AU2010343276B2 - Methods for determining fraction of fetal nucleic acid in maternal samples - Google Patents

Methods for determining fraction of fetal nucleic acid in maternal samples Download PDF

Info

Publication number
AU2010343276B2
AU2010343276B2 AU2010343276A AU2010343276A AU2010343276B2 AU 2010343276 B2 AU2010343276 B2 AU 2010343276B2 AU 2010343276 A AU2010343276 A AU 2010343276A AU 2010343276 A AU2010343276 A AU 2010343276A AU 2010343276 B2 AU2010343276 B2 AU 2010343276B2
Authority
AU
Australia
Prior art keywords
fetal
polymorphic
nucleic acids
maternal
sequencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2010343276A
Other languages
English (en)
Other versions
AU2010343276A1 (en
Inventor
Manjula CHINNAPPA
Yue-Jen Chuu
David A. COMSTOCK
Gabrielle HEILEK
Michael Hunkapiller
Richard P. Rava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verinata Health Inc
Original Assignee
Verinata Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44307118&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010343276(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Verinata Health Inc filed Critical Verinata Health Inc
Priority claimed from PCT/US2010/058606 external-priority patent/WO2011090556A1/en
Publication of AU2010343276A1 publication Critical patent/AU2010343276A1/en
Application granted granted Critical
Publication of AU2010343276B2 publication Critical patent/AU2010343276B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Algebra (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
AU2010343276A 2010-01-19 2010-12-01 Methods for determining fraction of fetal nucleic acid in maternal samples Active AU2010343276B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US29635810P 2010-01-19 2010-01-19
US61/296,358 2010-01-19
US36083710P 2010-07-01 2010-07-01
US61/360,837 2010-07-01
US45584910P 2010-10-26 2010-10-26
US40701710P 2010-10-26 2010-10-26
US61/407,017 2010-10-26
US61/455,849 2010-10-26
PCT/US2010/058606 WO2011090556A1 (en) 2010-01-19 2010-12-01 Methods for determining fraction of fetal nucleic acid in maternal samples

Publications (2)

Publication Number Publication Date
AU2010343276A1 AU2010343276A1 (en) 2012-09-06
AU2010343276B2 true AU2010343276B2 (en) 2015-05-28

Family

ID=44307118

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2010343279A Active AU2010343279B2 (en) 2010-01-19 2010-12-01 Sequencing methods and compositions for prenatal diagnoses
AU2010343278A Active AU2010343278B2 (en) 2010-01-19 2010-12-01 Simultaneous determination of aneuploidy and fetal fraction
AU2010343277A Active AU2010343277B2 (en) 2010-01-19 2010-12-01 Method for determining copy number variations
AU2010343276A Active AU2010343276B2 (en) 2010-01-19 2010-12-01 Methods for determining fraction of fetal nucleic acid in maternal samples

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AU2010343279A Active AU2010343279B2 (en) 2010-01-19 2010-12-01 Sequencing methods and compositions for prenatal diagnoses
AU2010343278A Active AU2010343278B2 (en) 2010-01-19 2010-12-01 Simultaneous determination of aneuploidy and fetal fraction
AU2010343277A Active AU2010343277B2 (en) 2010-01-19 2010-12-01 Method for determining copy number variations

Country Status (12)

Country Link
US (12) US20110224087A1 (de)
EP (13) EP2376661B1 (de)
AU (4) AU2010343279B2 (de)
CA (4) CA2786357C (de)
CY (1) CY1124494T1 (de)
DK (6) DK2376661T3 (de)
ES (6) ES2534986T3 (de)
GB (5) GB2479471B (de)
HK (6) HK1160185A1 (de)
PL (4) PL3260555T3 (de)
TR (1) TR201807917T4 (de)
WO (3) WO2011090559A1 (de)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE406463T1 (de) 2005-04-06 2008-09-15 Maurice Stroun Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
EP2351858B1 (de) * 2006-02-28 2014-12-31 University of Louisville Research Foundation Erkennung von Chromosomabnormalitäten im Fötus mithilfe der Tandem-Einzelnukleotid-Polymorphismen
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
CA2717320A1 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
AU2009279734A1 (en) * 2008-08-04 2010-02-11 Natera, Inc. Methods for allele calling and ploidy calling
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
ES2640776T3 (es) 2009-09-30 2017-11-06 Natera, Inc. Métodos para denominar de forma no invasiva ploidía prenatal
US8620593B2 (en) 2009-11-06 2013-12-31 The Chinese University Of Hong Kong Size-based genomic analysis
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
EP2513341B1 (de) 2010-01-19 2017-04-12 Verinata Health, Inc Identifizierung von polymorphen sequenzen in mischungen aus genomischer dna durch gesamtgenomsequenzierung
US8700341B2 (en) 2010-01-19 2014-04-15 Verinata Health, Inc. Partition defined detection methods
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
DK2376661T3 (en) * 2010-01-19 2015-02-02 Verinata Health Inc SIMULTANEOUS DETERMINATION OF aneuploidy and fetal FRACTION
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
WO2012135730A2 (en) 2011-03-30 2012-10-04 Verinata Health, Inc. Method for verifying bioassay samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
CA2799746C (en) * 2010-05-17 2020-11-24 Sai Reddy Rapid isolation of monoclonal antibodies from animals
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
WO2013052557A2 (en) * 2011-10-03 2013-04-11 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
JP5992911B2 (ja) 2010-09-21 2016-09-14 ポピュレーション ジェネティクス テクノロジーズ リミテッド 分子計数による対立遺伝子呼び出しの信頼度の増加
EP4269623A3 (de) * 2010-11-30 2024-03-06 The Chinese University Of Hong Kong Analyse einer biologischen probe eines organismus auf mit krebs assoziierte chromosomale deletionen oder amplifikationen
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
CN106319047B (zh) 2011-04-12 2020-02-18 维里纳塔健康公司 使用多态计数来解析基因组分数
WO2012141712A1 (en) * 2011-04-14 2012-10-18 Verinata Health, Inc. Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US9411937B2 (en) * 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US9957558B2 (en) 2011-04-28 2018-05-01 Life Technologies Corporation Methods and compositions for multiplex PCR
US20130059762A1 (en) 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
US20130059738A1 (en) * 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
GB2485635B (en) * 2011-07-26 2012-11-28 Verinata Health Inc Method for determining the presence or absence of different aneuploidies in a sample
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
GB2496016B (en) * 2011-09-09 2016-03-16 Univ Leland Stanford Junior Methods for obtaining a sequence
WO2013040583A2 (en) * 2011-09-16 2013-03-21 Complete Genomics, Inc Determining variants in a genome of a heterogeneous sample
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
CA2850781C (en) 2011-10-06 2020-09-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3243908B1 (de) 2011-10-11 2019-01-02 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
AU2012327251A1 (en) 2011-10-27 2013-05-23 Verinata Health, Inc. Set membership testers for aligning nucleic acid samples
WO2013109981A1 (en) 2012-01-20 2013-07-25 Sequenom, Inc. Diagnostic processes that factor experimental conditions
WO2013130512A2 (en) 2012-02-27 2013-09-06 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
CN104364392B (zh) 2012-02-27 2018-05-25 赛卢拉研究公司 用于分子计数的组合物和试剂盒
EP2820155B1 (de) 2012-02-28 2017-07-26 Population Genetics Technologies Ltd. Verfahren zur befestigung einer zählersequenz an einer nucleinsäureprobe
EP3401399B1 (de) 2012-03-02 2020-04-22 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
ES2945311T3 (es) 2012-03-26 2023-06-30 Univ Johns Hopkins Detección rápida de aneuploidía
CN204440396U (zh) * 2012-04-12 2015-07-01 维里纳塔健康公司 用于确定胎儿分数的试剂盒
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3978621B1 (de) 2012-05-21 2023-08-30 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
WO2013173993A1 (zh) * 2012-05-23 2013-11-28 深圳华大基因健康科技有限公司 鉴定双胞胎类型的方法和系统
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014015269A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
EP2875149B1 (de) 2012-07-20 2019-12-04 Verinata Health, Inc. Erkennung und klassifizierung von kopienzahlvarianten in einem krebsgenom
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
IL305303A (en) 2012-09-04 2023-10-01 Guardant Health Inc Systems and methods for detecting rare mutations and changes in number of copies
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
AU2013326980B2 (en) 2012-10-04 2019-08-15 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2912587A4 (de) * 2012-10-24 2016-12-07 Complete Genomics Inc Genomuntersuchungssystem zur verarbeitung und darstellung von nukleotidvariationen in genomsequenzdaten
US10643738B2 (en) 2013-01-10 2020-05-05 The Chinese University Of Hong Kong Noninvasive prenatal molecular karyotyping from maternal plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102241051B1 (ko) 2013-02-28 2021-04-16 더 차이니즈 유니버시티 오브 홍콩 대량 동시 rna 서열분석에 의한 모체 혈장 전사물 분석
EP3597774A1 (de) 2013-03-13 2020-01-22 Sequenom, Inc. Primer zur analyse der dna-methylierung
US20140278127A1 (en) * 2013-03-15 2014-09-18 Battelle Memorial Institute Computer Files and Methods Supporting Forensic Analysis of Nucleotide Sequence Data
EP2971139A4 (de) * 2013-03-15 2016-12-07 Abbott Molecular Inc Systeme und verfahren zum nachweis der veränderung einer genomkopienanzahl
EP2971097B1 (de) * 2013-03-15 2018-08-01 Verinata Health, Inc Erstellen von zellfreien genbibliotheken direkt aus blut
HUE061261T2 (hu) 2013-04-03 2023-05-28 Sequenom Inc Eljárások és folyamatok genetikai variánsok nem invazív értékelésére
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2014281635B2 (en) 2013-06-17 2020-05-28 Verinata Health, Inc. Method for determining copy number variations in sex chromosomes
EP3011051B1 (de) 2013-06-21 2019-01-30 Sequenom, Inc. Verfahren zur nichtinvasiven beurteilung genetischer variationen
GB201318369D0 (en) * 2013-10-17 2013-12-04 Univ Leuven Kath Methods using BAF
KR20230074639A (ko) 2013-08-28 2023-05-30 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
PL3053071T3 (pl) 2013-10-04 2024-03-18 Sequenom, Inc. Metody i procesy nieinwazyjnej oceny zmienności genetycznych
CN105745528A (zh) 2013-10-07 2016-07-06 赛卢拉研究公司 用于以数字方式对阵列上的特征进行计数的方法和系统
EP3055427B1 (de) 2013-10-07 2018-09-12 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung chromosomaler veränderungen
CN106062214B (zh) 2013-12-28 2020-06-09 夸登特健康公司 用于检测遗传变异的方法和系统
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3134541B1 (de) 2014-04-21 2020-08-19 Natera, Inc. Nachweis von ploidien in chromosomalen segmenten in krebs
EP3760739A1 (de) 2014-07-30 2021-01-06 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10892035B2 (en) 2014-10-10 2021-01-12 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
EP3235010A4 (de) 2014-12-18 2018-08-29 Agilome, Inc. Chemisch empfindlicher feldeffekttransistor
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
AU2016218631B2 (en) 2015-02-10 2022-03-10 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
EP3259371B1 (de) 2015-02-19 2020-09-02 Becton, Dickinson and Company Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen
KR101533792B1 (ko) * 2015-02-24 2015-07-06 대한민국 Ngs 기반 인간 객체의 상염색체 분석방법
ES2836802T3 (es) 2015-02-27 2021-06-28 Becton Dickinson Co Códigos de barras moleculares espacialmente direccionables
EP4180535A1 (de) 2015-03-30 2023-05-17 Becton, Dickinson and Company Verfahren und zusammensetzungen für kombinatorische barcodierung
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
US10844428B2 (en) * 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EP3294906A1 (de) 2015-05-11 2018-03-21 Natera, Inc. Verfahren und zusammensetzungen zur bestimmung des ploidiegrades
AU2016269332B2 (en) 2015-05-22 2021-08-12 Medicover Public Co Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
EP3135770A1 (de) * 2015-08-28 2017-03-01 Latvian Biomedical Research and Study Centre Satz von oligonukleotiden und verfahren zum nachweis von fötaler dna-fraktion im mutterplasma
US11302416B2 (en) 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
ES2745694T3 (es) 2015-09-11 2020-03-03 Cellular Res Inc Métodos y composiciones para normalización de biblioteca de ácido nucleico
WO2017087206A1 (en) * 2015-11-16 2017-05-26 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3390668A4 (de) 2015-12-17 2020-04-01 Guardant Health, Inc. Verfahren zur bestimmung der tumorgenkopienzahl durch analyse von zellfreier dna
US10982286B2 (en) 2016-01-22 2021-04-20 Mayo Foundation For Medical Education And Research Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine
US11753682B2 (en) 2016-03-07 2023-09-12 Father Flanagan's Boys'Home Noninvasive molecular controls
EP4269616A3 (de) 2016-05-02 2024-02-14 Becton, Dickinson and Company Genaue molekulare barcodierung
WO2017201081A1 (en) 2016-05-16 2017-11-23 Agilome, Inc. Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
JP7046007B2 (ja) 2016-05-26 2022-04-01 ベクトン・ディキンソン・アンド・カンパニー 分子標識カウントの調節方法
EP3464626B1 (de) 2016-05-27 2022-04-06 Sequenom, Inc. Verfahren zum nachweis von genetischen variationen
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
WO2018022906A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Methods for non-invasive assessment of genomic instability
WO2018022890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
CN109937254B (zh) * 2016-09-15 2023-05-30 阿谢尔德克斯有限责任公司 核酸样品制备方法
US10683531B2 (en) * 2016-09-15 2020-06-16 ArcherDX, Inc. Methods of nucleic acid sample preparation for analysis of cell-free DNA
JP7091348B2 (ja) 2016-09-26 2022-06-27 ベクトン・ディキンソン・アンド・カンパニー バーコード付きオリゴヌクレオチド配列を有する試薬を用いたタンパク質発現の測定
EP3518974A4 (de) 2016-09-29 2020-05-27 Myriad Women's Health, Inc. Nichtinvasives pränatales screening unter verwendung von dynamischer iterativer tiefenoptimierung
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018064629A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
CA3042391A1 (en) 2016-11-02 2018-05-11 ArcherDX, Inc. Methods of nucleic acid sample preparation for immune repertoire sequencing
AU2017359047A1 (en) 2016-11-08 2019-05-02 Becton, Dickinson And Company Methods for cell label classification
CN109952612B (zh) 2016-11-08 2023-12-01 贝克顿迪金森公司 用于表达谱分类的方法
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3568234B1 (de) 2017-01-13 2023-09-06 Cellular Research, Inc. Hydrophile beschichtung von fluidischen kanälen
CN110313034B (zh) 2017-01-18 2023-06-06 伊鲁米那股份有限公司 对核酸分子进行测序的方法、机器可读介质和计算机系统
EP3571615B1 (de) 2017-01-20 2024-01-24 Sequenom, Inc. Verfahren zur nichtinvasiven beurteilung genetischer veränderungen
WO2018136882A1 (en) 2017-01-20 2018-07-26 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
EP3571317A1 (de) 2017-01-20 2019-11-27 Sequenom, Inc. Herstellung und verwendung eines sequenzierungsadapters
US11694768B2 (en) 2017-01-24 2023-07-04 Sequenom, Inc. Methods and processes for assessment of genetic variations
AU2018212272B2 (en) 2017-01-25 2022-04-28 Grail, Inc. Diagnostic applications using nucleic acid fragments
WO2018144240A1 (en) 2017-02-01 2018-08-09 Cellular Research, Inc. Selective amplification using blocking oligonucleotides
AU2018225348A1 (en) 2017-02-21 2019-07-18 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
EP3596233B1 (de) 2017-03-17 2022-05-18 Sequenom, Inc. Verfahren und vorgänge zur beurteilung von genetischem mosaizismus
JP7170711B2 (ja) * 2017-04-18 2022-11-14 アジレント・テクノロジーズ・ベルジャム・ナムローゼ・フェンノートシャップ Ｄｎａ分析のためのオフターゲット配列の使用
WO2018226293A1 (en) 2017-06-05 2018-12-13 Becton, Dickinson And Company Sample indexing for single cells
DK3649258T3 (da) 2017-07-07 2022-08-01 Nipd Genetics Public Company Ltd Target-beriget multiplekset parallel analyse til vurdering af foster-dna-prøver
US20220228219A1 (en) 2017-07-07 2022-07-21 Nipd Genetics Public Company Limited Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers
WO2019008148A1 (en) 2017-07-07 2019-01-10 Nipd Genetics Public Company Limited ENRICHMENT OF TARGETED GENOMIC REGIONS FOR MULTIPLEXED PARALLEL ANALYSIS
DK3649259T3 (da) 2017-07-07 2022-08-15 Nipd Genetics Public Company Ltd Target-beriget multiplekset parallel analyse til vurdering af risiko for genetiske tilstande
EP3658689B1 (de) 2017-07-26 2021-03-24 Trisomytest, s.r.o. Verfahren zum nicht-invasiven pränatalen nachweis von fetaler chromosomenaneuploidie aus mütterlichem blut auf der basis eines bayesischen netzwerks
CN111051511A (zh) 2017-08-04 2020-04-21 十亿至一公司 用于与生物靶相关的表征的靶相关分子
BR112020002260A2 (pt) 2017-08-04 2020-09-08 Billiontoone, Inc. método para facilitar o diagnóstico pré-natal de um distúrbio genético a partir de uma amostra materna associada a uma gestante, método para facilitação de caracterização de uma condição médica a partir de uma amostra compreendendo moléculas alvo e método para quantificação de alvo biológico a partir de uma amostra compreendendo moléculas alvo
EP3662479A1 (de) 2017-08-04 2020-06-10 Trisomytest, s.r.o. Verfahren zur nicht-invasiven pränatalen detektion von fetalen chromosomalen geschlechtsabnormitäten und fetalen geschlechtsbestimmung für einzel- und zwillingsschwangerschaften
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
CN108733982B (zh) * 2017-09-26 2021-02-19 上海凡迪基因科技有限公司 孕妇nipt结果校正方法、装置及计算机可读存储介质、设备
US20200299677A1 (en) 2017-10-27 2020-09-24 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
EP3728636A1 (de) 2017-12-19 2020-10-28 Becton, Dickinson and Company Mit oligonukleotiden assoziierte teilchen
KR102031841B1 (ko) * 2017-12-22 2019-10-15 테라젠지놈케어 주식회사 모체 시료 중 태아 분획을 결정하는 방법
DK3735470T3 (da) 2018-01-05 2024-02-26 Billiontoone Inc Kvalitetskontroltemplates til sikring af validiteten af sekventeringsbaserede analyser
US11365409B2 (en) 2018-05-03 2022-06-21 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
WO2019213294A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
EP3794141A4 (de) * 2018-05-17 2022-02-23 Illumina, Inc. Einzelzellsequenzierung mit hohem durchsatz mit reduzierter verstärkungsvorspannung
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
WO2020097315A1 (en) 2018-11-08 2020-05-14 Cellular Research, Inc. Whole transcriptome analysis of single cells using random priming
WO2020113577A1 (zh) * 2018-12-07 2020-06-11 深圳华大生命科学研究院 一种靶基因文库的构建方法、检测装置及其应用
CN113195717A (zh) 2018-12-13 2021-07-30 贝克顿迪金森公司 单细胞全转录组分析中的选择性延伸
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
WO2020154247A1 (en) 2019-01-23 2020-07-30 Cellular Research, Inc. Oligonucleotides associated with antibodies
CN113661249A (zh) 2019-01-31 2021-11-16 夸登特健康公司 用于分离无细胞dna的组合物和方法
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
WO2020226528A1 (ru) * 2019-05-08 2020-11-12 Общество с ограниченной ответственностью "ГЕНОТЕК ИТ" Способ определения кариотипа плода беременной женщины
EP4004231A1 (de) 2019-07-22 2022-06-01 Becton, Dickinson and Company Test für einzelzell-chromatin-immunpräzipitationssequenzierung
WO2021037016A1 (en) * 2019-08-30 2021-03-04 The Chinese University Of Hong Kong Methods for detecting absence of heterozygosity by low-pass genome sequencing
JP2022553829A (ja) 2019-10-31 2022-12-26 セクエノム， インコーポレイテッド 多胎児妊娠およびパーソナライズされたリスク評価におけるモザイク現象比の適用
WO2021092386A1 (en) 2019-11-08 2021-05-14 Becton Dickinson And Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
AU2020387423A1 (en) 2019-11-22 2021-09-30 Illumina, Inc. Circulating RNA signatures specific to preeclampsia
EP4090763A1 (de) 2020-01-13 2022-11-23 Becton Dickinson and Company Verfahren und zusammensetzungen zur quantifizierung von proteinen und rna
US11661625B2 (en) 2020-05-14 2023-05-30 Becton, Dickinson And Company Primers for immune repertoire profiling
CN111534604B (zh) * 2020-05-27 2024-01-23 广东华美众源生物科技有限公司 一种检测人常染色体dip-str遗传标记的荧光复合扩增试剂盒
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
US11377654B2 (en) 2020-09-11 2022-07-05 New England Biolabs, Inc. Application of immobilized enzymes for nanopore library construction
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
CN116157869A (zh) 2020-12-02 2023-05-23 伊鲁米纳软件公司 用于检测遗传改变的系统和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057094A1 (en) * 2009-11-05 2011-05-12 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5976790A (en) * 1992-03-04 1999-11-02 The Regents Of The University Of California Comparative Genomic Hybridization (CGH)
WO1994003638A1 (en) * 1992-07-30 1994-02-17 Applied Biosystems, Inc. Method of detecting aneuploidy by amplified short tandem repeats
US5776737A (en) 1994-12-22 1998-07-07 Visible Genetics Inc. Method and composition for internal identification of samples
US6057103A (en) 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
EP0938381B1 (de) 1996-10-04 2012-12-26 Veri-Q Inc. Proben-entnahmegeräte und methoden unter verwendung von markierungen und die anwerdung solcher markierungen als kontrollmittel zur probenanswertung, laborkontrolle und/oder zertifikation
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
ATE545710T1 (de) 1997-04-01 2012-03-15 Illumina Cambridge Ltd Verfahren zur vervielfältigung von nukleinsäuren
US5888740A (en) 1997-09-19 1999-03-30 Genaco Biomedical Products, Inc. Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
WO2001090415A2 (en) 2000-05-20 2001-11-29 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
AU2001273057A1 (en) 2000-06-27 2002-01-08 Fluidigm Corporation A microfluidic design automation method and system
WO2002002772A2 (en) 2000-06-30 2002-01-10 Incyte Genomics, Inc. Human extracellular matrix (ecm)-related tumor marker
US20020142324A1 (en) * 2000-09-22 2002-10-03 Xun Wang Fungal target genes and methods to identify those genes
WO2002060582A2 (en) 2000-11-16 2002-08-08 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
US6691042B2 (en) 2001-07-02 2004-02-10 Rosetta Inpharmatics Llc Methods for generating differential profiles by combining data obtained in separate measurements
US7226732B2 (en) 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US7893248B2 (en) 2002-02-20 2011-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
MXPA04008472A (es) 2002-03-01 2005-09-20 Ravgen Inc Analisis rapido de variaciones en un genoma.
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
WO2004065617A2 (en) * 2003-01-17 2004-08-05 The Trustees Of Boston University Haplotype analysis
CN101260429B (zh) 2003-01-17 2011-03-30 香港中文大学 作为妊娠相关病症的诊断标志物的循环mRNA
EP2159285B1 (de) 2003-01-29 2012-09-26 454 Life Sciences Corporation Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren
AU2004217872B2 (en) 2003-03-05 2010-03-25 Genetic Technologies Limited Identification of fetal DNA and fetal cell markers in maternal plasma or serum
WO2004081183A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
US20070087345A1 (en) 2003-07-10 2007-04-19 Third Wave Technologies, Inc. Assays for the direct measurement of gene dosage
EP1664077B1 (de) 2003-09-05 2016-04-13 Trustees of Boston University Verfahren zur nichtinvasiven pränatalen diagnose
WO2005039389A2 (en) 2003-10-22 2005-05-06 454 Corporation Sequence-based karyotyping
US7252946B2 (en) * 2004-01-27 2007-08-07 Zoragen, Inc. Nucleic acid detection
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20100216151A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
WO2005084380A2 (en) 2004-03-03 2005-09-15 The General Hospital Corporation System for delivering a diluted solution
US20090117542A1 (en) 2004-05-17 2009-05-07 The Ohio State University Research Foundation Unique short tandem repeats and methods of their use
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
TW200624106A (en) 2004-09-07 2006-07-16 Uni Charm Corp Warming article
JP2007327743A (ja) 2004-09-07 2007-12-20 Univ Of Tokyo 遺伝子コピーの解析方法及び装置
US20060178835A1 (en) 2005-02-10 2006-08-10 Applera Corporation Normalization methods for genotyping analysis
AU2006224971B2 (en) 2005-03-18 2009-07-02 Boston University A method for the detection of chromosomal aneuploidies
EP1891218A2 (de) 2005-06-08 2008-02-27 Compugen Ltd. Neue nukleotid- und aminosäuresequenzen sowie tests und verfahren für deren verwendung zur diagnose
US20060286558A1 (en) * 2005-06-15 2006-12-21 Natalia Novoradovskaya Normalization of samples for amplification reactions
DE102005057988A1 (de) 2005-08-04 2007-02-08 Bosch Rexroth Ag Axialkolbenmaschine
ES2739483T3 (es) 2006-02-02 2020-01-31 Univ Leland Stanford Junior Detección genética fetal no invasiva mediante análisis digital
US20100184043A1 (en) 2006-02-28 2010-07-22 University Of Louisville Research Foundation Detecting Genetic Abnormalities
EP2351858B1 (de) * 2006-02-28 2014-12-31 University of Louisville Research Foundation Erkennung von Chromosomabnormalitäten im Fötus mithilfe der Tandem-Einzelnukleotid-Polymorphismen
US20080064098A1 (en) * 2006-06-05 2008-03-13 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of maternal placental cells
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
AU2007260676A1 (en) 2006-06-14 2007-12-21 Artemis Health, Inc. Rare cell analysis using sample splitting and DNA tags
EP2029778B1 (de) 2006-06-14 2018-05-02 Verinata Health, Inc Diagnose fötaler anomalien
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2009035447A1 (en) 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
WO2008014516A2 (en) 2006-07-28 2008-01-31 Living Microsystems, Inc. Selection of cells using biomarkers
WO2008015396A2 (en) * 2006-07-31 2008-02-07 Solexa Limited Method of library preparation avoiding the formation of adaptor dimers
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2118298B1 (de) * 2007-02-08 2013-01-09 Sequenom, Inc. Tests auf nukleinsäurebasis für rhd-typisierung
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
DK2514842T3 (en) 2007-07-23 2016-05-30 Univ Hong Kong Chinese Diagnosis of fetal chromosomal aneuploidy using genome sequencing
WO2009046445A1 (en) 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
JP5676277B2 (ja) * 2008-02-01 2015-02-25 ザ ジェネラル ホスピタル コーポレイション 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用
CA2717320A1 (en) * 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US20090307179A1 (en) * 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
AU2009228312B2 (en) * 2008-03-26 2015-05-21 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US20090270601A1 (en) * 2008-04-21 2009-10-29 Steven Albert Benner Differential detection of single nucleotide polymorphisms
WO2010009398A1 (en) * 2008-07-18 2010-01-21 Xenomics, Inc. Methods for pcr-based detection of "ultra short" nucleic acid sequences
CA3069082C (en) * 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
WO2010115044A2 (en) 2009-04-02 2010-10-07 Fluidigm Corporation Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
ES2564656T3 (es) * 2009-10-26 2016-03-28 Lifecodexx Ag Medios y métodos para el diagnóstico no invasivo de la aneuploidía cromosómica
WO2011056094A2 (ru) * 2009-10-26 2011-05-12 Общество С Ограниченной Ответственностью "Апoгeй" Пожарный вентиль
WO2011060240A1 (en) 2009-11-12 2011-05-19 Genzyme Corporation Copy number analysis of genetic locus
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US8700341B2 (en) 2010-01-19 2014-04-15 Verinata Health, Inc. Partition defined detection methods
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
EP2513341B1 (de) 2010-01-19 2017-04-12 Verinata Health, Inc Identifizierung von polymorphen sequenzen in mischungen aus genomischer dna durch gesamtgenomsequenzierung
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120270739A1 (en) 2010-01-19 2012-10-25 Verinata Health, Inc. Method for sample analysis of aneuploidies in maternal samples
US20120237928A1 (en) 2010-10-26 2012-09-20 Verinata Health, Inc. Method for determining copy number variations
DK2376661T3 (en) 2010-01-19 2015-02-02 Verinata Health Inc SIMULTANEOUS DETERMINATION OF aneuploidy and fetal FRACTION
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
WO2011106314A2 (en) 2010-02-25 2011-09-01 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
US20120238738A1 (en) * 2010-07-19 2012-09-20 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
US20120034603A1 (en) * 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
CN102409043B (zh) 2010-09-21 2013-12-04 深圳华大基因科技服务有限公司 高通量低成本Fosmid文库构建的方法及其所使用标签和标签接头
EP4269623A3 (de) 2010-11-30 2024-03-06 The Chinese University Of Hong Kong Analyse einer biologischen probe eines organismus auf mit krebs assoziierte chromosomale deletionen oder amplifikationen
US8877442B2 (en) 2010-12-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale
CN102127818A (zh) 2010-12-15 2011-07-20 张康 利用孕妇外周血建立胎儿dna文库的方法
US20120184449A1 (en) 2010-12-23 2012-07-19 Sequenom, Inc. Fetal genetic variation detection
US20120190020A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
CN106319047B (zh) 2011-04-12 2020-02-18 维里纳塔健康公司 使用多态计数来解析基因组分数
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
GB2485635B (en) 2011-07-26 2012-11-28 Verinata Health Inc Method for determining the presence or absence of different aneuploidies in a sample
EP2875149B1 (de) 2012-07-20 2019-12-04 Verinata Health, Inc. Erkennung und klassifizierung von kopienzahlvarianten in einem krebsgenom

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057094A1 (en) * 2009-11-05 2011-05-12 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dhallan, R. et al., The Lancet. 2007 vol. 369 pages 474-481 *

Also Published As

Publication number Publication date
EP2848703A1 (de) 2015-03-18
CA2786544A1 (en) 2011-07-28
GB2485645A (en) 2012-05-23
US20170327883A1 (en) 2017-11-16
EP2376661A1 (de) 2011-10-19
US20110245085A1 (en) 2011-10-06
EP3492601A1 (de) 2019-06-05
US20240150828A1 (en) 2024-05-09
EP2883965A1 (de) 2015-06-17
EP3006573B1 (de) 2018-03-07
CA2786357A1 (en) 2011-07-28
EP2848704B1 (de) 2018-08-29
CA2786357C (en) 2018-08-21
AU2010343279B2 (en) 2015-04-23
AU2010343276A1 (en) 2012-09-06
HK1177232A1 (zh) 2013-08-16
EP2513339B1 (de) 2015-09-09
CA2786544C (en) 2020-11-10
EP3006573A1 (de) 2016-04-13
EP2370599A1 (de) 2011-10-05
AU2010343278B2 (en) 2015-05-21
EP2366031A1 (de) 2011-09-21
ES2534986T3 (es) 2015-05-04
CA2786351C (en) 2022-01-25
WO2011090557A1 (en) 2011-07-28
US20220106639A1 (en) 2022-04-07
HK1170270A1 (en) 2013-02-22
AU2010343277B2 (en) 2015-05-28
US10941442B2 (en) 2021-03-09
GB201108794D0 (en) 2011-07-06
AU2010343278A1 (en) 2012-09-06
CA2786351A1 (en) 2011-07-28
EP3492601B1 (de) 2022-01-05
CA2785718C (en) 2017-04-04
ES2870533T3 (es) 2021-10-27
US11286520B2 (en) 2022-03-29
US20220017958A1 (en) 2022-01-20
EP2366031A4 (de) 2012-03-21
EP4074838A1 (de) 2022-10-19
PL3260555T3 (pl) 2019-05-31
EP3260555A1 (de) 2017-12-27
HK1160186A1 (en) 2012-08-10
US20210340613A1 (en) 2021-11-04
US20120165203A1 (en) 2012-06-28
EP2376661B1 (de) 2015-01-21
EP3878973A1 (de) 2021-09-15
EP2370599A4 (de) 2012-03-21
DK2513339T3 (en) 2015-12-14
US9657342B2 (en) 2017-05-23
EP2848704A1 (de) 2015-03-18
GB2485644A (en) 2012-05-23
DK2376661T3 (en) 2015-02-02
PL3492601T3 (pl) 2022-05-23
DK3492601T3 (da) 2022-04-04
TR201807917T4 (tr) 2018-06-21
GB2479471A (en) 2011-10-12
DK2366031T3 (en) 2015-02-23
GB2479080A (en) 2011-09-28
HK1162197A1 (en) 2012-08-24
PL2366031T3 (pl) 2015-08-31
GB201108795D0 (en) 2011-07-06
ES2909841T3 (es) 2022-05-10
WO2011090559A1 (en) 2011-07-28
WO2011090558A1 (en) 2011-07-28
EP2376661A4 (de) 2012-03-21
GB2479080B (en) 2012-01-18
GB2485645B (en) 2012-11-21
US20170327884A1 (en) 2017-11-16
US11130995B2 (en) 2021-09-28
CY1124494T1 (el) 2022-07-22
US11884975B2 (en) 2024-01-30
EP3260555B1 (de) 2018-10-24
US20110224087A1 (en) 2011-09-15
GB2479471B (en) 2012-02-08
US20170327881A1 (en) 2017-11-16
GB2485644B (en) 2012-11-21
EP2883965B1 (de) 2018-05-09
GB2479476A (en) 2011-10-12
GB201118398D0 (en) 2011-12-07
EP2370599B1 (de) 2015-01-21
US11952623B2 (en) 2024-04-09
EP2513339A4 (de) 2013-05-29
EP3382037B1 (de) 2021-02-17
HK1170269A1 (en) 2013-02-22
EP2366031B1 (de) 2015-01-21
US20120094849A1 (en) 2012-04-19
HK1160185A1 (en) 2012-08-10
EP2513339A1 (de) 2012-10-24
GB201107268D0 (en) 2011-06-15
DK3382037T3 (da) 2021-05-25
GB2479476B (en) 2012-06-13
CA2785718A1 (en) 2011-07-28
DK3260555T3 (en) 2019-01-21
ES2560929T3 (es) 2016-02-23
AU2010343277A1 (en) 2012-09-06
ES2704701T3 (es) 2019-03-19
ES2534758T3 (es) 2015-04-28
AU2010343279A1 (en) 2012-09-06
EP3382037A1 (de) 2018-10-03
GB201118396D0 (en) 2011-12-07
PL2376661T3 (pl) 2015-06-30
US20110201507A1 (en) 2011-08-18
EP2883965B8 (de) 2018-06-27

Similar Documents

Publication Publication Date Title
US20200385810A1 (en) Methods for determining fraction of fetal nucleic acids in maternal samples
AU2010343276B2 (en) Methods for determining fraction of fetal nucleic acid in maternal samples
AU2018201992B2 (en) Sequencing methods and compositions for prenatal diagnoses

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)