AU2008259776A1 - Benzamide mGluR5 positive allosteric modulators and methods of making and using same - Google Patents
Benzamide mGluR5 positive allosteric modulators and methods of making and using same Download PDFInfo
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- AU2008259776A1 AU2008259776A1 AU2008259776A AU2008259776A AU2008259776A1 AU 2008259776 A1 AU2008259776 A1 AU 2008259776A1 AU 2008259776 A AU2008259776 A AU 2008259776A AU 2008259776 A AU2008259776 A AU 2008259776A AU 2008259776 A1 AU2008259776 A1 AU 2008259776A1
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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CA2784830C (en) | 2009-12-18 | 2018-03-27 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
US9174953B2 (en) | 2009-12-18 | 2015-11-03 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mGluR5 receptors |
EA021568B1 (ru) | 2009-12-23 | 2015-07-30 | Такеда Фармасьютикал Компани Лимитед | Конденсированные гетероароматические пирролидиноны как ингибиторы syk |
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CN103037693A (zh) * | 2010-05-24 | 2013-04-10 | 范德比尔特大学 | 作为mglur5正向变构调节剂的取代的6-甲基烟酰胺 |
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PH12013501928A1 (en) | 2011-04-26 | 2013-11-25 | Hoffmann La Roche | Pyrazolidin-3-one derivatives |
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UA110862C2 (uk) | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
UA110995C2 (uk) | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
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MY167810A (en) | 2012-07-17 | 2018-09-26 | Hoffmann La Roche | Arylethynyl derivatives |
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CN104684911B (zh) | 2012-09-27 | 2017-05-10 | 霍夫曼-拉罗奇有限公司 | 芳基乙炔基衍生物 |
EA025667B1 (ru) * | 2012-10-18 | 2017-01-30 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ЭТИНИЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ АКТИВНОСТИ РЕЦЕПТОРА mGluR5 |
JP5989253B2 (ja) * | 2012-10-18 | 2016-09-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | mGluR5受容体活性のモジュレータとしてのエチニル誘導体 |
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TWI649310B (zh) * | 2014-01-10 | 2019-02-01 | 赫孚孟拉羅股份公司 | 乙炔基衍生物 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
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PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
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- 2008-06-03 WO PCT/US2008/065647 patent/WO2008151184A1/en active Application Filing
- 2008-06-03 KR KR1020097027281A patent/KR20100033981A/ko not_active Withdrawn
- 2008-06-03 CN CN200880100770.6A patent/CN101795689B/zh not_active Expired - Fee Related
- 2008-06-03 EA EA200971143A patent/EA200971143A1/ru unknown
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IL202508A0 (en) | 2010-06-30 |
CN101795689B (zh) | 2014-11-19 |
SG185285A1 (en) | 2012-11-29 |
CN101795689A (zh) | 2010-08-04 |
KR20100033981A (ko) | 2010-03-31 |
EP2162136A1 (en) | 2010-03-17 |
BRPI0812363A2 (pt) | 2015-02-03 |
JP5622568B2 (ja) | 2014-11-12 |
CA2689282A1 (en) | 2008-12-11 |
WO2008151184A1 (en) | 2008-12-11 |
MX2009013169A (es) | 2010-04-30 |
AU2008259776A2 (en) | 2010-01-28 |
EA200971143A1 (ru) | 2010-06-30 |
JP2010529135A (ja) | 2010-08-26 |
HK1147068A1 (en) | 2011-07-29 |
NZ581817A (en) | 2012-05-25 |
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