KR101396461B1 - 옥살리플라틴의 나노 입자 및 이를 제조하는 방법 - Google Patents

옥살리플라틴의 나노 입자 및 이를 제조하는 방법 Download PDF

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Publication number
KR101396461B1
KR101396461B1 KR1020127003342A KR20127003342A KR101396461B1 KR 101396461 B1 KR101396461 B1 KR 101396461B1 KR 1020127003342 A KR1020127003342 A KR 1020127003342A KR 20127003342 A KR20127003342 A KR 20127003342A KR 101396461 B1 KR101396461 B1 KR 101396461B1
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South Korea
Prior art keywords
oxaliplatin
lipid
nanoparticles
mixed solution
solid
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Expired - Fee Related
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KR1020127003342A
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English (en)
Korean (ko)
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KR20120046243A (ko
Inventor
이승재
김영훈
이상헌
김갑식
Original Assignee
(주)바이오시네틱스
제이더블유중외제약 주식회사
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Publication of KR20120046243A publication Critical patent/KR20120046243A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020127003342A 2009-09-21 2010-09-20 옥살리플라틴의 나노 입자 및 이를 제조하는 방법 Expired - Fee Related KR101396461B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020090089079 2009-09-21
KR20090089079 2009-09-21
PCT/KR2010/006459 WO2011034394A2 (ko) 2009-09-21 2010-09-20 옥살리플라틴의 나노 입자 및 이를 제조하는 방법

Publications (2)

Publication Number Publication Date
KR20120046243A KR20120046243A (ko) 2012-05-09
KR101396461B1 true KR101396461B1 (ko) 2014-05-20

Family

ID=43759199

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127003342A Expired - Fee Related KR101396461B1 (ko) 2009-09-21 2010-09-20 옥살리플라틴의 나노 입자 및 이를 제조하는 방법

Country Status (11)

Country Link
US (1) US9393201B2 (https=)
EP (1) EP2481396A4 (https=)
JP (1) JP5759464B2 (https=)
KR (1) KR101396461B1 (https=)
CN (1) CN102665689B (https=)
AU (1) AU2010296180B2 (https=)
CA (1) CA2774669C (https=)
IN (1) IN2012DN02576A (https=)
MX (1) MX348668B (https=)
RU (1) RU2563997C2 (https=)
WO (1) WO2011034394A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2983490A1 (en) * 2013-03-15 2016-02-17 DSM IP Assets B.V. Solid lipid nanoparticles (ii)
AU2018255063A1 (en) * 2017-04-21 2018-11-22 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
KR101895237B1 (ko) * 2017-06-12 2018-09-07 목포대학교산학협력단 옥살리플라틴을 포함하는 경구용 약물전달 조성물 및 이의 제조방법
KR102184117B1 (ko) * 2017-10-31 2020-11-30 주식회사 삼양바이오팜 수용해도 및 생체이용율이 개선된 소라페닙 나노입자 경구용 조성물 및 이의 제조 방법
ES2927608T3 (es) 2018-09-14 2022-11-08 Inst Nat Sante Rech Med Sistema de liberación de fármacos para fármacos basados en platino
CN110917345B (zh) * 2019-09-26 2021-11-09 苏州百迈生物医药有限公司 一种化疗免疫组合药物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217735B1 (en) * 1999-04-09 2007-05-15 Au Jessie L-S Methods and compositions for enhancing delivery of therapeutic agents to tissues

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2989695A (en) * 1994-08-08 2000-03-07 Debiopharm S.A. Pharmaceutically stable oxaliplatinum preparation
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
CN1191067C (zh) * 1997-02-05 2005-03-02 法玛西雅厄普约翰美国公司 高不溶性铂配合物的脂质复合物和脂质体
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations
JP2003524624A (ja) * 1999-04-09 2003-08-19 ジェシー エル エス オウ 治療薬の組織への送達を高める方法及び組成物
WO2002047725A2 (fr) 2000-12-12 2002-06-20 Debiopharm S.A. Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation
US6476068B1 (en) * 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
CN101703467A (zh) 2003-08-28 2010-05-12 梅恩医药有限公司 含有酸的奥沙利铂制剂
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
CN1775216A (zh) * 2004-11-15 2006-05-24 胡才忠 一种新型的制剂——奥沙利铂脂质体
DE102005011786A1 (de) * 2005-03-11 2006-09-14 Pharmasol Gmbh Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen
BRPI0617663A2 (pt) * 2005-10-21 2011-08-02 Panacea Biotec Ltd composições aperfeiçoadas para terapia de cáncer
KR20070067768A (ko) 2005-12-23 2007-06-29 주식회사 삼양사 안정한 옥살리플라틴 조성물 및 이의 제조방법
GR20060100144A (el) * 2006-03-03 2007-10-17 Θεραπεια του καρκινου με χρηση οξαλιπλατινης εγκλεισμενης μεσα σε λιποσωματα και απο κοινου εγκλεισμος στο λιποσωμιακο μοριο περισσοτερων απο ενος φαρμακευτικου παρασκευασματος h gene
KR101342119B1 (ko) 2006-05-04 2013-12-18 (주)바이오시네틱스 디올 화합물을 이용한 나노수준의 활성물질 입자 제조 방법
JP4830019B2 (ja) * 2006-05-04 2011-12-07 バイオ−シネクティクス インク． ナノスケールの活物質粒子の製造方法
CN1868455A (zh) * 2006-05-20 2006-11-29 沈阳药科大学 奥沙利铂磷脂复合物静脉给药的纳米混悬注射剂
KR100913063B1 (ko) 2006-09-13 2009-08-21 주식회사유한양행 옥살리플라틴-함유 주사용 용액
JP2010515493A (ja) * 2007-01-12 2010-05-13 ヤンファン リー， Ｘ線不透過性生物分解微小球型血管栓塞材料
CN100563646C (zh) * 2007-07-13 2009-12-02 陈祥峰 一种奥沙利铂脂质体葡萄糖制剂的制备方法
US20100310661A1 (en) * 2007-07-16 2010-12-09 Poniard Pharmaceuticals, Inc. Oral formulations for picoplatin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217735B1 (en) * 1999-04-09 2007-05-15 Au Jessie L-S Methods and compositions for enhancing delivery of therapeutic agents to tissues

Also Published As

Publication number Publication date
AU2010296180A1 (en) 2012-04-19
JP5759464B2 (ja) 2015-08-05
RU2563997C2 (ru) 2015-09-27
US9393201B2 (en) 2016-07-19
CA2774669C (en) 2017-12-19
CN102665689B (zh) 2015-04-22
AU2010296180B2 (en) 2016-05-05
WO2011034394A3 (ko) 2011-11-03
WO2011034394A2 (ko) 2011-03-24
MX2012003393A (es) 2012-07-25
JP2013505291A (ja) 2013-02-14
EP2481396A4 (en) 2014-03-05
EP2481396A2 (en) 2012-08-01
US20120177728A1 (en) 2012-07-12
CA2774669A1 (en) 2011-03-24
KR20120046243A (ko) 2012-05-09
CN102665689A (zh) 2012-09-12
RU2012116085A (ru) 2013-10-27
IN2012DN02576A (https=) 2015-08-28
MX348668B (es) 2017-06-23

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