AU2010237302A1 - Novel P2X7R antagonists and their use - Google Patents

Novel P2X7R antagonists and their use Download PDF

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Publication number
AU2010237302A1
AU2010237302A1 AU2010237302A AU2010237302A AU2010237302A1 AU 2010237302 A1 AU2010237302 A1 AU 2010237302A1 AU 2010237302 A AU2010237302 A AU 2010237302A AU 2010237302 A AU2010237302 A AU 2010237302A AU 2010237302 A1 AU2010237302 A1 AU 2010237302A1
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Australia
Prior art keywords
indol
chloro
bromo
hydroxypropyl
cycloheptylacetamide
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Abandoned
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AU2010237302A
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English (en)
Inventor
Michael Boes
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Affectis Pharmaceuticals AG
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Affectis Pharmaceuticals AG
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
AU2010237302A 2009-04-14 2010-03-11 Novel P2X7R antagonists and their use Abandoned AU2010237302A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09005324.0 2009-04-14
EP09005324 2009-04-14
PCT/EP2010/053097 WO2010118921A1 (en) 2009-04-14 2010-03-11 Novel p2x7r antagonists and their use

Publications (1)

Publication Number Publication Date
AU2010237302A1 true AU2010237302A1 (en) 2011-12-01

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Application Number Title Priority Date Filing Date
AU2010237302A Abandoned AU2010237302A1 (en) 2009-04-14 2010-03-11 Novel P2X7R antagonists and their use

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US (2) US7919503B2 (enExample)
EP (1) EP2243772B1 (enExample)
JP (1) JP2012523440A (enExample)
KR (1) KR20120006547A (enExample)
CN (1) CN102395562A (enExample)
AT (1) ATE541832T1 (enExample)
AU (1) AU2010237302A1 (enExample)
BR (1) BRPI1014902A2 (enExample)
CA (1) CA2758474A1 (enExample)
CY (1) CY1112758T1 (enExample)
DK (1) DK2243772T3 (enExample)
EA (1) EA201101479A1 (enExample)
ES (1) ES2380908T3 (enExample)
HR (1) HRP20120271T1 (enExample)
IL (1) IL215444A0 (enExample)
MX (1) MX2011010810A (enExample)
PL (1) PL2243772T3 (enExample)
PT (1) PT2243772E (enExample)
SG (1) SG175232A1 (enExample)
SI (1) SI2243772T1 (enExample)
SM (1) SMT201200017B (enExample)
WO (1) WO2010118921A1 (enExample)
ZA (1) ZA201108305B (enExample)

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JP6282016B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
JP6282017B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
WO2014182601A1 (en) 2013-05-08 2014-11-13 Children's Medical Center Corporation A method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the atp/p2x7r axis)
TW202043198A (zh) * 2019-01-17 2020-12-01 美商Ｉｆｍ Ｄｕｅ有限公司 用於治療與sting活性相關之病況的化合物及組合物
AU2022326463A1 (en) 2021-08-10 2024-02-22 Novartis Pharma Ag Compounds and compositions for treating conditions associated with sting activity

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US7919503B2 (en) 2011-04-05
IL215444A0 (en) 2011-12-29
KR20120006547A (ko) 2012-01-18
EP2243772A1 (en) 2010-10-27
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PL2243772T3 (pl) 2012-05-31
SI2243772T1 (sl) 2012-05-31
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CN102395562A (zh) 2012-03-28
SG175232A1 (en) 2011-12-29

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