AU2010296180B2 - Oxaliplatin nanoparticles and method for preparing same - Google Patents

Oxaliplatin nanoparticles and method for preparing same Download PDF

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Publication number
AU2010296180B2
AU2010296180B2 AU2010296180A AU2010296180A AU2010296180B2 AU 2010296180 B2 AU2010296180 B2 AU 2010296180B2 AU 2010296180 A AU2010296180 A AU 2010296180A AU 2010296180 A AU2010296180 A AU 2010296180A AU 2010296180 B2 AU2010296180 B2 AU 2010296180B2
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AU
Australia
Prior art keywords
oxaliplatin
nanoparticles
nanoparticle
mixture solution
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010296180A
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English (en)
Other versions
AU2010296180A1 (en
Inventor
Kab Sig Kim
Young Hoon Kim
Sang Heon Lee
Sung Jae Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Synectics Inc
JW Pharmaceutical Corp
Original Assignee
Bio Synectics Inc
JW Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Bio Synectics Inc, JW Pharmaceutical Corp filed Critical Bio Synectics Inc
Publication of AU2010296180A1 publication Critical patent/AU2010296180A1/en
Application granted granted Critical
Publication of AU2010296180B2 publication Critical patent/AU2010296180B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010296180A 2009-09-21 2010-09-20 Oxaliplatin nanoparticles and method for preparing same Ceased AU2010296180B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2009-0089079 2009-09-21
KR20090089079 2009-09-21
PCT/KR2010/006459 WO2011034394A2 (ko) 2009-09-21 2010-09-20 옥살리플라틴의 나노 입자 및 이를 제조하는 방법

Publications (2)

Publication Number Publication Date
AU2010296180A1 AU2010296180A1 (en) 2012-04-19
AU2010296180B2 true AU2010296180B2 (en) 2016-05-05

Family

ID=43759199

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010296180A Ceased AU2010296180B2 (en) 2009-09-21 2010-09-20 Oxaliplatin nanoparticles and method for preparing same

Country Status (11)

Country Link
US (1) US9393201B2 (https=)
EP (1) EP2481396A4 (https=)
JP (1) JP5759464B2 (https=)
KR (1) KR101396461B1 (https=)
CN (1) CN102665689B (https=)
AU (1) AU2010296180B2 (https=)
CA (1) CA2774669C (https=)
IN (1) IN2012DN02576A (https=)
MX (1) MX348668B (https=)
RU (1) RU2563997C2 (https=)
WO (1) WO2011034394A2 (https=)

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* Cited by examiner, † Cited by third party
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EP2983490A1 (en) * 2013-03-15 2016-02-17 DSM IP Assets B.V. Solid lipid nanoparticles (ii)
AU2018255063A1 (en) * 2017-04-21 2018-11-22 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
KR101895237B1 (ko) * 2017-06-12 2018-09-07 목포대학교산학협력단 옥살리플라틴을 포함하는 경구용 약물전달 조성물 및 이의 제조방법
KR102184117B1 (ko) * 2017-10-31 2020-11-30 주식회사 삼양바이오팜 수용해도 및 생체이용율이 개선된 소라페닙 나노입자 경구용 조성물 및 이의 제조 방법
ES2927608T3 (es) 2018-09-14 2022-11-08 Inst Nat Sante Rech Med Sistema de liberación de fármacos para fármacos basados en platino
CN110917345B (zh) * 2019-09-26 2021-11-09 苏州百迈生物医药有限公司 一种化疗免疫组合药物及其制备方法

Citations (5)

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KR20050054819A (ko) * 2003-12-05 2005-06-10 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
CN1868455A (zh) * 2006-05-20 2006-11-29 沈阳药科大学 奥沙利铂磷脂复合物静脉给药的纳米混悬注射剂
US7217735B1 (en) * 1999-04-09 2007-05-15 Au Jessie L-S Methods and compositions for enhancing delivery of therapeutic agents to tissues
WO2008086756A1 (en) * 2007-01-12 2008-07-24 Yanfang Li Developable biodegradable microspheric blood vessel embolism materials
US20090053302A1 (en) * 2006-03-03 2009-02-26 Parthenios Boulikas Cancer treatments

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AU2989695A (en) * 1994-08-08 2000-03-07 Debiopharm S.A. Pharmaceutically stable oxaliplatinum preparation
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
CN1191067C (zh) * 1997-02-05 2005-03-02 法玛西雅厄普约翰美国公司 高不溶性铂配合物的脂质复合物和脂质体
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations
JP2003524624A (ja) * 1999-04-09 2003-08-19 ジェシー エル エス オウ 治療薬の組織への送達を高める方法及び組成物
WO2002047725A2 (fr) 2000-12-12 2002-06-20 Debiopharm S.A. Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation
US6476068B1 (en) * 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
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CN1775216A (zh) * 2004-11-15 2006-05-24 胡才忠 一种新型的制剂——奥沙利铂脂质体
DE102005011786A1 (de) * 2005-03-11 2006-09-14 Pharmasol Gmbh Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen
BRPI0617663A2 (pt) * 2005-10-21 2011-08-02 Panacea Biotec Ltd composições aperfeiçoadas para terapia de cáncer
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Also Published As

Publication number Publication date
AU2010296180A1 (en) 2012-04-19
JP5759464B2 (ja) 2015-08-05
RU2563997C2 (ru) 2015-09-27
US9393201B2 (en) 2016-07-19
CA2774669C (en) 2017-12-19
CN102665689B (zh) 2015-04-22
WO2011034394A3 (ko) 2011-11-03
WO2011034394A2 (ko) 2011-03-24
MX2012003393A (es) 2012-07-25
JP2013505291A (ja) 2013-02-14
EP2481396A4 (en) 2014-03-05
EP2481396A2 (en) 2012-08-01
US20120177728A1 (en) 2012-07-12
CA2774669A1 (en) 2011-03-24
KR101396461B1 (ko) 2014-05-20
KR20120046243A (ko) 2012-05-09
CN102665689A (zh) 2012-09-12
RU2012116085A (ru) 2013-10-27
IN2012DN02576A (https=) 2015-08-28
MX348668B (es) 2017-06-23

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