AU2008271800B2 - Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives - Google Patents

Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives Download PDF

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Publication number
AU2008271800B2
AU2008271800B2 AU2008271800A AU2008271800A AU2008271800B2 AU 2008271800 B2 AU2008271800 B2 AU 2008271800B2 AU 2008271800 A AU2008271800 A AU 2008271800A AU 2008271800 A AU2008271800 A AU 2008271800A AU 2008271800 B2 AU2008271800 B2 AU 2008271800B2
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Prior art keywords
chloro
amino
fluoro
purine
nitro
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AU2008271800A1 (en
Inventor
Karel Dolezal
Jitka Frebortova
Petr Galuszka
Marketa Gemrotova
Thomas Schmulling
Lukas Spichal
Miroslav Strnad
Tomas Werner
Marek Zatloukal
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Syngenta Participations AG
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Syngenta Participations AG
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Assigned to UNIVERZITA PALACKEHO V OLOMOUCI, WERNER, TOMAS, SCHMULLING, THOMAS reassignment UNIVERZITA PALACKEHO V OLOMOUCI Amend patent request/document other than specification (104) Assignors: FREIE UNIVERSITAT BERLIN, UNIVERZITA PALACKEHO V OLOMOUCI
Assigned to UNIVERZITA PALACKEHO V OLOMOUCI reassignment UNIVERZITA PALACKEHO V OLOMOUCI Request for Assignment Assignors: SCHMULLING, THOMAS, UNIVERZITA PALACKEHO V OLOMOUCI, WERNER, TOMAS
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Assigned to SYNGENTA PARTICIPATIONS AG reassignment SYNGENTA PARTICIPATIONS AG Request for Assignment Assignors: UNIVERZITA PALACKEHO V OLOMOUCI
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2008271800A 2007-07-04 2008-07-02 Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives Active AU2008271800B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2007-453 2007-07-04
CZ20070453A CZ302225B6 (cs) 2007-07-04 2007-07-04 Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny
PCT/CZ2008/000074 WO2009003428A2 (en) 2007-07-04 2008-07-02 Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives

Publications (2)

Publication Number Publication Date
AU2008271800A1 AU2008271800A1 (en) 2009-01-08
AU2008271800B2 true AU2008271800B2 (en) 2013-10-17

Family

ID=40226563

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008271800A Active AU2008271800B2 (en) 2007-07-04 2008-07-02 Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives

Country Status (13)

Country Link
US (1) US8222260B2 (ja)
EP (1) EP2173173B1 (ja)
JP (1) JP5539866B2 (ja)
AU (1) AU2008271800B2 (ja)
BR (1) BRPI0812865B8 (ja)
CA (1) CA2691625C (ja)
CZ (1) CZ302225B6 (ja)
DK (1) DK2173173T3 (ja)
ES (1) ES2431926T3 (ja)
NZ (1) NZ582642A (ja)
PL (1) PL2173173T3 (ja)
PT (1) PT2173173E (ja)
WO (1) WO2009003428A2 (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101612855B1 (ko) * 2008-10-20 2016-04-15 가부시키가이샤 리켄그린 벼과 잡초용 생육 조절제
CZ306894B6 (cs) 2013-02-08 2017-08-30 Univerzita PalackĂ©ho v Olomouci 2-Substituované-6-biarylmethylamino-9-cyklopentyl-9H-purinové deriváty, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující
US9938279B2 (en) * 2013-04-09 2018-04-10 Energenesis Biomedical Co., Ltd Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
BR112016013524B1 (pt) * 2013-12-11 2021-08-24 Fine Agrochemicals Limited Concentrado de suspensão dispersivo em água e composição de tratamento de plantas compreendendo o mesmo
EP3233860B1 (en) 2014-12-15 2020-01-29 Univerzita Palackého V Olomouci Substituted 6-anilino-9-heterocyclylpurine derivatives for inhibition of plant stress
ITUB20153115A1 (it) * 2015-08-13 2017-02-13 Diapath S P A Nuova composizione fissativa per campioni di materiale biologico.
GB201610264D0 (en) * 2016-06-13 2016-07-27 Syngenta Participations Ag Pesticidal compositions
WO2017216003A1 (en) 2016-06-14 2017-12-21 Syngenta Participations Ag Abiotic stress tolerance
WO2017216005A1 (en) 2016-06-14 2017-12-21 Syngenta Participations Ag Use of 6-anilino purine derivatives to improve heat stress tolerance of rice seedlings
AU2017345736B2 (en) 2016-10-21 2022-04-07 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
WO2018217884A1 (en) 2017-05-23 2018-11-29 Regents Of The University Of Minnesota Antibacterial agents including histidine kinase inhibitors
AU2018383990B2 (en) * 2017-12-12 2024-03-14 Syngenta Participations Ag Plant growth regulation
CN108371662B (zh) * 2018-02-06 2023-03-03 中国药科大学 一种五元杂环并嘧啶类化合物的应用
CN110407836B (zh) * 2019-08-15 2022-03-29 沈阳化工研究院有限公司 一种9-（2-甲氧基乙基）-9h-嘌呤-6-胺衍生物及其应用
CN110642859B (zh) * 2019-10-11 2021-11-09 青岛科技大学 一种含嘧啶硫酮嘌呤类化合物及其用途
CZ309368B6 (cs) * 2020-05-17 2022-10-12 Univerzita Palackého v Olomouci Mesylátové soli heterocyklických cytokininů, přípravky obsahující tyto deriváty a jejich použití
WO2022012702A1 (en) 2020-07-13 2022-01-20 Univerzita Palackeho V Olomouci Nitrogen heterocyclic cytokinin derivatives, compositions containing these derivatives and use thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0155911A1 (de) * 1984-03-19 1985-09-25 Ciba-Geigy Ag Purinderivate zur Regulierung des Pflanzenwachstums
WO1997016452A1 (en) * 1995-11-01 1997-05-09 Novartis Ag Purine derivatives and processes for their preparation

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US3118753A (en) * 1961-04-14 1964-01-21 Shive William Plant growth stimulating composition and method employing mixtures of a gibberellic acid and purine compound
ES2140392T5 (es) * 1991-05-16 2004-10-16 Senetek, Plc Metodo y composicion para mejorar los efectos adversos del envejecimiento.
US5663154A (en) * 1992-01-06 1997-09-02 Glaxo Wellcome Inc. 2',3'-dideoxy-3'-fluoro-purine ribonucleosides
AU715538B2 (en) 1996-03-15 2000-02-03 Syngenta Participations Ag Herbicidal synergistic composition and method of weed control
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20070161582A1 (en) * 2003-08-08 2007-07-12 Dusan Mijikovic Pharmaceutical compositions and methods for metabolic modulation
MXPA06001758A (es) * 2003-08-15 2006-08-11 Irm Llc Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk.
GB0407723D0 (en) * 2004-04-05 2004-05-12 Novartis Ag Organic compounds

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0155911A1 (de) * 1984-03-19 1985-09-25 Ciba-Geigy Ag Purinderivate zur Regulierung des Pflanzenwachstums
WO1997016452A1 (en) * 1995-11-01 1997-05-09 Novartis Ag Purine derivatives and processes for their preparation

Non-Patent Citations (8)

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Title
ANDERSEN, J. et al, "Synthesis of N6-Aryl-2-methyladenosines." Acta Chemica Scandanavica, Series B, 1987, B41(6), 473-475. *
ANDERSEN, K. et al, "A One-step Synthesis of 2-Methyl-N6-aryladenines from 5-Acetylamino-1H-imidazole- 4-carboxamide Hydrochloride." Liebigs Annalen der Chemie, 1985, 5, 921-928. *
BUSCA, P. et al, "Synthesis of C-Nucleosidic ATP Mimics as Potential FGFR3 Inhibitors." European Journal of Organic Chemistry, 2006, 10, 2403-2409. *
ERBA, E. et al, "v-Triazolines. Part 38. New Synthesis of 4-aminoquinazolines and 6-aminopurines." Journal of the Chemical Society, Perkin Transactions 1, 1997, 20, 3021-3024. *
HUANG, L.-K., et al, "An Efficient Synthesis of Substituted cytosines and Purines Under Focused Microwave Irradiation." Tetrahedron, 2007, 63(24), 5323-5327. *
Qu, G. et al, "Microwave Assisted Synthesis of 6-Substituted Aminopurine Analogs in Water." Journal of the Brazilian Chemical Society, 2006, 17(5), 915-922. *
Qu, G. et al, "Microwave-assisted Regioselective Synthesis of Acyclic Nucleosides Through an Alkylating Reaction with 2-oxa-1,4-butanediol Diacetate." Canadian Journal of Chemistry, 2006, 84(5), 819-824. *
YAKOUT, E.-S. et al, "Phosphorus Pentoxide in Organic Synthesis. XXXVII. Synthesis of 2-Amino-6-arylaminopurines." Acta Chemica Scandanavica, Series B, 1988, B42(4), 257-258. *

Also Published As

Publication number Publication date
CZ2007453A3 (cs) 2009-02-11
AU2008271800A1 (en) 2009-01-08
BRPI0812865A2 (pt) 2014-10-07
DK2173173T3 (da) 2013-11-04
JP5539866B2 (ja) 2014-07-02
BRPI0812865B8 (pt) 2022-09-20
CZ302225B6 (cs) 2010-12-29
WO2009003428A3 (en) 2009-09-03
EP2173173A2 (en) 2010-04-14
EP2173173B1 (en) 2013-07-24
CA2691625A1 (en) 2009-01-08
BRPI0812865B1 (pt) 2019-09-03
ES2431926T3 (es) 2013-11-28
PT2173173E (pt) 2013-10-22
NZ582642A (en) 2011-06-30
US20100190806A1 (en) 2010-07-29
US8222260B2 (en) 2012-07-17
CA2691625C (en) 2014-12-09
JP2010531818A (ja) 2010-09-30
PL2173173T3 (pl) 2014-07-31
WO2009003428A2 (en) 2009-01-08

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Owner name: UNIVERZITA PALACKEHO V OLOMOUCI

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Owner name: SYNGENTA PARTICIPATIONS AG

Free format text: FORMER OWNER WAS: UNIVERZITA PALACKEHO V OLOMOUCI