AU2008206441B2 - N-substituted glycine derivatives: hydroxylase inhibitors - Google Patents

N-substituted glycine derivatives: hydroxylase inhibitors Download PDF

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Publication number
AU2008206441B2
AU2008206441B2 AU2008206441A AU2008206441A AU2008206441B2 AU 2008206441 B2 AU2008206441 B2 AU 2008206441B2 AU 2008206441 A AU2008206441 A AU 2008206441A AU 2008206441 A AU2008206441 A AU 2008206441A AU 2008206441 B2 AU2008206441 B2 AU 2008206441B2
Authority
AU
Australia
Prior art keywords
oxo
hydroxy
dihydro
glycine
pyridazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008206441A
Other languages
English (en)
Other versions
AU2008206441A1 (en
Inventor
Kevin J. Duffy
William Henry Miller
Andrea K. Myers
Antony N. Shaw
Michael N. Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39636631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2008206441(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of AU2008206441A1 publication Critical patent/AU2008206441A1/en
Application granted granted Critical
Publication of AU2008206441B2 publication Critical patent/AU2008206441B2/en
Assigned to GLAXOSMITHKLINE LLC reassignment GLAXOSMITHKLINE LLC Request to Amend Deed and Register Assignors: SMITHKLINE BEECHAM CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2008206441A 2007-01-12 2008-01-11 N-substituted glycine derivatives: hydroxylase inhibitors Ceased AU2008206441B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88471007P 2007-01-12 2007-01-12
US60/884,710 2007-01-12
PCT/US2008/050833 WO2008089052A2 (en) 2007-01-12 2008-01-11 N-substituted glycine derivatives: hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
AU2008206441A1 AU2008206441A1 (en) 2008-07-24
AU2008206441B2 true AU2008206441B2 (en) 2014-06-19

Family

ID=39636631

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008206441A Ceased AU2008206441B2 (en) 2007-01-12 2008-01-11 N-substituted glycine derivatives: hydroxylase inhibitors

Country Status (20)

Country Link
US (2) US7608621B2 (enExample)
EP (2) EP2124565B1 (enExample)
JP (1) JP5313925B2 (enExample)
KR (1) KR101458655B1 (enExample)
CN (1) CN101626685B (enExample)
AR (1) AR064878A1 (enExample)
AU (1) AU2008206441B2 (enExample)
BR (1) BRPI0806566A2 (enExample)
CA (1) CA2675252C (enExample)
CL (1) CL2008000066A1 (enExample)
DK (1) DK2124565T3 (enExample)
EA (1) EA017112B1 (enExample)
ES (2) ES2528745T3 (enExample)
HR (1) HRP20150119T1 (enExample)
MX (1) MX2009007548A (enExample)
PL (1) PL2124565T3 (enExample)
PT (1) PT2124565E (enExample)
SI (1) SI2124565T1 (enExample)
TW (1) TW200845991A (enExample)
WO (1) WO2008089052A2 (enExample)

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US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
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EP2064207B1 (en) * 2006-09-19 2013-11-06 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
ES2523720T3 (es) 2008-04-28 2014-12-01 Janssen Pharmaceutica, N.V. Benzoimidazoles como inhibidores de prolilhidroxilasa
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WO2011048611A1 (en) * 2009-10-07 2011-04-28 Torrent Pharmaceuticals Limited Novel fused pyridazine derivatives
PT2492266E (pt) 2009-10-21 2015-11-18 Daiichi Sankyo Co Ltd Derivado de 5-hidroxipirimidino-4-carboxamida
PL2496236T4 (pl) 2009-11-06 2015-11-30 Aerpio Therapeutics Inc Inhibitory hydroksylazy prolilowej
US20130065833A1 (en) * 2010-03-19 2013-03-14 Northwestern University Alkylated sp-b peptoid compounds and related lung surfactant compositions
CN103608346B (zh) 2011-02-02 2016-06-15 菲布罗根有限公司 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物
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CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
ES2574262T3 (es) 2011-10-25 2016-06-16 Janssen Pharmaceutica, N.V. Formulaciones de sal de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico
ES2674813T3 (es) 2012-07-30 2018-07-04 Taisho Pharmaceutical Co., Ltd. Compuesto heterocíclico que contiene nitrógeno parcialmente saturado
PT3007695T (pt) 2013-06-13 2024-03-07 Akebia Therapeutics Inc Composições e métodos para tratamento de anemia
CN109810104B (zh) 2013-11-08 2022-05-03 因赛特控股公司 用于合成吲哚胺2,3-双加氧酶抑制剂的方法
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
US10065928B2 (en) 2014-09-02 2018-09-04 Sunshine Lake Pharma Co., Ltd. Quinolinone compound and use thereof
CN107427503A (zh) 2015-01-23 2017-12-01 阿克比治疗有限公司 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
CR20170450A (es) 2015-04-01 2018-04-03 Akebia Therapeutics Inc Composiciones y métodos para el tratamiento de la anemia
CN105130888A (zh) * 2015-10-09 2015-12-09 中国药科大学 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途
JP7011830B2 (ja) 2015-10-14 2022-01-27 エックス－サーマ インコーポレイテッド 氷晶形成を低減するための組成物および方法
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
WO2021127273A1 (en) * 2019-12-20 2021-06-24 Gb004, Inc. 1 -((6-oxo-1,6-dihydropyridazin-4-yl)methyl)piperazine and 1 -((6-oxo-1,6-dihydropyrimidin-4-yl)methyl)piperazine derivatives as prolyl hydroxylase, hif-1 alpha and pgk modulators for use in treating inflammatory diseases, cancer or infections
WO2022179967A1 (en) 2021-02-23 2022-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Vadadustat for treating covid-19 in a hospitalized subject

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Also Published As

Publication number Publication date
WO2008089052A3 (en) 2008-09-18
AR064878A1 (es) 2009-04-29
ES2528745T3 (es) 2015-02-12
JP5313925B2 (ja) 2013-10-09
ES2614355T3 (es) 2017-05-30
WO2008089052A2 (en) 2008-07-24
US20080214549A1 (en) 2008-09-04
CA2675252A1 (en) 2008-07-24
EP2124565A4 (en) 2011-06-29
PL2124565T3 (pl) 2015-05-29
SI2124565T1 (sl) 2015-04-30
HRP20150119T1 (hr) 2015-05-08
MX2009007548A (es) 2009-07-22
AU2008206441A1 (en) 2008-07-24
EP2124565A2 (en) 2009-12-02
CN101626685A (zh) 2010-01-13
EP2889289B1 (en) 2016-12-21
US7608621B2 (en) 2009-10-27
PT2124565E (pt) 2015-03-26
DK2124565T3 (en) 2015-02-09
EA200970680A1 (ru) 2010-02-26
TW200845991A (en) 2008-12-01
JP2010515756A (ja) 2010-05-13
CN101626685B (zh) 2013-03-13
EP2889289A1 (en) 2015-07-01
BRPI0806566A2 (pt) 2014-05-06
USRE44613E1 (en) 2013-11-26
EP2124565B1 (en) 2015-01-07
KR101458655B1 (ko) 2014-11-05
CL2008000066A1 (es) 2008-08-01
KR20090101376A (ko) 2009-09-25
CA2675252C (en) 2015-05-26
EA017112B1 (ru) 2012-09-28

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: GLAXOSMITHKLINE LLC

Free format text: FORMER NAME(S): SMITHKLINE BEECHAM CORPORATION

MK14 Patent ceased section 143(a) (annual fees not paid) or expired