AU2010216374A1 - Isolated monocyte populations and related therapeutic applications - Google Patents
Isolated monocyte populations and related therapeutic applications Download PDFInfo
- Publication number
- AU2010216374A1 AU2010216374A1 AU2010216374A AU2010216374A AU2010216374A1 AU 2010216374 A1 AU2010216374 A1 AU 2010216374A1 AU 2010216374 A AU2010216374 A AU 2010216374A AU 2010216374 A AU2010216374 A AU 2010216374A AU 2010216374 A1 AU2010216374 A1 AU 2010216374A1
- Authority
- AU
- Australia
- Prior art keywords
- cells
- isolated
- monocyte
- population
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000001616 monocyte Anatomy 0.000 title claims abstract description 218
- 230000001225 therapeutic effect Effects 0.000 title description 30
- 210000004027 cell Anatomy 0.000 claims abstract description 266
- 238000000034 method Methods 0.000 claims abstract description 119
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 43
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims abstract description 35
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims abstract description 34
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims abstract description 31
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims abstract description 31
- 208000014245 Ocular vascular disease Diseases 0.000 claims abstract description 31
- 210000004369 blood Anatomy 0.000 claims abstract description 23
- 239000008280 blood Substances 0.000 claims abstract description 23
- 210000001185 bone marrow Anatomy 0.000 claims abstract description 20
- 238000000338 in vitro Methods 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 34
- 210000001525 retina Anatomy 0.000 claims description 31
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 24
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 24
- 208000002780 macular degeneration Diseases 0.000 claims description 24
- 206010038923 Retinopathy Diseases 0.000 claims description 23
- 208000017442 Retinal disease Diseases 0.000 claims description 22
- 210000005259 peripheral blood Anatomy 0.000 claims description 17
- 239000011886 peripheral blood Substances 0.000 claims description 17
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 16
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 16
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 15
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 15
- 208000022873 Ocular disease Diseases 0.000 claims description 14
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 14
- 239000007924 injection Substances 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 14
- 238000005119 centrifugation Methods 0.000 claims description 12
- 210000003714 granulocyte Anatomy 0.000 claims description 12
- 230000000302 ischemic effect Effects 0.000 claims description 12
- 230000014509 gene expression Effects 0.000 claims description 9
- 208000024891 symptom Diseases 0.000 claims description 9
- 210000001772 blood platelet Anatomy 0.000 claims description 8
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 7
- 210000000887 face Anatomy 0.000 claims description 7
- 229940064366 hespan Drugs 0.000 claims description 7
- 229920001917 Ficoll Polymers 0.000 claims description 6
- 206010030113 Oedema Diseases 0.000 claims description 6
- 239000003550 marker Substances 0.000 claims description 6
- 208000010412 Glaucoma Diseases 0.000 claims description 5
- 241001529936 Murinae Species 0.000 claims description 5
- 210000004700 fetal blood Anatomy 0.000 claims description 5
- 108010031801 Lipopolysaccharide Receptors Proteins 0.000 claims description 4
- 201000003142 neovascular glaucoma Diseases 0.000 claims description 4
- 210000001957 retinal vein Anatomy 0.000 claims description 4
- 238000000432 density-gradient centrifugation Methods 0.000 claims description 3
- 238000001085 differential centrifugation Methods 0.000 claims description 3
- 210000005260 human cell Anatomy 0.000 claims description 3
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 claims description 2
- 102000001555 Sialic Acid Binding Ig-like Lectin 3 Human genes 0.000 claims description 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 31
- 238000002372 labelling Methods 0.000 abstract description 6
- 230000003412 degenerative effect Effects 0.000 abstract description 3
- 239000002158 endotoxin Substances 0.000 description 33
- 229920006008 lipopolysaccharide Polymers 0.000 description 33
- 238000011282 treatment Methods 0.000 description 26
- 239000000523 sample Substances 0.000 description 25
- 201000010099 disease Diseases 0.000 description 22
- 230000002792 vascular Effects 0.000 description 22
- 230000000694 effects Effects 0.000 description 19
- 210000004698 lymphocyte Anatomy 0.000 description 19
- 238000003556 assay Methods 0.000 description 18
- 210000001508 eye Anatomy 0.000 description 17
- 206010064930 age-related macular degeneration Diseases 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 15
- 230000002207 retinal effect Effects 0.000 description 15
- 230000003213 activating effect Effects 0.000 description 14
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 14
- 102000004127 Cytokines Human genes 0.000 description 13
- 108090000695 Cytokines Proteins 0.000 description 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
- 210000000265 leukocyte Anatomy 0.000 description 13
- 229910052760 oxygen Inorganic materials 0.000 description 13
- 239000001301 oxygen Substances 0.000 description 13
- 241000699666 Mus <mouse, genus> Species 0.000 description 12
- 238000000684 flow cytometry Methods 0.000 description 12
- 102000000018 Chemokine CCL2 Human genes 0.000 description 11
- 241000699670 Mus sp. Species 0.000 description 11
- 230000004913 activation Effects 0.000 description 11
- 230000008439 repair process Effects 0.000 description 11
- 230000028327 secretion Effects 0.000 description 11
- 210000000130 stem cell Anatomy 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 8
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 8
- 102000004890 Interleukin-8 Human genes 0.000 description 8
- 108090001007 Interleukin-8 Proteins 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 201000004569 Blindness Diseases 0.000 description 7
- 108090001005 Interleukin-6 Proteins 0.000 description 7
- 241000124008 Mammalia Species 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000000427 antigen Substances 0.000 description 7
- 210000000601 blood cell Anatomy 0.000 description 7
- 238000002955 isolation Methods 0.000 description 7
- 210000002540 macrophage Anatomy 0.000 description 7
- 208000015122 neurodegenerative disease Diseases 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 206010029113 Neovascularisation Diseases 0.000 description 6
- 102100040247 Tumor necrosis factor Human genes 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 6
- 230000004438 eyesight Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000004393 visual impairment Effects 0.000 description 6
- 102000004889 Interleukin-6 Human genes 0.000 description 5
- 206010025421 Macule Diseases 0.000 description 5
- 101000897464 Mus musculus C-C motif chemokine 2 Proteins 0.000 description 5
- 238000013355 OIR mouse model Methods 0.000 description 5
- 201000007737 Retinal degeneration Diseases 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 230000000222 hyperoxic effect Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000004258 retinal degeneration Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 230000035899 viability Effects 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- 206010003694 Atrophy Diseases 0.000 description 4
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 4
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 4
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 4
- -1 LPS Chemical class 0.000 description 4
- 208000001344 Macular Edema Diseases 0.000 description 4
- 208000001140 Night Blindness Diseases 0.000 description 4
- 208000007135 Retinal Neovascularization Diseases 0.000 description 4
- 230000037444 atrophy Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000007925 intracardiac injection Substances 0.000 description 4
- 210000005087 mononuclear cell Anatomy 0.000 description 4
- 230000001537 neural effect Effects 0.000 description 4
- 230000004770 neurodegeneration Effects 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000000069 prophylactic effect Effects 0.000 description 4
- 230000004233 retinal vasculature Effects 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 description 3
- 206010055665 Corneal neovascularisation Diseases 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 3
- 206010058490 Hyperoxia Diseases 0.000 description 3
- 102000005482 Lipopolysaccharide Receptors Human genes 0.000 description 3
- 206010025415 Macular oedema Diseases 0.000 description 3
- 206010057430 Retinal injury Diseases 0.000 description 3
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000035605 chemotaxis Effects 0.000 description 3
- 201000000159 corneal neovascularization Diseases 0.000 description 3
- 230000007850 degeneration Effects 0.000 description 3
- 208000030533 eye disease Diseases 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 102000046768 human CCL2 Human genes 0.000 description 3
- 238000000099 in vitro assay Methods 0.000 description 3
- 201000010230 macular retinal edema Diseases 0.000 description 3
- 238000010172 mouse model Methods 0.000 description 3
- 230000000508 neurotrophic effect Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 208000019553 vascular disease Diseases 0.000 description 3
- OZFAFGSSMRRTDW-UHFFFAOYSA-N (2,4-dichlorophenyl) benzenesulfonate Chemical compound ClC1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=CC=C1 OZFAFGSSMRRTDW-UHFFFAOYSA-N 0.000 description 2
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 2
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 208000008069 Geographic Atrophy Diseases 0.000 description 2
- 102100035716 Glycophorin-A Human genes 0.000 description 2
- 201000002563 Histoplasmosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010065630 Iris neovascularisation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108010025020 Nerve Growth Factor Proteins 0.000 description 2
- 108090000099 Neurotrophin-4 Proteins 0.000 description 2
- 102100033857 Neurotrophin-4 Human genes 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 2
- 206010038848 Retinal detachment Diseases 0.000 description 2
- 206010045178 Tunnel vision Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010046851 Uveitis Diseases 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 210000001130 astrocyte Anatomy 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000004163 cytometry Methods 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 206010023332 keratitis Diseases 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000000066 myeloid cell Anatomy 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 108091008695 photoreceptors Proteins 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000004264 retinal detachment Effects 0.000 description 2
- 201000000306 sarcoidosis Diseases 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 208000007056 sickle cell anemia Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 208000006379 syphilis Diseases 0.000 description 2
- 238000007910 systemic administration Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 230000006459 vascular development Effects 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
- 102100028187 ATP-binding cassette sub-family C member 6 Human genes 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 206010001257 Adenoviral conjunctivitis Diseases 0.000 description 1
- 101000640990 Arabidopsis thaliana Tryptophan-tRNA ligase, chloroplastic/mitochondrial Proteins 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 238000011731 BALB/cByJ (JAX™ mouse strain) Methods 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 1
- 229940124294 CD33 monoclonal antibody Drugs 0.000 description 1
- 102000049320 CD36 Human genes 0.000 description 1
- 108010045374 CD36 Antigens Proteins 0.000 description 1
- 101100365877 Caenorhabditis elegans cdl-1 gene Proteins 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 102100025470 Carcinoembryonic antigen-related cell adhesion molecule 8 Human genes 0.000 description 1
- 208000002691 Choroiditis Diseases 0.000 description 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 description 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 206010058202 Cystoid macular oedema Diseases 0.000 description 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 208000019878 Eales disease Diseases 0.000 description 1
- 206010014476 Elevated cholesterol Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000002702 GPI-Linked Proteins Human genes 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 description 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
- 108091005250 Glycophorins Proteins 0.000 description 1
- 102000006354 HLA-DR Antigens Human genes 0.000 description 1
- 108010058597 HLA-DR Antigens Proteins 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 206010019899 Hereditary retinal dystrophy Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101000914320 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 8 Proteins 0.000 description 1
- 101001074244 Homo sapiens Glycophorin-A Proteins 0.000 description 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010051151 Hyperviscosity syndrome Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 108091058560 IL8 Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102100022338 Integrin alpha-M Human genes 0.000 description 1
- 102100025390 Integrin beta-2 Human genes 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
- 208000016604 Lyme disease Diseases 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102100025136 Macrosialin Human genes 0.000 description 1
- 206010025412 Macular dystrophy congenital Diseases 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 description 1
- 108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 description 1
- 208000024599 Mooren ulcer Diseases 0.000 description 1
- 101001065556 Mus musculus Lymphocyte antigen 6G Proteins 0.000 description 1
- 241000428199 Mustelinae Species 0.000 description 1
- 206010062207 Mycobacterial infection Diseases 0.000 description 1
- 102000015336 Nerve Growth Factor Human genes 0.000 description 1
- 102000007072 Nerve Growth Factors Human genes 0.000 description 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 1
- 108090000742 Neurotrophin 3 Proteins 0.000 description 1
- 102000004230 Neurotrophin 3 Human genes 0.000 description 1
- 241000906034 Orthops Species 0.000 description 1
- 208000010191 Osteitis Deformans Diseases 0.000 description 1
- 208000027868 Paget disease Diseases 0.000 description 1
- 208000004788 Pars Planitis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000003971 Posterior uveitis Diseases 0.000 description 1
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 description 1
- 208000010362 Protozoan Infections Diseases 0.000 description 1
- 201000004613 Pseudoxanthoma elasticum Diseases 0.000 description 1
- 201000002154 Pterygium Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
- 206010049190 Red blood cell agglutination Diseases 0.000 description 1
- 206010038910 Retinitis Diseases 0.000 description 1
- 206010038934 Retinopathy proliferative Diseases 0.000 description 1
- 206010039705 Scleritis Diseases 0.000 description 1
- 102100038081 Signal transducer CD24 Human genes 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 101150052863 THY1 gene Proteins 0.000 description 1
- 208000018656 Terrien marginal degeneration Diseases 0.000 description 1
- 102000002689 Toll-like receptor Human genes 0.000 description 1
- 108020000411 Toll-like receptor Proteins 0.000 description 1
- 201000005485 Toxoplasmosis Diseases 0.000 description 1
- 102100034300 Tryptophan-tRNA ligase, cytoplasmic Human genes 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000010011 Vitamin A Deficiency Diseases 0.000 description 1
- 206010047663 Vitritis Diseases 0.000 description 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 230000000964 angiostatic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
- 230000002424 anti-apoptotic effect Effects 0.000 description 1
- 239000003529 anticholesteremic agent Substances 0.000 description 1
- 229940127226 anticholesterol agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 210000003161 choroid Anatomy 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000037416 cystogenesis Effects 0.000 description 1
- 201000010206 cystoid macular edema Diseases 0.000 description 1
- 210000004395 cytoplasmic granule Anatomy 0.000 description 1
- 230000004300 dark adaptation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000011190 diabetic macular edema Diseases 0.000 description 1
- 235000013367 dietary fats Nutrition 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 208000021373 epidemic keratoconjunctivitis Diseases 0.000 description 1
- 210000005081 epithelial layer Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000001497 fibrovascular Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 108091005631 glycosylphosphatidylinositol-linked proteins Proteins 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 238000012203 high throughput assay Methods 0.000 description 1
- 208000013653 hyalitis Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000013388 immunohistochemistry analysis Methods 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000017532 inherited retinal dystrophy Diseases 0.000 description 1
- 230000037041 intracellular level Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 230000035984 keratolysis Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- WLHQHAUOOXYABV-UHFFFAOYSA-N lornoxicam Chemical compound OC=1C=2SC(Cl)=CC=2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 WLHQHAUOOXYABV-UHFFFAOYSA-N 0.000 description 1
- 208000018769 loss of vision Diseases 0.000 description 1
- 231100000864 loss of vision Toxicity 0.000 description 1
- 208000018773 low birth weight Diseases 0.000 description 1
- 231100000533 low birth weight Toxicity 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 208000027202 mammary Paget disease Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003003 monocyte-macrophage precursor cell Anatomy 0.000 description 1
- 210000002433 mononuclear leukocyte Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229940053128 nerve growth factor Drugs 0.000 description 1
- 239000003900 neurotrophic factor Substances 0.000 description 1
- 229940032018 neurotrophin 3 Drugs 0.000 description 1
- 229940097998 neurotrophin 4 Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000007959 normoxia Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000006053 organic reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 208000023558 pseudoxanthoma elasticum (inherited or acquired) Diseases 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004242 retinal defects Effects 0.000 description 1
- 208000032253 retinal ischemia Diseases 0.000 description 1
- 230000004282 retinal neural degeneration Effects 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 208000004644 retinal vein occlusion Diseases 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 201000006476 shipyard eye Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000006496 vascular abnormality Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/051—Lipid A (MPA, MPL)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/052—Lipopolysaccharides [LPS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1497—Particle shape
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20817309P | 2009-02-20 | 2009-02-20 | |
| US61/208,173 | 2009-02-20 | ||
| US28324409P | 2009-11-30 | 2009-11-30 | |
| US61/283,244 | 2009-11-30 | ||
| PCT/US2010/000477 WO2010096177A1 (en) | 2009-02-20 | 2010-02-19 | Isolated monocyte populations and related therapeutic applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2010216374A1 true AU2010216374A1 (en) | 2011-08-18 |
Family
ID=42634163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010216374A Abandoned AU2010216374A1 (en) | 2009-02-20 | 2010-02-19 | Isolated monocyte populations and related therapeutic applications |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2398900A4 (ru) |
| JP (1) | JP2012518407A (ru) |
| KR (1) | KR20110123778A (ru) |
| CN (1) | CN102317446A (ru) |
| AU (1) | AU2010216374A1 (ru) |
| BR (1) | BRPI1008392A2 (ru) |
| CA (1) | CA2752679A1 (ru) |
| EA (1) | EA201190109A1 (ru) |
| MX (1) | MX2011008826A (ru) |
| WO (1) | WO2010096177A1 (ru) |
| ZA (1) | ZA201105869B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2999479B1 (en) * | 2013-05-22 | 2021-01-06 | Yeda Research and Development Co., Ltd. | Human monocyte sub-population for treatment of eye diseases and disorders |
| KR101668462B1 (ko) * | 2015-02-26 | 2016-10-24 | 충북대학교 산학협력단 | 혈액성분을 유효성분으로 포함하는 녹내장의 예방 또는 치료용 약제학적 조성물 |
| FR3084463B1 (fr) * | 2018-07-30 | 2023-04-21 | Francais Du Sang Ets | Procede d'analyse des plaquettes d'un echantillon sanguin |
| CN114441419B (zh) * | 2022-01-29 | 2022-11-22 | 杭州翔宇医学检验实验室有限公司 | 流式圈门方法及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006031467A2 (en) * | 2002-07-25 | 2006-03-23 | The Scripps Research Institute | Isolated lineage negative hematopoietic stem cells and methods of treatment therewith |
| JP2007521831A (ja) * | 2004-02-11 | 2007-08-09 | アルダジェン， インコーポレイテッド | 幹細胞集団および使用方法 |
| US20070231306A1 (en) * | 2005-02-24 | 2007-10-04 | The Scripps Research Institute | Isolated myeloid-like cell populations and methods of treatment therewith |
| EP2046366B1 (en) * | 2006-06-28 | 2016-08-31 | Yeda Research And Development Company Limited | Copolymer-1 for treatment of age-related macular degeneration |
-
2010
- 2010-02-19 CA CA2752679A patent/CA2752679A1/en not_active Abandoned
- 2010-02-19 BR BRPI1008392-8A patent/BRPI1008392A2/pt not_active IP Right Cessation
- 2010-02-19 KR KR1020117021989A patent/KR20110123778A/ko not_active Application Discontinuation
- 2010-02-19 WO PCT/US2010/000477 patent/WO2010096177A1/en active Application Filing
- 2010-02-19 EP EP10744061A patent/EP2398900A4/en not_active Withdrawn
- 2010-02-19 AU AU2010216374A patent/AU2010216374A1/en not_active Abandoned
- 2010-02-19 CN CN2010800079738A patent/CN102317446A/zh active Pending
- 2010-02-19 MX MX2011008826A patent/MX2011008826A/es not_active Application Discontinuation
- 2010-02-19 JP JP2011551065A patent/JP2012518407A/ja not_active Withdrawn
- 2010-02-19 EA EA201190109A patent/EA201190109A1/ru unknown
-
2011
- 2011-08-11 ZA ZA2011/05869A patent/ZA201105869B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201190109A1 (ru) | 2012-07-30 |
| BRPI1008392A2 (pt) | 2015-08-25 |
| WO2010096177A1 (en) | 2010-08-26 |
| CA2752679A1 (en) | 2010-08-26 |
| KR20110123778A (ko) | 2011-11-15 |
| MX2011008826A (es) | 2011-11-02 |
| EP2398900A1 (en) | 2011-12-28 |
| JP2012518407A (ja) | 2012-08-16 |
| CN102317446A (zh) | 2012-01-11 |
| EP2398900A4 (en) | 2012-08-22 |
| ZA201105869B (en) | 2012-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8951793B2 (en) | Method of making an isolated population of FOXP3+ regulatory T cells | |
| RU2331669C2 (ru) | Популяция стволовых кроветворных клеток и ее применение | |
| US20150210982A1 (en) | Isolation and Use of Human Regulatory T Cells | |
| RU2403906C2 (ru) | Способ лечения ретинопатии при недоношенности и родственных ретинопатических заболеваний | |
| Friedlander et al. | Progenitor cells and retinal angiogenesis | |
| JP2015529084A (ja) | Ｂ細胞の増加及び評価方法並びに疾患治療のための増加ｂ細胞の使用方法 | |
| CA2556018A1 (en) | Stem cell populations and methods of use | |
| TW201130978A (en) | Method of isolation of stem cell populations from peripheral blood using sized-based separation (elutriation) | |
| DE69734989T2 (de) | Antigenpräsentierende zellen, ein verfahren zur deren herstellung und deren verwendung als zelluläre impfstoffen | |
| JP2020518260A (ja) | 向上した免疫抑制作用を有する間葉系前駆または幹細胞 | |
| AU2010216374A1 (en) | Isolated monocyte populations and related therapeutic applications | |
| JPH08509377A (ja) | ヒトのエリスロイド前駆細胞集団 | |
| WO2023216799A1 (zh) | 一种人nkt细胞系及其应用 | |
| US20120009166A1 (en) | Isolated monocyte populations and related therapeutic applications | |
| JP5549014B2 (ja) | 免疫調節剤及びその利用 | |
| Owen et al. | Monocytes recruited to sites of inflammation express a distinctive proinflammatory (P) phenotype | |
| US20110268716A1 (en) | Methods for the enrichment of viable foxp3+ cells and uses thereof | |
| JP3917652B2 (ja) | 造血促進細胞及びその使用 | |
| Drakes et al. | Isolation and purification of colon lamina propria dendritic cells from mice with colitis | |
| CN107050436B (zh) | Mbl在制备预防或治疗效应t细胞引发疾病药物中的应用 | |
| Collins et al. | T Cell Depletion of Allogeneic Human Bone Marrow Grafts by Soybean Lectin Agglutination and Either Sheep Red Blood Cell Rosetting or Adherence on the CD5/CD8 Cellector™ | |
| EP2527428A1 (en) | Tolerogenic dendritic cells and their use in cell therapy | |
| EA035338B1 (ru) | Композиция гемопоэтических стволовых клеток с пониженной воспалительной активностью, ее получение и применение | |
| Barton et al. | Isolation of retinal lymphocytes in experimental autoimmune uveoretinitis: phenotypic and functional characterization. | |
| SILVA‐TEIXEIRA et al. | Human schistosomiasis: Modulation of in vitro granulomatous hypersensitivity and lymphocyte proliferative response by macrophages undergoing differentiation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |