AU2009204568B2 - Novel cytostatic 7-deazapurine nucleosides - Google Patents

Novel cytostatic 7-deazapurine nucleosides Download PDF

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Publication number
AU2009204568B2
AU2009204568B2 AU2009204568A AU2009204568A AU2009204568B2 AU 2009204568 B2 AU2009204568 B2 AU 2009204568B2 AU 2009204568 A AU2009204568 A AU 2009204568A AU 2009204568 A AU2009204568 A AU 2009204568A AU 2009204568 B2 AU2009204568 B2 AU 2009204568B2
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ddd
compound
nmr
mhz
pct
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AU2009204568A1 (en
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Michal Hocek
Petr Naus
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Institute of Organic Chemistry and Biochemistry of ASCR vvi
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Institute of Organic Chemistry and Biochemistry of ASCR vvi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries
    • H02J7/40—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries characterised by the exchange of charge or discharge related data
    • H02J7/44—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries characterised by the exchange of charge or discharge related data between battery management systems and power sources
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries
    • H02J7/485—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries with provisions for charging different types of batteries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2009204568A 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides Active AU2009204568B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2224708P 2008-01-18 2008-01-18
US61/022,247 2008-01-18
PCT/CZ2009/000004 WO2009089804A1 (en) 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides

Publications (2)

Publication Number Publication Date
AU2009204568A1 AU2009204568A1 (en) 2009-07-23
AU2009204568B2 true AU2009204568B2 (en) 2013-10-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009204568A Active AU2009204568B2 (en) 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides

Country Status (18)

Country Link
US (1) US8093226B2 (https=)
EP (2) EP3133080B1 (https=)
JP (2) JP5485172B2 (https=)
CN (1) CN101977923B (https=)
AU (1) AU2009204568B2 (https=)
CA (1) CA2711384C (https=)
CY (2) CY1118104T1 (https=)
DK (2) DK2231689T3 (https=)
ES (2) ES2693551T3 (https=)
HR (2) HRP20161344T1 (https=)
HU (2) HUE041598T2 (https=)
LT (2) LT2231689T (https=)
NZ (1) NZ586610A (https=)
PL (2) PL2231689T3 (https=)
PT (2) PT2231689T (https=)
SI (2) SI3133080T1 (https=)
TR (1) TR201815961T4 (https=)
WO (1) WO2009089804A1 (https=)

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PT2421879E (pt) * 2009-04-22 2013-12-09 Acad Of Science Czech Republic Novos 7-deazapurina nucleósidos para utilizações terapêuticas
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
SI2432472T1 (sl) * 2009-05-22 2019-11-29 Incyte Holdings Corp 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (en) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
PE20130216A1 (es) 2010-05-21 2013-02-27 Incyte Corp Formulacion topica para un inhibidor de jak
KR101817221B1 (ko) * 2010-11-18 2018-01-10 카시나 라일라 이노바 파마슈티칼스 프라이빗 리미티드 치환된 4-(셀레노펜-2(또는 3)-일아미노)피리미딘 화합물 및 이의 사용방법
PE20140146A1 (es) 2010-11-19 2014-02-06 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
CN103797010B (zh) 2011-06-20 2016-02-24 因塞特控股公司 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
PH12020551186B1 (en) 2012-11-15 2024-03-20 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
RS62867B1 (sr) 2013-03-06 2022-02-28 Incyte Holdings Corp Postupci i intermedijeri za dobijanje inhibitora jak
SMT202000315T1 (it) 2013-08-07 2020-07-08 Incyte Corp Forme di dosaggio a rilascio prolungato per un inibitore di jak1
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
CA3029170C (en) 2016-06-29 2021-02-16 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
SG11202007164UA (en) 2018-01-30 2020-08-28 Incyte Corp Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
SMT202400306T1 (it) 2018-03-30 2024-09-16 Incyte Corp Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
WO2020206289A1 (en) * 2019-04-05 2020-10-08 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5
CN114008064A (zh) * 2019-06-18 2022-02-01 大鹏药品工业株式会社 具有吡咯并嘧啶骨架的新型的磷酸酯化合物或其药学上可接受的盐
CN115515593A (zh) * 2020-02-17 2022-12-23 勒芬天主教大学 作为药物的新的6-取代的7-脱氮嘌呤和相应的核苷
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN112190590A (zh) * 2020-11-06 2021-01-08 牡丹江医学院 一种治疗动脉粥样硬化的硒核苷及其药物组合物

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WO2003051899A1 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
WO2005021568A2 (en) * 2003-08-27 2005-03-10 Biota, Inc. Novel tricyclic nucleosides or nucleotides as therapeutic agents
WO2006065335A2 (en) * 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection

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WO2003051899A1 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
WO2005021568A2 (en) * 2003-08-27 2005-03-10 Biota, Inc. Novel tricyclic nucleosides or nucleotides as therapeutic agents
WO2006065335A2 (en) * 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection

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Also Published As

Publication number Publication date
HUE041598T2 (hu) 2019-05-28
JP2011509949A (ja) 2011-03-31
HUE030767T2 (en) 2017-05-29
CN101977923B (zh) 2014-10-08
CN101977923A (zh) 2011-02-16
EP2231689B1 (en) 2016-07-20
DK3133080T3 (en) 2018-11-26
HRP20181774T1 (hr) 2018-12-28
HRP20161344T1 (hr) 2016-11-18
SI2231689T1 (sl) 2016-11-30
ES2598503T3 (es) 2017-01-27
PL2231689T3 (pl) 2017-01-31
TR201815961T4 (tr) 2018-11-21
EP3133080A1 (en) 2017-02-22
NZ586610A (en) 2012-08-31
SI3133080T1 (sl) 2018-12-31
LT3133080T (lt) 2018-11-12
LT2231689T (lt) 2016-10-25
ES2693551T3 (es) 2018-12-12
DK2231689T3 (en) 2016-09-19
PL3133080T3 (pl) 2018-12-31
AU2009204568A1 (en) 2009-07-23
JP5485172B2 (ja) 2014-05-07
US8093226B2 (en) 2012-01-10
CA2711384A1 (en) 2009-07-23
EP3133080B1 (en) 2018-08-01
JP2014058567A (ja) 2014-04-03
CY1118104T1 (el) 2017-06-28
PT3133080T (pt) 2018-11-16
WO2009089804A1 (en) 2009-07-23
CA2711384C (en) 2016-07-26
US20090203637A1 (en) 2009-08-13
CY1121364T1 (el) 2020-05-29
EP2231689A1 (en) 2010-09-29
PT2231689T (pt) 2016-10-07

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