A2 (enExample)
CR (1) CR20120635A (enExample)
EA (1) EA201291236A1 (enExample)
IL (1) IL222898A (enExample)
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MX (1) MX2012013130A (enExample)
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PE (1) PE20130576A1 (enExample)
PH (1) PH12012502212A1 (enExample)
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TW (1) TW201206902A (enExample)
UA (1) UA109438C2 (enExample)
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