AU2008319122A1 - A novel alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production - Google Patents

A novel alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production Download PDF

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Publication number
AU2008319122A1
AU2008319122A1 AU2008319122A AU2008319122A AU2008319122A1 AU 2008319122 A1 AU2008319122 A1 AU 2008319122A1 AU 2008319122 A AU2008319122 A AU 2008319122A AU 2008319122 A AU2008319122 A AU 2008319122A AU 2008319122 A1 AU2008319122 A1 AU 2008319122A1
Authority
AU
Australia
Prior art keywords
amino
trifluoropentanamide
methyl
fluoro
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2008319122A
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English (en)
Inventor
Kevin W. Gillman
Richard E. Olson
John E. Starret Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40193955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2008319122(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU2008319122A1 publication Critical patent/AU2008319122A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2008319122A 2007-10-31 2008-10-14 A novel alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production Abandoned AU2008319122A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98411807P 2007-10-31 2007-10-31
US60/984,118 2007-10-31
PCT/US2008/079798 WO2009058552A1 (en) 2007-10-31 2008-10-14 A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production

Publications (1)

Publication Number Publication Date
AU2008319122A1 true AU2008319122A1 (en) 2009-05-07

Family

ID=40193955

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008319122A Abandoned AU2008319122A1 (en) 2007-10-31 2008-10-14 A novel alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production

Country Status (28)

Country Link
US (2) US8084477B2 (https=)
EP (3) EP2205575B1 (https=)
JP (1) JP5460605B2 (https=)
KR (1) KR20100075575A (https=)
CN (2) CN101910141B (https=)
AR (1) AR069135A1 (https=)
AT (1) ATE502022T1 (https=)
AU (1) AU2008319122A1 (https=)
BR (1) BRPI0818837A2 (https=)
CA (1) CA2704360A1 (https=)
CL (1) CL2008003271A1 (https=)
CO (1) CO6270332A2 (https=)
CY (2) CY1112337T1 (https=)
DE (1) DE602008005636D1 (https=)
DK (2) DK2205575T3 (https=)
EA (2) EA201171439A1 (https=)
ES (2) ES2390042T3 (https=)
HR (2) HRP20110219T1 (https=)
IL (1) IL205406A0 (https=)
MX (1) MX2010004319A (https=)
NZ (1) NZ584545A (https=)
PE (1) PE20091394A1 (https=)
PL (2) PL2205575T3 (https=)
PT (2) PT2295417E (https=)
SG (2) SG174044A1 (https=)
SI (2) SI2295417T1 (https=)
TW (1) TW200927099A (https=)
WO (1) WO2009058552A1 (https=)

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CN1289469C (zh) 2001-12-20 2006-12-13 布里斯托尔-迈尔斯斯奎布公司 α-(N-磺酰氨基)乙酰胺衍生物作为β-淀粉样蛋白抑制剂
US8093276B2 (en) * 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8044077B2 (en) * 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
JP2012520875A (ja) * 2009-03-19 2012-09-10 ブリストル−マイヤーズ スクイブ カンパニー ベータアミロイドペプチド産生阻害剤としての新規アルファ−(n−スルホンアミド)アセトアミド化合物
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US8252821B2 (en) * 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
BR122017023123B1 (pt) 2010-03-12 2018-04-24 Nippon Soda Co., Ltd. Método para produzir derivado de picolina halogenada
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
EP2643299B1 (en) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions
WO2014047370A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Fluoroalkyl dibenzodiazepinone compounds
WO2014047369A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinone compounds
EP2897960B1 (en) 2012-09-21 2016-08-03 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds as notch inhibitors
EP2897954B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Fluoroalkyl-1,4-benzodiazepinone compounds
CN103058913B (zh) * 2012-12-13 2015-09-30 江苏弘和药物研发有限公司 5-氯异吲哚酮的合成方法
CN104163784B (zh) * 2014-06-20 2019-01-08 湖南天地恒一制药有限公司 一种奥拉西坦的合成工艺
MX390370B (es) 2016-12-16 2025-03-20 Pipeline Therapeutics Inc Metodos para tratar la sinaptopatia coclear
WO2018201056A1 (en) 2017-04-28 2018-11-01 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3615068A1 (en) 2017-04-28 2020-03-04 Novartis AG Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
CN107935957B (zh) * 2017-12-02 2020-08-21 江苏仁明生物科技有限公司 一种合成高纯度沙坦侧链ttbb的方法
UY38251A (es) 2018-06-01 2019-12-31 Novartis Ag Moléculas de unión contra bcma y usos de las mismas
CN108640886A (zh) * 2018-08-01 2018-10-12 余锋 一种作为β-淀粉样肽产生的抑制剂BMS-708163的合成方法
KR20220024729A (ko) 2019-06-24 2022-03-03 노파르티스 아게 B-세포 성숙 항원을 표적으로 하는 다중특이성 항체에 대한 투여 요법 및 병용 요법
CN113466367B (zh) * 2021-06-25 2023-04-14 深圳万乐药业有限公司 乌苯美司原料药中α-苯乙胺杂质检测方法
CN113816874B (zh) * 2021-10-30 2024-01-26 大连双硼医药化工有限公司 一种合成4-氰基-2-氟苄醇的工艺方法

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US8044077B2 (en) * 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production

Also Published As

Publication number Publication date
HK1141801A1 (en) 2010-11-19
HRP20110219T1 (hr) 2011-04-30
PE20091394A1 (es) 2009-09-25
JP2011502153A (ja) 2011-01-20
PL2205575T3 (pl) 2011-09-30
EP2295417B1 (en) 2012-07-04
DK2205575T3 (da) 2011-07-11
IL205406A0 (en) 2010-12-30
DK2295417T3 (da) 2012-10-15
CY1112337T1 (el) 2015-12-09
PT2205575E (pt) 2011-05-23
CN102718689A (zh) 2012-10-10
CN101910141B (zh) 2012-12-19
SG174044A1 (en) 2011-09-29
EP2295417A1 (en) 2011-03-16
US20090111858A1 (en) 2009-04-30
BRPI0818837A2 (pt) 2015-04-22
US20120088925A1 (en) 2012-04-12
ES2390042T3 (es) 2012-11-06
EA201171439A1 (ru) 2012-05-30
DE602008005636D1 (de) 2011-04-28
CL2008003271A1 (es) 2009-07-10
HRP20120703T1 (hr) 2012-09-30
US8084477B2 (en) 2011-12-27
PL2295417T3 (pl) 2012-11-30
NZ584545A (en) 2011-04-29
EA016447B1 (ru) 2012-05-30
ATE502022T1 (de) 2011-04-15
HK1155161A1 (en) 2012-05-11
SG174043A1 (en) 2011-09-29
ES2361283T3 (es) 2011-06-15
US8350084B2 (en) 2013-01-08
MX2010004319A (es) 2010-04-30
AR069135A1 (es) 2009-12-30
CA2704360A1 (en) 2009-05-07
EP2205575B1 (en) 2011-03-16
TW200927099A (en) 2009-07-01
EA201000714A1 (ru) 2010-10-29
EP2205575A1 (en) 2010-07-14
EP2471769A1 (en) 2012-07-04
CO6270332A2 (es) 2011-04-20
CY1113346T1 (el) 2016-06-22
CN101910141A (zh) 2010-12-08
SI2295417T1 (sl) 2012-11-30
PT2295417E (pt) 2012-09-26
KR20100075575A (ko) 2010-07-02
JP5460605B2 (ja) 2014-04-02
SI2205575T1 (sl) 2011-07-29
WO2009058552A1 (en) 2009-05-07

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Legal Events

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application