AU2009262241B2 - 1, 2 disubstituted heterocyclic compounds - Google Patents

1, 2 disubstituted heterocyclic compounds Download PDF

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Publication number
AU2009262241B2
AU2009262241B2 AU2009262241A AU2009262241A AU2009262241B2 AU 2009262241 B2 AU2009262241 B2 AU 2009262241B2 AU 2009262241 A AU2009262241 A AU 2009262241A AU 2009262241 A AU2009262241 A AU 2009262241A AU 2009262241 B2 AU2009262241 B2 AU 2009262241B2
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Australia
Prior art keywords
quinoline
och
optionally substituted
phenyl
mmol
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AU2009262241A
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AU2009262241A1 (en
Inventor
Richard Chesworth
Amy Ripka
Gideon Shapiro
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Forum Pharmaceuticals Inc
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EnVivo Phamaceuticals Inc
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Assigned to FORUM PHARMACEUTICALS INC. reassignment FORUM PHARMACEUTICALS INC. Request to Amend Deed and Register Assignors: ENVIVO PHARMACEUTICALS, INC.
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Psychiatry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009262241A 2008-06-25 2009-06-24 1, 2 disubstituted heterocyclic compounds Ceased AU2009262241B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US7559408P 2008-06-25 2008-06-25
US61/075,594 2008-06-25
US10916208P 2008-10-28 2008-10-28
US61/109,162 2008-10-28
US13886608P 2008-12-18 2008-12-18
US61/138,866 2008-12-18
US17641309P 2009-05-07 2009-05-07
US61/176,413 2009-05-07
PCT/US2009/048426 WO2009158393A1 (en) 2008-06-25 2009-06-24 1, 2 disubstituted heterocyclic compounds

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Publication Number Publication Date
AU2009262241A1 AU2009262241A1 (en) 2009-12-30
AU2009262241B2 true AU2009262241B2 (en) 2014-05-22

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AU2009262241A Ceased AU2009262241B2 (en) 2008-06-25 2009-06-24 1, 2 disubstituted heterocyclic compounds
AU2009262156A Abandoned AU2009262156A1 (en) 2008-06-25 2009-06-25 5- and 6-membered heterocyclic compounds

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AU2009262156A Abandoned AU2009262156A1 (en) 2008-06-25 2009-06-25 5- and 6-membered heterocyclic compounds

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US (7) US8071595B2 (cg-RX-API-DMAC7.html)
EP (2) EP2297133B1 (cg-RX-API-DMAC7.html)
JP (4) JP5658664B2 (cg-RX-API-DMAC7.html)
KR (2) KR20110031355A (cg-RX-API-DMAC7.html)
CN (2) CN102131801B (cg-RX-API-DMAC7.html)
AU (2) AU2009262241B2 (cg-RX-API-DMAC7.html)
BR (2) BRPI0914772A2 (cg-RX-API-DMAC7.html)
CA (2) CA2729259A1 (cg-RX-API-DMAC7.html)
MX (2) MX2011000175A (cg-RX-API-DMAC7.html)
TW (2) TWI542590B (cg-RX-API-DMAC7.html)
WO (2) WO2009158393A1 (cg-RX-API-DMAC7.html)

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MX2011000175A (es) * 2008-06-25 2011-06-27 Envivo Pharmaceuticals Inc Compuestos heterociclicos 1,2-di-substituidos.
PE20120900A1 (es) * 2009-05-07 2012-08-14 Envivo Pharmaceuticals Inc Compuestos heterociclicos de fenoximetilo
AU2010264698C1 (en) 2009-06-26 2013-05-16 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP 17
JP5785548B2 (ja) 2010-08-04 2015-09-30 武田薬品工業株式会社 縮合複素環化合物
JP5760085B2 (ja) * 2010-08-04 2015-08-05 武田薬品工業株式会社 縮合複素環化合物
TWI541244B (zh) 2010-09-20 2016-07-11 福倫製藥股份有限公司 咪唑三酮化合物
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