AU2010279575B2 - Swallowable capsule and method for stimulating incretin production within the intestinal tract - Google Patents

Swallowable capsule and method for stimulating incretin production within the intestinal tract Download PDF

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Publication number
AU2010279575B2
AU2010279575B2 AU2010279575A AU2010279575A AU2010279575B2 AU 2010279575 B2 AU2010279575 B2 AU 2010279575B2 AU 2010279575 A AU2010279575 A AU 2010279575A AU 2010279575 A AU2010279575 A AU 2010279575A AU 2010279575 B2 AU2010279575 B2 AU 2010279575B2
Authority
AU
Australia
Prior art keywords
cells
capsule
intestinal tract
incretin
intestinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010279575A
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English (en)
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AU2010279575A1 (en
Inventor
Emily Arnsdorf
Mir Hashim
Mir Imran
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Incube Laboratories LLC
Original Assignee
Incube Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incube Laboratories LLC filed Critical Incube Laboratories LLC
Publication of AU2010279575A1 publication Critical patent/AU2010279575A1/en
Application granted granted Critical
Publication of AU2010279575B2 publication Critical patent/AU2010279575B2/en
Priority to AU2016203077A priority Critical patent/AU2016203077B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0509—Stomach and intestinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
AU2010279575A 2009-08-03 2010-08-03 Swallowable capsule and method for stimulating incretin production within the intestinal tract Ceased AU2010279575B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016203077A AU2016203077B2 (en) 2009-08-03 2016-05-12 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27338909P 2009-08-03 2009-08-03
US61/273,389 2009-08-03
PCT/US2010/044265 WO2011017335A1 (en) 2009-08-03 2010-08-03 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016203077A Division AU2016203077B2 (en) 2009-08-03 2016-05-12 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Publications (2)

Publication Number Publication Date
AU2010279575A1 AU2010279575A1 (en) 2012-03-01
AU2010279575B2 true AU2010279575B2 (en) 2016-05-05

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010279575A Ceased AU2010279575B2 (en) 2009-08-03 2010-08-03 Swallowable capsule and method for stimulating incretin production within the intestinal tract
AU2016203077A Ceased AU2016203077B2 (en) 2009-08-03 2016-05-12 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016203077A Ceased AU2016203077B2 (en) 2009-08-03 2016-05-12 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Country Status (6)

Country Link
US (9) US8682440B2 (enExample)
EP (2) EP2461818B1 (enExample)
JP (8) JP5854513B2 (enExample)
CN (2) CN109157742B (enExample)
AU (2) AU2010279575B2 (enExample)
WO (1) WO2011017335A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017335A1 (en) 2009-08-03 2011-02-10 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
WO2011112229A2 (en) * 2010-03-10 2011-09-15 Incube Labs, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8721620B2 (en) 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2013143603A1 (en) * 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US20140051924A1 (en) * 2012-08-16 2014-02-20 Capso Vision, Inc In Vivo Capsule Device with Electrodes
WO2015042558A1 (en) * 2013-09-23 2015-03-26 Board Of Regents, The University Of Texas System Wireless tissue stimulation devices
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
AU2015258859B2 (en) 2014-05-15 2020-07-23 Rani Therapeutics, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
WO2016073728A1 (en) * 2014-11-05 2016-05-12 Enterastim, Inc. Conditional gastrointestinal stimulation for improved motility
US20160183878A1 (en) * 2014-12-27 2016-06-30 John C. Weast Technologies for managing device functions of an ingestible computing device
US10500127B2 (en) * 2016-04-18 2019-12-10 Ankon Medical Technologies (Shanghai) Co., Ltd. Vivo device and method of using the same
WO2018026720A1 (en) * 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
EP3296727B1 (en) * 2016-09-19 2019-04-17 Murata Integrated Passive Solutions Electrical stimulation and monitoring device
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11369574B2 (en) 2017-05-17 2022-06-28 Massachusetts Institute Of Technology Self-righting systems and related components and methods
CN108742590A (zh) * 2018-04-08 2018-11-06 南京宽诚科技有限公司 一种胃肠电信号的采集方法、装置、采集设备及存储介质
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
EP3801758A4 (en) * 2018-05-31 2022-03-23 Lynne Bilston SYSTEMS, DEVICES AND METHODS FOR THE TREATMENT OF ORAL AND THROAT DISEASES
CN109498989A (zh) * 2018-12-20 2019-03-22 宁波贝思转化医学研究中心有限公司 一种用于判断胃肠电刺激是否有效的装置及其使用方法
JP2020108454A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108457A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108458A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108456A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2022523121A (ja) 2019-02-01 2022-04-21 マサチューセッツ インスティテュート オブ テクノロジー 液体注入のためのシステムおよび方法
CN116870341A (zh) * 2019-03-01 2023-10-13 拉尼医疗有限公司 用于将治疗剂递送到胃壁中的装置、系统和方法
CN114051391B (zh) * 2019-09-24 2024-06-04 松下知识产权经营株式会社 菜谱输出方法、菜谱输出系统
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
KR102608853B1 (ko) * 2021-11-15 2023-12-01 재단법인 아산사회복지재단 대사질환 개선용 생체발광 캡슐

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050183733A1 (en) * 2003-11-11 2005-08-25 Olympus Corporation Capsule type medical device system, and capsule type medical device
US20070161851A1 (en) * 2004-09-08 2007-07-12 Olympus Corporation Capsulu type medical device
US20090030473A1 (en) * 2007-06-13 2009-01-29 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes

Family Cites Families (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
DE2928477C3 (de) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS60129057A (ja) 1983-12-14 1985-07-10 住友化学工業株式会社 針状固形製剤投与針
US4596819A (en) 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
US4663308A (en) 1984-07-18 1987-05-05 Medical College Of Ohio Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract
FR2597351B1 (fr) * 1986-04-16 1994-03-25 Celsa Composants Electriques Capsule distributrice de drogue implantable et procede et dispositif facilitant son utilisation.
US5137669A (en) 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
US5271945A (en) 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
US5129915A (en) * 1988-07-05 1992-07-14 Jose Cantenys Intragastric balloon
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
JPH07500264A (ja) * 1991-10-10 1995-01-12 アルザ・コーポレーション 疎水性壁材料による浸透圧薬物投与デバイス
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
DK42093D0 (da) 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
US5437291A (en) * 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US5652216A (en) 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
US5849327A (en) * 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5750926A (en) * 1995-08-16 1998-05-12 Alfred E. Mann Foundation For Scientific Research Hermetically sealed electrical feedthrough for use with implantable electronic devices
US5620476A (en) * 1995-11-13 1997-04-15 Pacesetter, Inc. Implantable medical device having shielded and filtered feedthrough assembly and methods for making such assembly
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5987358A (en) * 1998-02-17 1999-11-16 Intermedics, Inc. Semiconductor device packaging and method of fabrication
IT1299266B1 (it) 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6395273B1 (en) 1998-06-10 2002-05-28 Promega Corporation Prevention and treatment of inflammatory bowel disease
US8700161B2 (en) * 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
EP1159030B1 (en) * 1999-03-05 2007-06-13 Impulse Dynamics N.V. Blood glucose level control
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6832114B1 (en) * 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6638246B1 (en) * 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
JP4731793B2 (ja) 2000-12-28 2011-07-27 アルセア テクノロジーズ インコーポレイテッド 抗体全体またはそのフラグメントの結晶、ならびにこの結晶を作製および使用するための方法
US6975906B2 (en) * 2001-02-08 2005-12-13 Wilson Greatbatch Ltd. One piece header assembly over molded to an implantable medical device
WO2002084249A2 (en) 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
US7787958B2 (en) * 2001-04-13 2010-08-31 Greatbatch Ltd. RFID detection and identification system for implantable medical lead systems
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
EP1578246B1 (en) * 2001-07-12 2014-09-03 Given Imaging Ltd. Device for examining a body lumen
US20070162085A1 (en) * 2001-07-23 2007-07-12 Dilorenzo Biomedical, Llc Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity
US20030226155A1 (en) 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
JP2002186672A (ja) 2001-09-28 2002-07-02 Olympus Optical Co Ltd 医療用カプセル装置
WO2003028653A2 (en) 2001-10-03 2003-04-10 Glaxo Group Limited Sustained release pharmaceutical compositions
US6656155B2 (en) 2001-12-17 2003-12-02 Scimed Life Systems, Inc. Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic
FR2835730B1 (fr) 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
US20030186892A1 (en) 2002-03-28 2003-10-02 Rajneesh Taneja Enhancement of endogenous gonadotropin production
US8062573B2 (en) 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
AU2002951740A0 (en) * 2002-09-30 2002-10-17 Cochlear Limited Feedthrough for electrical connectors
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
WO2004037071A2 (en) * 2002-10-25 2004-05-06 Raphael Schumert Gastrointestinal pacemaker
JP2006512130A (ja) 2002-12-26 2006-04-13 ギブン・イメージング・リミテツド 不動化可能な生体内センシング装置
US20040143221A1 (en) 2002-12-27 2004-07-22 Shadduck John H. Biomedical implant for sustained agent release
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
CA2514392A1 (en) * 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
JP2005021677A (ja) 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
CN1838978B (zh) * 2003-06-20 2010-05-26 超治疗股份有限公司 用于治疗疾病的胃肠方法和装置
CN1816324A (zh) 2003-07-04 2006-08-09 尼克麦德丹麦公司 口服用的含甲状旁腺激素(pth)的药物组合物
US20070060971A1 (en) * 2003-07-21 2007-03-15 Ofer Glasberg Hepatic device for treatment or glucose detection
CA2533796A1 (en) 2003-08-01 2005-02-10 Amgen Inc. Crystalline tumor necrosis factor receptor 2 polypeptides
US20050038415A1 (en) * 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
JP2007507527A (ja) 2003-09-30 2007-03-29 スフェリックス， インコーポレイテッド 生物学的に活性なナノ粒子治療用因子
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
JP4733918B2 (ja) 2003-10-01 2011-07-27 オリンパス株式会社 カプセル投薬システム
CA2543779A1 (en) 2003-10-24 2005-05-06 Medtronic, Inc. Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators
JP2005143560A (ja) * 2003-11-11 2005-06-09 Olympus Corp カプセル型医療装置
JP4094543B2 (ja) * 2003-12-26 2008-06-04 オリンパス株式会社 カプセル型医療装置システム
US20050152941A1 (en) 2003-11-20 2005-07-14 Angiotech International Ag Soft tissue implants and anti-scarring agents
US8585771B2 (en) 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
MY162179A (en) 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
DE102004026615A1 (de) 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
JP2006000307A (ja) 2004-06-16 2006-01-05 Pentax Corp 酸素発生装置を有するカプセル型医療用具
US20060153894A1 (en) 2004-06-30 2006-07-13 Ragae Ghabrial Multi-compartment delivery system
US9399054B2 (en) 2004-07-12 2016-07-26 Emisphere Technologies, Inc. Compositions for delivering peptide YY and PYY agonists
US20060063719A1 (en) 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
US20070265598A1 (en) 2004-09-30 2007-11-15 Duocure, Inc. Device and Method for Treating Weight Disorders
US20080275430A1 (en) * 2004-12-14 2008-11-06 Ziv Belsky Prolonged Transit Time of Permeability-Enhancing Drug Eluting Pill
EP1841448A2 (en) 2004-12-30 2007-10-10 Diakine Therapeutics, Inc. Pharmaceutical compositions and methods for restoring beta-cell mass and function
US7556826B2 (en) 2005-01-04 2009-07-07 Gp Medical, Inc. Nanoparticles for protein drug delivery
JP2008532568A (ja) * 2005-01-18 2008-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 電子制御されるカプセル
US7785291B2 (en) * 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
CN2860501Y (zh) 2005-03-10 2007-01-24 李华 一次性注射器
WO2006123346A2 (en) * 2005-05-19 2006-11-23 E-Pill Pharma, Ltd. Ingestible device for nitric oxide production in tissue
JP5148274B2 (ja) 2005-05-27 2013-02-20 オリンパス株式会社 被検体内導入装置
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes
US8021384B2 (en) * 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
EP1906830B1 (en) 2005-07-26 2013-09-04 Ram Weiss Extending intrabody capsule
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
PL2347762T3 (pl) 2005-08-19 2019-09-30 Amylin Pharmaceuticals, Llc Eksendyna do leczenia cukrzycy i zmniejszania masy ciała
WO2007035759A1 (en) * 2005-09-19 2007-03-29 Johnson & Johnson Pharmaceutical Research & Development L.L.C. Modulation of glucocorticoid receptor expression
US7957796B2 (en) * 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
JP4402648B2 (ja) 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
LT2676967T (lt) 2006-02-28 2019-09-10 Biogen Ma Inc. Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu
US20060229529A1 (en) 2006-03-30 2006-10-12 Wright Robert C System, apparatus, and method for marking orientation of a tissue sample
US7818876B2 (en) * 2006-04-25 2010-10-26 Gregg Jorgen Suaning Method for fabrication of hermetic electrical conductor feedthroughs
CA2652569C (en) 2006-05-18 2015-12-22 Tulip Medical Ltd. Bioerodible self-deployable intragastric and non-gastric implants
US20070288033A1 (en) * 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
US8034906B2 (en) 2006-10-27 2011-10-11 Abbott Biotechnology Ltd. Crystalline anti-hTNFalpha antibodies
RU2009120512A (ru) * 2006-10-31 2010-12-10 Конинклейке Филипс Электроникс Н.В. (Nl) Конструкция глотаемого дозирующего устройства с множеством форсунок для выпуска лекарств в желудочно-кишечный тракт
US20080214919A1 (en) 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
AU2008216316A1 (en) 2007-02-13 2008-08-21 Virender K. Sharma Method and apparatus for electrical stimulation of the pancreatico-biliary system
US8160708B2 (en) * 2007-04-11 2012-04-17 Pacesetter, Inc. Capacitor-integrated feedthrough assembly with improved grounding for an implantable medical device
US20080260820A1 (en) 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
CN104000779A (zh) 2007-04-23 2014-08-27 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
US9364666B2 (en) 2007-05-07 2016-06-14 Transtimulation Research, Inc. Method of using a gastrointestinal stimulator device for digestive and eating disorders
US20090030743A1 (en) 2007-07-24 2009-01-29 Las Vegas Central Reservation Corp. Intelligent Hotel Reservation System and Method
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US7930033B2 (en) 2007-08-17 2011-04-19 Jianfeng Chen Appendicular and rectal stimulator device for digestive and eating disorders
CN101808567B (zh) 2007-09-26 2012-09-05 奥林巴斯医疗株式会社 被检体内导入系统
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
EP2262442B1 (en) * 2008-04-11 2015-03-25 BAL Seal Engineering Connector cartridge stack for electrical transmission
US7875711B2 (en) 2008-04-17 2011-01-25 Alnylam Pharamaceuticals, Inc. Compositions and methods for inhibiting expression of XBP-1 gene
NZ589390A (en) * 2008-05-05 2011-11-25 Oramed Ltd Methods and compositions for oral administration of exenatide
ATE505128T1 (de) 2008-06-04 2011-04-15 Olympus Medical Systems Corp Kapselförmige medizinische vorrichtung
US20090317372A1 (en) 2008-06-20 2009-12-24 Zoltan Kiss Small molecules for the reduction of high blood glucose level
US8287902B2 (en) * 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
BRPI0917925A2 (pt) * 2008-08-26 2015-11-10 Centocor Ortho Biotech Inc estimulação da liberação de hormônio da saciedade
WO2010030700A1 (en) 2008-09-09 2010-03-18 Incube Labs, Llc Energy harvesting mechanism
MX2011002794A (es) 2008-09-25 2011-04-05 Hoffmann La Roche Indazol 2,3-sustituido o 4,5,6,7-tetrahidro-indazol como moduladores fxr contra dislipidemia y enfermedades relacionadas.
US8535260B2 (en) 2008-10-15 2013-09-17 Dtherapeutics, Llc Devices, systems, and methods for localized drug delivery
US8162969B2 (en) * 2008-10-16 2012-04-24 Obalon Therapeutics, Inc. Intragastric device
WO2010045656A2 (en) 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
EP2351511B1 (en) 2008-11-13 2014-04-02 Olympus Medical Systems Corp. Capsule medical apparatus
US20100131043A1 (en) 2008-11-26 2010-05-27 Casas Jesus W Endoluminal Implants For Bioactive Material Delivery
WO2010093834A2 (en) 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
EP2440210A4 (en) 2009-06-12 2014-01-29 Meritage Pharma Inc METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES
WO2011017335A1 (en) 2009-08-03 2011-02-10 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US8721620B2 (en) 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
EP3756657B1 (en) 2009-12-24 2025-03-05 Rani Therapeutics, LLC Swallowable drug delivery device
WO2011112229A2 (en) 2010-03-10 2011-09-15 Incube Labs, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20110295178A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods
US20110295337A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Systems and Methods For Regulating Metabolic Hormone Producing Tissue
US8876761B2 (en) 2010-05-26 2014-11-04 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
US8603023B2 (en) 2010-05-26 2013-12-10 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
WO2012035559A2 (en) 2010-09-17 2012-03-22 Panacea Biotec Ltd Sustained release pharmaceutical compositions comprising pregabalin
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2013003824A1 (en) 2011-06-29 2013-01-03 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
PL3653223T3 (pl) 2011-06-29 2021-12-20 Rani Therapeutics, Llc Urządzenie do doustnego dostarczania związków leczniczych
WO2013143603A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013143600A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
WO2013143609A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US9750660B2 (en) 2012-03-30 2017-09-05 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013143599A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
US9770588B2 (en) 2012-04-30 2017-09-26 Carnegie Mellon University Ingestible, electrical device for stimulating tissues in a gastrointestinal tract of an organism
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
US9168000B2 (en) 2013-03-13 2015-10-27 Ethicon Endo-Surgery, Inc. Meal detection devices and methods
EP2968071B1 (en) 2013-03-15 2021-08-04 Rani Therapeutics, LLC Device for oral delivery of therapeutic compounds
US11116658B2 (en) 2015-06-28 2021-09-14 Oberon Sciences Ilan Ltd. Devices for gastrointestinal stimulation and uses thereof
CA2993215C (en) 2015-07-02 2023-10-31 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN105997466B (zh) 2016-06-16 2018-01-26 中南民族大学 智能型振动电子胶囊
WO2018026720A1 (en) 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
US10786681B2 (en) 2017-02-07 2020-09-29 Yaron Ilan Closed loop organ stimulation
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
WO2023178041A2 (en) 2022-03-14 2023-09-21 Massachusetts Institute Of Technology Vibrating ingestible capsule

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050183733A1 (en) * 2003-11-11 2005-08-25 Olympus Corporation Capsule type medical device system, and capsule type medical device
US20070161851A1 (en) * 2004-09-08 2007-07-12 Olympus Corporation Capsulu type medical device
US20090030473A1 (en) * 2007-06-13 2009-01-29 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes

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