AU2009204464B2 - Therapeutic inhibitors of PAI-1 function and methods of their use - Google Patents
Therapeutic inhibitors of PAI-1 function and methods of their use Download PDFInfo
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- AU2009204464B2 AU2009204464B2 AU2009204464A AU2009204464A AU2009204464B2 AU 2009204464 B2 AU2009204464 B2 AU 2009204464B2 AU 2009204464 A AU2009204464 A AU 2009204464A AU 2009204464 A AU2009204464 A AU 2009204464A AU 2009204464 B2 AU2009204464 B2 AU 2009204464B2
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- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US2013708P | 2008-01-09 | 2008-01-09 | |
| US61/020,137 | 2008-01-09 | ||
| US8064008P | 2008-07-14 | 2008-07-14 | |
| US61/080,640 | 2008-07-14 | ||
| PCT/US2009/000155 WO2009089059A2 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of pai-1 function methods of their use |
Publications (2)
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| AU2009204464A1 AU2009204464A1 (en) | 2009-07-16 |
| AU2009204464B2 true AU2009204464B2 (en) | 2014-12-04 |
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| AU2009204464A Ceased AU2009204464B2 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of PAI-1 function and methods of their use |
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| US (2) | US8431363B2 (https=) |
| EP (1) | EP2242501A4 (https=) |
| JP (2) | JP2011509093A (https=) |
| KR (1) | KR101712208B1 (https=) |
| CN (1) | CN102123721A (https=) |
| AU (1) | AU2009204464B2 (https=) |
| BR (1) | BRPI0906867A2 (https=) |
| CA (1) | CA2711878A1 (https=) |
| IL (1) | IL206891A0 (https=) |
| MX (1) | MX2010007586A (https=) |
| RU (1) | RU2010133847A (https=) |
| WO (1) | WO2009089059A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0906867A2 (pt) | 2008-01-09 | 2019-09-24 | Intrexon Corp | inibidores terapêuticos da função pai-1 e métodos de uso dos mesmo |
| CN103154236B (zh) * | 2010-05-12 | 2016-08-31 | 再生医学Tx有限责任公司 | 生物活性肾细胞 |
| CN104271593B (zh) * | 2012-05-01 | 2018-01-16 | 富士胶片株式会社 | 多能干细胞的培养方法及该方法中使用的多肽 |
| CN103421781B (zh) * | 2012-07-04 | 2014-12-31 | 华中农业大学 | 猪肌肉组织特异性表达基因myf6启动子及应用 |
| KR20160089390A (ko) * | 2013-12-10 | 2016-07-27 | 에프. 호프만-라 로슈 아게 | 다중-하부단위 구조에 대한 약학적 활성 개체의 표적화 전달을 위한 다중-하부단위 구조의 하부단위의 결합 도메인의 용도 |
| WO2018107686A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗动脉粥样硬化及其并发症的方法 |
| JP7168990B2 (ja) | 2016-12-15 | 2022-11-10 | タレンゲン インターナショナル リミテッド | 肥満症を予防および治療するための方法および薬物 |
| TWI677348B (zh) | 2016-12-15 | 2019-11-21 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種改善心臟病變的方法 |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| CA3123872A1 (en) | 2018-12-28 | 2020-07-02 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| CN119656313B (zh) * | 2024-12-13 | 2026-02-17 | 四川大学华西医院 | Serpine1基因作为靶点在制备预防或治疗心肌纤维化药物中的用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
| DE10053251A1 (de) * | 2000-10-26 | 2002-05-08 | Boehringer Ingelheim Pharma | Epitope von PAI-1 |
| WO2003095476A2 (en) * | 2002-05-08 | 2003-11-20 | Thrombotech Ltd. | PEPTIDES FOR REGULATION OF UROKINASE (uPA) AND TISSUE TYPE (tPA) PLASMINOGEN ACTIVATOR AND METHOD OF OPTIMIZING THERAPEUTIC EFFICACY |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1191001A (en) * | 1999-10-07 | 2001-05-10 | Human Genome Sciences, Inc. | Plasminogen-like polynucleotides, polypeptides, and antibodies |
| US20030199463A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | DNA enzyme to inhibit plasminogen activator inhibitor-1 |
| JP2006507297A (ja) * | 2002-05-13 | 2006-03-02 | チルドレンズ・ホスピタル・ロサンジェルス | ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防 |
| US7241613B1 (en) * | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| US7785871B2 (en) | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| US20080050808A1 (en) * | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
| US7071295B2 (en) * | 2002-12-02 | 2006-07-04 | Intrexon Corporation | Signal for targeting molecules to the sarco(endo)plasmic reticulum |
| CA2509222A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| JP2007537755A (ja) | 2004-05-18 | 2007-12-27 | イントレクソン コーポレイション | Ｄｎａクローニングベクタープラスミドのダイナミックなベクター構築のための方法 |
| US8153598B2 (en) | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| WO2007048103A2 (en) | 2006-10-18 | 2007-04-26 | Intrexon Corporation | Pkd ligands and polynucleotides encoding pkd ligands |
| US7943732B2 (en) * | 2006-06-05 | 2011-05-17 | Intrexon Corporation | AKT ligands and polynucleotides encoding AKT ligands |
| US8993263B2 (en) * | 2006-08-07 | 2015-03-31 | Intrexon Corporation | PKA ligands and polynucleotides encoding PKA ligands |
| US8999666B2 (en) * | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
| US8283445B2 (en) * | 2006-11-13 | 2012-10-09 | Intrexon Corporation | Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide |
| US8729225B2 (en) * | 2006-11-13 | 2014-05-20 | Intrexon Corporation | Glycogen synthase kinase heteropolyligand polypeptide |
| US7705122B2 (en) * | 2006-12-04 | 2010-04-27 | Intrexon Corporation | mTOR ligands and polynucleotides encoding mTOR ligands |
| EP2537924B1 (en) | 2007-03-27 | 2015-03-18 | Intrexon Corporation | MEK ligands and polynucleotides encoding mek ligands |
| CA2722754A1 (en) * | 2007-04-27 | 2009-01-29 | The University Of Toledo | Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
| BRPI0906867A2 (pt) | 2008-01-09 | 2019-09-24 | Intrexon Corp | inibidores terapêuticos da função pai-1 e métodos de uso dos mesmo |
-
2009
- 2009-01-09 BR BRPI0906867A patent/BRPI0906867A2/pt not_active IP Right Cessation
- 2009-01-09 RU RU2010133847/10A patent/RU2010133847A/ru not_active Application Discontinuation
- 2009-01-09 CN CN2009801088638A patent/CN102123721A/zh active Pending
- 2009-01-09 US US12/812,127 patent/US8431363B2/en not_active Expired - Fee Related
- 2009-01-09 WO PCT/US2009/000155 patent/WO2009089059A2/en not_active Ceased
- 2009-01-09 MX MX2010007586A patent/MX2010007586A/es active IP Right Grant
- 2009-01-09 CA CA2711878A patent/CA2711878A1/en not_active Abandoned
- 2009-01-09 EP EP09700772A patent/EP2242501A4/en not_active Withdrawn
- 2009-01-09 KR KR1020107017701A patent/KR101712208B1/ko not_active Expired - Fee Related
- 2009-01-09 AU AU2009204464A patent/AU2009204464B2/en not_active Ceased
- 2009-01-09 JP JP2010542283A patent/JP2011509093A/ja not_active Withdrawn
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2010
- 2010-07-08 IL IL206891A patent/IL206891A0/en unknown
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2012
- 2012-01-18 JP JP2012008069A patent/JP2012135307A/ja not_active Withdrawn
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2013
- 2013-02-15 US US13/769,144 patent/US8828686B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
| DE10053251A1 (de) * | 2000-10-26 | 2002-05-08 | Boehringer Ingelheim Pharma | Epitope von PAI-1 |
| WO2003095476A2 (en) * | 2002-05-08 | 2003-11-20 | Thrombotech Ltd. | PEPTIDES FOR REGULATION OF UROKINASE (uPA) AND TISSUE TYPE (tPA) PLASMINOGEN ACTIVATOR AND METHOD OF OPTIMIZING THERAPEUTIC EFFICACY |
Non-Patent Citations (1)
| Title |
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| Eitzman, D.T et al, The Journal of Clinical Investigation (1995), Volume 95, pages 2416-2420. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8431363B2 (en) | 2013-04-30 |
| US20130267022A1 (en) | 2013-10-10 |
| BRPI0906867A2 (pt) | 2019-09-24 |
| EP2242501A2 (en) | 2010-10-27 |
| AU2009204464A1 (en) | 2009-07-16 |
| RU2010133847A (ru) | 2012-05-20 |
| CN102123721A (zh) | 2011-07-13 |
| EP2242501A4 (en) | 2011-10-19 |
| JP2011509093A (ja) | 2011-03-24 |
| US20110055940A1 (en) | 2011-03-03 |
| IL206891A0 (en) | 2010-12-30 |
| CA2711878A1 (en) | 2009-07-16 |
| JP2012135307A (ja) | 2012-07-19 |
| WO2009089059A2 (en) | 2009-07-16 |
| KR20100129271A (ko) | 2010-12-08 |
| WO2009089059A3 (en) | 2009-09-24 |
| KR101712208B1 (ko) | 2017-03-03 |
| MX2010007586A (es) | 2011-02-22 |
| US8828686B2 (en) | 2014-09-09 |
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