AU2009297091B2 - Compositions and methods for achieving sustained therapeutic drug concentrations in a subject - Google Patents

Compositions and methods for achieving sustained therapeutic drug concentrations in a subject Download PDF

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Publication number
AU2009297091B2
AU2009297091B2 AU2009297091A AU2009297091A AU2009297091B2 AU 2009297091 B2 AU2009297091 B2 AU 2009297091B2 AU 2009297091 A AU2009297091 A AU 2009297091A AU 2009297091 A AU2009297091 A AU 2009297091A AU 2009297091 B2 AU2009297091 B2 AU 2009297091B2
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AU
Australia
Prior art keywords
days
administering
prodrug
once
irinotecan
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AU2009297091A
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AU2009297091A1 (en
Inventor
Tamra L. Barker
Michael A. Eldon
Shibani S. Harite
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Nektar Therapeutics
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Nektar Therapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AU2009297091A 2008-09-23 2009-09-23 Compositions and methods for achieving sustained therapeutic drug concentrations in a subject Active AU2009297091B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US9951608P 2008-09-23 2008-09-23
US61/099,516 2008-09-23
US10693108P 2008-10-20 2008-10-20
US61/106,931 2008-10-20
US17343309P 2009-04-28 2009-04-28
US61/173,433 2009-04-28
PCT/US2009/005284 WO2010036335A1 (en) 2008-09-23 2009-09-23 Compositions and methods for achieving sustained therapeutic drug concentrations in a subject

Publications (2)

Publication Number Publication Date
AU2009297091A1 AU2009297091A1 (en) 2010-04-01
AU2009297091B2 true AU2009297091B2 (en) 2015-03-05

Family

ID=41268391

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009297091A Active AU2009297091B2 (en) 2008-09-23 2009-09-23 Compositions and methods for achieving sustained therapeutic drug concentrations in a subject

Country Status (21)

Country Link
US (3) US8906353B2 (OSRAM)
EP (1) EP2349346B1 (OSRAM)
JP (3) JP2012503602A (OSRAM)
KR (1) KR20110063457A (OSRAM)
CN (1) CN102164617A (OSRAM)
AU (1) AU2009297091B2 (OSRAM)
CA (1) CA2736939C (OSRAM)
CY (1) CY1122208T1 (OSRAM)
DK (1) DK2349346T3 (OSRAM)
ES (1) ES2744975T3 (OSRAM)
HR (1) HRP20192120T1 (OSRAM)
HU (1) HUE047352T2 (OSRAM)
IL (1) IL211888A (OSRAM)
LT (1) LT2349346T (OSRAM)
MX (1) MX2011003063A (OSRAM)
PL (1) PL2349346T3 (OSRAM)
PT (1) PT2349346T (OSRAM)
RS (1) RS59607B1 (OSRAM)
SI (1) SI2349346T1 (OSRAM)
SM (1) SMT201900609T1 (OSRAM)
WO (1) WO2010036335A1 (OSRAM)

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RS59607B1 (sr) 2008-09-23 2020-01-31 Nektar Therapeutics Metod metronomskog doziranja kamptotecinskih prolekova (npr. peg-irinotekan)
WO2012137225A1 (en) * 2011-04-08 2012-10-11 Sphaera Pharma Pvt. Ltd Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
AU2013352223B2 (en) * 2012-11-28 2019-07-18 Nektar Therapeutics Method for assessing and predicting efficacy of breast cancer treatment with a long-acting topoisomerase I inhibitor
EP3258913A1 (en) * 2015-02-17 2017-12-27 Mallinckrodt Nuclear Medicine LLC Modified docetaxel liposome formulations and uses thereof
CN114224865A (zh) 2016-06-02 2022-03-25 因华生技制药股份有限公司 供癌症医疗的节拍式口服吉西他宾
CN106539557A (zh) * 2016-10-08 2017-03-29 西安交通大学 一种基于恒速静脉输入的药代动力学参数的测定方法
MX2021003116A (es) * 2018-09-17 2021-05-14 Childrens Hospital Philadelphia Profarmacos macromoleculares a base de polimero.
US20240156808A1 (en) * 2021-02-23 2024-05-16 Edison Oncology Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases
CN115317486B (zh) * 2022-08-17 2024-04-19 南昌大学 一种共载紫杉醇和伊立替康前药纳米制剂及其制备方法

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US20070197575A1 (en) * 2006-02-09 2007-08-23 Hong Zhao Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
CN101199857A (zh) * 2007-12-12 2008-06-18 中国药科大学 mPEG-PLA-喜树碱类药物的结合物

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Also Published As

Publication number Publication date
WO2010036335A1 (en) 2010-04-01
HRP20192120T1 (hr) 2020-02-21
ES2744975T3 (es) 2020-02-27
JP2012503602A (ja) 2012-02-09
MX2011003063A (es) 2011-04-21
US20150087668A1 (en) 2015-03-26
EP2349346A1 (en) 2011-08-03
PT2349346T (pt) 2019-10-24
IL211888A (en) 2015-08-31
IL211888A0 (en) 2011-06-30
PL2349346T3 (pl) 2020-03-31
SI2349346T1 (sl) 2019-12-31
US10525051B2 (en) 2020-01-07
JP2016216510A (ja) 2016-12-22
RS59607B1 (sr) 2020-01-31
US20180028525A1 (en) 2018-02-01
EP2349346B1 (en) 2019-08-28
CN102164617A (zh) 2011-08-24
CA2736939C (en) 2021-09-14
JP6076317B2 (ja) 2017-02-08
KR20110063457A (ko) 2011-06-10
AU2009297091A1 (en) 2010-04-01
CY1122208T1 (el) 2020-11-25
HUE047352T2 (hu) 2020-04-28
US20110269789A1 (en) 2011-11-03
CA2736939A1 (en) 2010-04-01
US8906353B2 (en) 2014-12-09
JP2015034180A (ja) 2015-02-19
LT2349346T (lt) 2019-09-25
US9801873B2 (en) 2017-10-31
SMT201900609T1 (it) 2020-01-14
DK2349346T3 (da) 2019-10-07

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