AU2010295288A1 - O-benzyl nicotinamide analogs as mGluR5 positive allosteric modulators - Google Patents
O-benzyl nicotinamide analogs as mGluR5 positive allosteric modulators Download PDFInfo
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- AU2010295288A1 AU2010295288A1 AU2010295288A AU2010295288A AU2010295288A1 AU 2010295288 A1 AU2010295288 A1 AU 2010295288A1 AU 2010295288 A AU2010295288 A AU 2010295288A AU 2010295288 A AU2010295288 A AU 2010295288A AU 2010295288 A1 AU2010295288 A1 AU 2010295288A1
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- optionally substituted
- compound
- alkyl
- cycloalkyl
- heterocycloalkyl
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24441709P | 2009-09-21 | 2009-09-21 | |
| US61/244,417 | 2009-09-21 | ||
| PCT/US2010/049697 WO2011035324A1 (en) | 2009-09-21 | 2010-09-21 | O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2010295288A1 true AU2010295288A1 (en) | 2012-05-03 |
Family
ID=43759065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010295288A Abandoned AU2010295288A1 (en) | 2009-09-21 | 2010-09-21 | O-benzyl nicotinamide analogs as mGluR5 positive allosteric modulators |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110183980A1 (enExample) |
| EP (1) | EP2482657A4 (enExample) |
| JP (1) | JP2013505297A (enExample) |
| CN (1) | CN102638979A (enExample) |
| AU (1) | AU2010295288A1 (enExample) |
| BR (1) | BR112012006330A2 (enExample) |
| CA (1) | CA2774981A1 (enExample) |
| IL (1) | IL218772A0 (enExample) |
| IN (1) | IN2012DN03322A (enExample) |
| MX (1) | MX2012003394A (enExample) |
| RU (1) | RU2012116124A (enExample) |
| WO (1) | WO2011035324A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| CN103037693A (zh) * | 2010-05-24 | 2013-04-10 | 范德比尔特大学 | 作为mglur5正向变构调节剂的取代的6-甲基烟酰胺 |
| RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
| TWI713497B (zh) | 2015-02-26 | 2020-12-21 | 南韓商愛思開生物製藥股份有限公司 | 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物 |
| CA3145305A1 (en) | 2019-07-11 | 2021-01-14 | ESCAPE Bio, Inc. | Indazoles and azaindazoles as lrrk2 inhibitors |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR208397A1 (es) * | 1973-02-20 | 1976-12-27 | Ciba Geigy Ag | Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan |
| JP2689093B2 (ja) * | 1986-01-30 | 1997-12-10 | 石原産業株式会社 | 置換ピリジンスルホンアミド系化合物、それらを含有する除草剤並びにそれらの化合物の製造方法 |
| JP2000212076A (ja) * | 1998-11-20 | 2000-08-02 | Takeda Chem Ind Ltd | βアミロイド蛋白産生・分泌阻害剤 |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| US20030031715A1 (en) * | 2000-10-11 | 2003-02-13 | Kinam Park | Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof |
| JP2002322163A (ja) * | 2001-04-20 | 2002-11-08 | Sumitomo Pharmaceut Co Ltd | ピペラジン誘導体 |
| US6667327B2 (en) * | 2002-02-04 | 2003-12-23 | Hoffmann-La Roche Inc. | Pyridine amido derivatives |
| US20040072802A1 (en) * | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| JPWO2004078719A1 (ja) * | 2003-03-06 | 2006-06-08 | 小野薬品工業株式会社 | インドール誘導体化合物およびその化合物を有効成分とする薬剤 |
| GB0418267D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| CN101155781B (zh) * | 2005-04-06 | 2012-11-07 | 霍夫曼-拉罗奇有限公司 | 作为cb1逆激动剂的吡啶-3-甲酰胺衍生物 |
| WO2007008963A1 (en) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| AR058554A1 (es) * | 2005-12-20 | 2008-02-13 | Novartis Ag | Compuestos heterociclicos nitrogenados de 6 miembros sustituidos, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por mglur5. |
| CN101321731A (zh) * | 2005-12-20 | 2008-12-10 | 诺瓦提斯公司 | 作为代谢型谷氨酸受体调节剂的烟酸衍生物 |
| CA2665804A1 (en) * | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
| WO2008031550A2 (en) * | 2006-09-11 | 2008-03-20 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutanate receptors |
| WO2008038841A1 (en) * | 2006-09-30 | 2008-04-03 | Japan Tobacco Inc. | Thiadiazolone derivative and use thereof |
| TW200821305A (en) * | 2006-10-05 | 2008-05-16 | Astrazeneca Ab | MGluR5 modulators |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| CA2706328C (en) * | 2007-11-20 | 2016-04-19 | Janssen Pharmaceutica N.V. | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
| JP5301557B2 (ja) * | 2007-12-04 | 2013-09-25 | エフ.ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピリジン誘導体 |
| US7897621B2 (en) * | 2008-03-31 | 2011-03-01 | Hoffmann-La Roche Inc. | 2-trifluoromethylnicotinamide derivatives as HDL-cholesterol raising agents |
| EP3725775A1 (en) * | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| US8222246B2 (en) * | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| CA2757412C (en) * | 2009-05-07 | 2016-04-05 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives as gaba modulators |
-
2010
- 2010-09-21 IN IN3322DEN2012 patent/IN2012DN03322A/en unknown
- 2010-09-21 RU RU2012116124/13A patent/RU2012116124A/ru not_active Application Discontinuation
- 2010-09-21 US US12/886,950 patent/US20110183980A1/en not_active Abandoned
- 2010-09-21 EP EP10818037.3A patent/EP2482657A4/en not_active Withdrawn
- 2010-09-21 AU AU2010295288A patent/AU2010295288A1/en not_active Abandoned
- 2010-09-21 WO PCT/US2010/049697 patent/WO2011035324A1/en not_active Ceased
- 2010-09-21 JP JP2012530978A patent/JP2013505297A/ja active Pending
- 2010-09-21 CN CN2010800523979A patent/CN102638979A/zh active Pending
- 2010-09-21 BR BR112012006330A patent/BR112012006330A2/pt not_active IP Right Cessation
- 2010-09-21 CA CA2774981A patent/CA2774981A1/en not_active Abandoned
- 2010-09-21 MX MX2012003394A patent/MX2012003394A/es not_active Application Discontinuation
-
2012
- 2012-03-21 IL IL218772A patent/IL218772A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012003394A (es) | 2012-08-15 |
| CA2774981A1 (en) | 2011-03-24 |
| WO2011035324A1 (en) | 2011-03-24 |
| RU2012116124A (ru) | 2013-10-27 |
| US20110183980A1 (en) | 2011-07-28 |
| BR112012006330A2 (pt) | 2017-07-04 |
| EP2482657A1 (en) | 2012-08-08 |
| IL218772A0 (en) | 2012-06-28 |
| CN102638979A (zh) | 2012-08-15 |
| JP2013505297A (ja) | 2013-02-14 |
| IN2012DN03322A (enExample) | 2015-10-23 |
| EP2482657A4 (en) | 2013-05-15 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |