AU2009299554B8 - P38 MAP kinase inhibitors - Google Patents

P38 MAP kinase inhibitors Download PDF

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Publication number
AU2009299554B8
AU2009299554B8 AU2009299554A AU2009299554A AU2009299554B8 AU 2009299554 B8 AU2009299554 B8 AU 2009299554B8 AU 2009299554 A AU2009299554 A AU 2009299554A AU 2009299554 A AU2009299554 A AU 2009299554A AU 2009299554 B8 AU2009299554 B8 AU 2009299554B8
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AU
Australia
Prior art keywords
compound
formula
allergic
asthma
conjunctivitis
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AU2009299554A
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AU2009299554B2 (en
AU2009299554A1 (en
Inventor
Catherine Elisabeth Charron
Kazuhiro Ito
John King-Underwood
Peter John Murray
Stuart Thomas Onions
William Garth Rapeport
Peter Strong
Jonathan Gareth Williams
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Respivert Ltd
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Respivert Ltd
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Publication of AU2009299554B2 publication Critical patent/AU2009299554B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2009299554A 2008-10-02 2009-10-02 P38 MAP kinase inhibitors Active AU2009299554B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0818033.3A GB0818033D0 (en) 2008-10-02 2008-10-02 Novel compound
GB0818033.3 2008-10-02
PCT/GB2009/051303 WO2010038085A2 (en) 2008-10-02 2009-10-02 P38 mapk kinase inhibitor

Publications (3)

Publication Number Publication Date
AU2009299554A1 AU2009299554A1 (en) 2010-04-08
AU2009299554B2 AU2009299554B2 (en) 2013-11-21
AU2009299554B8 true AU2009299554B8 (en) 2013-12-12

Family

ID=40019929

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009299554A Active AU2009299554B8 (en) 2008-10-02 2009-10-02 P38 MAP kinase inhibitors

Country Status (32)

Country Link
US (1) US8293771B2 (cg-RX-API-DMAC7.html)
EP (1) EP2350047B1 (cg-RX-API-DMAC7.html)
JP (1) JP5571088B2 (cg-RX-API-DMAC7.html)
KR (1) KR101660266B1 (cg-RX-API-DMAC7.html)
CN (1) CN102203078B (cg-RX-API-DMAC7.html)
AU (1) AU2009299554B8 (cg-RX-API-DMAC7.html)
CA (1) CA2738827C (cg-RX-API-DMAC7.html)
CL (1) CL2011000735A1 (cg-RX-API-DMAC7.html)
CO (1) CO6351785A2 (cg-RX-API-DMAC7.html)
CR (1) CR20110230A (cg-RX-API-DMAC7.html)
CY (1) CY1114665T1 (cg-RX-API-DMAC7.html)
DK (1) DK2350047T3 (cg-RX-API-DMAC7.html)
EA (1) EA019590B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP11010948A (cg-RX-API-DMAC7.html)
ES (1) ES2428917T3 (cg-RX-API-DMAC7.html)
GB (1) GB0818033D0 (cg-RX-API-DMAC7.html)
HN (1) HN2011000874A (cg-RX-API-DMAC7.html)
HR (1) HRP20130895T1 (cg-RX-API-DMAC7.html)
ME (1) ME01604B (cg-RX-API-DMAC7.html)
MX (1) MX2011003552A (cg-RX-API-DMAC7.html)
MY (1) MY150611A (cg-RX-API-DMAC7.html)
NI (1) NI201100062A (cg-RX-API-DMAC7.html)
NZ (1) NZ591426A (cg-RX-API-DMAC7.html)
PE (1) PE20110810A1 (cg-RX-API-DMAC7.html)
PL (1) PL2350047T3 (cg-RX-API-DMAC7.html)
PT (1) PT2350047E (cg-RX-API-DMAC7.html)
RS (1) RS52979B (cg-RX-API-DMAC7.html)
SI (1) SI2350047T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201300097B (cg-RX-API-DMAC7.html)
UA (2) UA105014C2 (cg-RX-API-DMAC7.html)
WO (1) WO2010038085A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201103181B (cg-RX-API-DMAC7.html)

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