AU2008209296B2 - Fused aromatic PTP-1B inhibitors - Google Patents
Fused aromatic PTP-1B inhibitors Download PDFInfo
- Publication number
- AU2008209296B2 AU2008209296B2 AU2008209296A AU2008209296A AU2008209296B2 AU 2008209296 B2 AU2008209296 B2 AU 2008209296B2 AU 2008209296 A AU2008209296 A AU 2008209296A AU 2008209296 A AU2008209296 A AU 2008209296A AU 2008209296 B2 AU2008209296 B2 AU 2008209296B2
- Authority
- AU
- Australia
- Prior art keywords
- optionally substituted
- halogens
- phenyl
- group
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
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- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3834—Aromatic acids (P-C aromatic linkage)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89770007P | 2007-01-26 | 2007-01-26 | |
| US60/897,700 | 2007-01-26 | ||
| PCT/CA2008/000172 WO2008089581A1 (en) | 2007-01-26 | 2008-01-24 | Fused aromatic ptp-1b inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008209296A1 AU2008209296A1 (en) | 2008-07-31 |
| AU2008209296B2 true AU2008209296B2 (en) | 2012-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008209296A Ceased AU2008209296B2 (en) | 2007-01-26 | 2008-01-24 | Fused aromatic PTP-1B inhibitors |
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| EP (1) | EP2114971B1 (enExample) |
| JP (1) | JP5570223B2 (enExample) |
| KR (1) | KR101568799B1 (enExample) |
| CN (1) | CN102317296B (enExample) |
| AU (1) | AU2008209296B2 (enExample) |
| BR (1) | BRPI0806789B8 (enExample) |
| CA (1) | CA2675142C (enExample) |
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| ES (1) | ES2547386T3 (enExample) |
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| MX (1) | MX2009007911A (enExample) |
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| RU (1) | RU2462469C2 (enExample) |
| WO (1) | WO2008089581A1 (enExample) |
| ZA (1) | ZA200904679B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2114971B1 (en) * | 2007-01-26 | 2015-06-17 | Kaneq Pharma Inc. | Fused aromatic ptp-1b inhibitors |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013155600A1 (en) | 2012-04-16 | 2013-10-24 | Kaneq Pharma | Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors |
| WO2014141110A2 (en) * | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
| CA2977839C (en) * | 2014-02-28 | 2022-07-26 | The Royal Institution For The Advancement Of Learning / Mcgill University | Tc-ptp inhibitors as apc activators for immunotherapy |
| CN108159069A (zh) * | 2018-01-26 | 2018-06-15 | 广东省微生物研究所（广东省微生物分析检测中心） | 灰树花多糖f2在制备治疗高脂血症药物、预防或延缓动脉粥样硬化药物中的应用 |
| WO2023220833A1 (en) * | 2022-05-19 | 2023-11-23 | Kanyr Pharma Inc. | Combined inhibition of tyrosine phosphatases tcptp and ptp1b and pd-1 blockage immunotherapy in the treatment of cancer |
| WO2024123585A1 (en) * | 2022-12-05 | 2024-06-13 | Merck Sharp & Dohme Llc | Substituted quinazoline derivatives and methods of use thereof |
Citations (1)
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|---|---|---|---|---|
| WO2001070754A1 (en) * | 2000-03-22 | 2001-09-27 | Merck Frosst Canada & Co. | Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors |
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|---|---|---|---|---|
| FI83421C (fi) * | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| US6174874B1 (en) * | 1998-09-21 | 2001-01-16 | Merck Frosst Canada & Co. | Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) |
| JP2003518130A (ja) * | 1999-12-22 | 2003-06-03 | メルク フロスト カナダ アンド カンパニー | 蛋白チロシンホスファターゼ１ｂ（ｐｔｐ−１ｂ）阻害薬としてのホスホン酸誘導体 |
| ATE362468T1 (de) | 2000-07-25 | 2007-06-15 | Merck & Co Inc | N-substituierte indole mit anwendung in der behandlung von diabetes |
| KR20050057074A (ko) | 2002-08-29 | 2005-06-16 | 머크 앤드 캄파니 인코포레이티드 | 항당뇨 활성을 갖는 인돌 |
| MY153011A (en) * | 2004-01-30 | 2014-12-31 | Medivir Ab | Hcv ns-3 serine protease inhibitors |
| AU2005233160B2 (en) | 2004-04-13 | 2011-06-02 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| CN101094677A (zh) | 2004-11-15 | 2007-12-26 | 塞普泰尔公司 | 蛋白酪氨酸磷酸酶抑制剂及其使用方法 |
| EP2114971B1 (en) * | 2007-01-26 | 2015-06-17 | Kaneq Pharma Inc. | Fused aromatic ptp-1b inhibitors |
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2008
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- 2008-01-24 AU AU2008209296A patent/AU2008209296B2/en not_active Ceased
- 2008-01-24 MX MX2009007911A patent/MX2009007911A/es active IP Right Grant
- 2008-01-24 JP JP2009546627A patent/JP5570223B2/ja not_active Expired - Fee Related
- 2008-01-24 NZ NZ600947A patent/NZ600947A/xx not_active IP Right Cessation
- 2008-01-24 BR BRPI0806789A patent/BRPI0806789B8/pt not_active IP Right Cessation
- 2008-01-24 RU RU2009132092/04A patent/RU2462469C2/ru not_active IP Right Cessation
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- 2008-01-24 ES ES08706319.4T patent/ES2547386T3/es active Active
- 2008-01-24 KR KR1020097017809A patent/KR101568799B1/ko not_active Expired - Fee Related
- 2008-01-24 NZ NZ578296A patent/NZ578296A/en not_active IP Right Cessation
- 2008-01-24 DK DK08706319.4T patent/DK2114971T3/en active
- 2008-01-24 CA CA2675142A patent/CA2675142C/en not_active Expired - Fee Related
- 2008-01-24 WO PCT/CA2008/000172 patent/WO2008089581A1/en not_active Ceased
- 2008-01-24 CN CN200880010110.9A patent/CN102317296B/zh not_active Expired - Fee Related
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2009
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2012
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2013
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2014
- 2014-10-28 US US14/525,396 patent/US9334295B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001070754A1 (en) * | 2000-03-22 | 2001-09-27 | Merck Frosst Canada & Co. | Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors |
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| Montalibet J. et aI, "Residues distant from the active site influence proteintyrosine phosphatase lB inhibitor binding", J. Biol. Chem. 2006,281(8), 5258-5266. * |
| Montalibet J. et aI, "Using yeast to screen for inhibitors of protein tyrosine phosphatase lB" "Biochem. Pharmacol. 2004,68,1807-1814. * |
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